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Clonal Variations in Pseudomonas aeruginosa

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References

  1. Alonso, A., Rojo, F., and Martínez, J.L., 1999, Environmental and clinical isolates of Pseudomonas aeruginosa show pathogenic and biodegradative properties irrespective of their origin. Environ. Microbiol., 1:421–443.

    Article  PubMed  CAS  Google Scholar 

  2. Anthony, M., Rose, B., Pegler, M.B., Elkins, M., Service, H., Thamotharampillai, K., Watson, J., Robinson, M., Bye, P., Merlino, J., and Harbour, C., 2002, Genetic analysis of Pseudomonas aeruginosa isolates from the sputa of Australian adult cystic fibrosis patients. J. Clin. Microbiol., 40:2772–2778.

    Article  PubMed  CAS  Google Scholar 

  3. Arevalo-Ferro, C., Buschmann, J., Reil, G., Görg, A., Wiehlmann, L., Tümmler, B., Eberl, L., and Riedel, K., 2004, Proteome analysis of intraclonal diversity of two Pseudomonas aeruginosa TB clone isolates. Proteomics, 4:1241–1246.

    Article  PubMed  CAS  Google Scholar 

  4. Arora, S., Bangera, S., Lory, S., and Ramphal, R., 2001, A genomic island in Pseudomonas aeruginosa carries the determinants of flagellin glycosylation. Proc. Natl. Acad. Sci. USA, 98:9342–9347.

    Article  PubMed  CAS  Google Scholar 

  5. Arora, S.K., Dasgupta, N., Lory, S., and Ramphal, R., 2000, Identification of two distinct types of flagellar cap proteins, FliD, in Pseudomonas aeruginosa. Infect. Immun., 68:1474–1479.

    Article  PubMed  CAS  Google Scholar 

  6. Arora, S.K., Ritchings, B.W., Almira, E.C., Lory, S., and Ramphal, R., 1998, The Pseudomonas aeruginosa flagellar cap protein, FliD, is responsible for mucin adhesion. Infect. Immun., 66:1000–1007.

    PubMed  CAS  Google Scholar 

  7. Arora, S.K., Wolfgang, M.C., Lory, S., and Ramphal, R., 2004, Sequence polymorphism in the glycosylation island and flagellins of Pseudomonas aeruginosa. J. Bacteriol., 186:2115–2122.

    Article  PubMed  CAS  Google Scholar 

  8. Barbieri J.T., 2000, Pseudomonas aeruginosa exoenzyme S, a bifunctional type-III secreted cytotoxin. Int. J. Med. Microbiol., 290:381–387.

    PubMed  CAS  Google Scholar 

  9. Boucher, J.C., Martinez-Salaza, J., Schurr, M.J., Mudd, M., Yu, H., and Deretic, V., 1996, Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtlA. J. Bacteriol., 178:511–523.

    PubMed  CAS  Google Scholar 

  10. Boucher, J.C., Yu, H., Mudd, M.H., and Deretic, V., 1997, Mucoid Pseudomonas aeruginosa in cystic fibrosis: characterization of muc mutations in clinical isolates and analysis of clearance in a mouse model of respiratory infection. Infect. Immun., 65:3838–3846.

    PubMed  CAS  Google Scholar 

  11. Bragonzi, A., Worlitzsch, D., Tümmler, B., Salerno, P., Pier, G.P., and Döring, G., 2006, Impact of mutational changes in genetic regulatory loci on the expression of Pseudomonas aeruginosa alginate in clinical isolates from patients with cystic fibrosis. Submitted.

    Google Scholar 

  12. Brimer, C.D., and Montie, T.C., 1998, Cloning and comparison of fliC genes and identification of glycosylation in the flagellin of Pseudomonas aeruginosa a-type strains. J. Bacteriol., 180:3209–3217.

    PubMed  CAS  Google Scholar 

  13. Castric, P.A., and Deal, C.D., 1994, Differentiation of Pseudomonas aeruginosa pili based on sequence and B-cell epitope analyses. Infect. Immun., 62:371–376.

    PubMed  CAS  Google Scholar 

  14. Curran, B., Jonas, D., Grundmann, H., Pitt, T., and Dowson, C.G., 2004, Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa. J. Clin. Microbiol., 42:5644–5649.

    Article  PubMed  CAS  Google Scholar 

  15. De Chial, M., Ghysels, B., Beatson, S.A., Geoffroy, V., Meyer, J.M., Pattery, T., Baysse, C., Chablain, P., Parsons, Y.N., Winstanley, C., Cordwell, S.J., and Cornelis, P., 2003, Identification of type II and type III pyoverdine receptors from Pseudomonas aeruginosa. Microbiology, 149:821–831.

    Article  PubMed  CAS  Google Scholar 

  16. Denervaud, V., TuQuoc, P., Blanc, D., Favre-Bonte, S., Krishnapillai, V., Reimmann, C., Haas, D., and van Delden, C., 2004, Characterization of cell-to-cell signaling-deficient Pseudomonas aeruginosa strains colonizing intubated patients. J. Clin. Microbiol., 42:554–562.

    Article  PubMed  CAS  Google Scholar 

  17. De Vos, D., De Chial, M., Cochez, C., Jansen, S., Tümmler, B., Meyer, J.M., and Cornelis, P., 2001, Study of pyoverdine type and production by Pseudomonas aeruginosa isolated from cystic fibrosis patients: prevalence of type II pyoverdine isolates and accumulation of pyoverdine-negative mutations. Arch. Microbiol., 175:384–388.

    Article  PubMed  Google Scholar 

  18. Dinesh, S.D., Grundmann, H., Pitt, T.L., and Römling, U., 2003, European-wide distribution of Pseudomonas aeruginosa clone C. Clin. Microbiol. Infect., 9:1228–1233.

    Article  PubMed  CAS  Google Scholar 

  19. Eberl, L., and Tümmler, B., 2004, Pseudomonas aeruginosa and Burkholderia cepacia in cystic fibrosis: genome evolution, interactions and adaptation. Int. J. Med. Microbiol., 294:123–131.

    Article  PubMed  CAS  Google Scholar 

  20. Ernst, R.K., D’Argenio, D.A., Ichikawa, J.K., Bangera, M.G., Selgrade, S., Burns, J.L., Hiatt, P., McCoy, K., Brittnacher, M., Kas, A., Spencer, D.H., Olson, M.V., Ramsey, B.W., Lory, S., and Miller, S.I., 2003, Genome mosaicism is conserved but not unique in Pseudomonas aeruginosa isolates from the airways of young children with cystic fibrosis. Environ. Microbiol., 5:1341–1349.

    Article  PubMed  CAS  Google Scholar 

  21. Ernst, R.K., Yi, E.C., Guo, L., Lim, K.B., Burns, J.L., Hackett, M., and Miller, S.I., 1999, Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa. Science, 286:1561–1565.

    Article  PubMed  CAS  Google Scholar 

  22. Feltman, H., Schulert, G., Khan, S., Jain, M., Peterson, L., and Hauser, A.R., 2001, Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa. Microbiology, 147:2659–2669.

    PubMed  CAS  Google Scholar 

  23. Foght, J.M., Westlake, D.W.S., Johnson, W.M., and Ridgway, H.F., 1996, Environmental gasoline-utilizing isolates and clinical isolates of Pseudomonas aeruginosa are taxonomically indistinguishable by chemotaxonomic and molecular techniques. Microbiology, 142:2333–2340.

    PubMed  CAS  Google Scholar 

  24. Geisenberger, O., Givskov, M., Riedel, K., Hoiby, N., Tümmler, B., and Eberl, L., 2000, Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis. FEMS Microbiol. Lett., 184:273–278.

    PubMed  CAS  Google Scholar 

  25. Ghysels, B., Dieu, B.T., Beatson, S.A., Pirnay, J.P., Ochsner, U.A., Vasil, M.L., and Cornelis, P., 2004, FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa. Microbiology, 150:1671–1680.

    Article  PubMed  CAS  Google Scholar 

  26. Govan, J.R., and Deretic, V., 1996, Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol. Rev., 60:539–574.

    PubMed  CAS  Google Scholar 

  27. Hancock, R.E., Mutharia, L.M., Chan, L., Darveau, R.P., Speert, D.P., and Pier, G.B., 1983, Pseudomonas aeruginosa isolates from patients with cystic fibrosis: a class of serum-sensitive, nontypable strains deficient in lipopolysaccharide O side chains. Infect. Immun., 42:170–177.

    PubMed  CAS  Google Scholar 

  28. Häussler, S., Tümmler, B., Weissbrodt, H., Rohde, M., and Steinmetz, I., 1999, Small-colony variants of Pseudomonas aeruginosa in cystic fibrosis. Clin. Infect. Dis., 29:621–625.

    Article  PubMed  Google Scholar 

  29. Häussler, S., Ziegler, I., Lottel, A., von Götz, F., Rohde, M., Wehmhöner, D., Saravanamuthu, S., Tümmler, B., and Steinmetz, I., 2003, Highly adherent small-colony variants of Pseudomonas aeruginosa in cystic fibrosis lung infection. J. Med. Microbiol., 52:295–301.

    Article  PubMed  Google Scholar 

  30. He, J., Baldini, R.L., Deziel, E., Saucier, M., Zhang, Q., Liberati, N.T., Lee, D., Urbach, J., Goodman, H.M., and Rahme, L.G., 2004, The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes. Proc. Natl. Acad. Sci. USA, 101:2530–2535.

    Article  PubMed  CAS  Google Scholar 

  31. Heuer, T., Bürger, C., Maaß, G., and Tümmler, B., 1998, Cloning of prokaryotic genomes in yeast artificial chromosomes: application to the population genetics of Pseudomonas aeruginosa. Electrophoresis, 19:486–494.

    Article  PubMed  CAS  Google Scholar 

  32. Hocquet, D., Bertrand, X., Köhler, T., Talon, D., and Plesiat, P., 2003, Genetic and phenotypic variations of a resistant Pseudomonas aeruginosa epidemic clone. Antimicrob. Agents Chemother., 47:1887–1894.

    Article  PubMed  CAS  Google Scholar 

  33. Holloway, B.W., Römling, U., and Tümmler, B., 1994, Genomic mapping of Pseudomonas aeruginosa PAO. Microbiology, 140:2907–2929.

    PubMed  CAS  Google Scholar 

  34. Jones, R.N., Deshpande, L., Fritsche, T.R., and Sader H.S., 2004, Determination of epidemic clonality among multidrug-resistant strains of Acinetobacter spp. and Pseudomonas aeruginosa in the MYSTIC Programme (USA, 1999–2003). Diagn. Microbiol. Infect. Dis., 49:211–216.

    Article  PubMed  CAS  Google Scholar 

  35. Kiewitz, C., Larbig, K., Klockgether, J., Weinel, C., and Tümmler, B., 2000, Monitoring genome evolution ex vivo: reversible chromosomal integration of a 106 kb plasmid at two tRNA(Lys) gene loci in sequential Pseudomonas aeruginosa airway isolates. Microbiology, 146:2365–2373.

    PubMed  CAS  Google Scholar 

  36. Kiewitz, C., and Tümmler, B., 2000, Sequence diversity of Pseudomonas aeruginosa: impact on population structure and genome evolution. J. Bacteriol., 182:3125–3135.

    Article  PubMed  CAS  Google Scholar 

  37. Kiewitz, C., and Tümmler, B., 2002, Similar profile of single nucleotide substitution types in bacteria and human genetic disease. Genome Lett., 1:111–114.

    Article  CAS  Google Scholar 

  38. Klockgether, J., 2004, Geninseln als Quelle der Genomdiversität von Pseudomonas aeruginosa. Dissertation. University of Hannover.

    Google Scholar 

  39. Klockgether, J., Reva, O., Larbig, K., and Tümmler, B., 2004, Sequence analysis of the mobile genome island pKLC102 of Pseudomonas aeruginosa C. J. Bacteriol., 186:518–534.

    Article  PubMed  CAS  Google Scholar 

  40. Kresse, A.U., Dinesh, S.D., Larbig, K., and Römling, U., 2003, Impact of large chromosomal inversions on the adaptation and evolution of Pseudomonas aeruginosa chronically colonizing cystic fibrosis lungs. Mol. Microbiol., 47:145–158.

    Article  PubMed  CAS  Google Scholar 

  41. Laabs, U., Gudowius, P., Wiehlmann, L., Limpert, A.S., Filloux, A., Tümmler, B., and de Bentzmann, S., 2006, High binding capacity of Pseudomonas aeruginosa cystic fibrosis isolates during chronic infection is associated with worse clinical outcome. (submitted).

    Google Scholar 

  42. Lamont, I.L., and Martin, L.W., 2003, Identification and characterization of novel pyoverdine synthesis genes in Pseudomonas aeruginosa. Microbiology, 149:833–842.

    Article  PubMed  CAS  Google Scholar 

  43. Larbig, K.D., Christmann, A., Johann, A., Klockgether, J., Hartsch, T., Merkl, R., Wiehlmann, L., Fritz, H.J., and Tümmler, B., 2002, Gene islands integrated into tRNA(Gly) genes confer genome diversity on a Pseudomonas aeruginosa clone. J. Bacteriol., 184:6665–6680.

    Article  PubMed  CAS  Google Scholar 

  44. Lee, V.T., Smith, R.S., Tümmler, B., and Lory, S., 2005, Activities of Pseudomonas aeruginosa effectors secreted by the Type III secretion system in vitro and during infection. Infect. Immun., 73:1695–1705.

    Article  PubMed  CAS  Google Scholar 

  45. Liang, X., Pham, X.Q., Olson, M.V., and Lory, S., 2001, Identification of a genomic island present in the majority of pathogenic isolates of Pseudomonas aeruginosa. J. Bacteriol., 183:843–853.

    Article  PubMed  CAS  Google Scholar 

  46. Macia, M.D., Blanquer, D., Togores, B., Sauleda, J., Perez, J.L., and Oliver, A., 2005, Hypermutation is a key factor for multiple antimicrobial resistance development in Pseudomonas aeruginosa chronic lung infections. Antimicrob. Agents Chemother., 49: 3382–3386.

    Article  PubMed  CAS  Google Scholar 

  47. Mahenthiralingam, E., Campbell, M.E., and Speert, D.P., 1994, Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis. Infect. Immun., 62:596–605.

    PubMed  CAS  Google Scholar 

  48. Marrs, C.F., Schoolnik, G., Koomey, J.M., Hardy, J., Rothbard, J., and Falkow, S., 1985, Cloning and sequencing of a Moraxella bovis pilin gene. J. Bacteriol., 163:132–139.

    PubMed  CAS  Google Scholar 

  49. Martin, D.W., Schurr, M.J., Mudd, M.H., Govan, J.R.W., Holloway, B.W., and Deretic, V., 1993, Mechanisms of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients. Proc. Natl. Acad. Sci. USA, 90:8377–8381.

    Article  PubMed  CAS  Google Scholar 

  50. Miranda, G., Leanos, B., Marquez, L., Valenzuela, A., Silva, J., Carrillo, B., Munoz, O., and Solorzano, F., 2001, Molecular epidemiology of a multiresistant Pseudomonas aeruginosa outbreak in a paediatric intensive care unit. Scand. J. Infect. Dis., 33:738–743.

    Article  PubMed  CAS  Google Scholar 

  51. Mohd-Zain, Z., Turner, S.L., Cerdeno-Tarraga, A.M., Lilley, A.K., Inzana, T.J., Duncan, A.J., Harding, R.M., Hood, D.W., Peto, T.E., and Crook, D.W., 2004, Transferable antibiotic resistance elements in Haemophilus influenzae share a common evolutionary origin with a diverse family of syntenic genomic islands. J. Bacteriol., 186:8114–8122.

    Article  PubMed  CAS  Google Scholar 

  52. Morales, G., Wiehlmann, L., Gudowius, P., van Delden, C., Tümmler, B., Martínez, J.L., and Rojo, F., 2004, Structure of Pseudomonas aeruginosa populations analyzed by single nucleotide polymorphism and pulsed-field gel electrophoresis genotyping. J. Bacteriol., 186:4228–4237.

    Article  PubMed  CAS  Google Scholar 

  53. Nelson, K.E., Weinel, C., Paulsen, I.T., Dodson, R.J., Hilbert, H., Martins dos Santos, V.A., Fouts, D.E., Gill, S.R., Pop, M., Holmes, M., Brinkac, L., Beanan, M., DeBoy, R.T., Daugherty, S., Kolonay, J., Madupu, R., Nelson, W., White, O., Peterson, J., Khouri, H., Hance, I., Chris Lee, P., Holtzapple, E., Scanlan, D., Tran, K., Moazzez, A., Utterback, T., Rizzo, M., Lee, K., Kosack, D., Moestl, D., Wedler, H., Lauber, J., Stjepandic, D., Hoheisel, J., Straetz, M., Heim, S., Kiewitz, C., Eisen, J.A., Timmis, K.N., Düsterhöft, A., Tümmler, B., and Fraser, C.M., 2002, Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440. Environ. Microbiol., 4:799–808.

    Article  PubMed  CAS  Google Scholar 

  54. Nouwens, A.S., Willcox, M.D., Walsh, B.J., and Cordwell, S.J., 2002, Proteomic comparison of membrane and extracellular proteins from invasive (PAO1) and cytotoxic (6206) strains of Pseudomonas aeruginosa. Proteomics, 2:1325–1346.

    Article  PubMed  CAS  Google Scholar 

  55. Oliver, A., Baquero, F., and Blazquez, J., 2002, The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants. Mol. Microbiol., 43:1641–1650.

    Article  PubMed  CAS  Google Scholar 

  56. Oliver, A., Canton, R., Campo, P., Baquero, F., and Blaźquez, J., 2000, High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science, 288:1251–1254.

    Article  PubMed  CAS  Google Scholar 

  57. Pedersen, S.S., Hoiby, N., Espersen, F., and Koch, C., 1992, Role of alginate in infection with mucoid Pseudomonas aeruginosa in cystic fibrosis. Thorax, 47:6–13.

    Article  PubMed  CAS  Google Scholar 

  58. Pellegrino, F.L., Teixeira, L.M., Carvalho, Md., Mda, G., Aranha Nouer, S., Pinto De Oliveira, M., Mello Sampaio, J.L., D’Avila Freitas, A., Ferreira, A.L., Amorim, Ed., Ede, L., Riley, L.W., and Moreira, B.M., 2002, Occurrence of a multidrug-resistant Pseudomonas aeruginosa clone in different hospitals in Rio de Janeiro, Brazil. J. Clin. Microbiol., 40:2420–2424.

    Article  PubMed  CAS  Google Scholar 

  59. Pirnay, J.P., De Vos, D., Cochez, C., Bilocq, F., Pirson, J., Struelens, M., Duinslaeger, L., Cornelis, P., Zizi, M., and Vanderkelen, A., 2003, Molecular epidemiology of Pseudomonas aeruginosa colonization in a burn unit: persistence of a multidrug-resistant clone and a silver sulfadiazine-resistant clone. J. Clin. Microbiol., 41:1192–1202.

    Article  PubMed  CAS  Google Scholar 

  60. Pirnay, J. P., De Vos, D., Cochez, C., Bilocq, F., Vanderkelen, A., Zizi, M., Ghysels, B., and Cornelis, P., 2002, Pseudomonas aeruginosa displays an epidemic population structure. Environ. Microbiol., 4:898–911.

    Article  PubMed  CAS  Google Scholar 

  61. Pirnay, J.P., De Vos, D., Mossialos, D., Vanderkelen, A., Cornelis, P., and Zizi, M., 2002, Analysis of the Pseudomonas aeruginosa oprD gene from clinical and environmental isolates. Environ. Microbiol., 4:872–882.

    Article  PubMed  CAS  Google Scholar 

  62. Ramphal, R., and Arora, S.K., 2001, Recognition of mucin components by Pseudomonas aeruginosa. Glycoconj. J., 18:709–713.

    Article  PubMed  CAS  Google Scholar 

  63. Ravel, J., and Cornelis, P., 2003, Genomics of pyoverdine-mediated iron uptake in pseudomonads. Trends Microbiol., 11:195–200.

    PubMed  CAS  Google Scholar 

  64. Raymond, C.K., Sims, E.H., Kas, A., Spencer, D.H., Kutyavin, T.V., Ivey, R.G., Zhou, Y., Kaul, R., Clendenning, J.B., and Olson, M.V., 2002, Genetic variation at the O-antigen biosynthetic locus in Pseudomonas aeruginosa. J. Bacteriol., 184:3614–3622.

    Article  PubMed  CAS  Google Scholar 

  65. Römling, U., Fiedler, B., Bosshammer, J., Grothues, D., Greipel, J., von der Hardt, H., and Tümmler, B., 1994, Epidemiology of chronic Pseudomonas aeruginosa infections in cystic fibrosis. J. Infect. Dis., 170:1616–1621.

    PubMed  Google Scholar 

  66. Römling, U., Greipel, J., and Tümmler, B., 1995, Gradient of genomic diversity in the Pseudomonas aeruginosa chromosome. Mol. Microbiol., 17:323–332.

    PubMed  Google Scholar 

  67. Römling, U., Schmidt, K.D., and Tümmler, B., 1997, Large genome rearrangements discovered by the detailed analysis of 21 Pseudomonas aeruginosa clone C isolates found in environment and disease habitats. J. Mol. Biol., 271:386–404.

    Article  PubMed  Google Scholar 

  68. Römling, U., Wingender, J., Müller, H., and Tümmler, B., 1994, A major Pseudomonas aeruginosa clone common to patients and aquatic habitats. Appl. Environ. Microbiol., 60:1734–1738.

    PubMed  Google Scholar 

  69. Salunkhe, P., Götz, F., Wiehlmann, L., Lauber, J., Buer, J., and Tümmler B., 2002, GeneChip expression analysis of the response of Pseudomonas aeruginosa to paraquat-induced superoxide stress. Genome Lett., 1:165–174.

    Article  CAS  Google Scholar 

  70. Salunkhe, P., Töpfer, T., Buer, J., and Tümmler, B., 2005, Genome-wide transcriptional profiling of the steady state response of Pseudomonas aeruginosa to hydrogen peroxide. J. Bacteriol., 187: 2565–2572.

    Article  PubMed  CAS  Google Scholar 

  71. Sato, H., Frank, D.W., Hillard, C.J., Feix, J.B., Pankhaniya, R.R., Moriyama, K., Finck-Barbancon, V., Buchaklian, A., Lei, M., Long, R.M., Wiener-Kronish, J., and Sawa, T., 2003, The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. EMBO J., 22:2959–2969.

    Article  PubMed  CAS  Google Scholar 

  72. Scharfman, A., Arora, S.K., Delmotte, P., Van Brussel, E., Mazurier, J., Ramphal, R., and Roussel, P., 2001, Recognition of Lewis x derivatives present on mucins by flagellar components of Pseudomonas aeruginosa. Infect. Immun., 69:5243–5248.

    Article  PubMed  CAS  Google Scholar 

  73. Schmidt, K.D., Tümmler, B., and Römling, U., 1996, Comparative genome mapping of Pseudomonas aeruginosa PAO with P. aeruginosa C, which belongs to a major clone in cystic fibrosis patients and aquatic habitats. J. Bacteriol., 178:85–93.

    PubMed  CAS  Google Scholar 

  74. Schurr, M.J., Martin, D.W., Mudd, M.H., and Deretic, V., 1994, Gene cluster controlling conversion to alginate-overproducing phenotype in Pseudomonas aeruginosa: functional analysis in a heterologous host and role in the instability of mucoidy. J. Bacteriol., 176:3375–3382.

    PubMed  CAS  Google Scholar 

  75. Schurr, M.J., Yu, H., Martinez-Salazar, J.M., Boucher, J.C., and Deretic, V., 1996, Control of AlgU, a member of the σ E-like family of stress sigma factors, by the negative regulators MucA and MucB and Pseudomonas aeruginosa conversion to mucoidy in cystic fibrosis. J. Bacteriol., 178:4997–5004.

    PubMed  CAS  Google Scholar 

  76. Scott, F.W., and Pitt, T.L., 2004, Identification and characterization of transmissible Pseudomonas aeruginosa strains in cystic fibrosis patients in England andWales. J. Med. Microbiol., 53:609–615.

    Article  PubMed  CAS  Google Scholar 

  77. Selander, R.K., and Musser, J.M., 1990, Population genetics of bacterial pathogenesis, pp. 11–36. In B.H. Iglewski, and V.L. Clark (eds.), Molecular Basis of Bacterial Pathogenesis, Vol. X. The Bacteria. Academic Press, San Diego, CA.

    Google Scholar 

  78. Simpson, A.J., Reinach, F.C., Arruda, P., Abreu, F.A., Acencio, M., Alvarenga, R., Alves, L.M., Araya, J.E., Baia, G.S., Baptista, C.S., Barros, M.H., Bonaccorsi, E.D., Bordin, S., Bove, J.M., Briones, M.R., Bueno, M.R., Camargo, A.A., Camargo, L.E., Carraro, D.M., Carrer, H., Colauto, N.B., Colombo, C., Costam F.F., Costa, M.C., Costa-Neto, C.M., Coutinho, L.L., Cristofani, M., Dias-Neto, E., Docena, C., El-Dorry, H., Facincani, A.P., Ferreira, A.J., Ferreira, V.C., Ferro, J.A., Fraga, J.S., Franca, S.C., Franco, M.C., Frohme, M., Furlan, L.R., Garnier, M., Goldman, G.H., Goldman, M.H., Gomes, S.L., Gruber, A., Ho, P.L., Hoheisel, J.D., Junqueira, M.L., Kemper, E.L., Kitajima, J.P., Krieger, J.E., Kuramae, E.E., Laigret, F., Lambais, M.R., Leite, L.C., Lemos, E.G., Lemos, M.V., Lopes, S.A., Lopes, C.R., Machado, J.A., Machado, M.A., Madeira, A.M., Madeira, H.M., Marino, C.L., Marques, M.V., Martins, E.A., Martins, E.M., Matsukuma, A.Y., Menck, C.F., Miracca, E.C., Miyaki, C.Y., Monteriro-Vitorello, C.B., Moon, D.H., Nagai, M.A., Nascimento, A.L., Netto, L.E., Nhani, A. Jr., Nobrega, F.G., Nunes, L.R., Oliveira, M.A., de Oliveira, M.C., de Oliveira, R.C., Palmieri, D.A., Paris, A., Peixoto, B.R., Pereira, G.A., Pereira, H.A. Jr., Pesquero, J.B., Quaggio, R.B., Roberto, P.G., Rodrigues, V., de M Rosa, A.J., de Rosa, V.E. Jr., de Sa, R.G., Santelli, R.V., Sawasaki, H.E., da Silva, A.C., da Silva, A.M., da Silva, F.R., da Silva, W.A. Jr., da Silveira, J.F., Silvestri, M.L., Siqueira, W.J., de Souza, A.A., de Souza, A.P., Terenzi, M.F., Truffi, D., Tsai, S.M., Tsuhako, M.H., Vallada, H., Van Sluys, M.A., Verjovski-Almeida, S., Vettore, A.L., Zago, M.A., Zatz, M., Meidanis, J., and Setubal, J.C., 2000, The genome sequence of the plant pathogen Xylella fastidiosa. The Xylella fastidiosa consortium of the organization for nucleotide sequencing and analysis. Nature, 406:151–157.

    Article  PubMed  CAS  Google Scholar 

  79. Smith, E.E., Sims, E.H., Spencer, D.H., Kaul, R., and Olson, M.V., 2005, Evidence for diversifying selection at the pyoverdine locus of Pseudomonas aeruginosa. J. Bacteriol., 187:2138–2147.

    Article  PubMed  CAS  Google Scholar 

  80. Smith, J.M., Smith, N.H., O’Rourke, M., and Spratt, B.G., 1993, How clonal are bacteria? Proc. Natl. Acad. Sci. USA, 90:4384–4388.

    Article  PubMed  CAS  Google Scholar 

  81. Spangenberg, C., Fislage, R., Römling, U., and Tümmler B., 1997, Disrespectful type IV pilins. Mol. Microbiol., 25:203–204.

    PubMed  CAS  Google Scholar 

  82. Spangenberg, C., Heuer, T., Bürger, C., and Tümmler, B., 1996, Genetic diversity of flagellins of Pseudomonas aeruginosa. FEBS Lett., 396:213–217.

    Article  PubMed  CAS  Google Scholar 

  83. Spangenberg, C., Montie, T.C., and Tümmler, B., 1998, Structural and functional implications of sequence diversity of Pseudomonas aeruginosa genes oriC, ampC and fliC. Electrophoresis, 19:545–550.

    Article  PubMed  CAS  Google Scholar 

  84. Spencer, D.H., Kas, A., Smith, E.E., Raymond, C.K., Sims, E.H., Hastings, M., Burns, J.L., Kaul, R., and Olson M.V., 2003, Whole-genome sequence variation among multiple isolates of Pseudomonas aeruginosa. J. Bacteriol., 185:1316–1325.

    Article  PubMed  CAS  Google Scholar 

  85. Stover, C.K., Pham, X.Q., Erwin, A.L., Mizoguchi, S.D., Warrener, P., Hickey, M.J., Brinkman, F.S., Hufnagle, W.O., Kowalik, D.J., Lagrou, M., Garber, R.L., Goltry, L., Tolentino, E., Westbrock-Wadman, S., Yuan, Y., Brody, L.L., Coulter, S.N., Folger, K.R., Kas, A., Larbig, K., Lim, R., Smith, K., Spencer, D., Wong, GK., Wu, Z., Paulsen, I.T., Reizer, J., Saier, M.H., Hancock, R.E., Lory, S., and Olson, M.V., 2000, Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen. Nature, 406:959–964.

    Article  PubMed  CAS  Google Scholar 

  86. Taylor, R.F., Hodson, M.E., and Pitt, T.L., 1992, Auxotrophy of Pseudomonas aeruginosa in cystic fibrosis. FEMS Microbiol. Lett., 71:243–246.

    Article  PubMed  CAS  Google Scholar 

  87. Thomas, S.R., Ray, A., Hodson, M.E., and Pitt, T.L., 2000, Increased sputum amino acid concentrations and auxotrophy of Pseudomonas aeruginosa in severe cystic fibrosis lung disease. Thorax, 55:795–797.

    Article  PubMed  CAS  Google Scholar 

  88. Tümmler, B., Bosshammer, J., Breitenstein, S., Brockhausen, I., Gudowius, P., Herrmann, C., Herrmann, S., Heuer, T., Kubesch, P., Mekus, F., Römling, U., Schmidt, K.D., Spangenberg, C., and Walter, S., 1997, Infections with Pseudomonas aeruginosa in patients with cystic fibrosis. Behring Inst. Mitt., 98:249–255.

    PubMed  Google Scholar 

  89. Tümmler, B., and Kiewitz C., 1999, Cystic fibrosis: an inherited susceptibility to bacterial respiratory infections. Mol. Med. Today, 5:351–358.

    Article  PubMed  Google Scholar 

  90. Vallis, A.J., Finck-Barbancon, V., Yahr, T.L., and Frank, D.W., 1999, Biological effects of Pseudomonas aeruginosa type III-secreted proteins on CHO cells. Infect. Immun., 67:2040–2044.

    PubMed  CAS  Google Scholar 

  91. von Götz, F., Häussler, S., Jordan, D., Saravanamuthu, S.S., Wehmhöner, D., Strüssmann, A., Lauber, J., Attree, I., Buer, J., Tümmler, B., and Steinmetz, I., 2004, Expression analysis of a highly adherent and cytotoxic small colony variant of Pseudomonas aeruginosa isolated from a lung of a patient with cystic fibrosis. J. Bacteriol., 186:3837–3847.

    Article  CAS  Google Scholar 

  92. Wehmhöner, D., Häussler, S., Tümmler, B., Jansch, L., Bredenbruch, F., Wehland, J., and Steinmetz, I., 2003, Inter-and intraclonal diversity of the Pseudomonas aeruginosa proteome manifests within the secretome. J. Bacteriol., 185:5807–5814.

    Article  PubMed  CAS  Google Scholar 

  93. West, S.E., and Iglewski B.H., 1988, Codon usage in Pseudomonas aeruginosa. Nucleic Acids Res., 16:9323–9335.

    PubMed  CAS  Google Scholar 

  94. Winstanley, C., Coulson, M.A., Wepner, B., Morgan, J.A., and Hart, C.A., 1996, Flagellin gene and protein variation amongst clinical isolates of Pseudomonas aeruginosa. Microbiology, 142:2145–2151.

    Article  PubMed  CAS  Google Scholar 

  95. Wolfgang, M.C., Kulasekara, B.R., Liang, X., Boyd, D., Wu, K., Yang, Q., Miyada, C.G., and Lory S., 2003, Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA, 100:8484–8489.

    Article  PubMed  CAS  Google Scholar 

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Tümmler, B. (2006). Clonal Variations in Pseudomonas aeruginosa . In: Ramos, JL., Levesque, R.C. (eds) Pseudomonas. Springer, Boston, MA . https://doi.org/10.1007/0-387-28881-3_2

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