Nuclear Import and Export of Mammalian Viruses

  • Michael Bukrinsky
Part of the Molecular Biology Intelligence Unit book series (MBIU)


Viruses are intracellular parasites that commandeer cellular processes, such as RNA processing or protein synthesis, to perform virus-specific functions. For this purpose, many viral proteins shuttle between the nuclear and cytoplasmic compartments, even when the viral genome is replicated in the cytoplasm. This shutding process is usually regulated by classical nuclear import and export signals (NLSs and NESs, respeaively), which are also found in many cellular proteins and are described elsewhere in this book. In this Chapter, we will focus on viruses that replicate in the nucleus, and in particular on the mechanisms by which they transport their genomes into and out of the nucleus.


Human Immunodeficiency Virus Type Nuclear Export Nuclear Import Nuclear Export Signal Constitutive Transport Element 
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© and Kluwer Academic / Plenum Publishers 2005

Authors and Affiliations

  • Michael Bukrinsky
    • 1
  1. 1.Department of Microbiology and Tropical MedicineGeorge Washington UniversityWashington, DCUSA

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