Conclusion
Recent progress in the understanding of the Hedgehog pathway and the development of molecules that modulate its activity opens new avenues for the treatment of a number of devastating diseases. Inhibitors of the pathway, small molecules or antibodies may prove useful for highly aggressive cancers such as pancreatic tumors or medulloblastoma, the most common childhood brain tumor. On the other hand, small molecule agonists of the pathway provide new therapeutic options for the treatment of neurodegenerative disorders such as Parkinson’s disease.
Keywords
- Basal Cell Carcinoma
- Sonic Hedgehog
- Hedgehog Signaling
- Hedgehog Pathway
- Nevoid Basal Cell Carcinoma Syndrome
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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de Sauvage, F.J., Rubin, L.L. (2006). Modulating the Hedgehog Pathway in Diseases. In: Hedgehog-Gli Signaling in Human Disease. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-33777-6_16
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DOI: https://doi.org/10.1007/0-387-33777-6_16
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