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Intracellular pH in Gastric and Rectal Tissue Post Cardiac Arrest

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Part of the Advances in Experimental Medicine and Biology book series (volume 578)

5. Conclusion

We directly measured pHi using the pH sensitive dye, neutral red. We defined pHi for rectal and gastric tissue in whole tissue and by layer under control and arrest conditions. Fifteen minutes of arrest was not sufficient time to alter the pHi at the rectal or gastric site. On initial inspection, the stomach may be more sensitive to ischemic changes than the rectum. Understanding the mechanism by which PCO2 generation is used to track clinical changes is vital to the early detection of tissue dysoxia in order to effectively treat and manage critically ill patients.

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7. References

  1. Gutierrez G, Brown SD. Gastrointestinal tonometry: a monitor of regional dysoxia. New Horiz 1996; 4:413–419.

    Google Scholar 

  2. Maynard N, Bihari D, Beale R, Smithies M, Baldock G, Mason R, McColl I. Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure. JAMA 1993; 270:1203–1210.

    CrossRef  Google Scholar 

  3. Fisher EM, LaManna JC. Gut dysoxia: Comparison of sites to detect regional gut dysoxia. Advances in Experimental Medicine and Biology In press.

    Google Scholar 

  4. Hoxworth JM, Xu K, Zhou Y, Lust WD, LaManna JC. Cerebral metabolic profile, selective neuron loss, and survival of acute and chronic hyperglycemic rats following cardiac arrest and resuscitation. Brain Res 1999; 821:467–479.

    CrossRef  Google Scholar 

  5. Zhang RG, Kelsen SG, LaManna JC. Measurement of intracellular pH in hamster diaphragm by absorption spectrophotometry. J Appl Physiol 1990; 68:1101–1106.

    Google Scholar 

  6. Crumrine RC, LaManna JC, Lust WD. Regional changes in intracellular pH determined by neutral red histophotometry and high energy metabolites during cardiac arrest and following resuscitation in the rat. Metab Brain Dis 1991; 6:145–155.

    CrossRef  Google Scholar 

  7. Hogben CA. Gastric secretion of hydrochloric acid. Introduction: the natural history of the isolated bullfrog gastric mucosa. Fed Proc 1965; 24:1353–1359.

    Google Scholar 

  8. Hersey SJ, High WL. Effect of unstirred layers on oxygenation of frog gastric mucosa. Am J Physiol 1972; 223:903–909.

    Google Scholar 

  9. Hiltebrand LB, Krejci V, tenHoevel ME, Banic A, Sigurdsson GH. Redistribution of microcirculatory blood flow within the intestinal wall during sepsis and general anesthesia. Anesthesiology 2003; 98:658–669.

    CrossRef  Google Scholar 

  10. Sanders SS, Hayne VB, Jr., Rehm WS. Normal H+ rates in frog stomach in absence of exogenous CO2 and a note on pH stat method. Am J Physiol 1973; 225:1311–1321.

    Google Scholar 

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© 2006 Springer Science+Business Media, Inc.

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Fisher, E.M., Steiner, R.P., LaManna, J.C. (2006). Intracellular pH in Gastric and Rectal Tissue Post Cardiac Arrest. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_2

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