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Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense

  • Pascal Bigey
  • Daniel Scherman
Chapter
  • 910 Downloads
Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Harnessing the full therapeutic potential of DNA methylation machinery proteins would require efficient techniques of introducing either anti sense, iRNA or expression vectors into tumors in vivo. Efficient techniques for introducing DNA in vivo are also required for target validation. This chapter discusses the electrotransfer of introducing DNA in vivo and its use in validation of MBD2 as anticancer target as well as its potential as an anticancer gene therapy.

Keywords

Gene Therapy Gene Transfer Electric Pulse Cancer Gene Therapy Nonviral Vector 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Eurekah.com and Kluwer Academic/Plenum Publishers 2005

Authors and Affiliations

  • Pascal Bigey
    • 1
  • Daniel Scherman
    • 1
  1. 1.Unite de Pharmacologie Chimique et GenetiqueUniversite Ren DescartesParisFrance

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