Inositol Phosphates and Phosphoinositides in Health and Disease

  • Yihui Shi
  • Abed N. Azab
  • Morgan N. Thompson
  • Miriam L. Greenberg
Part of the Subcellular Biochemistry book series (SCBI, volume 39)

4. Summary

In the past two decades, considerable progress has been made toward understanding inositol phosphates and PI metabolism. However, there is still much to learn. The present challenge is to understand how inositol phosphates and PIs are compartmentalized, identify new targets of inositol phosphates and PIs, and elucidate the mechanisms underlying spatial and temporal regulation of the enzymes that metabolize inositol phosphates and PIs. Answers to these questions will help clarify the mechanisms of the diseases associated with these molecules and identify new possibilities for drug design.


Inositol Phosphate Malignant Hyperthermia Malignant Hyperthermia GLUT4 Translocation Inositol Polyphosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2006

Authors and Affiliations

  • Yihui Shi
    • 1
  • Abed N. Azab
    • 1
  • Morgan N. Thompson
    • 1
  • Miriam L. Greenberg
    • 1
  1. 1.Department of Biological SciencesWayne State UniversityDetroitUSA

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