Abstract
The peripheral arterial chemoreceptors in the carotid body (CB) are the first step in a closed–loop feedback control system that acts to normalize arterial oxygen and carbon dioxide levels by rapidly modulating ventilation. Type I cells in the CB are excitable and contain O2 - sensitive K+ channels (Gonzalez et al., 1995; Montoro et al., 1996; Wyatt et al., 1995). Reduction of K+ conductance in response to hypoxia is the signal that triggers Type I cell depolarization, Ca2+ entry, and secretion of neurotransmitters that bind to receptors on the first order sensory nerve endings of the carotid sinus nerve with cell bodies in the petrosal ganglion {(Gonzalez et al., 1994;Gonzalez et al., 1992). These first order sensory neurons (chemoafferents) project to second order neurons within the nucleus tractus solitarii (nTS), which send projections to the muscles of respiration. While the cascade of molecular and cellular events occurs in multiple CB preparations from multiple mammalian species, key aspects of the cascade are still unknown, particularly identification of the specific oxygen sensor within the Type I cell that initiates the cascade and the specific excitatory neurotransmitter systems that are involved in chemoexcitation. Furthermore, in multiple immature mammalian species, including human infants, hypoxic chemosensitivity matures during the first several weeks of postnatal life. Specific mechanisms mediating that maturation are unknown.
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References
Fink, J.S., Weaver, D.R., Rivkees, S.A., Peterfreund, R.A., Pollack, A.E., Adler, E.M., & Reppert, S.M. 1992, Molecular cloning of the rat A2 adenosine receptor: selective co- expression with D2 dopamine receptors in rat striatum. Brain Res. Mol. Brain Res., 14, 186–195.
Fredholm, B.B., Arslan, G., Halldner, L., Kull, B., Schulte, G., & Wasserman, W. 2000, Structure and function of adenosine receptors and their genes. Naunyn Schmiedebergs Arch.Pharmacol., 362, 364–374.
Gauda, E.B., Northington, F.J., Linden, J., & Rosin, D.L. 2000, Differential expression of A2A, A1-adenosine and D2-dopamine receptor genes in rat peripheral arterial chemoreceptors during postnatal development. Brain Res., 872, 1–10.
Gonzalez, C., Almaraz, L., Obeso, A., & Rigual, R. 1992, Oxygen and acid chemoreception in the carotid body chemoreceptors. Trends Neurosci., 15, 146–153.
Gonzalez, C., Dinger, B. G., & Fidone, S.J. (1994) Mechanisms of carotid body chemoreception. Regulation of Breathing (ed. by J. A. Dempsey & A. I. Pack), pp. 391–470. Marcel Dekker, Inc.
Gonzalez, C., Lopez-Lopez, J. R., Obeso, A., Perez-Garcia, M.T., & Rocher, A. 1995, Cellular mechanisms of oxygen chemoreception in the carotid body. Respir. Physiol, 102, 137–147.
Kobayashi, S., Conforti, L., & Millhorn, D.E. 2000, Gene expression and function of adenosine A2A receptor in the rat carotid body. Am. J. Physiol Lung Cell Mol. Physiol, 279, L273–L282.
McQueen, D.S. & Ribeiro, J.A. 1981, Effect of adenosine on carotid chemoreceptor activity in the cat. British Journal Of Pharmacology, 74, 129–136.
Monteiro, E. C. & Ribeiro, J.A. 1987, Ventilatory effects of adenosine mediated by carotid body chemoreceptors in the rat. Naunyn Schmiedebergs Arch. Pharmacol, 335, 143–148.
Monteiro, E.C. & Ribeiro, J.A. 1989, Adenosine deaminase and adenosine uptake inhibitions facilitate ventilation in rats. Naunyn Schmiedebergs Arch. Pharmacol., 340, 230–238.
Montoro, R.J., Urena, J., Fernandez-Chacon, R., Alvarez, T., & Lopez-Barneo, J. 1996, Oxygen sensing by ion channels and chemotransduction in single glomus cells. J Gen.Physiol, 107, 133–143.
Runold, M., Lagercrantz, H, Prabhakar N.R., & Fredholm B.B. Role of adenosine in hypoxic ventilatory depression. J Appl Physiol [2], 541–546. 1989. Ref Type: Journal (Full)
Runold, M., Cherniack, N.S., & Prabhakar, N.R. 1990, Effect of adenosine on isolated and superfused cat carotid body activity. Neuroscience Letters, 113, 111–114.
Weaver, D.R. 1996, A1-adenosine receptor gene expression in fetal rat brain. Developmental Brain Research, 94, 205–223.
Wyatt, C.N., Wright, C., Bee, D., & Peers, C. 1995, O2-sensitive K+ currents in carotid body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransduction. Proc. Natl. Acad. Sci. U.S.A, 92, 295–299.
Zimmermann, H. & Braun, N. 1996, Extracellular metabolism of nucleotides in the nervous system. J. Auton. Pharmacol., 16, 397–400.
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GAUDA, E.B., COOPER, R.Z., DONNELLY, D.F., MASON, A., McLEMORE, G.L. (2006). The Effect of Development on the Pattern of A1 and A2a-Adenosine Receptor Gene and Protein Expression in Rat Peripheral Arterial Chemoreceptors. In: Hayashida, Y., Gonzalez, C., Kondo, H. (eds) THE ARTERIAL CHEMORECEPTORS. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 580. Springer, Boston, MA. https://doi.org/10.1007/0-387-31311-7_19
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DOI: https://doi.org/10.1007/0-387-31311-7_19
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