3. Conclusions
Direct cooling of the cerebral cortex with the ChillerStrip™ to 15°C followed by spontaneous rewarming to 37°C is safe. Direct cooling of the brain reduces the severity of the ischemic insult as judged by the reduction in the hyperemia after reperfusion which appeared to be directly related to the temperature of the brain.
Keywords
- Traumatic Brain Injury
- Cerebral Blood Flow
- Internal Carotid Artery
- Focal Cerebral Ischemia
- Cortical Surface
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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4. References
Nolan, J.P., Morley, P.T., Vanden Hoek, T.L., Hickey, R.W. 2003, Therapeutic Hypothermia After Cardiac Arrest. Circulation 108:118
Clifton GL. Miller ER. Choi SC. Levin HS. 2001, McCauley S. Smith KR Jr. Muizelaar JP. Wagner FC Jr. Marion DW. Luerssen TG. Chesnut RM. Schwartz M. Lack of effect of induction of hypothermia after acute brain injury. New England Journal of Medicine. 344(8):556.
Clifton GL. Miller ER. Choi SC. Levin HS. McCauley S. Smith KR Jr. Muizelaar JP. Marion DW. Luerssen TG. 2002, Hypothermia on admission in patients with severe brain injury. [Clinical Trial. Journal Article. Multicenter Study. Randomized Controlled Trial] Journal of Neurotrauma. 19(3):293.
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Nemoto, E.M. et al. (2006). Safety of Direct Local Cooling (15° C) of the Cerebral Cortex with the Chillerstrip™ During Focal Cerebral Ischemia in Monkeys. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_50
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