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Structures and Motifs Involved in Toll Signaling

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Toll and Toll-Like Receptors: An Immunologic Perspective

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

In this chapter we aim to provide a detailed overview of Toll-like receptor (TLR) structure. Initially we focus on the different ways in which the related vertebrate and invertebrate TLRs recognize pathogen patterns, with particular reference to the LPS sensor (hTLR4/ CD14/MD2) and Drosophila ToU/Spätzle. In the second part of our chapter we discuss the evidence that signal transduction involves receptor driven recruitment of multitypic protein complexes and the activation and autoregulation of the IRAK family of Serine/Threonine protein kinases.

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  1. Department of Biochemistry, University of Cambridge, Cambridge, UK

    Monique Gangloff, Phumzile L. Ludidi & Nicholas J. Gay

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  1. Monique Gangloff
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Gangloff, M., Ludidi, P.L., Gay, N.J. (2005). Structures and Motifs Involved in Toll Signaling. In: Toll and Toll-Like Receptors: An Immunologic Perspective. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27445-6_3

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