Significance of Reverse Signal Transduction for the Biology of the CD137 Receptor/Ligand System

  • Herbert Schwarz


CD137 is a member of the TNF receptor family and it has originally been identified as a potent T cell costimulatory molecule. Recently, it has become evident that CD137 signals can also inhibit T cell activity under certain conditions.


CD137 Ligand Soluble CD137 Follicular Dendritic Cell Activation Induce Cell Death Tumor Necrosis Factor Family 
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Copyright information

© Springer 2006

Authors and Affiliations

  • Herbert Schwarz
    • 1
  1. 1.Department of PhysiologyNational University of SingaporeSingapore

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