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Molecular Genetics of the BK Virus

  • Christopher L. Cubitt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 577)

Abstract

The BK Virus (BKV) genome is a double-stranded, circular DNA molecule with genetic organization similar to other polyomaviruses, and high homology to JC Virus (JCV) and SV40. The archetypal form of BKV noncoding regulatory region (NCRR) is the infectious form of BKV that replicates in the urothelium and is excreted in the urine. Rearranged forms of the NCRR are found in kidney and other tissues often in association with disease. BKV strains can be assigned to genotype/serotype groups based on sequence variation in the VP1 gene. Sequencing of the complete genomes from patient samples will enhance BKV phylogenetic studies and identify genotypic differences and naturally occurring mutations in BKV that may correlate with incidence and/or severity of a disease. This chapter is a review of the molecular genetics of the BK virus in respect to BKV disease.

Keywords

Progressive Multifocal Leukoencephalopathy Human Polyomavirus Transcriptional Control Region Archetype Form Human Papovavirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  • Christopher L. Cubitt
    • 1
  1. 1.Translational Research LaboratoryH. Lee Moffitt Cancer and Research InstituteTampaUSA

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