Regulation of DNA Methyltransferases in Cancer

  • Nancy Detich
  • Moshe Szyf
Part of the Medical Intelligence Unit book series (MIUN)


The DNA methyltransferases (DNMTs) are critical proteins involved in establishing proper control of epigenetic information. They are responsible for maintaining the cell’s methylation pattern, as well for transcriptional repression through both methylation dependent and independent mechanisms. It is therefore fitting that the cell has evolved a number of layers of regulation to manage the appropriate expression of the DNMTs. While transcriptional control is the major player in regulation of DNMT1 by signaling pathways, post-transcriptional mechanisms appear to be critical for regulation during cell cycle progression and differentiation. In addition, regulatory interactions between DNMT1 and proteins involved in replication and cell cycle progression, as well as between all three DNMTs, have recently been elucidated. This review will discuss cellular processes in which these various mechanisms are involved, and provide suggestions as to how misregulation at these levels might lead to the development of certain pathologies.


Human Immunodeficiency Virus Type Latent Membrane Protein Cellular Transformation Estrogen Receptor Negative Breast Cancer Cell Cycle Associate Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© and Kluwer Academic/Plenum Publishers 2005

Authors and Affiliations

  • Nancy Detich
    • 1
  • Moshe Szyf
    • 1
  1. 1.Department of Pharmacology and TherapeuticsMcGill UniversityMontrealCanada

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