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Hot Topics in Infection and Immunity in Children III pp 101–110Cite as

The Role of Inflammation and Infection in the Development of Chronic Lung Disease of Prematurity

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 582))

8. Summary

CLD is a significant cause of infant morbidity and mortality. The lung injury is multifactorial in origin with supplemental oxygen and ventilatory damage being only part of the picture. Antenatal and postnatal infection and inflammation are also important in the development of CLD, although their precise role has still to be fully ascertained.

In the future, therapeutic strategies need to be considered to decrease the incidence and severity of CLD. In particular a definitive trial investigating the role of antibiotics against Ureaplasma urealyticum in preventing CLD needs to be performed. Increased use of newer microbiological methods will also improve our understanding of the role of infection in CLD and further guide research and clinical management.

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References

  • Albertine, K.H., Jones, G.P., Starcher, B.C., Bohnsack, J.F., Davis, P.L., Cho, S.C., Carlton, D.P., Bland, R.D. (1999). Chronic lung injury in preterm lambs. Disordered respiratory tract development. Am J Respir Crit Care Med. 159: 945–58.

    PubMed  CAS  Google Scholar 

  • Bancalari, E., Claure, N., Sosenko, I.R. (2003). Bronchopulmonary dysplasia: changes in pathogenesis, epidemiology and definition. Semin Neonatol. 8: 63–71.

    Article  PubMed  Google Scholar 

  • Charafeddine, L., D’Angio, C.T., Phelps, D.L. (1999). Atypical chronic lung disease patterns in neonates. Pediatrics. 103: 759–65.

    Article  PubMed  CAS  Google Scholar 

  • Clement, A., Chadelat, K., Sardet, A., Grimfeld, A., Tournier, G. (1988). Alveolar macrophage status in bronchopulmonary dysplasia. Pediatr Res. 23: 470–3.

    PubMed  CAS  Google Scholar 

  • Coalson, J.J. (2003). Pathology of new bronchopulmonary dysplasia. Semin Neonatol. 8: 73–81.

    Article  PubMed  Google Scholar 

  • Cordero, L., Ayers, L.W., Davis, K. (1997). Neonatal airway colonization with gram-negative bacilli: association with severity of bronchopulmonary dysplasia. Pediatr Infect Dis J. 16: 18–23.

    Article  PubMed  CAS  Google Scholar 

  • Couroucli, X.I., Welty, S.E., Ramsay, P.L., Wearden, M.E., Fuentes-Garcia, F.J., Ni, J., Jacobs, T.N., Towbin, J.A., Bowles, N.E. (2000). Detection of microorganisms in the tracheal aspirates of preterm infants by polymerase chain reaction: association of adenovirus infection with bronchopulmonary dysplasia. Pediatr Res. 47: 225–32.

    PubMed  CAS  Google Scholar 

  • DiCosmo, B.F., Geba, G.P., Picarella, D., Elias, J.A., Rankin, J.A., Stripp, B.R., Whitsett, J.A., Flavell, R.A. (1994). Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J Clin Invest. 94: 2028–35.

    Article  PubMed  CAS  Google Scholar 

  • Fanaroff, A.A., Wright, L.L., Stevenson, D.K., Shankaran, S., Donovan, E.F., Ehrenkranz, R.A., Younes, N., Korones, S.B., Stoll, B.J., Tyson, J.E., et al. (1995). Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, May 1991 through December 1992. Am J Obstet Gynecol. 173: 1423–31.

    Article  PubMed  CAS  Google Scholar 

  • Ghezzi, F., Gomez, R., Romero, R., Yoon, B.H., Edwin, S.S., David, C., Janisse, J., Mazor, M. (1998). Elevated interleukin-8 concentrations in amniotic fluid of mothers whose neonates subsequently develop bronchopulmonary dysplasia. Eur J Obstet Gynecol Reprod Biol. 78: 5–10.

    Article  PubMed  CAS  Google Scholar 

  • Goldenberg, R.L., Rouse, D.J. (1998). Prevention of premature birth. N Engl J Med. 339: 313–20.

    Article  PubMed  CAS  Google Scholar 

  • Goldenberg, R.L., Hauth, J.C., Andrews, W.W. (2000). Intrauterine infection and preterm delivery. N Engl J Med. 342: 1500–7.

    Article  PubMed  CAS  Google Scholar 

  • Groneck, P., Gotze-Speer, B., Oppermann, M., Eiffert, H., Speer, C.P. (1994). Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates. Pediatrics. 93: 712–8.

    PubMed  CAS  Google Scholar 

  • Hannaford, K., Todd, D.A., Jeffery, H., John, E., Blyth, K., Gilbert, G.L. (1999). Role of ureaplasma urealyticum in lung disease of prematurity. Arch Dis Child Fetal Neonatal Ed. 81: F162–7.

    PubMed  CAS  Google Scholar 

  • Hardie, W.D., Bruno, M.D., Huelsman, K.M., Iwamoto, H.S., Carrigan, P.E., Leikauf, G.D., Whitsett, J.A., Korfhagen, T.R. (1997). Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-alpha. Am J Pathol. 151: 1075–83.

    PubMed  CAS  Google Scholar 

  • Hillier, S.L., Martius, J., Krohn, M., Kiviat, N., Holmes, K.K., Eschenbach, D.A. (1988). A case-control study of chorioamniotic infection and histological chorioamnionitis in prematurity. N Engl J Med. 319: 972–8.

    Article  PubMed  CAS  Google Scholar 

  • Jobe, A.J. (1999). The new BPD: an arrest of lung development. Pediatr Res. 46: 641–3.

    PubMed  CAS  Google Scholar 

  • Jonsson, B., Rylander, M., Faxelius, G. (1998). Ureaplasma urealyticum, erythromycin and respiratory morbidity in high-risk preterm neonates. Acta Paediatr. 87: 1079–84.

    Article  PubMed  CAS  Google Scholar 

  • Kenyon, S.L., Taylor, D.J., Tarnow-Mordi, W. (2001a). Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group. Lancet. 357: 979–88.

    Article  PubMed  CAS  Google Scholar 

  • Kenyon, S.L., Taylor, D.J., Tarnow-Mordi, W. (2001b). Broad spectrum antibiotics for spontaneous preterm labour: the ORACLE II randomised trial. Lancet. 357: 991–6.

    Google Scholar 

  • Kenyon, S.L., Boulvain, M., Neilson, J. (2003). Antibiotics for preterm rupture of membranes. The Cochrane Database of Systematic Reviews. 2: CD001058.

    Google Scholar 

  • King, J., Fenady, V. (2002). Prophylactic antibiotics for inhibiting preterm labour with intact membranes. Cochrane Database Syst Rev. 4: CD000246.

    Google Scholar 

  • Kotecha, S. (1996). Cytokines in chronic lung disease of prematurity. Eur J Pediatr. 155: S14–7.

    Article  PubMed  Google Scholar 

  • Kotecha, S. (2000). Lung growth: implications for the newborn infant. Arch Dis Child Fetal Neonatal Ed. 82: F69–74.

    Article  PubMed  CAS  Google Scholar 

  • Kotecha, S., Chan, B., Azam, N., Silverman, M., Shaw, R.J. (1995). Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease. Arch Dis Child Fetal Neonatal Ed. 72: F90–6.

    Article  PubMed  CAS  Google Scholar 

  • Kotecha, S., Wilson, L., Wangoo, A., Silverman, M., Shaw, R.J. (1996). Increase in interleukin (IL)-1 beta and IL-6 in bronchoalveolar lavage fluid obtained from infants with chronic lung disease of prematurity. Pediatr Res. 40: 250–6.

    PubMed  CAS  Google Scholar 

  • Kotecha, S., Silverman, M. (1999). Chronic Respiratory complications of neonatal disorders. Textbook of Pediatric Respiratory Medicine. Eds. Landau, L.I., Tausssig, L.M. Mosby. 488–521.

    Google Scholar 

  • Kotecha, S., Hodge, R., Schaber, J.A., Miralles, R., Silverman, M., Grant, W.D. (2004). Pulmonary Ureaplasma urealyticum is associated with the development of acute lung inflammation and chronic lung disease in preterm infants. Pediatr Res. 55: 61–8.

    Article  PubMed  Google Scholar 

  • Kramer, B.W., Kramer, S., Ikegami, M., Jobe, A.H. (2002). Injury, inflammation, and remodeling in fetal sheep lung after intra-amniotic endotoxin. Am J Physiol Lung Cell Mol Physiol. 283: L452–9.

    PubMed  CAS  Google Scholar 

  • Liljedahl, M., Bodin, L., Schollin, J. (2004). Coagulase-negative staphylococcal sepsis as a predictor of bronchopulmonary dysplasia. Acta Paediatr. 93: 211–5.

    Article  PubMed  Google Scholar 

  • Lyon, A.J., McColm, J., Middlemist, L., Fergusson, S., McIntosh, N., Ross, P.W. (1998). Randomised trial of erythromycin on the development of chronic lung disease in preterm infants. Arch Dis Child Fetal Neonatal Ed. 78: F10–4.

    Article  PubMed  CAS  Google Scholar 

  • Mabanta, C.G., Pryhuber, G.S., Weinberg, G.A., Phelps, D.L. (2003). Erythromycin for the prevention of chronic lung disease in intubated preterm infants at risk for, or colonized or infected with Ureaplasma urealyticum. Cochrane Database Syst Rev. 4: CD003744.

    Google Scholar 

  • Miralles, R., Hodge, R., McParland, P.C., Field, D.J., Bell, S.C., Taylor, D.J., Grant, W.D., Kotecha, S. (2005). Relationship between antenatal inflammation and antenatal infection identified by detection of microbial genes by polymerase chain reaction. Pediatr Res. 57: 570–7.

    Article  PubMed  CAS  Google Scholar 

  • Moss, T.J., Nitsos, I., Ikegami, M., Jobe, A.H., Newnham, J.P. (2005). Experimental intrauterine Ureaplasma infection in sheep. Am J Obstet Gynecol. 192: 1179–86.

    Article  PubMed  Google Scholar 

  • Nelson, K.B., Dambrosia, J.M., Grether, J.K., Phillips, T.M. (1998). Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol. 44: 665–75.

    Article  PubMed  CAS  Google Scholar 

  • Northway, W.H., Rosan, R.C., Porter, D.V. (1967). Pulmonary disease following respirator therapy of hyaline membrane disease: bronchopulmonary dysplasia. N Engl J Med. 276: 357–68.

    Article  PubMed  Google Scholar 

  • Prösch, S., Lienicke, U., Priemer, C., Flunker, G., Seidel, W.F., Kruger, D.H., Wauer, R.R. Human adenovirus and human cytomegalovirus infections in preterm newborns: no association with bronchopulmonary dysplasia. Pediatr Res. 52: 219–24.

    Google Scholar 

  • Rojas, M.A., Gonzalez, A., Bancalari, E., Claure, N., Poole, C., Silva-Neto, G. (1995). Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease. J Pediatr. 126: 605–10.

    Article  PubMed  CAS  Google Scholar 

  • Sawyer, M.H., Edwards, D.K., Spector, S.A. (1987). Cytomegalovirus infection and bronchopulmonary dysplasia in premature infants. Am J Dis Child. 141: 303–5.

    PubMed  CAS  Google Scholar 

  • Shankaran, S., Szego, E., Eizert, D., Siegel, P. (1984). Severe bronchopulmonary dysplasia. Predictors of survival and outcome. Chest 86: 607–10.

    PubMed  CAS  Google Scholar 

  • Speer, C.P. (1999). Inflammatory mechanisms in neonatal chronic lung disease. Eur J Pediatr. 158: S18–22.

    Article  PubMed  CAS  Google Scholar 

  • Stancombe, B.B., Walsh, W.F., Derdak, S., Dixon, P., Hensley, D. (1993). Induction of human neonatal pulmonary fibroblast cytokines by hyperoxia and Ureaplasma urealyticum. Clin Infect Dis. 17: S154–7.

    PubMed  Google Scholar 

  • Tucker, J.M., Goldenberg, R.L., Davis, R.O., Copper, R.L., Winkler, C.L., Hauth, J.C. (1991). Etiologies of preterm birth in an indigent population: is prevention a logical expectation? Obstet Gynecol. 77: 343–7.

    PubMed  CAS  Google Scholar 

  • van Waarde, W.M., Brus, F., Okken, A., Kimpen, J.L. (1997). Ureaplasma urealyticum colonization, prematurity and bronchopulmonary dysplasia. Eur Respir J. 10: 886–90.

    PubMed  Google Scholar 

  • Teberg, A.J., Pena, I., Finello, K., Aguilar, T., Hodgman, J.E. (1991). Prediction of neurodevelopmental outcome in infants with and without bronchopulmonary dysplasia. Am J Med Sci. 301: 369–74.

    Article  PubMed  CAS  Google Scholar 

  • Wang, E.E., Ohlsson, A., Kellner, J.D. (1995). Association of Ureaplasma urealyticum colonization with chronic lung disease of prematurity: results of a metaanalysis. J Pediatr. 127: 640–4.

    Article  PubMed  CAS  Google Scholar 

  • Watterberg, K.L., Demers, L.M., Scott, S.M., Murphy, S. (1996). Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics. 97: 210–5.

    PubMed  CAS  Google Scholar 

  • Yoder, B.A., Coalson, J.J., Winter, V.T., Siler-Khodr, T., Duffy, L.B., Cassell, G.H. (2003). Effects of antenatal colonization with ureaplasma urealyticum on pulmonary disease in the immature baboon. Pediatr Res. 54: 797–807.

    Article  PubMed  Google Scholar 

  • Yoon, B.H., Romero, R., Jun, J.K., Park, K.H., Park, J.D., Ghezzi, F., Kim, B.I. (1997). Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol. 177: 825–30.

    Article  PubMed  CAS  Google Scholar 

  • Yoon, B.H., Romero, R., Park, J.S., Chang, J.W., Kim, Y.A., Kim, J.C., Kim, K.S. (1998). Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol. 179: 1254–60.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Child Health, Cardiff University, Cardiff, CF14 4XN, UK

    Philip L. Davies, Nicola C. Maxwell & Sailesh Kotecha

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  1. Philip L. Davies
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  2. Nicola C. Maxwell
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  3. Sailesh Kotecha
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Editors and Affiliations

  1. University of Oxford, Level 4, John Radclif Hospital, Oxford, UK, OX3 9DU

    Andrew J. Pollard

  2. University of Bristol, Tyndall Avenue, Bristol, UK, B58 1TH

    Adam Finn

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Davies, P.L., Maxwell, N.C., Kotecha, S. (2006). The Role of Inflammation and Infection in the Development of Chronic Lung Disease of Prematurity. In: Pollard, A.J., Finn, A. (eds) Hot Topics in Infection and Immunity in Children III. Advances in Experimental Medicine and Biology, vol 582. Springer, Boston, MA . https://doi.org/10.1007/0-387-33026-7_9

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