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History and Morphology of the Lysosome

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Lysosomes

Part of the book series: Medical Intelligence Unit ((MIUN))

Abstract

The lysosome is the cell’s main digestive compartment to which all sorts of macromolecules are delivered for degradation. The structure of the lysosome is variable and depends on the cell type and the actual conditions. In terms of function and cytochemistry, the lysosome is identified by the following criteria: acid pH, hydrolases with acid pH optimum, specific highly glycosylated membrane-associated proteins, and the absence of the mannose-6-phosphate receptor. The purposes of the present chapter are (a) to give a short overview on the morphology of the lysosome/endosome system for readers who are nonexperts in this field; and (b) to briefly trail the tracks and approaches which, during the first decades after the discovery of the lysosome, led to the present concept, with particular reference to morphology.

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  1. Department of Anatomy, University of Kiel, Olshausenstraße 40, 24098, Kiel, Germany

    Renate Lüllmann-Rauch

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Lüllmann-Rauch, R. (2005). History and Morphology of the Lysosome. In: Lysosomes. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-28957-7_1

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