McManus MT, Sharp PA. Gene silencing in mammals by small interfering RNAs. Nat Rev Genet 2002; 3(10):737–47.
Tuschl T. Expanding small RNA interference. Nat Biotechnol 2002; 20(5):446–8.
Paul CP, Good PD, Winer I et al. Effective expression of small interfering RNA in human cells. Nat Biotechnol 2002; 20(5):505–8.
Lee NS, Dohjima T, Bauer G et al. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol 2002; 20(5):500–5.
Paul CP, Good PD, Li SX et al. Localized expression of small RNA inhibitors in human cells. Mol Ther 2003; 7(2):237–47.
Wilson JA, Jayasena S, Khvorova A et al. RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells. PNAS 2003; 252758799.
Barton GM, Medzhitov R. Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci USA 2002; 99(23):14943–5.
Abbas-Terki T, BlancoBose W, Deglon N et al. Lentiviral-mediated RNA interference. Hum Gene Ther 2002; 13(18):2197–201.
Rubinson DA, Dillon CP, Kwiatkowski AV et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003; 33(3):401–6.
Qin X-F, An DS, Chen ISY et al. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. PNAS 2003; 100(1):183–188.
Tiscornia G, Singer O, Ikawa M et al. A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci USA 2003; 100(4):1844–1848.
Holen T, Amarzguioui M, Wiiger MT et al. Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucleic Acids Res 2002; 30(8):1757–66.
Yang D, Buchholz F, Huang Z et al. Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. Proc Natl Acad Sci USA 2002; 99(15):9942–7.
Kawasaki H, Suyama E, Iyo M et al. siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells. Nucleic Acids Res 2003; 31(3):981–7.
Yu JY, DeRuiter SL, Turner DL. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci USA 2002; 99(9):6047–52.
Elbashir SM, Harborth J, Lendeckel W et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411(6836):494–8.
Chiu YL, Rana TM. RNAi in human cells: Basic structural and functional features of small interfering RNA. Mol Cell 2002; 10(3):549–61.
Scherr M, Rossi JJ. Rapid determination and quantitation of the accessibility to native RNAs by antisense oligodeoxynucleotides in murine cell extracts. Nucleic Acids Res 1998; 26(22):5079–85.
Scherr M, Reed M, Huang CF et al. Oligonucleotide scanning of native mRNAs in extracts predicts intracellular ribozyme efficiency: Ribozyme-mediated reduction of the murine DNA methyltransferase. Mol Ther 2000; 2(1):26–38.
Scherr M, LeBon J, Castanotto D et al. Detection of antisense and ribozyme accessible sites on native mRNAs: Application to NCOA3 mRNA. Mol Ther 2001; 4(5):454–60.
Castanotto D, Li H, Rossi JJ. Functional siRNA expression from transfected PCR products. RNA 2002; 8(11):1454–60.
Myers JW, Jones JT, Meyer T et al. Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing. Nat Biotechnol 2003.
Heidenreich O, Krauter J, Riehle H et al. AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive Leukemic Cells. Blood 2002.
Zhang H, Kolb FA, Brondani V et al. Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. Embo J 2002; 21(21):5875–85.
Provost P, Dishart D, Doucet J et al. Ribonuclease activity and RNA binding of recombinant human Dicer. Embo J 2002; 21(21):5864–74.
Hooberman AL, Carrino JJ, Leibowitz D et al. Unexpected heterogeneity of BCR-ABL fusion mRNA detected by polymerase chain reaction in Philadelphia chromosome-positive acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1989; 86(11):4259–63.
Rubin CM, Carrino JJ, Dickler MN et al. Heterogeneity of genomic fusion of BCR and ABL in Philadelphia chromosome-positive acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1988; 85(8):2795–9.
Chan LC, Karhi KK, Rayter SI et al. A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia. Nature 1987; 325(6105):635–7.
Wilda M, Fuchs U, Wossmann W et al. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene 2002; 21(37):5716–24.
Scherr M, Battmer K, Winkler T et al. Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood 2003; 101(4):1566–9.
Jakubowiak A, Pouponnot C, Berguido F et al. Inhibition of the transforming growth factor beta 1 signaling pathway by the AML1/ETO leukemia-associated fusion protein. J Biol Chem 2000; 275(51):40282–7.
Pabst T, Mueller BU, Harakawa N et al. AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia. Nat Med 2001; 7(4):444–51.
Dohjima J, Lee NS, Li H et al. Small interfering RNAs expressed from a Pol III promoter suppress the EWS/Fli-1 transcript in an Ewing sarcoma cell line. Mol Ther 2003; 7(6):811–6.
Jacque JM, Triques K, Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature 2002; 418(6896):435–8.
Coburn GA, Cullen BR. Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. J Virol 2002; 76(18):9225–31.
Surabhi RM, Gaynor RB. RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1 replication. J Virol 2002; 76(24):12963–73.
Park WS, Miyano-Kurosaki N, Hayafune M et al. Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference. Nucleic Acids Res 2002; 30(22):4830–5.
Novina CD, Murray MF, Dykxhoorn DM et al. siRNA-directed inhibition of HIV-1 infection. Nat Med 2002; 8(7):681–6.
Martinez MA, Clotet B, Este JA. RNA interference of HIV replication. Trends Immunol 2002; 23(12):559–61.
Kitabwalla M, Ruprecht RM. RNA interference—a new weapon against HIV and beyond. N Engl J Med 2002; 347(17):1364–7.
Martinez MA, Gutierrez A, Armand-Ugon M et al. Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication. Aids 2002; 16(18):2385–90.
Blight KJ, Kolykhalov AA, Rice CM. Efficient initiation of HCV RNA replication in cell culture. Science 2000; 290(5498):1972–4.
Lohmann V, Korner F, Koch J et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999; 285(5424):110–3.
Ikeda M, Yi M, Li K et al. Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells. J Virol 2002; 76(6):2997–3006.
Krieger N, Lohmann V, Bartenschlager R. Enhancement of hepatitis C virus RNA replication by cell cultureadaptive mutations. J Virol 2001; 75(10):4614–24.
Pietschmann T, Lohmann V, Rutter G et al. Characterization of cell lines carrying self-replicating hepatitis C virus RNAs. J Virol 2001; 75(3):1252–64.
Kishine H, Sugiyama K, Hijikata M et al. Subgenomic replicon derived from a cell line infected with the hepatitis C virus. Biochem Biophys Res Commun 2002; 293(3):993–9.
Randall G, Grakoui A, Rice CM. Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs. Proc Natl Acad Sci USA 2003; 100(1):235–40.
Kapadia SB, Brideau-Andersen A, Chisari FV. Interference of hepatitis C virus RNA replication by short interfering RNAs. Proc Natl Acad Sci USA 2003; 100(4):2014–8.
Song E, Lee SK, Wang J et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003; 9(3):347–51.
Los M, Burek CJ, Stroh C et al. Anticancer drugs of tomorrow: Apoptotic pathways as targets for drug design. Drug Discov Today 2003; 8(2):67–77.
Kamath RS, Fraser AG, Dong Y et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 2003; 421(6920):231–7.
Ashrafi K, Chang FY, Watts JL et al. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 2003; 421(6920):268–72.
Pothof J, Van Haaften G, Thijssen K et al. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev 2003; 17(4):443–8.
Lee SS, Lee RY, Fraser AG et al. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 2003; 33(1):40–8.
Pekarik V, Bourikas D, Miglino N et al. Screening for gene function in chicken embryo using RNAi and electroporation. Nat Biotechnol 2003; 21(1):93–6.
Calegari F, Haubensak W, Yang D et al. Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA. Proc Natl Acad Sci USA 2002; 99(22):14236–40.
Bailey SN, Wu RZ, Sabatini DM. Applications of transfected cell microarrays in high-throughput drug discovery. Drug Discov Today 2002; 7(Suppl 18):S113–8.
Wu RZ, Bailey SN, Sabatini DM. Cell-biological applications of transfected-cell microarrays. Trends Cell Biol 2002; 12(10):485–8.
Amarzguioui M, Holen T, Babaie E et al. Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Res 2003; 31(2):589–95.
Capodici J, Kariko K, Weissman D. Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference. J Immunol 2002; 169(9):5196–201.
Zeng Y, Cullen BR. RNA interference in human cells is restricted to the cytoplasm. Rna 2002; 8(7):855–60.
Michienzi A, Cagnon L, Bahner I et al. Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA. Proc Natl Acad Sci USA 2000; 97(16):8955–60.
Lee NS, Sun B, Williamson R et al. Functional colocalization of ribozymes and target mRNAs in Drosophila oocytes. Faseb J 2001; 15(13):2390–400.
Lee NS, Bertrand E, Rossi J. mRNA localization signals can enhance the intracellular effectiveness of hammerhead ribozymes. Rna 1999; 5(9):1200–9.
Castanotto D, Scherr M, Rossi JJ. Intracellular expression and function of antisense catalytic RNAs. Methods Enzymol 2000; 313:401–20.
Kawasaki H, Taira K. Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acids Res 2003; 31(2):700–7.
Doench JG, Petersen CP, Sharp PA. siRNAs can function as miRNAs. Genes Dev 2003; 17(4):438–42.
Zeng Y, Cullen BR. Sequence requirements for micro RNA processing and function in human cells. Rna 2003; 9(1):112–123.