Proteins in Antiperoxidation

  • G. S. Gupta


Germ Cell Glutathione Peroxidase Sertoli Cell Leydig Cell Seminal Plasma 


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30.7. References

  1. Aitken RJ. The human sprermatozoon — a cell in crisis. J Reprod Fertil 1999; 115: 1–7.PubMedGoogle Scholar
  2. Andonian S, Hermo L. Immunocytochemical localization of the Ya, Yb1, Yc, Yf, and Yo subunits of glutathione S-Transferaes in the cauda epididymidis and vas deferens of adult rats. J Androl 1999; 20:145–57.PubMedGoogle Scholar
  3. Anuradha D, Reddy KV, Kumar TC, Neeraja S, Reddy PR, Raddanna P. Purification and characterization of rat testicular glutathione S-transferases: role in the synthesis of eicosanoids. Asian J Androl 2000; 2:277–82.PubMedGoogle Scholar
  4. Bauche F, Fouchard MH, Jegou B. Antioxdant system in rat testicular cells. FEBS Lett 1994; 349: 392–6.PubMedGoogle Scholar
  5. Bauche F, Stephan JP, Touzalin AM, Jegou B. In vitro regulation of an inducible-type NO synthase in the rat seminiferous tubule cells. Biol Reprod 1998; 58: 431–38.PubMedGoogle Scholar
  6. Behne D, Kyriakopoulos A, Kalchlosch M, Weiss-Nowak C, Pfeifer H, Gessner H, Hammel C. Two new selenoproteins found in the prostatic glandular epithelium and in the spermatid nuclei. Biomed Environ Sci 1997; 10: 340–5.PubMedGoogle Scholar
  7. Borchert A, Savaskan NE, Kuhn H. Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis-and trans-regulatory elements. J Biol Chem 2003; 278: 2571–80.PubMedGoogle Scholar
  8. Boyer TD, Kenney WC. Acidic glutathione S-transferases of rat testis. Biochem J 1985; 230: 125–32.PubMedCentralPubMedGoogle Scholar
  9. Brigelius-Flohe R. Tissue-specific functions of individual glutathione peroxidases. Free Radical Biol Med 1999; 27: 951–65.Google Scholar
  10. Cai L, Deng DX, Jiang J, Chen S, Zhong R, Cherian MG, Chakrabarti S. Induction of metallothinein synthesis with preservation of testicular function in rats following long term renal transplantation. Urol Res 2000; 28: 97–103.PubMedGoogle Scholar
  11. Campbell E, Takahashi Y, Abramovitz M, Peretz M, Listowsky I. A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes. J Biol Chem 1990; 265; 9188–93.PubMedGoogle Scholar
  12. Cataldo L, Baig K, Oko R, Mastrangelo MA, Kleene ICC. Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm. Mol Reprod Dev 1996; 45: 320–31.PubMedGoogle Scholar
  13. Chainy GB, Samantaray S, Samanta L. Testosterone-induced changes in testicular antioxidant system. Andrologia 1997; 29: 343–9.PubMedGoogle Scholar
  14. Comstock KE, Johnson KJ, Rifenbery D, Henner WD. Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase GSTM4. J Biol Chem 1993; 268: 16958–65.PubMedGoogle Scholar
  15. De Lamirande E, Gagnon C. A positive role for the superoxide anion in the triggering of human sperm hyperactivation and capacitation. Int J Andol 1993a; 16: 21–25.Google Scholar
  16. De Lamirande E, Gagnon C. Human sperm hyperactivation and capacitation as parts of an oxidative process. Free Radical Biol Med 1993b; 14: 157–63Google Scholar
  17. De Lamirande E, Jiang H, Zini A, Kodama H, Gagnon C. Reactive oxygen species and sperm physiology. Rev Reprod 1997; 2: 48–54.PubMedGoogle Scholar
  18. De Lamirande E. Harakat A, Gagnon C. Human sperm capacitation induced by biological fluids and progesterone, but not by NADH or NADPH, is associated with the production of superoxide anion. J Androl 1998; 19: 215–25.PubMedGoogle Scholar
  19. De SK, Enders GC, Andrews GK. High levels of metallothionein mssenger RNAs in male germ cells of the adult mouse. Mol Endocrinol 1991; 5: 628–36.PubMedGoogle Scholar
  20. Drevet JR, Lareyre JJ, Schwaab V, Vernet P, Dufaure JP. PEA3 protein of the Ets oncogene family is a putative transcriptional modulator of the mouse epididymis-specific glutathione peroxidase gene gpx5. J Reprod Dev 1998; 49: 131–40.Google Scholar
  21. Ewing JF, Maines MD. Distribution of constitutive (HO-2) and heat inducible heme oxygenase (HO-1) isoenzymes in rat testes: HO-2 displays stage-specific expression in germ cells. Endocrinology 1995;136: 2294–302.PubMedGoogle Scholar
  22. Ford WC, Whittington K, Williams AC. Reactive oxygen species in human sperm suspensions: production by leukocytes and the generation of NADPH to protect sperm against their effects. Int J Androl 1997;20: 44–9.PubMedGoogle Scholar
  23. Foresta C, Flohe L, Garolla A, Roveri A, Ursini F, Maiorino M. Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase. Biol Reprod 2002; 67: 967–71.PubMedGoogle Scholar
  24. Francavilla F, Santucci R, Macerola B, Ruvolo G, Romano R. Nitric oxide synthase inhibition in human sperm affects sperm-oocytes fusion but not zona pellucida binding. Biol Reprod 2000; 63: 425–29.PubMedGoogle Scholar
  25. Fulcher KD, Welch JE, Klapper DG, O’Brien DA, Eddy EM. Identification of a unique mu-class glutathione S-transferase in mouse spermatogenic cells. Mol Reprod Dev 1995; 42: 415–24.PubMedGoogle Scholar
  26. Giannattasio A, Girotti M, Williams K, Hall L, Bellastella A. Puberty influences expression of phospholipid hydroperoxide glutathione peroxidase (GPX4) in rat testis: probable hypophysis regulation of the enzyme in male reproductive tract. J Endocrinol Invest 1997; 20: 439–44.PubMedGoogle Scholar
  27. Godeas C, Sandri G, Panfili E. Distribution of phospholipid hydroperoxide glutathione peroxidase in rat testis mitochondria. Biochim Biophys Acta 1994; 1191: 147–50.PubMedGoogle Scholar
  28. Godeas C, Tramer F, Micali F, Roveri A, Maiorino M, Nisii C, Sandri G, Panfili E. Phospholipid hydroperoxide glutathione peroxidase (PHGPx) in rat testis nuclei is bound to chromatin. Biochem Mol Med 1996;59: 118–24.PubMedGoogle Scholar
  29. Godeas C, Tramer F, Micali F, Soranzo M, Sandri G, Panfili E. Distribution and possible novel role of phospholipid hydroperoxide gluathione peroxidase in rat epididymal spermatozoa. Biol Reprod 1997;57: 1502–8.PubMedGoogle Scholar
  30. Gopalakrishnan B, Aravinda S, Pawshe CH, Totey SM, Nagpal S, Salunke DM Shaha C. Studies on glutathione S-transferases important for sperm function: evidence of catalytic activity independent functions. Biochem J 1998a; 329: (Pt 2) 231–41.PubMedCentralPubMedGoogle Scholar
  31. Gopalakrishnan B, Shaha C. Inhibition of sperm glutathione S-transferase leads to functional impairment due to membrane damage. FEBS Lett 1998b; 422: 296–300.PubMedGoogle Scholar
  32. Gu W, Hecht NB. Developmental expression of glutathione peroxidase, catalase, and managanese superoxide dismutase mRNAs during spermatogenesis in the mouse. J Androl 1996; 17: 256–62.PubMedGoogle Scholar
  33. Gu W, Hecht NB. Translation of a tesis-specific Cu/Zn superoxide dismutase (SOD-1) mRNA is regulated by a 65-kilodalton protein, which binds to its 5′ untranslated region. Mol Cell Biol 1996; 16: 4535–43.PubMedCentralPubMedGoogle Scholar
  34. Gu W, Morales C, Hecht NB. In male mouse germ cells, copper-zinc superoxide dismutase utilizes alternative promoters that product multiple transcripts with different translation. J Biol Chem 1995: 270: 236–43.PubMedGoogle Scholar
  35. Hall L, Williams K, Perry AC, Frayne J, Jury JA. Majority of human glutathione peroxidase type 5 (GPX5) transcripts are correctly spliced: implications for the role of GPX5 in the male reproductive tract. Biochem J 1998; 333: 5–9.PubMedCentralPubMedGoogle Scholar
  36. Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 1995; 30: 445–600.PubMedGoogle Scholar
  37. Hayes JD. Purification and characterization of glutathione S-transferases P, S and N. Isolation from rat liver of Ybl Yn protein, the existence of which was predicted by subunit hybridization in vitro. Biochem J 1984; 224: 839–52.PubMedCentralPubMedGoogle Scholar
  38. Hermo, Papp S, Robaire B. Developmental expression of the Yf subunit of glutathione S-transferase P in epithelial cells of the testis, efferent ducts, and epididymis of rat. Anat Rec 1994; 239: 421–40.PubMedGoogle Scholar
  39. Herr JC, Thomas D, Bush LA, Coonrod S, Khole V, Howards SS, Flickinger CJ. Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in lewis rats. Biol Reprod 1999; 61: 428–35.PubMedGoogle Scholar
  40. Hill KE, Lloyd RS, Yang JG, Read R, Burk RF. The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame. J Biol Chem 1991; 266: 10050–53.PubMedGoogle Scholar
  41. Hsieh CH, Tsai SP, Yeh HI, Sheu TC, Tam MF. Mass spectrometric analysis of rat ovary and testis cytosolic glutathione S-transferases (GSTs): Identification of a novel class-αGST, rGSTA6*, in rat testis. Biochem J 1997; 323 (Pt2): 503–10.PubMedCentralPubMedGoogle Scholar
  42. Hussey AJ, Hayes JD. Human Mu-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue. Biochim Biophys Acta 1993; 1203: 131–41.PubMedGoogle Scholar
  43. Ichikawa T, Oeda T, Ohmori H, Schill WB. Reactive oxygen species influence the acrosome reaction but not acrosin activity in human spermatozoa. Int J Androl 1999; 22: 37–42.PubMedGoogle Scholar
  44. Imai H, Suzuki K, Ishizaka K, Ichinose S, Oshima H, Okayasu I, Emoto K, Umeda M, Nakagawa Y. Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human interfile males. Biol Reprod 2001; 64: 674–83.PubMedGoogle Scholar
  45. Institoris E, Eid H, Bodrogi I, Bak M. Glutathione related enzymes in human testicular germ cell tumors and normal testes. Anti Res 1995; 15: 1371–4.Google Scholar
  46. Ishida N, Katayama Y, Sato F, Hasegawa T, Mukoyama H. The cDNA sequences of equine antioxidative enzyme genes Cu/Zn-SOD and Mn-SOD, and their expressions in equine tissues. J Vet Med Sci 1999;61: 291–4.PubMedGoogle Scholar
  47. Jow WW, Schlegel PN, Cichon Z, Phillips D, Goldstein M, Bardin CW. Identification and localization of copper zinc superoxide dismutase gene expression in rat testicular development. J Androl 1993; 14:439–47.PubMedGoogle Scholar
  48. Kaur G, Nath R, Gupta GS. Purification and characterization of low molecular weight metal binding protein from human testis. Trace Elem Expt Med 1993; 6: 1–11.Google Scholar
  49. Knopp EA, Arnodt TL, Eng KL, Caldwell M, LeBoeuf RC, Deeb SS, O’Brien KD. The phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression and mapping. Mamm Genome 1999; 10: 601–5.PubMedGoogle Scholar
  50. Koga M, Tanaka H, Yomogida K, Tsuchida J, Uchida K, Kitamura M, Sakoda S, Matsumiya K, Okuyama A, Nishimune Y. Expression of Selenoprotein-P-messenger ribonucleic acid in the rat testis. Biol Reprod 1998; 58: 261–65.PubMedGoogle Scholar
  51. Kuo RC, Baxter GT, Thompson SH, Strieker SA, Patton C, Bonaventura J, Epel D. NO is necessary and sufficient for egg activation at fertilization. Nature 2000; 406: 633–35.PubMedGoogle Scholar
  52. Lahti PP, Shariatmadari R, Penttinen JK, Drevet JR, Haendler B, Vierula M, Parvinen M, Huhtaniemi IT, Poutanen M. Evaluation of the 5′-flanking regions of murine glutathione peroxidase five and cysteine-rich secretory protein-1 genes for directing transgene expression in mouse epididymis. Biol Reprod 2001; 64: 1115–21.PubMedGoogle Scholar
  53. Lapointe S, Legare C, Gaudreault C, Sullivan R, Sirard MA. cDNA sequence and deduced amino acid sequence of bovine oviductal fluid catalase. Mol Reprod Dev 1998; 51: 265–73.PubMedGoogle Scholar
  54. Latchoumycandane C, Chitra KC, Mathur PP. The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antioxidant system in mitochondrial and microsomal fractions of rat testis. Toxicology 2002; 28:127–35.Google Scholar
  55. Lei XG, Ross DA, Parks JE, Combs GF Jr. Effects of dietary selenium and vitamin E concentrations on phospholipid hydroperoxide glutathione peroxidase expression in reproductive tissues of pubertal maturing male rats. Biol Trace Elem Res 1997; 59: 195–206.PubMedGoogle Scholar
  56. Lieberman MW, Wiseman AL, Shi Z-Z, Carter BZ, Barrios R et al., Growth retardation and cysteine deficiency in γ-glutamyl transpeptidase-deficient mice. Proc Natl Acad Sci USA 1996; 93:7923:26.Google Scholar
  57. Listowsky I, Rowe JD, Patskovsky YV, Tchaikovskaya T, Shintani N, Novikova E, Nieves E. Human testicular glutathione-S-transferases: insights into tissue-specific expression of the diverse subunit classes. Chem Biol Interact 1998; 24: 111–12.Google Scholar
  58. Liu J, Corton C, Dix Dj, Liu Y, Waalkes MP, Klaassen CD. Genetic background butnot metallothionenin phenotype dictates sensitivity to cadmium-induced testicular injury in mice. Toxicol Appl Pharmacol 2001; 1: 1–9.Google Scholar
  59. Lopes S, Jurisicova A, Sun JG, Casper RF. Reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa. Reproduction 1998; 13: 896–900.Google Scholar
  60. Mahboob M, Shireen KF, Atkinson A, Khan AT. Lipid peroxidation and antioxidant enzyme activity in different organs of mice exposed to low level of mercury. J Environ Sci Health B 2001; 36: 687–97.PubMedGoogle Scholar
  61. Mains MD. The heme oxygenase system: a regulator of second messanger gases. Annu Rev Pharmacol Toxicol 1997; 37: 517–54.Google Scholar
  62. Maiorino M, Wissing JB, Brigelius-Flohe R, Calabrese F, Roveri A, Steinert P, Ursini F, Flohe L. Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation. FASEB J 1998; 12: 1359–70.PubMedGoogle Scholar
  63. Matsuura T, Kawasaki Y, Miwa K, Sutou S, Ohinata Y, Yoshida F, Mitsui Y. Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes. J Inorg Biochem 2002; 88: 183–91.PubMedGoogle Scholar
  64. McCoubrey WK Jr, Ewing JF, Maines MD. Human heme oxygenase-2: chacterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. Arch Biochem Biophys 1992; 295: 13–20.PubMedGoogle Scholar
  65. Middendorff R, Kumm M, Davidoff MS, Holstein AF, Muller D. Generation of cyclic guanosine monophosphate by heme oxygenases in the human testis-a regulatory role for carbon monoxide in sertoli cells. Biol Reprod 2000; 63: 651–57.PubMedGoogle Scholar
  66. Middendorff R, Muller D, Wichers S, Holstein AF, Davidoff MS. Evidence for production and functional activity of nitric oxide in seminiferous tubules and blood vessels of the human testis. J Clin Endocrinol Metab 1997; 82: 4154–61.PubMedGoogle Scholar
  67. Mizuno K, Hirata S, Hoshi K, Shinohara A, Chiba M. Analysis of the phospholipid hydroperoxide glutathione peroxidase mRNA in the rat spermatozoon and effect of selenium deficiency on the mRNA. Biol Trace Elem Res 2000; 74: 71–9.PubMedGoogle Scholar
  68. Mruk D, Cheng CH, Cheng YH, Mo MY, Grima J, Silvestrini B, Lee WM, Cheng CY. Rat testicular extracellular dismutase: its purification, cellular distribution, and regulation. Biol Reprod 1998; 59:298–308.PubMedGoogle Scholar
  69. Mruk DD, Cheng CY. In vitro regulation of extracellular superoxide dismutase in Sertoli cells. Life Sci 2000; 67: 133–45.PubMedGoogle Scholar
  70. Mueller A, Hermo L, Robaire B. The effects of aging on the expression of glutathione S-transfereses in the testis and epididymis of the Brown Norway rat. J Androl 1998; 19: 450–65.PubMedGoogle Scholar
  71. Mukherjee SB, Aravinda S, Gopalakrishnan B, Nagpal S, Salunke DM, Shaha C. Secretion of glutathione S-transferase isoforms in the seminiferous tubular fluid, tissue distribution and sex steroid binding by rat GSTM1. Biochem J 1999; 340 (Pt 1): 309–20.PubMedCentralPubMedGoogle Scholar
  72. Nam S, Nakamuta N, Kurohmaru M, Hayashi Y. Cloning and sequencing of the mouse cDNA encoding a phospholipids hydroperoxide glutathione perioxidase. Gene 1997; 198: 245–9.PubMedGoogle Scholar
  73. Nam SY, Fujisawa M, Kim JS, Kurohmaru M, Hayashi Y. Expression pattern of phospholipid hydroperoxide glutathione peroxidase messenger ribonucleic acid in mouse testis. Biol Reprod 1998a; 58: 1272–6.PubMedGoogle Scholar
  74. Nam SY, Maeda S, Gujisawa M, Kurohmaru M, Hayashi Y. Cloning and expression of mitochondrial capsule selenoprotein gene in the golden hamster. J Vet Med Sci 1998b; 60: 1113–8.PubMedGoogle Scholar
  75. Nonogaki T, Noda Y, Narimoto K, Shiotani M, Mori T, Matsuda T, Yoshida O. Localization of CuZn-superoxide dismutase in the human male gental organs. Hum Reprod 1992; 7: 81–5.PubMedGoogle Scholar
  76. O’Flaherty CM, Beonegui NB, Beconi MT. Reactive oxygen species requirements for bovine sperm capacitation and acrosome reaction. Thcriogenology 1999; 15: 289–301.Google Scholar
  77. Okamura N, Iwaki Y, Hiramoto S, Tamba M, Bannai S, Sugita Y, Syntin P, Dacheux F, Dacheux JL. Molecular cloning and characterization of the epididymis-specific glutathione peroxidase-like protein secreted in the porcine epididymal fluid. Biochim Biophys Acta 1997; 1316: 99–109.Google Scholar
  78. Ookawara T, Imazeki N, Matsubara O, Kizaki T, Oh-Ishi S, Nakao C, Sato Y, Ohno H. Tissue distribution of immunoreactive mouse extracellular superoxide dismutase. Am J Physiol 1998; 275(3 Pt 1):C 840–7.Google Scholar
  79. Palladino MA, Hinton BT. Expression of multiple-γ-glutamyl transpeptidase messenger ribonucleic acid transcripts in the adult rat epididymis is differentially regulated by androgens and testicular factors in a region-specific manner. Endocrinology 1994; 135: 1146–56.PubMedGoogle Scholar
  80. Papp S, Robaire B, Hermo L. Developmental expression of the glutathione S-transferase Yo subunit in the rat testis and epididymis using light microscope immunocytochemistry. Anat Rec 1994; 240: 345–57.PubMedGoogle Scholar
  81. Papp S, Robaire B, Hermo L. Immunocytochemical localization of the Ya, Yc, Ybl and Yb2 subunits of glutathione S-transferases in the testis and epididymis of adult rats. Microsc Res Tech 1995; 30: 1–23.PubMedGoogle Scholar
  82. Perry AC, Jones R, Hall L. Isolation and characterization of a rat cDNA clone encoding a secreted superoxide dismutase reveals the epididymis to be a major site of its expression. Biochem J 1993; 293 (Pt 1): 21–5.PubMedCentralPubMedGoogle Scholar
  83. Pharmacol Exp Therap 1994; 269: 230–37.Google Scholar
  84. Puspha-Rekha TR, Burdsall AL, Leksa LM, Chisolm GM, Driscoll DM. Rat phospholpid hydroperoxide glutathione peroxidase: cDNA cloning and identification of multiple transcription and translation start sites, J Biol Chem 1995; 270: 26993–99.Google Scholar
  85. Rao AV, Shaha C. Role of glutathione S-transferases in oxidative stress-induced male germ cell apoptosis. Free Radical Biol Med 2000; 29: 1015–27.Google Scholar
  86. Roberts KP. Y chromosome deletions and male infertility: state of the art and clinical implications. J Androl 1998; 19: 255–59.PubMedGoogle Scholar
  87. Roveri A, Casasco A, Maiorino M, Dalan P, Calligaro A and Ursini F. Phospholipid hydroperoxide glutathione peroxidase of rat tesis. Gonadotropin dependence and immunocytochemical indentification. J Biol Chem 1992; 267: 6142–46.PubMedGoogle Scholar
  88. Roveri A, Maiorino M, Nisii C, Ursini F. Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranes. Biochim Biophys Acta 1994; 1208:211–21.PubMedGoogle Scholar
  89. Rowe JD, Nieves E, Listowsky I. Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera. Biochem J 1997; 325 (Pt2): 481–6.PubMedCentralPubMedGoogle Scholar
  90. Rowe JD, Patskovsky YV, Patskovska LN, Novikova E, Listowsky I. Rationale for reclassification of a distinctive subdivision of mammalian class Mu glutathione S, transferases that are primarily expressed in testis. J Biol Chem 1998; 273: 9593–601.PubMedGoogle Scholar
  91. Rublevskaya IN, Maines MD. Interaction of Fe-protoporphyrin IX and heme analogues with purified recombinant heme oxygenase-2, the constitutive isoenzyme of the brain and testes. J Biol Chem 1994; 269: 26390–95.PubMedGoogle Scholar
  92. Schwaab V, Faure J, Dufaure JP, Drevet JR. The plasma-type glutathione peroxidase is expressed under androgenic control in the mouse epididymis and vas deferens. Mol Reprod Dev 1998; 51: 362–72.PubMedGoogle Scholar
  93. Schwaab V, Lareyre JJ, Vernet P, Pons E, Faure J, Dufaure JP, Drevet JR. Characterization, regulation of the expression and putative roles of two glutathione peroxidase proteins found in the mouse epididymis. J Reprod Fertil Suppl 1998; 53: 157–62.PubMedGoogle Scholar
  94. Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology 1996; 48: 835–50.PubMedGoogle Scholar
  95. Sheehan D, Ryle CM, Mantle TJ. Selective induction of glutathione S-transferase D in rat testis by phenobarbital. Biochem J 1984; 219: 687–8.PubMedCentralPubMedGoogle Scholar
  96. Shinde UA, Mehta AA, Goyal RK. Nitric oxide: a molecule of the millennium. Ind J Expt Biol 2000; 38:201–10.Google Scholar
  97. Stephan JP. Guillemois C, Jegou B, Bauche F. Nitric oxide production by Sertoli cells in response to cytokines and lipopolysaccharide. Biochem Biophys Res Commun 1995; 213: 218–24.PubMedGoogle Scholar
  98. Sugihara T, Wadhwa R, Kaul SC, Mitsui Y. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. Genomics 1999; 57: 130–6.PubMedGoogle Scholar
  99. Sutou S, Miwa K, Matsuura T, Kawasaki Y, Ohinata Y, Mitsui Y. Native tesmin is a 60-kilodalton protein that undergoes dynamic changes in its localization during spermatogenesis in mice. Biol Reprod 2003; 68: 1861–9.PubMedGoogle Scholar
  100. Tam MF, Hsieh CH, Tsai SP and S.Tam TC. Amino acid sequence of glutathione S-transferase rGSTM5* from rat testis. Biochem J 1998; 333: 735–39.PubMedCentralPubMedGoogle Scholar
  101. Thundathil J, de Lamirande E, Gagnon C. Nitric oxide regulates the phosphorylation of the threonine-glutamine-tyrosine motif in proteins of human spermatozoa during capacitation. Biol Reprod 2003; 68: 1291–8.PubMedGoogle Scholar
  102. Ufer C, Borchert A, Kuhn H. Functional characterization of cis-and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase. Nucleic Acids Res 2003; 31: 4293–303.PubMedCentralPubMedGoogle Scholar
  103. Ursini F, Heim S, Kiess M, Maiorino M, Roveri A, Wissing J, Flohe L. Dual function of the selenoprotein PHGPx during sperm maturation. Science 1999; 285(5432): 1393–6.PubMedGoogle Scholar
  104. Veri JP, Hermo L, Robaire B. Immunocytochemical localization of glutathione S-transferase Yo subunits in the rat testis and epididymis. J Androl 1994; 15: 415–34.PubMedGoogle Scholar
  105. Veri JP, Hermo L, Robaire B. Immunocytochemical localization of the Yf subunit of glutathione S-transferase P shows regional variation in the staining of epithelial cells of the testis. J Androl 1993;14: 23–44.PubMedGoogle Scholar
  106. Vernet P, Rock E, Mazur A, Rayssiguier Y, Dufaure JP, Drevet JR. Selenium-independent epididymis-restricted glutathione peroxidase 5 protein (GPX) can back up failing Se-dependent GPXs in mice subjected to selenium deficiency. Mol Reprod Dev 1999; 54: 362–70.PubMedGoogle Scholar
  107. Wang Y, Goligorsky MS, Lin M, Wilcox JN, Marsden PA. A novel testis-specific mRNA transcript encoding an NH2-terminal truncated nitric oxide synthase. J Biol Chem 1997; 272: 11392–401.PubMedGoogle Scholar
  108. Whanger PD, Vendeland SC, Gu QP, Beilstein MA, Ream LW. Selenoprotein W cDNAs from five species of animals. Biomed Environ Sci 1997; 10: 190–97.PubMedGoogle Scholar
  109. Williams K, Frayne J, Hall L. Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract. Mol Hum Reprod 1998; 4: 841–8.PubMedGoogle Scholar
  110. Yang Y, Cheng JZ, Singhal SS, Saini M, Pandya U, Awasthi S, Awasthi YC. Role of glutathione S-transferases in protection against lipid peroxidation: Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation. J Biol Chem 2001;276: 19220–30.PubMedGoogle Scholar
  111. Yeh JY, Vendland SC, Gu Q, Butler JA, Ou BR, Whanger PD. Dietary selenium increases selenoprotein W levels in rat tissues. J Nutr 1997; 127: 2165–72.PubMedGoogle Scholar
  112. Zhang H, Zheng RL. Promotion of human sperm capacitation by superoxide anion. Free Radical Res 1996;24: 261–68.Google Scholar
  113. Zini A, de Lamirande E, Gagnon C. Reactive oxygen species in semen of infertile patients: levels of superoxide dismutase-and catalase-like activities in seminal plasma and spermatozoa. Int J Androl 1993; 16: 183–88.PubMedGoogle Scholar
  114. Zini A, Schlegel PN. Identification and characterizatio of antioxidant enzyme mRNAs in the rat epididymis. J Androl 1997; 20: 86–91Google Scholar

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© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • G. S. Gupta
    • 1
  1. 1.Department of BiophysicsPanjab UniversityChandigarhIndia

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