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Autologous Mononuclear Bone Marrow Transplantation for Myocardial Infarction: The Spanish Experience

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6. References

  1. British Heart Foundation. Coronary heart disease statistics. www.bhf.org.uk. 2002; BHF Statistics Database.

    Google Scholar 

  2. Reddy KS, Global perspective on cardiovascular disease. In: Yusuf S, Cairns JA, Camm AJ, Fallen EL, Gersh BJ, eds, 2nd end (BMJ Books; London, 2003) 91–102.

    Google Scholar 

  3. Antman EM, Van de Werf F. Pharmacoinvasive therapy. The future of treatment for ST-elevation myocardial infarction. Circulation 2004; 109: 2480–2486.

    Article  Google Scholar 

  4. Eagle KA, Goodman SG, Avezum A, Budaj A, Sullivan CM, Lopez-Sendon J; GRACE Investigators. Practice variation and missed opportunities for reperfusion in ST-segment-elevation myocardial infarction: findings from the Global Registry of Acute Coronary Events (GRACE). Lancet 2002;359:373–377.

    Article  Google Scholar 

  5. Ryan TJ, Antman EM, Brooks NH, et al. 1999 update: ACC/AHA Guidelines for the Management of Patients With Acute Myocardial Infarction: Executive Summary and Recommendations: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). Circulation 1999;100:1016–1030.

    Google Scholar 

  6. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction: experimental observations and clinical implications. Circulation 1990; 81: 1161–1172.

    Google Scholar 

  7. Bolognese L, Carrabba N, Parodi G, Santori GM, Buonamici P, Cerisano G, et al. Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction. Circulation 2004; 109: 1121–1126.

    Article  Google Scholar 

  8. Tosh D, Slack JMW. How cells change their phenotype. Nat Rev Mol Cell Biol 2002; 3: 187–194.

    Article  Google Scholar 

  9. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003; 114: 763–776.

    Article  Google Scholar 

  10. Beltrami AP, Urbanek K, Kajstura J, Yan SM, Finato N, Bussani R, et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001; 344: 1750–1757.

    Article  Google Scholar 

  11. Anversa P, Nadal-Ginard B. Myocyte renewal and ventricular remodeling. Nature 2002; 415: 240–243.

    Article  Google Scholar 

  12. Nadal-Ginard B, Kajstura J, Leri A, Anversa P. Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ Res 2003; 92: 139–150.

    Article  Google Scholar 

  13. Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Ginard B, et al. Chimerism of the transplanted heart. New Engl J Med 2002; 346: 5–15.

    Article  Google Scholar 

  14. Thiele J, Varus E, Wickenhauser C, Kvasnicka HM, Metz KA, Beelen DW. Regeneration of heart muscle tissue: quantification of chimeric cardiomyocytes and endothelial cells following transplantation. Histol Histopathol 2004; 19: 201–209.

    Google Scholar 

  15. Deb A, Wang S, Skelding KA, Miller D, Simper D, Caplice NM. Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patients. Circulation 2003;107:1247–9.

    Article  Google Scholar 

  16. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410: 701–705.

    Article  Google Scholar 

  17. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci 2001; 98: 10344–10349.

    Article  Google Scholar 

  18. Tomita S, Mickle DA, Weisel RD, Jia ZQ, Tumiati LC, Allidina Y, et al. Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J Thorac Cardiovasc Surg 2002; 123: 1132–1140.

    Article  Google Scholar 

  19. Mangi AA, Noiseux N, Kong K, He H, Rezvani N, Ingwall JS, et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infracted hearts. Nat Med 2003; 9: 1195–1201.

    Article  Google Scholar 

  20. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 2004; 428: 668–73.

    Article  Google Scholar 

  21. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial Infarcts. Nature 2004; 428: 664–668.

    Article  Google Scholar 

  22. Vulliet PR, Greeley M, Halloran M, MacDonald A, Kittelson MD. Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet 2004; 363: 783–84.

    Article  Google Scholar 

  23. Silvestre JS, Gojova A, Brun V, Potteaux S, Esposito B, Duriez M, et al. Transplantation of bone marrow-derived mononuclear cells in ischemic apolipoprotein E-knockout mice accelerates atherosclerosis without altering plaque composition. Circulation 2003; 108: 2839–2842.

    Article  Google Scholar 

  24. Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilized with granulocytecolony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomized clinical trial. Lancet 2004; 363: 751–756.

    Article  Google Scholar 

  25. Chien KR. Lost in translation. Nature 2004; 428: 607–608.

    Google Scholar 

  26. Matsubara H. Risk to the coronary arteries of intracoronary stem cell infusion and G-CSF cytokine therapy. Lancet 2004: 746–747.

    Google Scholar 

  27. Hamano K, Nishida M, Hirata K, Mikamo A, Li TS, Harada M, et al. Local implantation of autologous bone marrow for therapeutic angiogenesis in patients with ischemic heart disease: clinical trial and preliminary results. Jpn Circ J 2001;65:845–847.

    Google Scholar 

  28. Menasche P, Hagege AA, Vilquin JT, Desnos M, Abergel E, Pouzet B, Bel A, Sarateanu S, Scorsin M, Schwartz K, Bruneval P, Benbunan M, Marolleau JP, Duboc D. Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J Am Coll Cardiol. 2003;41:1078–83.

    Article  Google Scholar 

  29. Herreros J, Prosper F, Perez A, Gavira JJ, Garcia-Velloso MJ, Barba J, et al. Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction. Eur Heart J 2003;24:2012–2020.

    Article  Google Scholar 

  30. Pagani FD, DerSimonian H, Zawadzka A, Wetzel K, Edge AS, Jacoby DB, et al. Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J Am Coll Cardiol 2003;41:879–888.

    Article  Google Scholar 

  31. Galinanes M, Loubani M, Davies J, Chin D, Pasi J, Bell PR. Autotransplantation of unmanipulated bone marrow into scarred myocardium is safe and enhances cardiac function in humans. Cell Transplant 2004;13:7–13.

    Google Scholar 

  32. Smits PC, van Geuns RJ, Poldermans D, Bountioukos M, Onderwater EE, Lee CH, et al. Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up. J Am Coll Cardiol 2003;42:2063–2069.

    Article  Google Scholar 

  33. Tse HF, Kwong YL, Chan JK, Lo G, Ho CL, Lau CP. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 2003;361:47–49.

    Article  Google Scholar 

  34. Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT, et al. Transendocardial, auotologous bone marrow cell transplantation for severe, chronic ischemic heart failure Circulation. 2003;107:2294–2302.

    Google Scholar 

  35. Fuchs S, Satler LF, Kornowski R, Okubagzi P, Weisz G, Baffour R, et al. Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease. A feasibility study. J Am Coll Cardiol 2003;41:1721–1724.

    Google Scholar 

  36. Kuethe F, Figulla HR, Voth M, Richartz BM, Opfermann T, Sayer HG, et al. Mobilization of stem cells by granulocyte colony-stimulating factor for the regeneration of myocardial tissue after myocardial infarction. Dtsch Med Wochenschr 2004;129:424–428.

    Google Scholar 

  37. Assmus B, Schächinger V, Teupe C, Britten M, Lehmann R, Döbert N, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 2002; 106: 3009–3017.

    Article  Google Scholar 

  38. Strauer BE, Brehm M, Zeus T, Köstering M, Hernandez A, Sorg RV, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002; 106: 1913–1918.

    Article  Google Scholar 

  39. Fernandez-Aviles F, San Roman JA, Garcia-Frade J, Fernandez ME, Penarrubia MJ, de la Fuente L, et al. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res. 2004;95:742–748.

    Article  Google Scholar 

  40. Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004;364:141–148.

    Article  Google Scholar 

  41. Chen SL, Fang WW, Ye F, Liu YH, Qian J, Shan SJ, Zhang JJ, Chunhua RZ, Liao LM, Lin S, Sun JP. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol. 2004;94:92–5.

    Article  Google Scholar 

  42. Sakakibara Y, Tambara K, Lu F, Nishina T, Nagaya N, Nishimura K et al. Cardiomyocyte transplantation does not reverse cardiac remodelling in rats with chronic myocardial infarction. Ann Thorac Surg 2002; 74: 25–30.

    Article  Google Scholar 

  43. Li RK, Mickle DA, Weisel RD, Rao V, Jia ZQ.. Optimal time for cardiomyocyte transplantation to maximize myocardial function after left ventricular injury. Ann Thorac Surg 2001; 72: 1957–1963.

    Google Scholar 

  44. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. Circulation 2002; 105: 539–542.

    Article  Google Scholar 

  45. Baer FM, Voth E, Scheneider CA, Theissen P, Schicha H, Sechtem U. Comparison of low-dose dobutamine-gradiente-echo magnetic resonance imaging and positron emission tomography with [18F] fluorodeoxyglucose in patients with chronic coronary artery disease. Circulation 1995; 91: 1006–1015.

    Google Scholar 

  46. Baer FM, Voth E, Scheneider CA, Theissen P, Schicha H, Sechtem U. Comparison of low-dose dobutamine-gradiente-echo magnetic resonance imaging and positron emission tomography with [18F] fluorodeoxyglucose in patients with chronic coronary artery disease. Circulation 1995; 91: 1006–1015.

    Google Scholar 

  47. Cwajg JM, Cwajg E, Nagueh SF, He ZX, Qureshi U, Olmos LI, et al. End-diastolic wall thickness as a predictor of recovery of function in myocardial hibernation: relation to rest-redistribution T1-201 tomography and dobutamine stress echocardiography. J Am Coll Cardiol 2000; 35: 1152–1161.

    Article  Google Scholar 

  48. Barbato E, Aarnoudse W, Aengevaeren WR, Werner G, Klauss V, Bojara W, et al; Week 25 study group. Validation of coronary flow reserve measurements by thermodilution in clinical practice. Eur Heart J 2004; 25: 219–223.

    Google Scholar 

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Fernández-Avilés, F. et al. (2006). Autologous Mononuclear Bone Marrow Transplantation for Myocardial Infarction: The Spanish Experience. In: Dib, N., Taylor, D.A., Diethrich, E.B. (eds) Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair. Springer, Boston, MA. https://doi.org/10.1007/0-387-30939-X_12

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  • DOI: https://doi.org/10.1007/0-387-30939-X_12

  • Publisher Name: Springer, Boston, MA

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