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CD137 in the Regulation of T Cell Response to Antigen

  • Yuwen Zhu
  • Lieping Chen

Abstract

CD4+ and CD8+ T cells express high level of CD137 on the cell surface upon activation. A well-documented function of CD137 is its costimulatory effect on both CD4+ and CD8+ T cell growth and differentiation in vitro. In vivo experiments, however, reveal a far more complex effect of CD137 signaling on T cell-mediated immunity. Administration of CD137 agonistic mAb delivers a potent stimulatory signal and leads to CD8 T cell-mediated viral clearance and tumor regression in various models. In sharp contrast, the same agonist mAb is also effective to prevent or even reverse ongoing autoimmune responses, largely mediated through inhibition of CD4+ T cell. In addition to T cells, CD137 is also found on other cells. Therefore, the effect of CD137 should be analyzed in the context of regulator of both innate and adoptive immunity in addition to simply be a T cell costimulator.

Keywords

Treg Cell CD137 Signal Activation Induce Cell Death Recall Response Cell Anergy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • Yuwen Zhu
    • 1
  • Lieping Chen
    • 1
  1. 1.Department of Dermatology and OncologyJohns Hopkins University School of MedicineBaltimoreUSA

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