Abstract
Control of cellular functions by extracellular signal-induced elevation of intracellular Ca is a common theme in excitable biosystems including the carotid body chemoreception. The Ca-signal is delivered to appropriate intracellular target proteins via phosphorylation catalyzed by multifunctional Ca/calmodulindependent protein kinases (CaM kinases), which are composed of types I, II and IV (Hanson and Schulman, 1992; Sakagami and Kondo, 1998). In order to see how CaM kinases are involved in the chemoreception, the present study examined the localization of CaM kinase I in immuno-light and electron microscopy in the rat carotid body as well as its adjacent superior cervical ganglion. The latter contains SIF (small intensely fluorescent) cells, at least some of which exhibit cytological features including the innervation similar to those of the carotid body chief cells (Kondo, 1977).
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HOSHI, H., SAKAGAMI, H., OWADA, Y., KONDO, H. (2006). Localization of Ca/Calmodulin-Dependent Protein Kinase I in the Carotid Body Chief Cells and the Ganglionic Small Intensely Fluorescent (SIF) Cells of Adult Rats. In: Hayashida, Y., Gonzalez, C., Kondo, H. (eds) THE ARTERIAL CHEMORECEPTORS. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 580. Springer, Boston, MA. https://doi.org/10.1007/0-387-31311-7_13
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DOI: https://doi.org/10.1007/0-387-31311-7_13
Publisher Name: Springer, Boston, MA
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