Perchlorate pp 153-168 | Cite as

The Ecotoxicology of Perchlorate in the Environment

  • Philip N. Smith


Thyroid Hormone Ammonium Perchlorate Sodium Perchlorate Prairie Vole Below Detection Limit 
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  1. 1.
    Urbansky, E.T. Perchlorate chemistry: Implications for analysis and remediation. Bioremediat J 1998; 2:81–95.CrossRefGoogle Scholar
  2. 2.
    Urbansky, E.T., Collette, T.W., Robarge, W.P., Hall, W.L., Skillen, J.M., Kane, P.F., Survey of fertilizers and related materials for perchlorate (C1O4 ). EPA/600/R-01/049. Final Report. U.S. Environmental Protection Agency Office of Research and Development, Cincinnati, OH. 2001.Google Scholar
  3. 3.
    Susarla, S., Bacchus, S.T., Wolfe, N.L., McCutcheon, S.C. Phytotransformation of perchlorate and identification of metabolic products in Myriophyllum aquaticum. Intern J Phytoremed 1999; 1(1): 97–107.CrossRefGoogle Scholar
  4. 4.
    Nzengung, V.A., Wang, C.H., Harvey, G. Plant-mediated transformation of perchlorate into chloride. Environ Sci Technol 1999; 33:1478–9.CrossRefGoogle Scholar
  5. 5.
    Ellington, J.J., Wolfe, N.L., Garrison, A.W., Evans, J.J., Avants, J.K., Teng, Q. Determination of perchlorate in tobacco plants and tobacco products. Environ Sci Technol 2001; 35: 3213–8.CrossRefGoogle Scholar
  6. 6.
    Parsons. 2001. Scientific and technical report for perchlorate biotransport investigation: A study of perchlorate occurrence in selected ecosystems. Interim Final Report. Air Force Institute for Environment, Safety and Occupational Health Risk Analysis, Brooks AFB, TX, USA.Google Scholar
  7. 7.
    Smith, P.N., Theodorakis, C.W., Anderson, T.A., Kendall, R.J. Preliminary assessment of perchlorate in ecological receptors at the Longhorn Army Ammunition Plan (LHAAP), Karnack, TX. Ecotoxicology 2001; 10:305–13.CrossRefGoogle Scholar
  8. 8.
    Susarla, S., Bacchus, S.T., Harvey, G., McCutcheon, S.C. Phytotransformations of perchlorate contaminated waters. Environ Technol 2000; 21:1055–65.CrossRefGoogle Scholar
  9. 9.
    Urbansky, E.T., Magnuson, M.L., Kelty, C.A., Brown, S.K. Perchlorate uptake by salt cedar (Tamarix ramosissima) in the Las Vegas Wash riparian ecosystem. Sci Total Environ 2000; 256:227–232.CrossRefGoogle Scholar
  10. 10.
    Aken, B.V., Schnoor, J.L. Evidence of perchlorate (ClO4-) reduction in plant tissues (poplar tree) using radio-labeled 36ClO4 . Environ Sci Technol 2002; 36: 2783–88.CrossRefGoogle Scholar
  11. 11.
    Tan, K., Anderson, T.A., Jones, M.W., Smith, P.N., Jackson, W.A. Uptake of perchlorate in aquatic and terrestrial plants at field scale. J Environ Qual 2004; 33:1638–46.CrossRefGoogle Scholar
  12. 12.
    Yu, L., Canas, J.E., Cobb, G.P., Jackson, W.A., Anderson, T.A. Uptake of perchlorate in terrestrial plants. Ecotoxicol Environ Saf 2004; 58:44–9.CrossRefGoogle Scholar
  13. 13.
    Urbansky, E., Schock, M. Issues in Managing the Risks Associated with Perchlorate in Drinking Water. J Environ Manage 1999; 56:79–95.CrossRefGoogle Scholar
  14. 14.
    Jackson, W.A., Joseph, P., Laxman, P., Tan, K., Smith, P.N., Yu, L., Anderson, T.A. Perchlorate accumulation in forage and edible vegetation. Journal of Agric Food Chem; 53:369–373.Google Scholar
  15. 15.
    Beyer, W.N., Connor, E.E., Gerould, S. Estimates of soil ingestion by wildlife. J Wildl Manage 1994; 582:375–82.Google Scholar
  16. 16.
    Smith, P.N., Wireman, J., Carr, J.A., Smith, E.E., Kendall, R.J. “Ecological Risk Assessment” In Perchlorate Ecotoxicology, Kendall, R.J., P.N. Smith, eds. Pensacola, FL: SETAC Press, in press.Google Scholar
  17. 17.
    Hogue, C. Rocket-fueled river. Chem Engin News 2003; 81(33): 37–46.Google Scholar
  18. 18.
    Smith, P.N., Yu, L., McMurry, S.T., Anderson, T.A. Perchlorate in water, soil, vegetation, and rodents collected from the Las Vegas Wash, Nevada. Environmental Pollution 2004; 132:121–7.CrossRefGoogle Scholar
  19. 19.
    Wolff, J. Perchlorate and the thyroid gland. Pharmacol Rev 1998; 50:89–105.Google Scholar
  20. 20.
    Capen, C. “Toxic Responses of the Endocrine System” In Casarett and Doull’s Toxicology The Basic Science of Poisons, 6th ed. Klaassen C ed. New York: McGraw-Hill Companies 2001.Google Scholar
  21. 21.
    Pop, V., Kuijpens, J., van Baar, A., Verkerk, G., van Son, M, Vijlder, J., Vulsma, T., Wiersinga, W., Drexhage, H., Vader, H. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol 1999; 50:149–155.CrossRefGoogle Scholar
  22. 22.
    Kendall, R.J., Dickerson, R.L., Giesy, J.P., Suk, W.P. Principles and Processes for Evaluating Endocrine Disruption in Wildlife. Pensacola, FL: SETAC, 1998.Google Scholar
  23. 23.
    Escobar, G., Obregon, M., Escobar del Rey, F. Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 2000; 85(11):3975–87.CrossRefGoogle Scholar
  24. 24.
    Isanhart, J.P., McNabb, F.M.A., Smith, P.N. Effects of perchlorate exposure on resting metabolism, peak metabolism, and thyroid function in the prairie vole, Microtus ochrogaster. Environ Toxicol Chem 2005; 24(3):678–84.CrossRefGoogle Scholar
  25. 25.
    Parsons. 2002. Sub-chronic toxicity and bioconcentration of perchlorate by the earthworm Eisenia fetida. Contract F41624-01-D-8009, Brooks AFB, TX.Google Scholar
  26. 26.
    EA Engineering, Science, and Technology. 1998. Results of acute and chronic toxicity testing with sodium perchlorate. Report 2900, Brooks AFB, TX.Google Scholar
  27. 27.
    Anderson, T.A., Landrum, M., Snyder, E. “Perchlorate Effects on Invertebrates” In Perchlorate Ecotoxicology, Kendall, R.J., P.N. Smith, eds. Pensacola, FL: SETAC Press, in press.Google Scholar
  28. 28.
    Bradford, C.M., Carr, J.A., Rinchard, J., Theodorakis, C. Perchlorate affects thyroid function in eastern mosquitofish (Gambusia holbrooki) at environmentally relevant concentrations. Eviron Sci Technol; 39:5190–5195.Google Scholar
  29. 29.
    Mukhi, S., Carr, J.A., Anderson, T.A., Patino, R. Development and validation of new biomarkers of perchlorate exposure in fishes. Environ Toxicol Chem 2005; 24:1107–1115.CrossRefGoogle Scholar
  30. 30.
    Theodorakis, C.W., Rinchard, J., Park, J.W., McDaniel, L, Liu, F., Carr, J.A., Wages, M. Thyroid endocrine disruption in stonerollers and cricket frogs from perchlorate-contaminated streams in east-central Texas. Ecotoxicology, in press.Google Scholar
  31. 31.
    Capps, T., Mukhi, S., Rinchard, J., Theodorakis, C.W., Blazer, V.S., Patiño, R. Exposure to perchlorate induces the formation of macrophage aggregates in the trunk kidney of zebrafish and mosquitofish. J Aquat Animal Health 2004; 16:145–51.CrossRefGoogle Scholar
  32. 32.
    Theodorakis, C, Patiño, R., Snyder, E., Albers, E. “Perchlorate Effects in Fish” In Perchlorate Ecotoxicology, Kendall, R.J., P.N. Smith, eds. Pensacola, FL: SETAC Press, in press.Google Scholar
  33. 33.
    Brown, S.B., Adams, B.A., Cyr, D.G., Eales, J.G. Contaminant effects on the teleost fish thyroid. Environ Toxicol Chem 2004; 23:1680–1701.CrossRefGoogle Scholar
  34. 34.
    Goleman, W.L., Urquidi, L.J., Anderson, T.A., Smith, E.E., Kendall, R.J., Carr, J.A. Environmentally relevant concentrations of ammonium perchlorate inhibit development and metamorphosis in Xenopus laevis. Environ Toxicol Chem 2002; 21:424–30.CrossRefGoogle Scholar
  35. 35.
    McDaniel, L.N. Ultraviolet Radiation-Induced Genotoxicity in Xenopus laevis Exposed to Sodium Perchlorate. MS. Thesis Texas Tech University, Lubbock, TX, 2004.Google Scholar
  36. 36.
    Tietge, J.E., Degitz, S.J. The effects of perchlorate on Xenopus laevis. Technical Report, Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. EPA, Duluth, MN. 2003.Google Scholar
  37. 37.
    Goleman, W.L., Carr, J.A., Anderson, T.A. Environmentally relevant concentrations of ammonium perchlorate inhibit thyroid function and alter sex ratios in developing Xenopus laevis. Environ Toxicol Chem 2002; 21:590–597.CrossRefGoogle Scholar
  38. 38.
    Carr, J.A., Urquidi, L.J., Goleman, W. L., Hu, F., Smith, P. N., Theodorakis, C.W., “Ammonium perchlorate disruption of thyroid function in natural amphibian populations: Assessment and potential impact” In “Multiple Stressor Effects in Relation to Declining Amphibian Populations”, ASTM STP 1443, G. Linder, ed. West Conshohocken, PA: ASTM International, 2003. pps. 131–142.Google Scholar
  39. 39.
    U.S. Army Corps of Engineers (USACE). Final Report: Bosque and Leon River Watersheds Study. 2004.Google Scholar
  40. 40.
    Carr, J.A., Theodorakis, C. “Effects of Perchlorate in Amphibians” In Perchlorate Ecotoxicology, Kendall, R.J., P.N. Smith, eds. Pensacola, FL: SETAC Press, in press.Google Scholar
  41. 41.
    Sparling, D.W., Harvey, G., Nzengung, V. “Interaction between perchlorate and iodine in the metamorphosis of Hyla versicolor” In Multiple Stressor Effects in Relation to Declining Amphibian Populations”, ASTM STP 1443, G. Linder, ed., West Conshohocken, PA: ASTM International, 2003. pps. 131–42.Google Scholar
  42. 42.
    Hu, F., Gentles, A., Goleman, W.L., Carr, J.A. Developmental stage and environmental iodide influence the antimetamorphic effects of perchlorate. Proc Soc Environ Toxicol Chem 24th Annual Meeting, 2003.p. 293.Google Scholar
  43. 43.
    Gentles, A., Surles, J., Smith, E.E. Evaluation of Adult Quail and Egg Production Following Exposure to Perchlorate-Treated Water. Environ Toxicol Chem; 24:1930–1934.Google Scholar
  44. 44.
    McNabb, F.M.A. Biomarkers for the assessment of avian thyroid disruption by chemical contaminants. Avian Poult Biol Rev; 16:3–10.Google Scholar
  45. 45.
    McNabb F.M.A., Larsen, C.T., Pooler, P.S. Ammonium perchlorate effects on thyroid function and growth in bobwhite quail chicks. Environ Toxicol Chem 2004; 23:997–1003.CrossRefGoogle Scholar
  46. 46.
    McNabb F.M.A., Jang, D.A., Larsen, C.T. Does thyroid function in developing birds adapt to sustained ammonium perchlorate exposure? Toxicol Sci 2004; 82:106–13.CrossRefGoogle Scholar
  47. 47.
    McNabb, F.M.A., Hooper, M.J., Smith, E.E., McMurry, S.T., Gentles, B.A. “Perchlorate Effects in Birds” In Perchlorate Ecotoxicology, Kendall, R.J., P.N. Smith, eds. Pensacola, FL: SETAC Press, in press.Google Scholar
  48. 48.
    Thuett, K.A., Roots, E.H., Mitchell, L.P., Gentles, B.A., Anderson, T.A., Smith, E. E. In utero and lactational exposure to ammonium perchlorate in drinking water: effects on developing deer mice at postnatal day 21. J Toxicol Environ Health A. 2002; 65(15):1061–76.CrossRefGoogle Scholar
  49. 49.
    Thuett, K.A., Roots, E.H., Mitchell, L.P., Gentles, B.A., Anderson, T., Kendall, R.J., Smith, E.E. Effects of in utero and lactational ammonium perchlorate exposure on thyroid gland histology and thyroid and sex hormones in developing deer mice (Peromyscus maniculatus) through postnatal day 21. J Toxicol Environ Health A, 2002; 65:2119–30.CrossRefGoogle Scholar
  50. 50.
    York, R.G., Barnett, J. Jr, Brown, W.R., Garman, R.H., Mattie, D.R., Dodd, D. A rat neurodevelopmental evaluation of offspring, including evaluation of adult and neonatal thyroid, from mothers treated with ammonium perchlorate in drinking water. Int J Toxicol 2004; 23:191–214.CrossRefGoogle Scholar
  51. 51.
    Guyton, A.C., Hall, J.E. Textbook of Medical Physiology, 10th ed. Philadelphia, PA: W.B. Saundcrs, 2001.Google Scholar
  52. 52.
    Smith, P.N., Utley, S.J., Cox, S.B., Anderson, T.A., McMurry, S.T. Monitoring perchlorate exposure and thyroid hormone status among raccoons inhabiting a perchlorate-contaminated site. Environ Monit Assess 2005; 102:337–347.CrossRefGoogle Scholar
  53. 53.
    Smith E.E., Isanhart, J., Smith, P.N., Dixon, K., McNabb, F.M.A. “Perchlorate Effects on Mammals” In Perchlorate Ecotoxicology, Kendall, R.J., P.N. Smith, eds. Pensacola, FL: SETAC Press, in press.Google Scholar
  54. 54.
    Cheng, Q., Perlmutter, L., Smith, P.N., McMurry, S.T., Jackson, W.A., Anderson, T.A. A study on perchlorate exposure and absorption in beef cattle. J Agric Food Chem 2004; 52:3456–61.CrossRefGoogle Scholar
  55. 55.
    Kirk, A.B., Smith, E.E., Tian, K., Anderson, T. A., Dasgupta, P.K. Perchlorate in milk. Environ Sci Technol 2003; 37(21):4979–81.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Philip N. Smith
    • 1
  1. 1.The Institute of Environmental & Human HealthTexas Tech UniversityLubbock

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