5. Conclusion
Relevant changes in cerebral circulation occur during “Piggy Back” liver transplantation. Particularly at the washout-reperfusion time the cerebral perfusion suddenly changes from its lowest to its highest values. Further investigation is required to evaluate whether patients with the greatest change in cerebral oxygenation at this time point will suffer neurological complications after transplantation.
It is remarkable that TOI and THI levels are higher in the most compromised patients, perhaps because of an increased CO and, mainly, because of a decreased vascular resistance.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
6. References
NA Lassen. Autoregulation of Cerebral blood flow. Circ. Res. 1992; 15:201–204
OB Paulson, S Strandgaard, L Edvinsson. Cerebral autoregulation. Cerebrovasc Brain Metab Rev 1990;2:161–192
FS Larsen, GM Knudsen, OB Paulson, H Vilstrup. Cerebral blood flow autoregulation is absent in rats with thioacetamide induced hepatic failure. J Hepatology 1994;21:465–468
FS Larsen, E Ejlersen, B Hansen, GM Kundsen, N Tygstrup, NH Secher. Functional loss of cerebral blood flow autoregulation in patients with fulminant hepatic failure. J Hepatology 1995;23:212–217
SJ Munoz. Difficult management problems in fulminant hepatic failure. Semin Liver Dis 1994;13:395–413
PL Madsen, NH Secher. Near infrared oxymetry of the brain. Prog Neurobiol 1999;58:541–560
DM Mancini, L Bolinger, H Li, K Kendrik, B. Chance. Validation of near-infrared spectroscopy. J Appl Physiol 1994;77:2740–2747
A Duncan, J H Meek, M Clemence, C E Elwell, L Tyszczuck, M Copy, D T Delpy 1995 optical pathlength measurements on adult head, calf and forearm and the head of newborn infant using phase resolved optical spectroscopy. Phys. Med. Biol. 40 295–304
T Mihaljevic, L von Segesser, M Tonz, B Leskosek, B Seifert, R Jenni, M Turina. Continuous versus bolus thermodilution cardiac output measurements-a comparative study. Crit Care Med 1995; 23:944–949
FS Larsen, KS Olsen, BA Hansen, OB Paulson, GM Kundsen. Transcranial Doppler is valid for determination of the lower limit of cerebral blood flow autoregulation. Stroke 1994;25:1985–1988
BJ Philips, IR Armstrong, A Pollock, A Lee. Cerebral blood flow and metabolism in patients with chronic liver disease undergoing liver transplantation. Hepatology 1998;27(2):369–376
P Pere, K Köckerstedt, H Isoniemi, L Lindgren. Cerebral blood flow and oxygenation in liver transplantation for acute or chronic hepatic disease without venovenous bypass. Liver Transplantation 2000;6(4):471–479
DD Doblar, YC Lim, L Frenette. The effect of acute hypocapnia on middle cerebral artery transcranial Doppler velocity during orthotopic liver transplantation: changes at reperfusion. Anesth Analg 1995;80:1194–8
FS Larsen, F Pott, BA Hansen et al. Transcranial Doppler sonography may predict brain death in patients with fulminant hepatic failure. Transplant Proc 1995;6:3510–11
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Science+Business Media, Inc.
About this paper
Cite this paper
Panzera, P. et al. (2006). Alteration of Brain Oxygenation During “Piggy Back” Liver Transplantation. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_43
Download citation
DOI: https://doi.org/10.1007/0-387-29540-2_43
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-29543-5
Online ISBN: 978-0-387-29540-4
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)