Auxiliary Proliferative Zones in the Developing and Adult Central Nervous System: Lessons from Studies on the Effects of Ethanol

  • Michael W. Miller
  • Marla B. Bruns


The differential effects of ethanol on the proliferative zones support the thesis that both neocortical proliferative zones generate neurons. Proliferative activity in the VZ is depressed by ethanol regardless of the location along the neuraxis and regardless of the ethanol concentration. In contrast, proliferation within derived zones (at least the SZ and IHZ) is bimodally affected by ethanol in a concentration-dependent manner. Indeed, the unique responses of the VZ and SZ may reflect an interaction between the two zones. For example, the increased proliferative activity in the SZ or IHZ at low concentrations results from a recruitment of new cells into the cycling population (increased GF). This may be an compensatory response to offset the depressed proliferation of VZ cells. After all, the derived zones are seeded by the VZ.


Prenatal Exposure Subventricular Zone Fetal Alcohol Spectrum Disorder Ventricular Zone Fetal Alcohol Syndrome 
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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Michael W. Miller
    • 1
    • 3
  • Marla B. Bruns
    • 2
  1. 1.Department of Neuroscience and PhysiologySUNY-Upstate Medical UniversitySyracuse
  2. 2.Department of Neuroscience and PhysiologySUNY Upstate Medical UniversitySyracuse
  3. 3.Research ServiceVeterans Affairs Medical CenterSyracuse

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