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CpG Island Hypermethylation of Tumor Suppressor Genes in Human Cancer

Concepts, Methodologies and Uses
  • Michel Herranz
  • Manel Esteller
Chapter
  • 913 Downloads
Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Aberrations in the DNA methylation patterns are nowadays recognized as a hallmark of human cancer. One of the most characteristic changes is the hypermethylation of CpG islands of tumor suppressor genes associated with their transcriptional silencing. The target genes are distributed in all cellular pathways (apoptosis, DNA repair, cell cycle, cell adherence, etc.). They are “classical” tumor suppressor genes with associated familial cancers (BRCA1, hMLH1, p16INK4a, VHL, etc.) and putative new tumor suppressor genes which loss may contribute to the transformed phenotype (MGMT, p14ARF, GSTP1, RARB2, etc.). A tumor-type specific profile of CpG island hypermethylation exist in human cancer that allows the use of these aberrantly hypermethylated loci as biomarkers of the malignant disease. The development of new technologies for the careful study of the DNA methylation patterns, and their genetic partners in accomplishing gene silencing, may also provide us with new drugs for the epigenetic treatment of human tumors.

Keywords

Tumor Suppressor Gene Promoter Hypermethylation Death Associate Protein Kinase Global Hypomethylation Restriction Landmark Genomic Scanning 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Eurekah.com and Kluwer Academic/Plenum Publishers 2005

Authors and Affiliations

  • Michel Herranz
    • 1
  • Manel Esteller
    • 1
  1. 1.Cancer Epigenerics LaboratorySpanish National Cancer Center (CNIO)MadridSpain

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