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THE ARTERIAL CHEMORECEPTORS pp 233–238Cite as

The Cell-Vessel Architecture Model for the Central Respiratory Chemoreceptor

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Part of the book series: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY ((AEMB,volume 580))

Abstract

The group of Loeschcke established that the superficial ventrolateral medulla contains chemosensitive regions (see the reviews [1-3]). Later, the group of Nattie conducted experiments of acetazolamide microinjection that induced local tissue acidosis, and found that the midline region (raphe), nucleus tractus solitarii and locus coeruleus are also chemosensitive (see the review [4]). To map the medullary chemosensitive regions using a more physiological stimulation technique, we microinjected CO2-enriched saline into various regions of the in vivo and in vitro rat medulla, and found that the superficial midline, parapyramidal and ventrolateral regions are chemosensitive [5]. These findings extend other microinjection studies [6,7] that showed only that the superficial ventrolateral medulla is chemosensitive.

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Author information

Authors and Affiliations

  1. Department of Medicine, Keio University Tsukigase Rehabilitation Center, Izu City, Shizuoka, 410-3215, Japan

    YASUMASA OKADA

  2. Department of Physiology, Teikyo University, Tokyo, 173-8605, Japan

    SHUN-ICHI KUWANA

  3. Department of Pulmonary Medicine, School of Medicine, Keio University, Tokyo, 160-8582, Japan

    YOSHITAKA OYAMADA

  4. Department of Biochemical and Analytical Pharmacology, GlaxoSmithKline, Research Triangle Park, NC, 27709, USA

    ZIBIN CHEN

Authors
  1. YASUMASA OKADA
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  2. SHUN-ICHI KUWANA
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  3. YOSHITAKA OYAMADA
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  4. ZIBIN CHEN
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Editor information

Editors and Affiliations

  1. International Buddhist University, Osaka, Japan

    Yoshiaki Hayashida

  2. University of Valladolid, Valladolid, Spain

    Constancio Gonzalez

  3. Tohoku University, Sendai, Japan

    Hisatake Kondo

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© 2006 Springer

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OKADA, Y., KUWANA, SI., OYAMADA, Y., CHEN, Z. (2006). The Cell-Vessel Architecture Model for the Central Respiratory Chemoreceptor. In: Hayashida, Y., Gonzalez, C., Kondo, H. (eds) THE ARTERIAL CHEMORECEPTORS. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 580. Springer, Boston, MA. https://doi.org/10.1007/0-387-31311-7_36

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