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How Is the Branching of Animal Blood Vessels Implemented?

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Branching Morphogenesis

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

For centuries, the cardiovascular system of animals has been described as a branching tree with the heart in its very centre. Although this description dates back to Galen (c. 130–200 A.D.), and structural similarities with trees are obvious, it has to be empha-sized that, unlike a tree, the animal blood circulation does not contain blind ending branches. The discoveries of Harvey (1578–1657) and Malpighi (1628–1694) demonstrated that the blood circulation, especially when studied at light microscopic dimensions, forms a “closed system” of circuits in which every single blood vessel is continuous with another one. Arterial vessels leave the heart, branch, and connect through a capillary network to corresponding veins that drain the blood back to the heart. It is therefore more appropriate to understand the circulatory system as a network of conductive units of varying sizes.

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  1. Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooldyn, New York, USA

    Sybill Patan

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Patan, S. (2005). How Is the Branching of Animal Blood Vessels Implemented?. In: Branching Morphogenesis. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-30873-3_6

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