Parathyroid Gland Hyperplasia in Renal Failure

  • Adriana S. Dusso
  • Mario Cozzolino
  • Eduardo Slatopolsky
Part of the Molecular Biology Intelligence Unit book series (MBIU)

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References

  1. 1.
    Parfitt AM. The hyperparathyroidism of chronic renal failure: A disorder of growth. Kidney Int 1997; 52:3–9.PubMedGoogle Scholar
  2. 2.
    Slatopolsky E, Finch J, Denda M et al. Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro. J Clin Invest 1996; 97:2534–2540.PubMedGoogle Scholar
  3. 3.
    Silver J, Bar Sela S, and Naveh-Many T. Regulation of parathyroid cell proliferation. Curr Op Nephrol Hyperten 1997; 6:321–326.Google Scholar
  4. 4.
    Gonzales EA, Martin KJ. Renal osteodystrophy: pathogenesis and management. Nephrol Dial Transplant 1995; 3:13–21.Google Scholar
  5. 5.
    Goodman WG, Goldin J, Kuizon BD et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 2000; 342:1478–1483.PubMedCrossRefGoogle Scholar
  6. 6.
    Cozzolino M, Dusso A, E. Slatopolsky. Role of calcium x phosphate product and bone-associated proteins on vascular calcification in renal failure. J Am Soc Nephrol 2001; 12:2511–2516.PubMedGoogle Scholar
  7. 7.
    Naveh-Many T, Rahaminow R, Livni N, and Silver J. Parathyroid cell proliferation in normal and chronic renal failure in rats: The effects of calcium, phosphate and vitamin D. J Clin Invest 1995; 96:1786–1793.PubMedGoogle Scholar
  8. 8.
    Kifor O, Moore FD, Wang P et al. Reduced immunostaining for the extracellular Ca sensing receptor in primary and uremic secondary hyperparathyroidism: J Clin Endocrinol Metab 1996; 81:1598–1606.PubMedCrossRefGoogle Scholar
  9. 9.
    Fukuda N, Tanaka H, Tominaga Y et al. Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest 1993; 92:1436–1443.PubMedGoogle Scholar
  10. 10.
    Slatopolsky E. The role of calcium, phosphorus and vitamin D metabolism in the development of secondary hyperparathyroidism. Nephrol Dial Transplant 1998; 13(S3):3–8.PubMedCrossRefGoogle Scholar
  11. 11.
    Silver J, Yalcindag C, Sela-Brown A et al. Regulation of the parathyroid hormone gene by vitamin D, calcium and phosphate. Kidney Int 1999; 73:S2–S8.CrossRefGoogle Scholar
  12. 12.
    Sela-Brown A, Silver J, Brewer G et al. Identification of AUF1 as a parathyroid hormone mRNA-3’-untranslated region-binding protein that determines parathyroid hormone mRNA stability. J Biol Chem 2000; 275:7424–7429.PubMedCrossRefGoogle Scholar
  13. 13.
    Denda M, Finch J, Slatopolsky E. Phosphorus accelerated the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure. Am J Kidney Dis 1996; 28:596–602.PubMedGoogle Scholar
  14. 14.
    Pestell RG Albanese C, Reutens AT et al. The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocrine Reviews 1999; 20(4):501–534.PubMedCrossRefGoogle Scholar
  15. 15.
    Nasmyth K. Viewpoint: Putting the cell cycle in order. Science 1996; 274:1643–1645.PubMedCrossRefGoogle Scholar
  16. 16.
    Roberts JM, Koff A, Polyak K et al. Cyclins, cdks and cyclin kinase inhibitors. Cold Spring Harbor Symp on Quantitative Biology LIX 1994:31–38.Google Scholar
  17. 17.
    Zhang P, Duchambon P, Gogusev J et al. Apoptosis in parathyroid hyperplasia of patients with primary or secondary uremic hyperparathyroidism. Kidney Int 2000; 57:437–445.PubMedCrossRefGoogle Scholar
  18. 18.
    Jara A, Gonzalez S, Felsenfeld AJ et al. Failure of high doses of calcitriol and hypercalcaemia to induce apoptosis in hyperplastic parathyroid glands of azotaemic rats: Nephrol Dial Transplant 2001; 16:506–512.PubMedCrossRefGoogle Scholar
  19. 19.
    Canalejo A, Almaden Y, Torregrosa V et al. The in vitro effects of calcitriol on parathyroid cell proliferation and apoptosis: J Am Soc Nephrol 2000; 11:1865–1872.PubMedGoogle Scholar
  20. 20.
    Vasef MA, Brynes RK, Sturm M et al. Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasia: a paraffin immunohistochemical study. Mod Pathol 1999; 12(4):412–416.PubMedGoogle Scholar
  21. 21.
    Imanishi Y, Hosokawa Y, Yoshimoto K et al. Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice: J Clin Ivest 2001; 107:1093–1101.Google Scholar
  22. 22.
    Tominaga Y, Tsuzuki T, Uchida K et al. Expression of Prad1/cyclin D1, retinoblastoma gene products, and Ki67 in parathyroid hyperplasia caused by chronic renal failure versus primary adenoma. Kidney Int 1999; 55:1375–1383.PubMedCrossRefGoogle Scholar
  23. 23.
    Erickson LA, Jin L, Thompson GB et al. Parathyroid hyperplasia, adenomas, and carcinomas: differential expression of p27Kip1 protein. Am J Surg Pathol 1999; 23(3):288–295.PubMedCrossRefGoogle Scholar
  24. 24.
    Brown AJ, Zhong M, Ritter C et al. Loss of calcium responsiveness in cultured bovine parathyroid cells is associated with decreased calcium receptor expression: Biochem Biophys Res Commun 1995; 212:861–867.PubMedCrossRefGoogle Scholar
  25. 25.
    Wang Q, Palnitkar S, Parfitt AM. Parathyroid cell proliferation in the rat. Effect of age, and of phosphate administration and recovery. Endocrinol 1996; 137:4558–4562.CrossRefGoogle Scholar
  26. 26.
    Wang Q, Palnitkar S, Parffitt AM. The basal rate of cell proliferation in normal human parathyroid tissue: implications for the pathogenesis of hyperparathyroidism. Clin Endocrinol 1997; 46:343–349.CrossRefGoogle Scholar
  27. 27.
    Dusso AS, Pavlopoulos T, Naumovich L et al. p21wafl and TGFa mediate dietary phosphate-regulation of parathyroid cell growth. Kidney Int 2001; 59:855–865.PubMedCrossRefGoogle Scholar
  28. 28.
    Portale AA, Halloran BP, Morris RC Jr. Physiologic regulation of serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest 1989; 83:1494–1499.PubMedGoogle Scholar
  29. 29.
    Portale AA, Booth BE, Halloran BP et al. Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency. J Clin Invest 1984; 73:1580–1589.PubMedCrossRefGoogle Scholar
  30. 30.
    Liu M, Lee MH, Cohen M et al. Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Gene Develop 1996; 10:142–153.Google Scholar
  31. 31.
    DiCunto F, Topley G, Calautti E et al. Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science 1998; 280:1069–1072.CrossRefGoogle Scholar
  32. 32.
    Zhuang SH, Burnstein KL. Antiproliferative effect of 1alpha, 25-dihydroxyvitamin D3 in human prostate cancer cell line LNCaP involves reduction of cyclin-dependent kinase 2 activity and persistent G1 accumulation. Endocrinol 1998; 139:1197–1207.CrossRefGoogle Scholar
  33. 33.
    Ohtsubo M, Gamou S, Shimizu N. Antisense oligonucleotide of WAF1 gene prevents EGF-induced cell cycle arrest in A431 cells. Oncogene 1998; 16:797–802.PubMedCrossRefGoogle Scholar
  34. 34.
    Miyazaki M, Ohashi R, Tsuji T et al. Transforming growth factor-beta 1 stimulates or inhibits cell growth via down-or up-regulation of p21/Waf1. Biochem Biophys Res Com 1998; 246:873–880.PubMedCrossRefGoogle Scholar
  35. 35.
    Shankland SJ, Floege J, Thomas SE et al. Cyclin kinase inhibitors are increased during experimental membranous nephropathy: Potential role in limiting glomerular epithelial cell proliferation in vivo. Kidney Int 1997; 52:404–413.PubMedGoogle Scholar
  36. 36.
    Macleod KF, Sherry N, Hannon G et al. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Gene Dev 1995; 9:935–944.PubMedGoogle Scholar
  37. 37.
    Bonfanti M, Taverna S, Salmona M et al. P21 WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth. Cancer Res 1997; 57:1442–1446.PubMedGoogle Scholar
  38. 38.
    Yang ZY, Perkins ND, Ohno T et al. The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicy in vivo. Nature Med 1995; 1:1052–1056.PubMedCrossRefGoogle Scholar
  39. 39.
    Gartel AL, Serfas MS, Tyner AL. p21-Negative regulator of the cell cycle. Proc Soc Exp Biol Med 1996; 213:138–149.PubMedGoogle Scholar
  40. 40.
    Kumar V, Bustiin SA, McKay IA. Transforming growth factor alpha. Cell Biol Int 1995; 19:373–388.PubMedCrossRefGoogle Scholar
  41. 41.
    Driman DK, Kobrin MS, Kudlow JE et al. Transforming growth factor-α in normal and neoplastic human endocrine tissues. Hum Pathol 1992; 23:1360–1365.PubMedCrossRefGoogle Scholar
  42. 42.
    Gogusev J, Duchambon P, Soermann-Chopard C et al. De novo expression of transforming growth factor-α in parathyroid gland tissue of patients with primary or secondary uraemic hyperparathyroidism. Nephrol Dial Transpl 1996; 11:2155–2162.Google Scholar
  43. 43.
    Wong ST, Winchell LF, McCune BK et al. The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction. Cell 1989; 56:495–500.PubMedCrossRefGoogle Scholar
  44. 44.
    Shum L, Reeves SA, Kuo AC et al. Association of the transmembrane TGFα precursor with a protein kinase complex. J Cell Biol 1994; 125:903–916.PubMedCrossRefGoogle Scholar
  45. 45.
    Wells A. Molecules in focus. EGF receptor. Int J Biochem Cell Biol 1999; 31:637–643.PubMedCrossRefGoogle Scholar
  46. 46.
    Lin SY, Makino K, Xia W et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor: Nature Cel Bio 2001; 3:802–808.CrossRefGoogle Scholar
  47. 47.
    Sadler GP, Morgan JM, Jasani B et al. Epidermal growth factor receptor status in hyperparathyroidism: Immunocytochemical and in situ hybridization study. World J Surg 1996; 20:736–743.PubMedCrossRefGoogle Scholar
  48. 48.
    Studer H, Derwahl M. Mechanisms of noneoplastic endocrine hyperplasia-A changing concept: A review focused on the thyroid gland: Endocrin Rev 1995; 16:411426.CrossRefGoogle Scholar
  49. 49.
    Kremer R, Bolivar I, Goltzman D et al. Influence of calcium and 1,25-dihydroxycholecalciferol on proliferation and proto-oncogene expression in primary cultures of bovine parathyroid cells. Endocrinology 1989; 125(2):935–941.PubMedCrossRefGoogle Scholar
  50. 50.
    Szabo A, Merke J, Beier E et al. 1,25(OH)2 vitamin D3 inhibits parathyroid cell proliferation in experimental uremia. Kidney Int 1989; 35:1049–1056.PubMedGoogle Scholar
  51. 51.
    Cozzolino M, Lu Y, Finch JL et al. p21 waf1 and TGFα mediate parathyroid growth arrest by vitamin D and high calcium. Kidney Intern 2001; 60:2109–2117.CrossRefGoogle Scholar
  52. 52.
    Tokumoto M, Hirakawa M, Tsuruya K et al. Diminished expressions of cyclin-dependent kinase inhibitor p21 and vitamin D receptor in nodular hyperplasia and in secondary hyperparathyroidism. J Am Soc Nephrol 2000; 11:584A.Google Scholar
  53. 53.
    Tong WM, Kallay E, Hofer H et al. Growth regulation of human cancer cells by epidermal growth factor and 1,25-dihydroxyvitamin D3 is mediated by mutual modulation of receptor expression: Eur J Cancer 1998; 34:2119–2125.PubMedCrossRefGoogle Scholar
  54. 54.
    Taoka T, Collins ED, Irino S et al. 1,25-(OH)2-vitamin D3 mediated changes in mRNA for c-myc and 1,25-(OH)2D3 receptor in HL60 cells and related subclones. Mol Cell Endocrinol 1993; 95:51–57.PubMedCrossRefGoogle Scholar
  55. 55.
    Simpson RU, Hsu T, Wendt MD et al. 1,25-dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C. J Biol Chem 1989; 264:19710–19715.PubMedGoogle Scholar
  56. 56.
    Grandis JR, Chakraborty A, Zeng Q et al. Downmodulation of TGFα protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. J Cell Biochem 1998; 69:55–62.PubMedCrossRefGoogle Scholar
  57. 57.
    Tong WM, Hofer H, Ellinger A et al. Mechanism of antimitogenic action of vitamin D in human colon carcinoma cells: Relevance for suppression of epidermal growth factor stimulated cell growth: Oncol Res 1999; 11:77–84.PubMedGoogle Scholar
  58. 58.
    Sheinin Y, Kaserer, Wrba F et al. In situ mRNA hybridization analysis and immunolocalization of the vitamin D receptor in normal and carcinomatous human colonic mucosa: relation to epidermal growth factor receptor expression: Virchows Arch 2000; 437:501–507.PubMedCrossRefGoogle Scholar
  59. 59.
    Jensen SS, Madsen MW, Lukas J et al. Inhibitory effects of 1,25-dihydroxyvitamin D3 on the G1-S phase-controlling machinery. Mol Endocrinol 2001; 15:1370–1380.PubMedCrossRefGoogle Scholar
  60. 60.
    Ritter C, Lu Y, Finch JL et al. 19-Nor-1,25 (OH)2D2 (19-Nor), an analog of calcitriol, suppresses parathyroid gland growth in uremic rats with established secondary hyperparathyroidism: J Am Soc Nephrol 2000; 11:581 A.Google Scholar
  61. 61.
    Nakagawa K, Kurobe M, Konno K et al. Structure-specific control of differentiation and apoptosis of human promyelocytic leukemia (HL-60) cells by A-ring diasteroisomers of 2-methyl-l, 25-dihydroxyvitamin D3 and its 20-epimer: Biochem Pharmacol 2000; 60:1937–1947.PubMedCrossRefGoogle Scholar
  62. 62.
    Amling M, Priemel M, Holzmann T et al. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biochemical analyses. Endocrinology 1999; 140:4982–4987.PubMedCrossRefGoogle Scholar
  63. 63.
    Motellon JL, Jimenez FJ, de Miguel F et al. Relationship of plasma bone cytokines with hypercalcemia in cancer patients. Clin Chim Acta 2000; 302:59–68.PubMedCrossRefGoogle Scholar

Copyright information

© Eurekah.com and Kluwer Academic / Plenum Publishers 2005

Authors and Affiliations

  • Adriana S. Dusso
    • 1
  • Mario Cozzolino
    • 1
  • Eduardo Slatopolsky
    • 1
  1. 1.Renal DivisionWashington University School of MedicineSt. LouisUSA

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