Skip to main content
SpringerLink
Log in

Synthesis of N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Axons and Glia of the Crayfish Medial Giant Nerve Fiber

  • Conference paper
N-Acetylaspartate

Part of the book series: Advances in Experimental Medicine and Biology ((volume 576))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 229.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

7. References

  1. A. Curatelo, P. D’Archangelo, A. Lino, and A. Brancati, Distribution of N-acetyl-aspartic and N-acetylaspartyl-glutamic acids in nervous tissue. J. Neurochem. 12: 339–342 (1965)

    Article  Google Scholar 

  2. E. Miyamoto, Y. Kakimoto, and I. Sano, Identification of N-acetyl-alpha-aspartylglutamic acid in the bovine brain. J. Neurochem. 13(10):999–1003 (1966)

    Article  PubMed  CAS  Google Scholar 

  3. K.L. Reichelt and E. Kvamme, Histamine-dependent formation of N-acetyl-aspartyl peptides in mouse brain. J. Neurochem 21(4):849–859 (1973)

    Article  PubMed  CAS  Google Scholar 

  4. C.B. Cangro, M.A. Namboodiri, L.A. Sklar, A. Corigliano-Murphy, and J.H. Neale, Immunohistochemistry and biosynthesis of N-acetylaspartylglutamate in spinal sensory ganglia. J. Neurochem. 49(5):1579–88 (1987)

    Article  PubMed  CAS  Google Scholar 

  5. L.M. Gehl, O.H. Saab, T. Bzdega, B. Wroblewska and J.H. Neale, Biosynthesis of NAAG by an enzymemediated process in rat central nervous system neurons and glia. J. Neurochem, 90(4):989–997 (2004)

    Article  PubMed  CAS  Google Scholar 

  6. J.H. Neale, T. Bzdega and B. Wroblewska, N-acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J. Neurochem. 75: 443–452 (2000)

    Article  PubMed  CAS  Google Scholar 

  7. E.M. Lieberman, A. Urazaev, R.M. Grossfeld, and J. Christian, NAAG and NAALadase are present in the crayfish medial giant nerve fiber: Implication for axon-Schwann cell signaling. J. Neurochem. Suppl. 72: S56 (1999)

    Google Scholar 

  8. L.S. Kane, J.G. Buttram, A.K. Urazaev, and E.M. Lieberman, Uptake and metabolism of glutamate at non-synaptic regions of crayfish central nerve fibers: Implications for axon-glia signaling. Neuroscience 97:(3) 601–609 (2000)

    Article  PubMed  CAS  Google Scholar 

  9. A.K. Urazaev,. R.M., Grossfeld, P.L. Fletcher, H. Speno, B. Gafurov, J.G. Buttram Jr. and E.M. Lieberman, Synthesis and release of N-acetylaspartylglutamate (NAAG) by crayfish nerve fibers: Implications for axon-glia signaling. Neuroscience 106(1):237–247 (2001a)

    Article  PubMed  CAS  Google Scholar 

  10. A. Kh. Urazaev, J.G. Butram Jr., J.P. Deen, B. Sh. Gafurov, B.S., Slusher, R. M. Grossfeld, and E. M. Lieberman, Mechanisms of clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: Implications for axon-glia signaling. Neuroscience 107(4): 697–703 (2001b)

    Article  PubMed  CAS  Google Scholar 

  11. J.G. Buttram, Jr., J.A. Engler, A.Kh. Urazaev, R.M. Grossfeld, and E.M. Lieberman, Uptake and metabolism of glutamine at non-synaptic regions of crayfish central nerve fibers: Implications for axon-glia signaling. Comp. Biochem. Physiol. B 133:209–220 (2002)

    Article  PubMed  CAS  Google Scholar 

  12. R.A. Khairova, V. Harrell, M.T. Powers, A.K. Urazaev, E.M. Lieberman, The effect of endogenous and exogenous nitric oxide on action potential generation and propagation in crayfish medial giant nerve fibers: implications for axon-glia signaling. Program# 730.9 2004 Abstract Viewer and Itinerary Planner Washington DC, Society for Neuroscience 2004 online.

    Google Scholar 

  13. D.G. Brunder and E.M. Lieberman, Studies of axon-glial cell interactions and periaxonal K+ homeostasis: I. The influence of Na+, K+, Cl− and cholinergic agents on the membrane potential of the adaxonal glia of the crayfish medial giant axon. Neuroscience 25(3):951–959 (1988)

    Article  PubMed  CAS  Google Scholar 

  14. S. Hassan, and E.M. Lieberman, Studies of axon-glial cell interactions and periaxonal K+ homeostasis II. The effect of axonal stimulation, cholinergic agents and transport inhibitors on the resistance in series with the axon membrane. Neuroscience 25(3): 961–969 (1988)

    Article  PubMed  CAS  Google Scholar 

  15. E.M. Lieberman and S. Hassan, Studies of axon-glial cell interactions and perineural K+ homeostasis III. The effect of anisosmotic media and potassium on the relationship between the resistance in series with the axon membrane and glial cell volume. Neuroscience 25: 971–981 (1988)

    Article  PubMed  CAS  Google Scholar 

  16. E. McKinnon, P.T. Hargittai, R.M. Grossfeld, and E.M. Lieberman, Glutamine cycle enzymes in the crayfish giant nerve fiber: Implications for axon-to-glia signaling. Glia 14(3): 198–208 (1995)

    Article  PubMed  CAS  Google Scholar 

  17. B.G. Wallin, The relation between external potassium concentration, membrane potential and internal ion concentrations in crayfish axons, Acta Physiol Scand. 70(3):431–448 (1967)

    Article  PubMed  CAS  Google Scholar 

  18. E.M. Lieberman. Enzymatic determination of subpicomole quantities of phospho-L-arginine in nerve cytoplasm. Anal Biochem. Oct 15;134(2):413–23 (1983)

    Article  PubMed  CAS  Google Scholar 

  19. B. Gafurov, A.K. Urazaev, R.M. Grossfeld, and E.M. Lieberman, Evidence that Nacetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant axon. Neuroscience. 106(1): 227–235 (2001)

    Article  PubMed  CAS  Google Scholar 

  20. B. Gafurov, A.K. Urazaev, R.M. Grossfeld, and E.M. Lieberman, Mechanism of NMDA receptor contribution to axon-to-glia signaling in the crayfish medial giant nerve fiber. Glia 38(1): 80–86 (2002)

    Article  PubMed  Google Scholar 

  21. L.A. Passani, J.P. Vonsattel and J.T. Coyle, Distribution of N-acetylaspartylgluatamate immunoreactivity in human brain and its alteration in neurodegenerative disease. Brain Res.;772(1–2):9–22 (1997)

    Article  PubMed  CAS  Google Scholar 

  22. M. Cassidy and J.H. Neale, Localization and transport of N-acetylaspartylgluatamate in cells of whole murine brain in primary culture. J.Neurochem. 60(5):1631–1637 (1993)

    PubMed  CAS  Google Scholar 

  23. U.V. Berger, R. Luthi-Carter, L.A. Passani, S. Elkabes, I. Black, C. Konradi and J.T. Coyle. Gluatamate carboxypeptidase is expressed by astrocytes in the adult rat nervous system; J. Comp. Neurol. 415(1):52–64 (1999)

    Article  PubMed  CAS  Google Scholar 

  24. F. Conti, P. Barbaresi, M. Melone, and A. Ducati et al. Neuronal and glial localization of NR1 and NR2A/2B subunits of the NMDA receptor in the human cerebral cortex. Cerebral Cortex 9(2):110–120 (1999)

    Article  PubMed  CAS  Google Scholar 

  25. F. Conti, S. DeBiasi, A. Minelli, M. Melone. Expression of NR1 and NR2A/B subunits of the NMDA receptor in cortical astrocytes. Glia; 17(3): 254–8 (1996)

    Article  PubMed  CAS  Google Scholar 

  26. A. Pisani, P. Bonsi, M.V. Catania, R. Giuffrida, M. Morari, M. Marti, D. Centonze, G. Bernardi, A.E. Kingston and P. Calabresi. Metabotropic glutamate group 2 receptors modulate synaptic inputs and calcium signals in striatal cholinergic interneurons. J. Neurosci. 22(14): 6176–85 (2002)

    PubMed  CAS  Google Scholar 

  27. R.S. Petralia, Y.X. Wang, A.S. Niedzielski and R.J. Wenthold. The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations. Neuroscience 71(4):949–76 (1996)

    Article  PubMed  CAS  Google Scholar 

  28. B. Wroblewska M.R. Santi and J.H. Neale. N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes. Glia 24:172–179 (1998)

    Article  PubMed  CAS  Google Scholar 

  29. Y. Tanabe, A. Nomura, M. Masu, R. Shigemoto, N. Mizuno, S.. Nakanishi. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J.Neurosci. 13(4):1372–8 (1993)

    PubMed  CAS  Google Scholar 

  30. D.S. Bredt, P.M. Hwang, S.H. Snyder. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347(6295):768–70 (1990)

    Article  PubMed  CAS  Google Scholar 

  31. K. Iwase K. Iyama, K. Akagi, S. Yano, K. Fukunaga, E. Miyamoto, M. Mori and M. Takiguchi. Precise distribution of neuronal nitric oxide synthase mRNA in the rat brain revealed by non-radioisotopic in situ hybridization. Brain Research, Molecular Brain Research 53(1–2):1–12 (1998)

    Article  CAS  Google Scholar 

  32. M. Oka, M. Wada, A. Yamamoto, Y. Itoh and T. Fujita. Functional expression of constitutive nitric oxide synthases regulated by voltage-gated Na+ and Ca2+ channels in cultured human astrocytes. Glia 46(1):53–62 (2004)

    Article  PubMed  Google Scholar 

  33. A.E. Wiencken and V.A. Casagrande. Endothelial nitric oxide synthetase (eNOS) in astrocytes: another source of nitric oxide in neocortex. Glia 26(4):280–901(1999)

    Article  PubMed  CAS  Google Scholar 

  34. M. Schramm and J. Dudel. Metabotropic glutamate autoreceptors on nerve terminals of crayfish muscle depress or facilitate release. Neurosci Lett. 234(1):31–4. (1997)

    Article  PubMed  CAS  Google Scholar 

  35. K. Johansson and M. Carlberg. NADPH-diaphorase histochemistry and nitric oxide synthase activity in deutocerebrum of the crayfish, Pacifastacus leniusculus (Crustacea, Decapoda). Brain Res.; 649(1–2):36–42 (1994)

    Article  PubMed  CAS  Google Scholar 

  36. H. Schuppe, H. Aonuma and P.L. Newland. Distribution of NADPH-diaphorase-positive ascending interneurones in the crayfish terminal abdominal ganglion. Cell Tissue Res. 305(1):135–46 (2001)

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Albert K. Urazaev

    Present address: Dept. of Biological Sciences, Purdue University, West Lafayette, IN, 47907

Authors and Affiliations

  1. Dept. of Physiology, The Brody School of Medicine of East Carolina University, Greenville, NC, 27834

    Edward M. Lieberman & Mohit Achreja

Authors
  1. Edward M. Lieberman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mohit Achreja
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Albert K. Urazaev
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA

    John R. Moffett  & Aryan M. A. Namboodiri  & 

  2. University of Albany, Albany, NY, 12222, USA

    Suzannah B. Tieman

  3. National Institute of Mental Health, Bethesda, MD, 20814, USA

    Daniel R. Weinberger

  4. McLean Hospital, Belmont, MA, 02178, USA

    Joseph T. Coyle

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer Science+Business Media, Inc.

About this paper

Cite this paper

Lieberman, E.M., Achreja, M., Urazaev, A.K. (2006). Synthesis of N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Axons and Glia of the Crayfish Medial Giant Nerve Fiber. In: Moffett, J.R., Tieman, S.B., Weinberger, D.R., Coyle, J.T., Namboodiri, A.M.A. (eds) N-Acetylaspartate. Advances in Experimental Medicine and Biology, vol 576. Springer, Boston, MA . https://doi.org/10.1007/0-387-30172-0_22

Download citation

Publish with us

Policies and ethics

Search

Navigation