5. Conclusions
It can be seen from this brief review that the short period of time since the publication of the human genome sequences has been an era of considerable discovery in the human respirome. This era has revealed new molecules involved in intra-cellular oxygen binding and as components of ETC complexes, while new pathways have emerged in the process of apoptosis. In terms of the involvement of the human respirome in cancer susceptibility and responses, important new discoveries have also been reported.
The impact of some of these discoveries on our understanding of the oxygen cascade will be significant, requiring major adjustments in the models that have been developed in the past three decades. The impact of the revelations regarding association of mutations in human respirome components with particular cancers is of even wider significance. It is perhaps appropriate that these associations will force a reconsideration of the role of cellular respiration in cancer initiation and proliferation.
Keywords
- Electron Transport Chain
- Comparative Genomic Hybridisation
- Mitochondrial Permeability Transition Pore
- Sickle Cell Disease Patient
- Copy Number Aberration
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Maguire, D. (2006). Cancer and the Respirome. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_53
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