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Purine Analogues and Their Role in Methylation and Cancer Chemotherapy

  • Katherine L. Seley
  • Sylvester L. Mosley
Chapter
Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Despite promising leads in the search for new chemotherapeutic agents, there remains an urgent need to develop more effective and less toxic drugs. Nucleosides and their corresponding nucleobases are the fundamental building blocks of many biological systems and as a result, have been extensively investigated due to their inherent structural resemblance to the naturally occurring nucleosides and nucleobases. Due to the intertwined relationship between purine and pyrimidine nucleotide metabolism, cell proliferation and tumor cell differentiation, inhibition of key enzymes in nucleotide metabolism and DNA synthesis can be used as a chemotherapeutic approach to treating cancer.

Keywords

Purine Analogue African Swine Fever Virus Pyrimidine Nucleoside Squamous Carcinoma Cell Line NADH Cofactor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Eurekah.com and Kluwer Academic/Plenum Publishers 2005

Authors and Affiliations

  • Katherine L. Seley
    • 1
  • Sylvester L. Mosley
    • 1
  1. 1.School of Chemistry and BiochemistryGeorgia Institute of TechnologyAtlantaUSA

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