Advertisement

The FANC Genome Surveillance Complex

  • Takayuki Yamashita
Chapter
  • 428 Downloads
Part of the Medical Intelligence Unit book series

Keywords

Core Complex Fanconi Anemia Complementation Group Nuclear Focus Fanconi Anemia Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Duckworth-Rysiecki G, Cornish K, Clarke CA et al. Identification of two complementation groups in Fanconi anemia. Somat Cell Mol Genet 1985; 11:35–41.PubMedCrossRefGoogle Scholar
  2. 2.
    Strathdee CA, Duncan AM, Buchwald M. Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9. Nat Genet 1992; 1:196–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Strathdee CA, Gavish H, Shannon WR et al. Cloning of cDNAs for Fanconi’s anaemia by functional complementation. Nature 1992; 356:763–7.PubMedCrossRefGoogle Scholar
  4. 4.
    Lo Ten Foe JR, Rooimans MA, Bosnoyan-Collins L et al. Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA. Nat Genet 1996; 14:320–3.Google Scholar
  5. 5.
    The Fanconi anaemia/breast cancer consortium. Positional cloning of the Fanconi anaemia group A gene. The Fanconi anaemia/breast cancer consortium. Nat Genet 1996; 14:324–8.CrossRefGoogle Scholar
  6. 6.
    Kupfer GM, Naf D, Suliman A et al. The Fanconi anaemia proteins, FAA and FAC interact to form a nuclear complex. Nat Genet 1997; 17:487–490.PubMedCrossRefGoogle Scholar
  7. 7.
    Yamashita T, Barber DL, Zhu Y et al. The Fanconi anemia polypeptide FACC is localized to the cytoplasm. Proc Natl Acad Sci USA 1994; 91:6712–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Youssoufian H. Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells. Proc Natl Acad Sci USA 1994; 91:7975–9.PubMedCrossRefGoogle Scholar
  9. 9.
    Kruyt FA, Youssoufian H. The Fanconi anemia proteins FAA and FAC function in different cellular compartments to protect against cross-linking agent cytotoxicity. Blood 1998; 92:2229–36.PubMedGoogle Scholar
  10. 10.
    Joenje H, Oostra AB, Wijker M et al. Evidence for at least eight Fanconi anemia genes. Am J Hum Genet 1997; 61:940–4.PubMedGoogle Scholar
  11. 11.
    Joenje H, Levitus M, Waisfisz Q et al. Complementation analysis in Fanconi anemia: Assignment of the reference FA-H patient to group A. Am J Hum Genet 2000; 67:759–62.PubMedCrossRefGoogle Scholar
  12. 12.
    Yamashita T, Kupfer GM, Naf D et al. The Fanconi anemia pathway requires FAA phosphoryla-tion and FAA/FAC nuclear accumulation. Proc Natl Acad Sci USA 1998; 95:13085–13090.PubMedCrossRefGoogle Scholar
  13. 13.
    de Winter JP, Waisfisz Q, Rooimans MA et al. The Fanconi anaemia group G gene FANCG is identical with XRCC9. Nat Genet 1998; 20:281–283.PubMedCrossRefGoogle Scholar
  14. 14.
    de Winter JP, Leveille F, van Berkel CG et al. Isolation of a cDNA representing the Fanconi anemia complementation group E gene. Am J Hum Genet 2000; 67:1306–1308.PubMedGoogle Scholar
  15. 15.
    de Winter JP, Rooimans MA, van Der Weel L et al. The Fanconi anaemia gene FANCF encodes a novel protein with homology of ROM. Nat Genet 2000b; 24:15–16.PubMedCrossRefGoogle Scholar
  16. 16.
    Timmers C, Taniguchi T, Hejna J et al. Positional cloning of a novel Fanconi anemia gene, FANCD2. Mol Cell 2001; 7:241–8.PubMedCrossRefGoogle Scholar
  17. 17.
    Garcia-Higuera I, Taniguchi T, Ganesan S et al. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell 2001; 7:249–62.PubMedCrossRefGoogle Scholar
  18. 18.
    Howlett NG, Taniguchi T, Olson S et al. Biallelic inactivation of BRCA2 in Fanconi anemia. Science 2002; 297:606–9.PubMedCrossRefGoogle Scholar
  19. 19.
    D’Andrea AD, Grompe M. The Fanconi anaemia/BRCA pathway. Nat Rev Cancer 2003; 3:23–34.PubMedCrossRefGoogle Scholar
  20. 20.
    Nakanishi K, Taniguchi T, Ranganathan V et al. Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol 2002; 4:913–20.PubMedCrossRefGoogle Scholar
  21. 21.
    Thompson LH, Schild D. Recombinational DNA repair and human disease. Mutat Res 2002; 509:49–78.PubMedGoogle Scholar
  22. 22.
    Houghtaling S, Timmers C, Noll M et al. Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev 2003; 17:2021–35.PubMedCrossRefGoogle Scholar
  23. 23.
    Offit K, Levran O, Mullaney B et al. Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia. J Natl Cancer Inst 2003; 95:1548–51.PubMedGoogle Scholar
  24. 24.
    Vandenberg CJ, Gergely F, Ong CY et al. BRCA1-independent ubiquitination of FANCD2. Mol Cell 2003; 12:247–54.PubMedCrossRefGoogle Scholar
  25. 25.
    Meetei AR, de Winter JP, Medhurst AL et al. A novel ubiquitin ligase is deficient in Fanconi anemia. Nat Genet 2003; 35:165–70.PubMedCrossRefGoogle Scholar
  26. 26.
    Garcia-Higuera I, Kuang Y, Naf D et al. Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. Mol Cell Biol 1999; 19:4866–4873.PubMedGoogle Scholar
  27. 27.
    Waisfisz Q, de Winter JP, Kruyt FA et al. A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA. Proc Natl Acad Sci USA 1999; 96:10320–10325.PubMedCrossRefGoogle Scholar
  28. 28.
    Kruyt FA, Abou-Zahr F, Mok H et al. Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain. J Biol Chem 1999; 274:34212–8.PubMedCrossRefGoogle Scholar
  29. 29.
    de Winter JP, van der Weel L, de Groot J et al. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. Hum Mol Genet 2000; 9:2665–2674.PubMedCrossRefGoogle Scholar
  30. 30.
    Kuang Y, Garcia-Higuera I, Moran A et al. Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity. Blood 2000; 96:1625–32.PubMedGoogle Scholar
  31. 31.
    Medhurst AL, Huber PAJ, Waisfisz Q et al. Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway. Hum Mol Genet 2001; 10:423–429.PubMedCrossRefGoogle Scholar
  32. 32.
    Pace P, Johnson M, Tan WM et al. FANCE: The link between Fanconi anaemia complex assembly and activity. EMBO J 2002; 21:3414–3423.PubMedCrossRefGoogle Scholar
  33. 33.
    Adachi D, Oda T, Yagasaki H et al. Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants. Hum Mol Genet 2002; 11:3125–3134.PubMedCrossRefGoogle Scholar
  34. 34.
    Gordon SM, Buchwald M. Fanconi anemia protein complex: Mapping protein interactions in the yeast 2-and 3-hybrid systems. Blood 2003; 102:136–41.PubMedCrossRefGoogle Scholar
  35. 35.
    Adachi D, Oda T, Yagasaki H et al. Stable complex formation of the Fanconi anemia (FA) protein is not essential for activation of the FA pathway. Blood 2003; 100:43a.Google Scholar
  36. 36.
    Blom E, van de Vrugt HJ, de Vries Y et al. Multiple TPR motifs characterize the Fanconi anemia FANCG protein. DNA Repair (Amst) 2004; 3:77–84.PubMedCrossRefGoogle Scholar
  37. 37.
    Wang X-Z, Andrassen P, D’Andrea AD. Functional interaction of the Fanconi anemia protein, FANCD2, with the breast cancer susceptibility protein, BRCA2, in damaged chromatin. Blood Date 102:159a.Google Scholar
  38. 38.
    Hussain S, Witt E, Huber PA et al. Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1. Hum Mol Genet 2003; 12:2503–10.PubMedCrossRefGoogle Scholar
  39. 39.
    Digweed M, Rothe S, Demuth I et al. Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia. Carcinogenesis 2002; 23:1121–6.PubMedCrossRefGoogle Scholar
  40. 40.
    Taniguchi T, Garcia-Higuera I, Andreassen PR et al. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood 2002; 100:2414–20.PubMedCrossRefGoogle Scholar
  41. 41.
    Qiao F, Moss A, Kupfer GM. Fanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage-and cell cycle-regulated manner. J Biol Chem 2001; 276:23391–6.PubMedCrossRefGoogle Scholar
  42. 42.
    McMahon LW, Sangerman J, Goodman SR et al. Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links. Biochemistry 2001; 40:7025–34.PubMedGoogle Scholar
  43. 43.
    Sridharan D, Brown M, Lambert WC et al. Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links. J Cell Sci 2003; 116 (Pt 5):823–35.PubMedCrossRefGoogle Scholar
  44. 44.
    McHugh PJ, Spanswick VJ, Hartley JA. Repair of DNA interstrand crosslinks: Molecular mechanisms and clinical relevance. Lancet Oncol 2001; 2:483–90.PubMedCrossRefGoogle Scholar
  45. 45.
    Kumaresan KR, Lambert MW. Fanconi anemia, complementation group A, cells are defective in ability to produce incisions at sites of psoralen interstrand cross-links. Carcinogenesis 2000; 21:741–51.PubMedCrossRefGoogle Scholar
  46. 46.
    Rothfuss A, Grompe M. Repair kinetics of genomic interstrand DNA cross-links: Evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. Mol Cell Biol 2004; 24:123–34.PubMedCrossRefGoogle Scholar
  47. 47.
    Meetei AR, Sechi S, Wallisch M et al. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol Cell Biol 2003; 23:3417–26.PubMedCrossRefGoogle Scholar
  48. 48.
    Levitus M, Rooimans MA, Steltenpool J et al. Heterogeneity in Fanconi anemia: Evidence for two new genetic subtypes. Blood 2003; [10.1182/blood-2003-08-2915].Google Scholar
  49. 49.
    Taniguchi T, Tischkowitz M, Ameziane N et al. Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med 2003; 9:568–74.PubMedCrossRefGoogle Scholar
  50. 50.
    van der Heijden MS, Yeo CJ, Hruban RH et al. Fanconi anemia gene mutations in young-onset pancreatic cancer. Cancer Res 2003; 63:2585–8.PubMedGoogle Scholar
  51. 51.
    Lensch MW, Tischkowitz M, Christianson TA et al. Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia. Blood 2003; 102:7–16.PubMedCrossRefGoogle Scholar
  52. 52.
    Yagasaki H, Adachi D, Oda T et al. A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA. Blood 2001; 98:3650–7.PubMedCrossRefGoogle Scholar

Copyright information

© Eurekah.com and Springer Science+Business Media 2006

Authors and Affiliations

  • Takayuki Yamashita
    • 1
  1. 1.Division of Genetic Diagnosis, Institute of Medical ScienceUniversity of TokyoTokyoJapan

Personalised recommendations