Opposing Short-Term and Long-Term Effects of Amphetamine Sensitization on Operant Responding for a Food Reinforcer

  • Rebecca E. Nordquist
  • Pieter Voorn
  • J. G. de Mooij-van Malsen
  • R. N. J. M. A. Joosten
  • Cyriel M. A. Pennartz
  • Louk J. M. J. Vanderschuren
Conference paper
Part of the Advances in Behavioral Biology book series (ABBI, volume 56)

1. Abstract

Repeated exposure to drugs of abuse causes behavioral sensitization, a progressive and persistent increase in the psychomotor response to drugs. Behavioral sensitization is accompanied by altered responses to motivational stimuli and a wide array of neuroadaptations in limbic corticostriatal systems. Interestingly, both the behavioral and neural changes show markedly different effects when tested during induction of sensitization or after a period of drug abstinence. To directly compare short- and long-term effects of repeated drug administration on motivational behavior, we assessed performance of an operant conditioning task in rats either following a three week period of abstinence from amphetamine treatment or during the induction of amphetamine sensitization. We observed a biphasic response pattern for reward, in which operant responding was persistently potentiated following abstinence but transiently decreased when animals were tested during induction. We propose that drug-induced changes in the function of reward-related cortico-striatal systems underlie this pattern of sensitization-induced changes in motivated behavior.


Nucleus Accumbens Ventral Tegmental Area Ventral Striatum Lever Press Behavioral Sensitization 
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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Rebecca E. Nordquist
    • 1
    • 2
  • Pieter Voorn
    • 1
  • J. G. de Mooij-van Malsen
    • 2
    • 4
  • R. N. J. M. A. Joosten
    • 2
  • Cyriel M. A. Pennartz
    • 3
  • Louk J. M. J. Vanderschuren
    • 4
  1. 1.Department of AnatomyVrije Universiteit Medical CenterAmsterdam
  2. 2.Netherlands Institute for Brain ResearchNetherlands
  3. 3.Animal Physiology & Cognitive Neuroscience, Swammerdam Institute for Life SciencesUniversity of AmsterdamAmsterdam
  4. 4.Rudolf Magnus Institute of Neuroscience, Dept. of Pharmacology and AnatomyUniversity Medical Center UtrechtUtrecht

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