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Motor Performance and Regional Brain Metabolism of Four Spontaneous Murine Mutations with Degeneration of the Cerebellar Cortex

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Motor Control and Learning

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Abstract

Four spontaneous mutations with cerebellar atrophy exhibit ataxia and deficits in motor coordination tasks requiring balance and equilibrium. These mutants were compared to their respective controls for regional brain metabolism assessed by histochemical staining of the mitochondrial enzyme, cytochrome oxidase (CO). The enzymatic activity of Grid2Lc, Grid2ho, Rorasg, and Relnrl mutants was altered in cerebellum and cerebellar-related pathways at brainstem, midbrain, and telencephalic levels. The CO activity changes in cerebellar cortex and deep cerebellar nuclei as well as some cerebellar-related regions were linearly correlated with motor performance in stationary beam and rotorod tasks of Grid2Lc, Rorasg, and Relnrl mutants. These results indicate that in addition to its relation to neural activity, CO staining can be used as a predictor of motor capacity.

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Authors and Affiliations

  1. Faculté de Médecine et de Pharmacie, INSERM U614, Université de Rouen, 76183, Rouen, Cedex, France

    Robert Lalonde

  2. Neuroscience Research Center, CHUM/St-Luc, Montreal, Canada

    Robert Lalonde

  3. Nancy I, Laboratoire de Pathologie Moléculaire et Cellulaire en Nutrition, INSERM U724, Université Henri Poincaré, France

    Catherine Strazielle

  4. Service de Microscopie Electronique, Faculté de Médecine, 54500, Vandoeuvre-les-Nancy, France

    Catherine Strazielle

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  1. Robert Lalonde
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  2. Catherine Strazielle
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Editors and Affiliations

  1. The Pennsylvania State University, USA

    Mark L. Latash

  2. Université De Caen Basse-Normandie, France

    Francis Lestienne

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Lalonde, R., Strazielle, C. (2006). Motor Performance and Regional Brain Metabolism of Four Spontaneous Murine Mutations with Degeneration of the Cerebellar Cortex. In: Latash, M.L., Lestienne, F. (eds) Motor Control and Learning. Springer, Boston, MA. https://doi.org/10.1007/0-387-28287-4_11

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  • DOI: https://doi.org/10.1007/0-387-28287-4_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25390-9

  • Online ISBN: 978-0-387-28287-9

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