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BK Virus Infection after Non-Renal Transplantation

  • Martha Pavlakis
  • Abdolreza Haririan
  • David K. Klassen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 577)

Abstract

Infection with BK virus (BKV), a member of the Polyomavirus (PV) family, is ubiquitous, with the virus remaining in a latent form in the kidney and urinary tract.1, 2 This infection is usually asymptomatic, but with impairment of the cellular immune system the virus can reactivate and lead to tissue damage. In recipients of bone marrow and solid organ transplants, PV reactivation can be associated with disease in urinary tract and kidneys. BKV was first discovered in 1971 from the urine of a kidney transplant recipient who had developed ureteral stenosis 4 months after transplantation. While much of the subsequent research focuses on patients after renal transplantation, we will review PV impact in patients after bone marrow transplant (BMT) and those with non-renal solid organ transplants.

Keywords

Bone Marrow Transplant Solid Organ Transplant Hemorrhagic Cystitis Solid Organ Transplant Recipient Native Kidney 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Reploeg M., Storch GA, Clifford DB. BK virus: a clinical review. Clin Inf Dis 2001; 33:91–202.CrossRefGoogle Scholar
  2. 2.
    Myelonakis E, Goes N, Rubin RH et al. BK virus in solid organ transplant recipients: an emerging syndrome. Transplantation 2001; 72:1587–92.CrossRefGoogle Scholar
  3. 3.
    Demeter L. JC, BK, and other polyomaviruses; progressive leukoencephalopathy. In: Mandell GL, ed. Principles and Practice of Infectious Diseases. New York: Churchill Livingston, 200:1645–1651.Google Scholar
  4. 4.
    Dorries K, Molecular biology and pathogenesis of human polyomavirus infections. Dev Biol Stand 1998; 94:71–9.PubMedGoogle Scholar
  5. 5.
    Shah K, Human polyomavirus BKV and renal disease. Nephrol Dial Transplant 2000; 15:754–55.PubMedCrossRefGoogle Scholar
  6. 6.
    O’Reilly R., Lee FK, Grossbard E et al. Papovavirus excretion following marrow transplantation: incidence and association with hepatic dysfunction. Transplant Proc 1981; 13:262–6.PubMedGoogle Scholar
  7. 7.
    Efros M., Ahmed T, Coombe N et al. Urologic complications of high-dose chemotherapy and bone marrow transplantation. Urology 1994; 43(3):355–60PubMedCrossRefGoogle Scholar
  8. 8.
    Ilhan O, Koc H, Akan H et al. Hemorrhagic cystitis as a complication of bone marrow transplantation. J Chemother 1997; 9(1):56–61.PubMedGoogle Scholar
  9. 9.
    Arthur R, Shah KV, Baust SJ et al. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. N Engl J Med 1986; 315:230–4.PubMedCrossRefGoogle Scholar
  10. 10.
    Priftakis P, Bogdanovic G, Kokhaei P et al. BK virus (BKV) quantification in urine samples of bone marrow transplanted patients is helpful for diagnosis of hemorrhagic cystitis, although wide individual variations exist. J Clin Virol 2003; 26(1):71–7.PubMedCrossRefGoogle Scholar
  11. 11.
    Apperley J, Rice SJ, Bishop JA et al. Late-onset hemorrhagic cystitis associated with urinary excretion of polyomaviruses after bone marrow transplantation. Transplantation 1987. 43:108–12.PubMedCrossRefGoogle Scholar
  12. 12.
    Chan P, Ip KW, Shiu SY et al. Association between polyomaviruria and microscopic hematuria in bone marrow transplant recipients. J Infect 1994; 29:139–46.PubMedCrossRefGoogle Scholar
  13. 13.
    Bedi A, Miller CB, Hanson JL et al. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol 1995; 12:1103–9.Google Scholar
  14. 14.
    Azzi A, Fanci R, Bosi A et al. Monitoring of polyomavirus BK viruria in bone marrow transplantation patients by DNA hybridization assay and by polymerase chain reaction: an approach to assess the relationship between BK viruria and hemorrhagic cystitis. Bone Marrow Transplant 1994; 14:235–40.PubMedGoogle Scholar
  15. 15.
    Azzi A, Cesar S, Laszlo D et al. Human polyomavirus BK (BKV) load and haemorrhagic cystitis in bone marrow transplantation patients. J Clin Virol 1999; 14:79–86.PubMedCrossRefGoogle Scholar
  16. 16.
    Bogdanovic G, Ljungman P, Wang F et al. Presence of human polyomavirus DNA in the peripheral circulation of bone marrow transplant patients with and without hemorrhagic cystitis. Bone Marrow Transplant 1996; 17:573–76.PubMedGoogle Scholar
  17. 17.
    Priftakis P, Bogdanovic G, Kalantari M et al. Overrepresentation of point mutations in the Sp1 site of the non-coding control region of BK virus in bone marrow transplanted patients with haemorrhagic cystitis. J Clin Virol 2001; 21:1–7.PubMedCrossRefGoogle Scholar
  18. 17a.
    Azzi A, Fanci R, Bosi A et al. Monitoring of polyomavirns BK viruria in bone marrow transplantation patients by DNA hybridization assay and by polymerase chain reation: an approach to assess the relationnship between BK viruria and hemarrhagic cystitis. Bone Marrow Transplant 1994; 14(2):235–40PubMedGoogle Scholar
  19. 18.
    Leung A, Suen CK, Lie A et al. Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation. Blood 2001; 98:1971–78.PubMedCrossRefGoogle Scholar
  20. 19.
    Akiyama H, Kurosu T, Sakashita C et al. Adenovirus is a key pathogen in hemorrhagic cystitis associated with bone marrow transplantation. CID 2001; 32:1325–30.CrossRefGoogle Scholar
  21. 20.
    Chapman C, Flower AJE, Durrant STS. The use of vidarabine in the treatment of human polyomavirus associated acute haemorrhagic cystitis. Bone Marrow Transplant 1991; 7:481–83.PubMedGoogle Scholar
  22. 21.
    Held T, Biel SS, Nitsche A et al. Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir. Bone Marrow Transplant 2000; 26:47–50.CrossRefGoogle Scholar
  23. 22.
    Kawakami M, Ueda S, Maeda T et al. Vidarabine therapy for virus-associated cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant 1997; 20:485–90.PubMedCrossRefGoogle Scholar
  24. 23.
    Vianelli N, Renga M, Azzi A et al. Bone Marrow Transplant 2000; 25:319–20.PubMedCrossRefGoogle Scholar
  25. 24.
    Hatakeyama N, Suzuki N, Kudoh T et al. Successful cidofovir treatment of adenovirus-associated hemorrhagic cystitis and renal dysfunction after allogenic bone marrow transplant. Pediatr Infect Dis J 2003; 22(10):928–9.PubMedCrossRefGoogle Scholar
  26. 25.
    Barouch DH, Faquin WC, Chen Y et al. BK virus-associated hemorrhagic cystitis in a Human Immunodeficiency Virus-infected patient. Clin Infect Dis 2002; 35(3):326–9.PubMedCrossRefGoogle Scholar
  27. 26.
    Gonzalez-Fraile M, Canizo C, Caballer D et al. Cidofovir treatment of human polyomavirus-associated acute haemorrhagic cystitis. Transpl Infect Dis 2001; 3:44–6.PubMedCrossRefGoogle Scholar
  28. 27.
    Etienne I, Francois A, Redonnet M et al. Does polyomavirus infection induce renal failure in cardiac transplant recipients? Transplant Proc 2000; 32:2794–5.PubMedCrossRefGoogle Scholar
  29. 28.
    Masuda K, Akutagawa K, Yutani C et al. Persistent infection with human polyomavirus revealed by urinary cytology in a patient with heart transplantation: a case report. Acta Cytol 1998; 42:803.PubMedGoogle Scholar
  30. 29.
    Haririan A, Ramos ER, Drachenberg CB et al. Polyomavirus nephropathy in native kidneys of a solitary pancreas transplant recipient. Transplantation 2002; 73:1350–53.PubMedCrossRefGoogle Scholar
  31. 30.
    Haririan A, Hamze O, Drachenberg CB et al. Polyomavirus reactivation in native kidneys of pancreas alone allograft recipients. Transplantation 2003; 75(8):1186–90.PubMedCrossRefGoogle Scholar

Copyright information

© Eurekah.com and Springer Science+Business Media 2006

Authors and Affiliations

  • Martha Pavlakis
    • 1
  • Abdolreza Haririan
    • 2
  • David K. Klassen
    • 3
  1. 1.Beth Israel Deaconess HospitalBostonUSA
  2. 2.Wayne State UniversityDetroitUSA
  3. 3.University of Maryland School of MedicineBaltimoreUSA

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