4. Conclusions
Early results of endoventricular cell transplantation demonstrate that this approach is feasible and safe in the models tested. The procedure is likely to have application in a majority of patients with previous myocardial infarction and congestive heart failure as the risks associated with a minimally invasive endoventricular injection are potentially lower than those linked with direct epicardial injection. The use of 3-D guidance appears to be key in accurately targeting areas that need to be treated, and catheters and cell preparations to be used in humans should be pretested for biocompatibility and safety. While catheter injection of cells is a relatively new innovation, the ability to access the heart without having to perform a median sternotomy will certainly encourage further evaluation of its potential for delivering many therapeutic biologic agents.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
5. References
Fortuin FD, Vale P, Losordo DW et al. One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotmy in no-opion patients, J. Am. Coll. Cardiol. 92, 436–9 (2003).
Menasche P, Hagege AA, Vilquin JT, et al. Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J. Am. Coll. Cardiol. April 2, 1078–83 (2003).
Dib N, McCarthy P, Campbell A, et al. Feasiblility and Safety of Autologous Myoblast Transplantation in Patients with Ischemic Cardiomyopathy, Cell Transplantation. 14, (2003).
Dib N, McCarthy P, Dinsmore J, et al. Safety and Feasibility of autologous Myoblast Transplantation in Patients with Ischemic Cardiomyopathy: Interim results from the United States Experience, Circulation. 106, II-463 (2002).
Vale PR, Losordo DW, Milliken CD, et al. Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patiens with chronic myocardial ischemia, Circulation. 103, 2138–43 (2001).
Fuchs S, Dib N, Cohen B, et al. A Randomized Double Blind Placebo Controlled multicenter Pilot Study of the Safety and Feasiblity of AdGVVEGF121.10 via an Intramyocardial Injection Catheter in Patients With Advanced Coronary Artery Disease, J. Am. Coll. Cardiol. 41, 21A (2003)
Fuchs S, Satler LF, Kornowski R, et al. Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study, J. Am. Coll. Cardiol. 41, 1721–4 (2003).
Smits PC, van Geuns RJ, Poldermans D, et al. Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up, J. Am. Coll. Cardiol. 42,2063–9 (2003)
Ince H, Petzsch M, Rehders TC, et al. Transcatheter transplantation of autologous skeletal myoblasts in postinfarction patients with severe left ventricular dysfunction, J. Endovasc. Ther. 6, 695–704 (2004).
Dib N, Diethrich EB, Campbell A, et al. Endoventricular transplantation of allogenic skeletal myoblasts in a porcine model of myocardial infarction, J. Endovasc. Ther. 9, 313–9 (2002).
Perin EC, Dohmann HF, Borojevic R, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure, Circulation. 107, 2294–302 (2003).
Pagani FD, DerSimonian H, Zawadzka A, et al. Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation, J. Am. Coll. Cardiol. 41, 879–88 (2003).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Science+Business Media, Inc.
About this chapter
Cite this chapter
Dib, N. (2006). Percutaneous Myoblast Transplantation: Steps In Translational Research. In: Dib, N., Taylor, D.A., Diethrich, E.B. (eds) Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair. Springer, Boston, MA. https://doi.org/10.1007/0-387-30939-X_14
Download citation
DOI: https://doi.org/10.1007/0-387-30939-X_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-25788-4
Online ISBN: 978-0-387-30939-2
eBook Packages: EngineeringEngineering (R0)