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DNA Methylation in Colorectal Cancer

  • Jeremy R. Jass
  • Vicki L. J. Whitehall
  • Joanne Young
  • Barbara A. Leggett
Chapter
Part of the Medical Intelligence Unit book series (MIUN)

Abstract

In this chapter, it is pointed out that colorectal cancer is a heterogeneous disease. The case is made for a ‘serrated pathway’ of neoplasia that would evolve relatively rapidly through the early acquisition of DNA instability. DNA hypermethylation is likely to be of critical importance in driving this pathway. Inhibition of apoptosis is conceived as the first step. Thereafter, methylation of one of several DNA repair genes would result in a state of tolerated hypermutability. It remains to be shown whether this model applies to a small subset of colorectal cancers or in fact explains the great majority given the overall low risk of progression for an individual adenoma initiated by mutation of APC.

Keywords

Colorectal Cancer Familial Adenomatous Polyposis Lynch Syndrome Microsatellite Instability Hyperplastic Polyp 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Eurekah.com and Kluwer Academic/Plenum Publishers 2005

Authors and Affiliations

  • Jeremy R. Jass
    • 1
  • Vicki L. J. Whitehall
    • 2
  • Joanne Young
    • 2
  • Barbara A. Leggett
    • 2
  1. 1.Department of PathologyMcGill UniversityMontrealCanada
  2. 2.Conjoint Gastroenterology LaboratoryBancroft CentreBrisbaneAustralia

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