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Embryonic Salivary Gland Branching Morphogenesis

  • Chapter
Branching Morphogenesis

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Salivary submandibular gland (SMG) morphogenesis is regulated by the functional integration of stage-specific growth factor-, cytokine- and transcription factor-mediated signaling which mediates specific patterns of cell proliferation, cell quiescence, apoptosis, and histodifferentiation. We describe the stage-specific distribution of protein components of key signaling pathways during embryonic SMG development and correlate their protein expression patterns with cell proliferation and apoptosis. We then review the critical role of the Fibroblast Growth Factor (FGF), Hedgehog (Hh) and Ectodysplasin (Eda) signaling pathways and discuss how they may interact within the context of a nonlinear genetic network.

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Authors and Affiliations

  1. Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California, USA

    Tina Jaskoll & Michael Melnick

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  1. Tina Jaskoll
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  2. Michael Melnick
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Jaskoll, T., Melnick, M. (2005). Embryonic Salivary Gland Branching Morphogenesis. In: Branching Morphogenesis. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-30873-3_9

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