5. Conclusion
Repetitive apnea is associated with a significant increase in extracellular dopamine, generation of free radicals as determined by o-tyrosine formation and increase in Fluoro-Jade staining of degenerating neurons. This increase in extracellular dopamine and of hydroxyl radicals in striatum of newborn brain is likely to be at least partly responsible for the neuronal injury and neurological side effects of repetitive apnea.
Keywords
- Electron Paramagnetic Resonance
- Neuronal Injury
- Microdialysis Probe
- Extracellular Dopamine
- Newborn Piglet
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6. References
Schears, G., Creed, J., Zaitseva, T., Schultz, S., Wilson, D.F., and Pastuszko, A. (2004) Cerebral Oxygenation during repetitive apnea in newborn piglets. Adv. Exptl. Med. Biol., in press.
Pastuszko A, Lajevardi SN, Chen J, Tammela O, Wilson DF, Delivoria-Papadopoulos M. Effects of graded levels of tissue oxygen pressure on dopamine metabolism in striatum of newborn piglets. J Neurochem 1993;60:161–6.
Pastuszko A. Metabolic responses of the dopaminergic system during hypoxia in newborn brain. Biochem Med Metab Biol 1994;51:1–15.
Huang Ch-Ch, Lajevardi NS, Tammela O, Pastuszko A, Delivoria-Papadopoulos M, Wilson DF. Relationship of extracellular dopamine in striatum of newborn piglets to cortical oxygen pressure. Neurochem Res 1994;19:649–55.
Yonetani M, Huang Ch-Ch, Lajevardi N, Pastuszko A, Delivoria-Papadopoulos M, Wilson DF. Effect of hemorrhagic hypotension on extracellular level of dopamine, cortical oxygen pressure and blood flow in brain of newborn piglets. Neurosci Lett 1994;180:247–52.
Zini, I., Tomasi, A., Grimaldi, R., Vannini, V. and Agnati, L.F. (1992) Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis. Neurosci. Lett. 138, 279–282
Phillis, J.W. and Sen, S. (1993) Oxypurinol attenuates hydroxyl radicals production during ischemia/reperfusion injury of the rat cerebral cortex: an ESR study. Brain Res. 628, 309–312.
Hasegawa, K., Yoshioka, H., Sawada, T. and Nishikawa, H. (1993) Direct measurement of free radicals in the neonatal mouse brain subjected to hypoxia: an electron spin resonance spectroscopic study. Brain Res. 607, 161–166.
Taylor, D. L., Edwards, D. and Mehmet, H. (1999) Oxidative metabolism, apoptosis and perinatal brain injury. Brain Pathology. 9, 93–117.
Traystman RJ, Kirsch JR, Koehler RC. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appl Physiol 1991;71:1185–1195
Floyd RA. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 1990;4:2587–2597.
Halliwell B. Reactive oxygen species and the central nervous system. J Neurochem 1992;59:1609–1623.
Cohen G. (1988) Oxygen radicals and Parkinson’s disease. in: Halliwell B., ed. Oxygen radicals and tissue injury. Bethesda: FASEB, 130–135.
Youdim M.B.H. (1988) Iron in the brain: implications for Parkinson’s and Alzheimer’s disease. Mt. Sinai J. Med. 55, 97–101.
Gruener N., Gonzlan O., Goldstein T., Davis J., Besner I., and Iancu T.C. (1991) Iron, transferrin and ferritin in cerebrospinal fluid of children. Clin. Chem. 37, 263–265.
Schmued, L.C., Albertson, C. and Slikker Jr., W. (1997) Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res., 751, 37–46.
Hornfelt, M., Edstrom, A. and Ekstrom, P.A. (1999) Upregulation of cytosolic phospholipase A2 correlates with apoptosis in mouse superior cervical and dorsal root ganglia neurons. Neurosci. Letters. 265, 87–90.
Eisch, A.J. and Marshall, J.F. (1998) Methamphetamine neurotoxicity: dissociation of striatal dopamine terminal damage from parietal cortical cell body injury. Synapse. 30, 433–445.
Noraberg, J., Kristensen, B.W. and Zimmer, J. (1999) Markers for neuronal degeneration in organotypic slice cultures. Brain Res. 3, 278–90.
Olano, M., Song, D., Murphy, S., Wilson, D.F. and Pastuszko, A. (1995) Relationships of dopamine, cortical oxygen pressure, and hydroxyl radicals in brain of newborn piglets during hypoxia and posthypoxic recovery. J. Neurochemistry, 65, 1205–1212.
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Schears, G. et al. (2006). Brain Injury Following Repetitive Apnea in Newborn Piglets. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_51
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