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Changes in Perfusion Pattern of Experimental Tumors Due to Reduction in Arterial Oxygen Partial Pressure

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Part of the Advances in Experimental Medicine and Biology book series (volume 578)

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5. References

  1. M. Höckel and P. Vaupel, Tumor hypoxia: definitions and current clinical, biological, and molecular aspects, J. Natl. Cancer Inst. 93, 266–276 (2001).

    CrossRef  Google Scholar 

  2. M.A. Konerding, W. Malkusch, B. Klapthor, C. van Ackern, E. Fait, S.A. Hill, C. Parkins, D.J. Chaplin, M. Presta, and J. Denekamp, Evidence for characteristic vascular patterns in solid tumours: quantitative studies using corrosion casts, Br. J. Cancer 80, 724–732 (1999).

    CrossRef  Google Scholar 

  3. E.J. Hall, Radiobiology for the Radiologist (J.B. Lippincott, Philadelphia, 2000).

    Google Scholar 

  4. O. Thews, D.K. Kelleher, and P. Vaupel, Erythropoietin restores the anemia-induced reduction in cyclophosphamide cytotoxicity in rat tumors, Cancer Res. 61, 1358–1361 (2001).

    Google Scholar 

  5. T. Shibata, A.J. Giaccia, and J.M. Brown, Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy, Neoplasia. 4, 40–48 (2002).

    CrossRef  Google Scholar 

  6. B.G. Siim, D.R. Menke, M.J. Dorie, and J.M. Brown, Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia, Cancer Res. 57, 2922–2928 (1997).

    Google Scholar 

  7. P. Workman, P. Twentyman, F. Balkwill, A. Balmain, D.J. Chaplin, J.A. Double, J. Embleton, D. Newell, R. Raymond, J. Stables, T. Stephens, and J. Wallace, United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (2nd edit.), Br. J. Cancer 77, 1–10 (1998).

    Google Scholar 

  8. P. Vaupel, K. Schlenger, C. Knoop, and M. Höckel, Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements, Cancer Res. 51, 3316–3322 (1991).

    Google Scholar 

  9. K. Groebe and P. Vaupel, Evaluation of oxygen diffusion distances in human breast cancer xenografts using tumor-specific in vivo data: role of various mechanisms in the development of tumor hypoxia, Int. J. Radiat. Oncol. Biol. Phys. 15, 691–697 (1988).

    Google Scholar 

  10. O. Thews, D.K. Kelleher, and P. Vaupel, Disparate responses of tumour vessels to angiotensin II: tumour volume-dependent effects on perfusion and oxygenation, Br. J. Cancer 83, 225–231 (2000).

    CrossRef  Google Scholar 

  11. D.G. Hirst. Tumor blood flow modification therapeutic benefit: is this approach ready for clinical application? in: Gray Laboratory 1989 Annual Report, edited by B. Michael and M. Hance (Cancer Research Campaign, London, 1989), pp. 14–17.

    Google Scholar 

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Thews, O., Kelleher, D.K., Vaupel, P. (2006). Changes in Perfusion Pattern of Experimental Tumors Due to Reduction in Arterial Oxygen Partial Pressure. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_56

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