6. Conclusions
An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.
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Stanford, I.M., Loucif, K.C., Wilson, C.L., Cash, D., Lacey, M.G. (2005). Limitations of the Isolated GP-STN Network. In: Bolam, J.P., Ingham, C.A., Magill, P.J. (eds) The Basal Ganglia VIII. Advances in Behavioral Biology, vol 56. Springer, Boston, MA. https://doi.org/10.1007/0-387-28066-9_6
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