Motor Performance and Regional Brain Metabolism of Four Spontaneous Murine Mutations with Degeneration of the Cerebellar Cortex
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Four spontaneous mutations with cerebellar atrophy exhibit ataxia and deficits in motor coordination tasks requiring balance and equilibrium. These mutants were compared to their respective controls for regional brain metabolism assessed by histochemical staining of the mitochondrial enzyme, cytochrome oxidase (CO). The enzymatic activity of Grid2Lc, Grid2ho, Rorasg, and Relnrl mutants was altered in cerebellum and cerebellar-related pathways at brainstem, midbrain, and telencephalic levels. The CO activity changes in cerebellar cortex and deep cerebellar nuclei as well as some cerebellar-related regions were linearly correlated with motor performance in stationary beam and rotorod tasks of Grid2Lc, Rorasg, and Relnrl mutants. These results indicate that in addition to its relation to neural activity, CO staining can be used as a predictor of motor capacity.
Keywordscerebellum motor control equilibrium cytochrome oxidase
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