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Extracellular Matrix Remodeling in Mammary Gland Branching Morphogenesis and Breast Cancer

The Double-Edged Sword

  • Chapter
Branching Morphogenesis

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

That dififerentiation and malignancy are different faces of the same coin is now almost a cliche. Although widely accepted as fact, exactly what are the points of similarity and differences that contribute to normal morphogenesis on the one hand and to neoplastic progression on the other? How can mechanisms that permit, guide and determine differentiation also contribute to malignancy? More specifically, what are the molecules that guide nor-mal morphogenesis yet contribute to neoplastic transformation and progression? These pro-cesses probably involve arrays of genetic programs. For the purpose of this review, we will focus on the roles of several genes that appear to fill these contradictory functions.

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Authors and Affiliations

  1. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA

    Eva A. Turley

  2. Departments of Biochemistry/Oncology, London Regional Cancer Center, London, Ontario, Canada

    Mina J. Bissell

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  1. Eva A. Turley
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  2. Mina J. Bissell
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Turley, E.A., Bissell, M.J. (2005). Extracellular Matrix Remodeling in Mammary Gland Branching Morphogenesis and Breast Cancer. In: Branching Morphogenesis. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-30873-3_7

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