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Molar Pregnancies

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Pathology of the Human Placenta

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References

  • Acosta-Sison, H.: Changing attitudes in the management of hydatidiform mole. Amer. J. Obstet. Gynecol. 88:634–636, 1964.

    CAS  Google Scholar 

  • Al-Takroni, A.M., Mendis, K.B.L. and Agrawal, S.: Twin pregnancy consisting of a complete hydatidiform mole and a fetus. Ann. Saudi Med. 14:519–520, 1994.

    PubMed  CAS  Google Scholar 

  • Ambrani, L.M., Vaidya, R.A., Rao, C.S., Daftary, S.D. and Motashaw, N.D.: Familial occurrence of trophoblastic disease—report of recurrent molar pregnancies in sisters in three families. Clin. Genet. 18:27–29, 1980.

    Article  Google Scholar 

  • Amir, S.M., Osathanondh, R., Berkowitz, R.S. and Goldstein, D.P.: Human chorionic gonadotropin and thyroid function in patients with hydatidiform mole. Amer. J. Obstet. Gynecol. 150:723–728, 1984.

    CAS  Google Scholar 

  • Amr, M.F., Fisher, R.A., Foskett, M.A. and Paradinas, F.J.: Triplet pregnancy with hydatidiform mole. Intern. J. Gynecol. Cancer 10:76–81, 2000.

    Article  Google Scholar 

  • Anonymous: Editorial: flow cytometry and gestational trophoblastic disease. Lancet 2:950, 1987.

    Google Scholar 

  • Arkwright, P.D., Rademacher, T.W., Dwek, R.A. and Redman, C.W.G.: Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles. J. Clin. Invest. 91:2744–2753, 1993.

    PubMed  CAS  Google Scholar 

  • Atkin, N.B. and Klinger, H.P.: The superfemale mole. Lancet 2:727, 1962.

    Article  Google Scholar 

  • Atrash, H.K., Hogue, C.J.R. and Grimes, D.A.: Epidemiology of hydatidiform mole during early gestation. Amer. J. Obstet. Gynecol. 154:906–909, 1986.

    CAS  Google Scholar 

  • Azuma, C., Saji, F., Tokugawa, Y., Kimura, T., Nobunaga, T., Takemura, M., Kameda, T. and Tanizawa, O.: Application of gene amplification by polymerase chain reaction to genetic analysis of molar mitochondrial DNA: the detection of anuclear empty ovum as the cause of complete mole. Gynecol. Oncol. 40:29–33, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Bae, S.N., Kim, S.J.: Telomerase activity in complete hydatidiform mole. Amer. J. Obstet. Gynecol. 180:328–333, 1999.

    Article  CAS  Google Scholar 

  • Baergen, R.N., Kelly, T., McGinnis, M.J., Jones, O.W. and Benirschke, K.: Complete hydatidiform mole with a coexisting embryo. Hum. Pathol. 27:731–734, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Baggish, M.S., Woodruff, J.D., Tow, S.H. and Jones, H.W.: Sex chromatin pattern in hydatidiform mole. Amer. J. Obstet. Gynecol. 102:362–370, 1968.

    CAS  Google Scholar 

  • Bagshawe, K.D., Dent, J. and Webb, J.: Hydatidiform mole in England and Wales 1973–1983. Lancet 2:673–677, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Bagshawe, K.D., Lawler, S.D., Paradinas, F.J., Dent, J., Brown, P. and Boxer, G.M.: Gestational trophoblastic tumours following initial diagnosis of partial hydatidiform mole. Lancet 335:1074–1076, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Bandy, L.C., Clarke-Pearson, D.L. and Hammond, C.B.: Malignant potential of gestational trophoblastic disease at the extreme ages of reproductive life. Obstet. Gynecol. 64:395–399, 1984.

    PubMed  CAS  Google Scholar 

  • Bar-Ami, S., Seibel, M.M., Pierce, K.E. and Zilberstein, M.: Preimplantation genetic diagnosis for a couple with recurrent pregnancy loss and triploidy. Birth Def. Res. 67A:946–950, 2003.

    Article  CAS  Google Scholar 

  • Bardawil, W.A., Hertig, A.T. and Velardo, J.T.: Regression of trophoblast. I. Hydatidiform mole; a case of unusual features, possibly metastasis and regression; review of literature. Obstet. Gynecol. 10:614–625, 1957.

    Article  PubMed  CAS  Google Scholar 

  • Barlow, J.J., Goldstein, D.P. and Reid, D.E.: A study of in vivo estrogen biosynthesis and production rates in normal pregnancy, hydatidiform mole and choriocarcinoma. J. Clin. Endocrinol. Metab. 27:1028–1034, 1967.

    Article  PubMed  CAS  Google Scholar 

  • Barton, S.C., Surani, M.A.H. and Norris, M.L.: Role of paternal and maternal genomes in mouse development. Nature 311: 374–376, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Beischer, N.A.: Hydatidiform mole with co-existent foetus. J. Obstet. Gynaecol. Brit. Commonw. 68:231–237, 1961.

    CAS  Google Scholar 

  • Beischer, N.A.: Hydatidiform mole with coexistent foetus. Aust. N.Z. J. Obstet. Gynaecol. 6:127–141, 1966.

    PubMed  CAS  Google Scholar 

  • Beischer, N.A. and Fortune, D.W.: Significance of chromatin patterns in cases of hydatidiform mole with an associated fetus. Amer. J. Obstet. Gynecol. 100:276–282, 1968.

    Google Scholar 

  • Beischer, N.A., Fortune, D.W. and Fitzgerald, M.G.: Hydatidiform mole and coexisting foetus, both with triploid chromosome constitution. Brit. Med. J. 2:476–478, 1967.

    Google Scholar 

  • Bell, D.A., Flotte, T.J., Pastel-Levy, C., Ware, A., Preffer, F. and Colvin, R.B.: Flow cytometric analysis of DNA-ploidy in partial hydatidiform moles (PHM) utilizing paraffinembedded material. Mod. Pathol. 2:8A, 1989 (abstract No. 44).

    Google Scholar 

  • Bell, K.A., van Deerlin, V.M.D., Addya, K, Clevenger, C.V., van Deerlin, P.G. and Leonard, D.G.B.: Molecular genetic testing from paraffin embedded tissue distinguishes non-molar hydropic abortion from hydatidiform moles. Modern Pathol. 11:100A (abstract 579), 1998.

    Google Scholar 

  • Ben-Chetrit, A., Yagel, S., Ariel, I., Zacut, D., Shimonovitz, S. and Celnikier-Hochner, D.: Successful conservative management of primary nonmetastatic cervical choriocarcinoma. Amer. J. Obstet. Gynecol. 163:1161–1163, 1990.

    CAS  Google Scholar 

  • Bendon, R.W., Siddiqi, T., Soukup, S. and Srivastava, A.: Prenatal detection of triploidy. J. Pediatr. 112:149–153, 1988.

    Article  PubMed  CAS  Google Scholar 

  • Benirschke, K.: Abortions and moles. In, Perinatal Diseases. R.L. Naeye, J.M. Kissane and N. Kaufman, eds., pp. 23–48. Williams & Wilkins, Baltimore, 1981.

    Google Scholar 

  • Benirschke, K.: Editorial: flow cytometry for ALL mole-like abortion specimens. Hum. Pathol. 20:403–404, 1989.

    Article  PubMed  CAS  Google Scholar 

  • Benirschke, K., Spinosa, J.C., McGinnis, M.J., Marchevsky, A. and Sanchez, J.: Partial molar transformation of the placenta of presumably monozygotic twins. Pediat. Development. Pathol. 3:95–100, 2000.

    Article  CAS  Google Scholar 

  • Berezowsky, J., Zbieranowski, I., Demers, J. and Murray, D.: DNA ploidy of hydatidiform moles and nonmolar conceptuses: a study using flow and tissue section image cytometry. Mod. Pathol. 8:775–781, 1995.

    PubMed  CAS  Google Scholar 

  • Berkowitz, R.S., Mostoufizadeh, M., Kabawat, S.E., Goldstein, D.P. and Driscoll, S.G.: Immunopathologic study of the implantation site in molar pregnancy. Amer. J. Obstet. Gynecol. 144:925–930, 1982.

    CAS  Google Scholar 

  • Berkowitz, R.S., Anderson, D.J., Hunter, N.J. and Goldstein, D. P.: Distribution of major histocompatibility (HLA) antigens in chorionic villi of molar pregnancy. Amer. J. Obstet. Gynecol. 146:221–220, 1983a.

    CAS  Google Scholar 

  • Berkowitz, R.S., Goldstein, D.P. and Bernstein, M.R.: Natural history of partial molar pregnancy. Obstet. Gynecol. 66:677–681, 1983b.

    Google Scholar 

  • Berkowitz, R.S., Cramer, D.W., Bernstein, M.R., Cassells, S., Driscoll, S.G. and Goldstein, D.P.: Risk factors for complete molar pregnancy from a case-control study. Amer. J. Obstet. Gynecol. 152:1016–1020, 1985a.

    CAS  Google Scholar 

  • Berkowitz, R.S., Dubey, D.P, Goldstein, D.P. and Anderson, D. J.: Localization of transferrin receptor in the chorionic villi of complete molar pregnancy. Amer. J. Obstet. Gynecol. 151:128–129, 1985b.

    CAS  Google Scholar 

  • Berkowitz, R.S., Umpierre, S.A., Johnson, P.M., McIntyre, J.A. and Anderson, D.J.: Expression of trophoblast-leukocyte common antigens and placental-type alkaline phosphatase in complete molar pregnancy. Amer. J. Obstet. Gynecol. 155:443–446, 1986.

    CAS  Google Scholar 

  • Berkowitz, R., Ozturk, M., Goldstein, D., Bernstein, M., Hill, L. and Wands, J.R.: Human chorionic gonadotropin and free subunits’ serum levels in patients with partial and complete hydatidiform moles. Obstet. Gynecol. 74:212–216, 1989.

    PubMed  CAS  Google Scholar 

  • Berkowitz, R.S., Bernstein, M.R., Harlow, B.L., Rice, L.W., Lage, J.M., Goldstein, D.P. and Cramer, D.W.: Case-control study of risk factors for partial molar pregnancy. Amer. J. Obstet. Gynecol. 173:788–794, 1995.

    Article  CAS  Google Scholar 

  • Bewtra, C., Frankforter, S. and Marcus, J.: Clinicopathologic differences between diploid and tetraploid complete hydatidiform moles. Intern. J. Gynec. Pathol. 16:239–244, 1997.

    CAS  Google Scholar 

  • Beyth, Y.: Hypofibrinogenemia in hydatidiform mole. J. Reprod. Med. 11:223–224, 1973.

    PubMed  CAS  Google Scholar 

  • Block, M.F. and Merrill, J.A.: Hydatidiform mole with coexisting fetus. Obstet. Gynecol. 60:129–134, 1982.

    PubMed  CAS  Google Scholar 

  • Bonduelle, M.-L., Dodd, R., Liebaers, I., van Steirteghem, A., Williamson, R. and Akhurst, R.: Chorionic gonadotrophin-β mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes. Hum. Reprod. 3:909–914, 1988.

    PubMed  CAS  Google Scholar 

  • Bonnar, J. and Tennent, R.A.: Benign hydatidiform mole followed by late pulmonary choriocarcinoma. J. Obstet. Gynaecol. Brit. Commonw. 69:999–1005, 1962.

    Google Scholar 

  • Borek, E., Sharma, O.K. and Brewer, J.I.: Urinary nucleic acid breakdown products as markers for trophoblastic diseases. Amer. J. Obstet. Gynecol. 146:906–910, 1983.

    CAS  Google Scholar 

  • Borell, U., Fernström, I., Moberger, G. and Ohlson, L.: The Diagnosis of Hydatidiform Mole, Malignant Hydatidiform Mole and Choriocarcinoma with Special Reference to the Diagnostic Value of Pelvic Arteriography. Charles C Thomas, Springfield, IL, 1966.

    Google Scholar 

  • Bourgoin, P., Baylet, R. and Ballon, C.: Études des chromosomes de la grossesse molaire. C. R. Soc. Biol. 159:957, 1965a.

    Google Scholar 

  • Bourgoin, P., Baylet, R. and Grattepanche, H.: Exploration d’une hypothèse sur l’étiopathogénie des môles hydatiformes: étude chromosomique. Rev. Fr. Gynécol. Obstétr. 60:673–684, 1965b.

    CAS  Google Scholar 

  • Bracken, M.B.: Incidence and aetiology of hydatidiform mole: an epidemiological review. Brit. J. Obstet. Gynaecol. 94:1123–1135, 1987.

    CAS  Google Scholar 

  • Bracken, M.B.: Incidence of hydatidiform mole. Amer. J. Obstet. Gynecol. 158:1016–1017, 1988 (letter to the editor).

    CAS  Google Scholar 

  • Breit, A. and Schedel, E.: Ergebnisse der Beckenarteriographie bei Plazentatumoren. Fortschr. Geb. Roentgenstr. Nuklearmed. 112:431–439, 1970.

    CAS  Google Scholar 

  • Brinton, L.A., Wu, B.-Z., Wang, W., Ershow, A.G., Song, H.-Z., Li, J.-Y., Bracken, M.B. and Blot, W.J.: Gestational trophoblastic disease: a case-control study from the People’s Republic of China. Amer. J. Obstet. Gynecol. 161:121–127, 1989.

    CAS  Google Scholar 

  • Buckley, J.: Epidemiology of gestational trophoblastic diseases. In, A.E. Szulman and H.J. Buchsbaum eds., pp. 8–26. Gestational Trophoblastic Disease. Springer-Verlag, New York, 1987.

    Google Scholar 

  • Bur, G.E., Hertig, A.T., McKay, D.G. and Adams, E.C.: Histochemical aspects of hydatidiform mole and choriocarcinoma. Obstet. Gynecol. 19:156–182, 1962.

    PubMed  CAS  Google Scholar 

  • Butler, L.J., Chantler, C., France, N.E. and Keith, C.G.: A liveborn infant with complete triploidy (69,XXX). J. Med. Genet. 6:413–421, 1969.

    PubMed  CAS  Google Scholar 

  • Butler, W.J., Schwartz, C.E., Sauer, S.M., Wilson, J.T. and McDonough, P.G.: Discordance in deoxyribonucleic acid analysis of fetus and trophoblast. Amer. J. Obstet. Gynecol. 158:642–645, 1988.

    CAS  Google Scholar 

  • Carr, D.H.: Cytogenetics and the pathology of hydatidiform degeneration. Obstet. Gynecol. 33:333–342, 1969.

    PubMed  CAS  Google Scholar 

  • Carr, D.H.: Chromosome studies in selected spontaneous abortions: polyploidy in man. J. Med. Genet. 8:164–174, 1971.

    PubMed  CAS  Google Scholar 

  • Castrillon, D.H., Sun, D., Weremowicz, S., Fisher, R.A., Crum, C.P. and Genest, D.R.: Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2. Amer. J. Surg. Pathol. 25:1225–1230, 2001.

    Article  CAS  Google Scholar 

  • Cataldo, N.A., Nicholson, M. and Bihrle, D.: Uterine serosal trophoblastic implant after linear salpingostomy for ectopic pregnancy at laparotomy. Obstet. Gynecol. 76:523–525, 1990.

    PubMed  CAS  Google Scholar 

  • Chamberlain, G.: Hydatidiform mole in twin pregnancy. Amer. J. Obstet. Gynecol. 87:140–142, 1963.

    CAS  Google Scholar 

  • Chamberlain, J., Morris, N.F. and Smith, N.C.: Steroids of hydatidiform moles. J. Endocrinol. 41:289–290, 1968.

    PubMed  CAS  Google Scholar 

  • Choi-Hong, S.R., Genest, D., Crum, C.P., Berkowitz, R., Goldstein, D. and Schofield, D.: Evaluation of X-and Ychromosomal content in twin pregnancies with complete hydatidiform mole and coexisting fetus using fluorescent in situ hybridization (FISH). Med. Pathol. 8:87A (abstract 500), 1995.

    Google Scholar 

  • Chua, S., Wilkins, T., Sargent, I. and Redman, C.: Trophoblast deportation in pre-eclamptic pregnancy. Brit. J. Obstetr. Gynaecol. 98:973–979, 1991.

    CAS  Google Scholar 

  • Chun, D., Braga, C., Chow, C. and Lok, L.: Clinical observations on some aspects of hydatidiform mole. J. Obstet. Gynaecol. Brit. Commonw. 71:180–184, 1964.

    CAS  Google Scholar 

  • Cintio, E. di, Parazzini, F., Rosa, C., Chatenoud, L. and Benzi, G.: The epidemiology of gestational trophoblastic disease. Gen. Diagn. Pathol. 143:103–108, 1997.

    PubMed  Google Scholar 

  • Clayton, L.A., Tyrey, L., Weed, J.C. and Hammond, C.B.: Endocrine aspects of trophoblastic neoplasia. J. Reprod. Med. 26:192–199, 1981.

    PubMed  CAS  Google Scholar 

  • Cohen, B.A., Burkman, R.T., Rosenshein, N.B., Atienza, M.F., King, T.M. and Parmley, T.H.: Gestational trophoblastic disease within an elective abortion population. Amer. J. Obstet. Gynecol. 135:452–454, 1979.

    CAS  Google Scholar 

  • Cohle, S.D. and Petty, C.S.: Sudden death caused by embolization of trophoblast from hydatidiform mole. J. Forensic Sci. 30:1279–1283, 1985.

    PubMed  CAS  Google Scholar 

  • Conran, R.M., Hitchcock, C.L., Popek, E.J., Norris, H.J., Griffin, J.L., Geissel, A. and McCarthy, W.F.: Diagnostic considerations in molar gestations. Hum. Pathol. 24:41–48, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Couillin, P., Afoutou, J.M., Faye, O., Correa, P. and Boué, A.: Androgenetic origin of African complete hydatidiform moles demonstrated by HLA markers. Hum. Genet. 71:113–116, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Crooij, M.J., van der Harten, J.J., Puyenbroek, J.I., van Geijn, H.P. and Arts, N.F.: A partial hydatidiform mole, dispersed throughout the placenta, coexisting with a normal living fetus: case report. Brit. J. Obstet. Gynaecol. 92:104–106, 1985.

    CAS  Google Scholar 

  • Czernobilsky, B., Barash, A. and Lancet, M.: Partial moles: a clinicopathologic study of 25 cases. Obstet. Gynecol. 59:75–77, 1982.

    PubMed  CAS  Google Scholar 

  • Das, P.C.: Hydatidiform mole: a statistical and clinical study. J. Obstet. Gynaecol. Brit. Emp. 45:265–280, 1938.

    Google Scholar 

  • Davis, J.R., Kerrigan, D.P., Way, D.L. and Weiner, S.A.: Partial hydatidiform moles: deoxyribonucleic acid content and course. Amer. J. Obstet. Gynecol. 157:969–973, 1987.

    CAS  Google Scholar 

  • Debyser, I.W.J., Soma, H. and Zwart, P.: Partial hydatidiform mole in a pregnant chimpanzee (Pan troglodytes). Zoo Biol. 12:299–305, 1993.

    Article  Google Scholar 

  • De Grouchy, J., Roubin, M., Risse, J.-C. and Sarrut, S.: Enfant triploide (69,XXX) ayant vécu neuf jours. Ann. Génét. (Paris) 17:283–286, 1974.

    PubMed  Google Scholar 

  • Depypere, H.T., Dhont, M., Verschraegen-Spae, M.R. and Coppens, M.: Tubal hydatidiform mole. Amer. J. Obstet. Gynecol. 169:209–210, 1993.

    CAS  Google Scholar 

  • Douglas, G.W.: Malignant changes in trophoblastic tumors. Amer. J. Obstet. Gynecol. 84:884–894, 1962.

    Google Scholar 

  • Drieux, H. and Thiéry, G.: Les tumeurs du placenta chez les animaux domestiques. Rev. Pathol. Comp. 48:445–451, 1948.

    Google Scholar 

  • Driscoll, S.G.: Trophoblastic growths: morphologic aspects and taxonomy. J. Reprod. Med. 26:181–191, 1981.

    PubMed  CAS  Google Scholar 

  • Edmonds, H.W.: Genesis of hydatidiform mole: old and new concepts. Ann. N.Y. Acad. Sci. 80:86–104, 1959.

    PubMed  CAS  Google Scholar 

  • Egley, C.C., Simon, L.R. and Haddox, T.: Hydatidiform mole and disseminated intravascular coagulation. Amer. J. Obstet. Gynecol. 121:1122–1123, 1975.

    CAS  Google Scholar 

  • Ehnholm, C., Seppälä, M., Tallberg, T. and Widholm, O.: Immunological studies in human placental lactogen hormone in chorionepithelioma and hydatidiform mole. Ann. Med. Exp. Fenn. 45:318–319, 1967.

    PubMed  CAS  Google Scholar 

  • Endres, R.J.: Hydatidiform mole: report of a patient with 5 consecutive hydatidiform moles. Amer. J. Obstet. Gynecol. 81:711–714, 1961.

    CAS  Google Scholar 

  • Estellés, A., Grancha, S., Gilabert, J., Thinnes, T., Chirivella, M., España, F., Aznar, J. and Loskutoff, D.J.: Abnormal expression of plasminogen activator inhibitor in patients with gestational trophoblastic disease. Amer. J. Pathol. 149:1229–1239, 1996.

    Google Scholar 

  • Ewing, J.: Chorioma: a clinical and pathological study. Surg. Gynecol. Obstet. 10:366–392, 1910.

    Google Scholar 

  • Federschneider, J.M., Goldstein, D.P., Berkowitz, R.S., Marean, A.R. and Bernstein, M.R.: Natural history of recurrent molar pregnancy. Obstet. Gynecol. 55:457–459, 1980.

    PubMed  CAS  Google Scholar 

  • Feinberg, R.F., Lockwood, C.J., Salafia, C. and Hobbins, J.C.: Sonographic diagnosis of a pregnancy with a diffuse hydatidiform mole and coexisting 46,XX fetus: a case report. Obstet. Gynecol. 72:485–488, 1988.

    PubMed  CAS  Google Scholar 

  • Fejgin, M.D., Amiel, A., Goldberger, S., Barnes, I., Zer, T. and Kohn, G.: Placental insufficiency as a possible cause of low maternal serum human gonadotropin and low maternal serum unconjugated estriol levels in triploidy. Amer. J. Obstet. Gynecol. 167:766–767, 1992.

    CAS  Google Scholar 

  • Fine, C., Bundy, A.L., Berkowitz, R.S., Boswell, S.B., Berezin, A.F. and Doubilet, P.M.: Sonographic diagnosis of partial hydatidiform mole. Obstet. Gynecol. 73:414–418, 1989.

    PubMed  CAS  Google Scholar 

  • Fischer, H.E., Lichtiger, B. and Cox, I.: Expression of Rh0(D) antigen in choriocarcinoma of the uterus in an Rh0(D)-negative patient: report of a case. Human Pathol. 16:1165–1167, 1985.

    CAS  Google Scholar 

  • Fisher, R.A. and Lawler, S.D.: Heterozygous complete hydatidiform moles: do they have a worse prognosis than homozygous complete moles? Lancet 2:51, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Fisher, R.A. and Newlands, E.S.: Rapid diagnosis and classification of hydatidiform moles with polymerase chain reaction. Amer. J. Obstet. Gynecol. 168:563–569, 1993.

    CAS  Google Scholar 

  • Fisher, R.A., Lawler, S.D., Ormerod, M.G., Imrie, P.R. and Povey, S.: Flow cytometry used to distinguish between complete and partial hydatidiform moles. Placenta 8:249–256, 1987.

    PubMed  CAS  Google Scholar 

  • Fisher, R.A., Paradinas, F.J., Soteriou, B.A., Foskett, M. and Newlands, E.S.: Diploid hydatidiform moles with fetal red blood cells in molar villi. 2—genetics. J. Pathol. 181:189–195, 1997.

    Article  PubMed  CAS  Google Scholar 

  • Fisher, R.A., Khatoon, R., Paradinas, F.J., Roberts, A.P. and Newlands, E.S.: Repetitive complete hydatidiform mole can be biparental in origin and either male or female. Human Reprod. 15:594–598, 2000.

    Article  CAS  Google Scholar 

  • Fisher, R.A., Hodges, M.D. and Newlands, E.S.: Familial recurrent hydatidiform mole: a review. J. Reprod. Med. 49:595–601, 2004a.

    PubMed  Google Scholar 

  • Fisher, R.A., Nucci, M.R., Thaker, H.M., Weremowicz, S., Genest, D.R. and Castrillon, D.H.: Complete hydatidiform mole retaining a chromosome 11 of maternal origin: molecular genetic analysis of a case. Modern Pathol. 17:1155–1160, 2004b.

    Article  Google Scholar 

  • Folger, A.F.: Über die Blasenmole beim Rinde. Acta Pathol. Microbiol. Scand. [Suppl.] 18:104–128, 1934.

    Google Scholar 

  • Ford, J.H., Brown, J.K., Lew, W.Y. and Peters, G.B.: Diploid complete hydatidiform mole, mosaic for normally fertilized cells and androgenetic homozygous cells: case report. Brit. J. Obstet. Gynaecol. 93:1181–1186, 1986.

    CAS  Google Scholar 

  • Forrester, M.B. and Merz, R.D.: Epidemiology of triploidy in a population-based birth defects registry, Hawaii, 1986–1999. Amer. J. Med. Genet. 119A:319–323, 2003.

    Article  Google Scholar 

  • Fox, H.: Hydatidiform moles: editorial. Virchows Arch.[A] 415:387–389, 1989.

    CAS  Google Scholar 

  • Fox, H.: Differential diagnosis of hydatidiform moles. Gen. Diagn. Pathol. 143:117–125, 1997.

    PubMed  CAS  Google Scholar 

  • Fraikor, A.L., Vigneswaran, R. and Honeyfield, P.: Live-born triploid. Amer. J. Dis. Child. 134:988–989, 1980.

    PubMed  CAS  Google Scholar 

  • Franke, H.R., Risse, E.K.J., Kenemans, P., Vooijs, G.P. and Stolk, J.G.: Epidemiologic features of hydatidiform mole in The Netherlands. Obstet. Gynecol. 62:613–616, 1983a.

    PubMed  CAS  Google Scholar 

  • Franke, H.R., Risse, E.K.J., Kenemans, P., Houx, P.C.W., Solk, J.G. and Vooijs, G.P.: Plasma human chorionic gonadotropin disappearance in hydatidiform mole: a central registry report from the Netherlands. Obstet. Gynecol. 62:467–473, 1983b.

    PubMed  CAS  Google Scholar 

  • Franke, H.R., Alons, C.L., Caron, F.J.M., Boog, M.C., Oort, J. and Stolk, J.G.: Quantitative morphology: a study of the trophoblast. Virchows Arch. [Pathol. Anat.] 406:323–331, 1985.

    Article  CAS  Google Scholar 

  • Frost, A.C.G.: Death following intrauterine injection of hypertonic saline solution with hydatidiform mole. Amer. J. Obstet. Gynecol. 101:342–344, 1968.

    CAS  Google Scholar 

  • Fukunaga, M.: Immunohistochemical characterization of p57KIP2 expression in tetraploid hydropic placentas. Arch. Pathol. Lab. Med. 128:897–900, 2004.

    PubMed  Google Scholar 

  • Fukunaga, M., Ushigome, S., Fukunaga, M. and Sugishita, M.: Application of flow cytometry in diagnosis of hydatidiform moles. Mod. Pathol. 6:353–359, 1993.

    PubMed  CAS  Google Scholar 

  • Fukunaga, M., Endo, M. and Ushigome, S.: Clinicopathologic study of tetraploid hydropic villous tissue. Arch. Pathol. Lab. Med. 120:569–572, 1996.

    PubMed  CAS  Google Scholar 

  • Gaber, L.W., Redline, R.W., Mostoufi-Zadeh, M. and Driscoll, S.G.: Invasive partial mole. Amer. J. Clin. Pathol. 85:722–724, 1986.

    CAS  Google Scholar 

  • Garcia, M., Romaguera, R.L. and Gomez-Fernandez, C.: A hydatidiform mole in a postmenopausal woman. A case report and review of the literature. Arch. Pathol. Lab. Med. 128:1039–1042, 2004.

    PubMed  Google Scholar 

  • Gardner, H.A.R. and Lage, J.M.: Choriocarcinoma following a partial hydatidiform mole. A case report. Human Pathol. 23:468–471, 1992.

    Article  CAS  Google Scholar 

  • Genest, D.R.: Partial hydatidiform mole: Clinicopathologic features, differential diagnosis, ploidy and molecular studies, and gold standards for diagnosis. Int. J. Gynecol. Pathol. 20:315–322, 2001.

    Article  PubMed  CAS  Google Scholar 

  • Genest, D.R., Laborde, O., Berkowitz, R.S., Goldstein, D.P., Bernstein, M.R. and Lage, J.: A clinicopathologic study of 153 cases of complete hydatidiform mole (1980–1990): histologic grade lacks prognostic significance. Obstet. Gynecol. 78:402–409, 1991.

    PubMed  CAS  Google Scholar 

  • Gerber, A.H.: Amniographic diagnosis of trophoblastic disease. JAMA 212:630, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Gibson, B.R., Muir-Padilla, J., Champeaux, A. and Suarez, E.S.: Mesenchymal dysplasia of the placenta. Placenta 25:671–672, 2004.

    Article  PubMed  CAS  Google Scholar 

  • Goecke, C.: Partielle Blasenmole und fötale Mißbildungen. Z. Geburtsh. Gynäkol. 166:201–210, 1967.

    CAS  Google Scholar 

  • Goldman-Wohl, D., Ariel, I., Greenfield, C., Hochner-Celnikier, D., Lavy, Y. and Yagel, S.: A study of human leukocyte antigen G expression in hydatidiform moles. Amer. J. Obstet. Gynecol. 185:476–480, 2001.

    Article  CAS  Google Scholar 

  • Goldstein, D.P.: Prophylactic chemotherapy of patients with molar pregnancy. Obstet. Gynecol. 38:817–822, 1971.

    PubMed  CAS  Google Scholar 

  • Goldstein, D.P. and Berkowitz, R.S.: Gestational trophoblastic neoplasms: an invitational symposium. J. Reprod. Med. 26:179–229, 1981.

    Google Scholar 

  • Goldstein, D.P. and Berkowitz, R.S.: Gestational Trophoblastic Neoplasms. Clinical Principles of Diagnosis and Management. Saunders, Philadelphia, 1982.

    Google Scholar 

  • Golubovsky, M.D.: Postzygotic diploidization of triploids as a source of unusual cases of mosaicism, chimerism and twinning. Human Reprod. 18:236–242, 2003.

    Article  CAS  Google Scholar 

  • Gonzalez-Angulo, A., Márquez-Monter, H., Zavala, B.J., Yabur, E. and Salazar, H.: Electron microscopic observations in hydatidiform mole. Obstet. Gynecol. 27:455–467, 1966.

    PubMed  CAS  Google Scholar 

  • Goshen, R. and Hochberg, A.A.: The genomic basis of the β-subunit of human chorionic gonadotropin diversity in triploidy. Amer. J. Obstet. Gynecol. 170:700–701, 1994.

    CAS  Google Scholar 

  • Goto, S., Nishi, H. and Tomoda, Y.: Blood group Rh-D factor in human trophoblast determined by immunofluorescent method. Amer. J. Obstet. Gynecol. 137:707–712, 1980.

    CAS  Google Scholar 

  • Graham, J.M., Rawnsley, E.F., Simmons, G.M., Wurster-Hill, D.H., Park, J.P., Marin-Padilla, M. and Crow, H.C.: Triploidy: pregnancy complications and clinical findings. in seven cases. Prenat. Diagn. 9:409–419, 1989.

    PubMed  Google Scholar 

  • Grimes, D.A.: Epidemiology of gestational trophoblastic disease. Amer. J. Obstet. Gynecol. 150:309–318, 1984.

    CAS  Google Scholar 

  • Gschwendtner, A., Neher, A., Kreczy, A., Müller-Holzner, E., Volgger, B. and Mairinger, T.: DNA ploidy determination of early molar pregnancies by image analysis. Comparison to histologic classification. Arch. Pathol. Lab. Med. 122:1000–1004, 1998.

    PubMed  CAS  Google Scholar 

  • Gul, A., Agrali, G., Ulker, V., Numanoglu, C., Aslan, H. and Tekirdag, A.I.: Complete hydatidiform mole and coexisting live fetus in dichorionic twin pregnancy; report of two cases. Twin Res. 7(4):Abstract, 2004.

    Google Scholar 

  • Gunasegaram, R., Peh, K.L., Loganath, A., Kottegoda, S.R. and Ratnam, S.S.: Elevated intravesicular fluid thyroidstimulating hormone concentration in hydatidiform mole. Intern. J. Gynaecol. Obstet. 24:177–181, 1986.

    Article  CAS  Google Scholar 

  • Habibian, R. and Surti, U.: Cytogenetics of trophoblasts from complete hydatidiform moles. Cancer Genet. Cytogenet. 29:271–287, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Hankins, G.D.V., Wendel, G.D., Snyder, R.R. and Cunningham, F.G.: Trophoblastic embolization during molar evacuation—central hemodynamic observations. Obstet. Gynecol. 69:368–372, 1987.

    PubMed  CAS  Google Scholar 

  • Harper, W.F. and MacVicar, J.: Hydatidiform mole and pregnancy diagnosed by sonar. Brit. Med. J. 2:1178–1179, 1963.

    PubMed  CAS  Google Scholar 

  • Harrison, K.B.: X-chromosome inactivation in the human cytotrophoblast. Cytogenet. Cell Genet. 52:37–41, 1989.

    PubMed  CAS  Google Scholar 

  • Harrison, K.B. and Warburton, D.: Preferential X-chromosome activity in human female placental tissues. Cytogenet. Cell Genet. 41:163–168, 1986.

    PubMed  CAS  Google Scholar 

  • Hasegawa, T., Harada, N., Ikeda, K., Ishii, T., Hokuto, I., Kasai, K., Tanaka, M., Fukuzawa, R., Niikawa, N. and Matsuo, N.: Digynic triploid surviving for 46 days. Amer. J. Med. Genet. 87:306–310, 1999.

    Article  CAS  Google Scholar 

  • Heifetz, S.A. and Czaja, J.: In situ choriocarcinoma arising in partial hydatidiform mole: Implications for the risk of persistent trophoblastic disease. Pediatr. Pathol. 12:601–611, 1992.

    PubMed  CAS  Google Scholar 

  • Helwani, M.N., Seoud, M., Zahed, L., Zaatari, G., Khalil, A. and Slim, R.: A familial case of recurrent hydatidiform molar pregnancies with biparental genomic contribution. Human Genet. 105:112–115, 1999.

    Article  CAS  Google Scholar 

  • Hemming, J.D., Quirke, P., Womack, C., Wells, M., Elston, C.W. and Bird, C.C.: Diagnosis of molar pregnancy and persistent trophoblastic disease by flow cytometry. J. Clin. Pathol. 40:615–620, 1987.

    PubMed  CAS  Google Scholar 

  • Hendrickse, J.P.de V., Cockshott, W.P., Evans, K.T.E. and Barton, C.J.: Pelvic angiography in the diagnosis of malignant trophoblastic disease. NEJM 271:859–866, 1964.

    Google Scholar 

  • Hershman, J.M. and Higgins, H.P.: Hydatidiform mole—a cause of clinical hyperthyroidism: report of two cases with evidence that molar tissue secreted a thyroid stimulator. NEJM 284:573–577, 1971.

    PubMed  CAS  Google Scholar 

  • Hertig, A.T.: Hydatidiform mole and chorionepithelioma. In, Progress in Gynecology, Vol. II. J.V. Meigs and S.H. Sturgis, eds., pp. 372–394. Grune & Stratton, New York, 1950.

    Google Scholar 

  • Hertig, A.T.: Human Trophoblast. Charles C. Thomas, Springfield, IL, 1968.

    Google Scholar 

  • Hertig, A.T. and Sheldon, W.H.: Hydatidiform mole—a pathologico-clinical correlation of 200 cases. Amer. J. Obstet. Gynecol. 53:1–36, 1947.

    CAS  Google Scholar 

  • Hertz, R., Ross, G.T. and Lipsett, M.B.: Primary chemotherapy of nonmetastatic trophoblastic disease in women. Amer. J. Obstet. Gynecol. 86:808–814, 1963.

    CAS  Google Scholar 

  • Higashino, M., Harad, N., Hataya, I., Nishimura, N., Kato, M. and Niikawa, N.: Trizygotic pregnancy consisting of two fetuses and a complete hydatidiform mole with dispermic androgenesis. Amer. J. Med. Genet. 82:67–69, 1999.

    Article  CAS  Google Scholar 

  • Hitchcock, C.L., Conran, R.M. and Griffin, J.L.: Hydatidiform moles and the use of flow cytometry in their diagnosis. In, Pediatric Molecular Pathology. Garvin, A.J., O’Leary, T.J., Bernstein, J. and Rosenberg, H.S. eds. Perspective Pediatr. Pathol. 15:117–141, 1991, Karger, Basel.

    Google Scholar 

  • Ho, P.-C., Wong, L.C., Lawton, J.W.M. and Ma, H.K.: Mixed lymphocyte reaction in hydatidiform mole. Amer. J. Reprod. Immunol. 6:25–27, 1984.

    Article  CAS  Google Scholar 

  • Ho, P.-C., Lawton, J.W.M., Wong, L.-C. and Ma, H.-K.: T-cell subsets and natural killer cell activity in patients with gestational trophoblastic neoplasia. Amer. J. Obstet. Gynecol. 155:330–334, 1986.

    CAS  Google Scholar 

  • Hohe, P.T., Cochrane, C.R., Gmelich, J.T. and Austin, J.A.: Coexisting trophoblastic tumor and viable pregnancy. Obstet. Gynecol. 38:899–904, 1971.

    PubMed  CAS  Google Scholar 

  • Holland, J.F. and Hreshchyshyn, M.M., eds.: Choriocarcinoma. Springer-Verlag, Heidelberg, 1967.

    Google Scholar 

  • Honoré, L.H.: Recurrent partial hydatidiform mole: report of a case. Amer. J. Obstet. Gynecol. 156:922–924, 1987.

    Google Scholar 

  • Honoré, L.H., Lin, E.C. and Morrish, D.W.: Recurrent partial mole. Amer. J. Obstet. Gynecol. 158:442, 1988.

    Google Scholar 

  • Horn, L.-C. and Bilek, K.: Histologic classification and staging of gestational trophoblastic disease. Gen. Diagn. Pathol. 143:87–101, 1997.

    PubMed  CAS  Google Scholar 

  • Houtzager, H.L., van Leusden, H.A. and Siemerink, M.: Conversion of androgens into oestrogens by hydatidiform moles in vitro. Acta Endocrinol. (Copenh.) 64:17–37, 1970.

    PubMed  CAS  Google Scholar 

  • Howat, A.J., Beck, S., Fox, H., Harris, S.C., Hill, A.S., Nicholson, C.M. and Williams, R.A.: Can histopathologists reliably diagnose molar pregnancy? J. Clin. Pathol. 46:599–602, 1993.

    PubMed  CAS  Google Scholar 

  • Hsu, C.-T., Huang, L.-C. and Chen, T.-Y.: Metastases in benign hydatidiform mole and chorioadenoma destruens. Amer. J. Obstet. Gynecol. 84:1412–1424, 1962.

    CAS  Google Scholar 

  • Hsu, C.-T., Lai, C.H., Chanchien, C.-L. and Changchien, B.-C.: Repeat hydatidiform moles. Amer. J. Obstet. Gynecol. 87:543–547, 1963.

    CAS  Google Scholar 

  • Hunt, W., Dockerty, M.B. and Randall, L.M.: Hydatidiform mole: a clinicopathologic study “grading” as a measure of possible malignant change. Obstet. Gynecol. 1:593–609, 1953.

    PubMed  CAS  Google Scholar 

  • Ishiguro, T.: Serum α-fetoprotein in hydatidiform mole, choriocarcinoma, and twin pregnancy. Amer. J. Obstet. Gynecol. 12:539–541, 1975.

    Google Scholar 

  • Ishii, J., Iitsuka, Y., Takano, H., Matsui, H., Osada, H. and Sekiya, S.: Genetic differentiation of complete hydatidiform moles coexisting with normal fetuses by short tandem repeatderived deoxyribonucleic acid polymorphism analysis. Amer. J. Obstet. Gynecol. 179:628–634, 1998.

    Article  CAS  Google Scholar 

  • Iverson, L. and the Joint Project Investigators: Geographic variation in the occurrence of hydatidiform mole and choriocarcinoma. Ann. N.Y. Acad. Sci. 80:178–195, 1959.

    Google Scholar 

  • Jacobs, P.A., Hassold, T.J., Matsuyama, A.M. and Newlands, I.M.: Chromosome constitution of gestational trophoblastic disease. Lancet 2:49, 1978.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, P.A., Wilson, C.M., Sprenkle, J.A., Rosenheim, N.B. and Migeon, B.R.: Mechanism of complete hydatidiform moles. Nature 286:714–716, 1980.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, P.A., Szulman, A.E., Funkhouser, J., Matsuura, J.S. and Wilson, C.C.: Human triploidy: relationship between parental origin of the additional haploid complement and development of partial hydatidiform mole. Ann. Hum. Genet. 46:223–231, 1982.

    PubMed  CAS  Google Scholar 

  • Jarotzky, v. and Waldeyer: Traubenmole in Verbindung mit dem Uterus: intraparietale und intravasculäre Weiterentwicklung der Chorionzotten. Arch. Pathol. Anat. Physiol. Klin. Med. 44:88–94, 1868.

    Article  Google Scholar 

  • Jauniaux, E., Kadri, R. and Hustin, J.: Partial mole and triploidy: screening patients with first-trimester spontaneous abortion. Obstet. Gynecol. 88:616–619, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Jauniaux, E., Brown, R., Snijders, R.J.M., Noble P. and Nicolaides, K.H.: Early prenatal diagnosis of triploidy. Amer. J. Obstet. Gynecol. 176:550–554, 1997.

    Article  CAS  Google Scholar 

  • Jauniaux, E., Gulbis, B., Hyett, J. and Nicolaides, K.H.: Biochemical analyses of mesenchymal fluid in early pregnancy. Amer. J. Obstet. Gynecol. 178:765–769, 1998.

    Article  CAS  Google Scholar 

  • Javey, H., Borazjani, G., Behnard, S. and Langley, F.A.: Discrepancies in the diagnosis of hydatidiform mole. Brit. J. Obstet. Gynaecol. 86:480–483, 1979.

    CAS  Google Scholar 

  • Jock, D.E., Schwartz, P.E. and Portnoy, L.: Primary ovarian hydatidiform mole: addition of a sixth case to the literature. Obstet. Gynecol. 58:657–660, 1981.

    PubMed  CAS  Google Scholar 

  • Johnson, F.L.: Recurrent hydatidiform mole. Can. Med. Assoc. J. 94:344, 1966.

    PubMed  CAS  Google Scholar 

  • Johnson, T.R., Comstock, C.H. and Anderson, D.G.: Benign gestational trophoblastic disease metastatic to pleura: unusual cause of hemothorax. Obstet. Gynecol. 53:509–511, 1979.

    PubMed  Google Scholar 

  • Jones, W.B. and Lauersen, N.H.: Hydatidiform mole with coexisting fetus. Amer. J. Obstet. Gynecol. 122:267–272, 1975.

    CAS  Google Scholar 

  • Jun, S.Y., Ro, J.Y. and Kim, K.R.: p57kip2 is useful in the classi-fication and differential diagnosis of complete and partial hydatidiform moles. Histopathol. 43:17–25, 2003.

    Article  Google Scholar 

  • Kabawat, S.E., Mostoufi-Zadeh, M., Berkowitz, R.S., Driscoll, S.G., Goldstein, D.P. and Bhan, A.K.: Implantation site in complete molar pregnancy: a study of immunologically competent cells with monoclonal antibodies. Amer. J. Obstet. Gynecol. 152:97–99, 1985.

    CAS  Google Scholar 

  • Kajii, T. and Ohama, K.: Androgenetic origin of hydatidiform mole. Nature 268:633–634, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Kajii, T., Kurashige, H., Ohama, K. and Uchino, F.: XY and XX complete moles: clinical and morphological correlations. Amer. J. Obstet. Gynecol. 150:57–64, 1984.

    CAS  Google Scholar 

  • Kashimura, Y., Kashimura, M., Sugimori, H., Tsukamoto, N., Matsuyama, T., Matsukuma, K., Kamura, T., Saito, T., Kawano, D., Nose, R., Nose, Y., Nakano, H. and Taki, I.: Prophylactic chemotherapy for hydatidiform mole: five to 15 years followup. Cancer 58:624–629, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Kazazian, L.C., Baramki, T.A. and Thomas, R.L.: Triploid fetus: an important consideration in the evaluation of very high maternal serum alpha-fetoprotein. Prenat. Diagn. 9:27–30, 1989.

    PubMed  CAS  Google Scholar 

  • Keep, D., Zaragoza, M.V., Hassold, T. and Redline, R.W.: Very early complete hydatidiform mole. Hum. Pathol. 27:708–713, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Khazaeli, M.B., Hedayat, M.M., Hatch, K.D., To, A.C.W., Soong, S.-J., Shingleton, H.M., Boots, L.R. and LoBuglio, A.F.: Radioimmunoassay of free β-subunit of human chorionic gonadotropin as a prognostic test for persistent trophoblastic disease in molar pregnancy. Amer. J. Obstet. Gynecol. 155:320–324, 1986.

    CAS  Google Scholar 

  • Khazaeli, M.B., Buchina, E.S., Pattillo, R.A., Soon, S.-J. and Hatch, K.D.: Radioimmunoassay of free β-unit of human chorionic gonadotropin in diagnosis of high-risk and low-risk gestational trophoblastic disease. Amer. J. Obstet. Gynecol. 160:444–449, 1989.

    CAS  Google Scholar 

  • Khoo, S.K., Monks, P.L. and Davies, N.T.: Hydatidiform mole coexisting with a live fetus: a dilemma of management. Aust. N.Z. J. Obstet. Gynaecol. 26:129–135, 1986.

    PubMed  CAS  Google Scholar 

  • Kim, D.S., Moon, H., Kim, K.T., Moon, Y.J. and Hwang, Y.Y.: Effects of prophylactic chemotherapy for persistent trophoblastic disease in patients with complete hydatidiform mole. Obstet. Gynecol. 67:690–694, 1986.

    PubMed  CAS  Google Scholar 

  • Kim, D.T., Riddell, D.C., Welch, J.P., Scott, H., Fraser, R.B. and Wright, J.R.Jr.: Association between Breus’ mole and partial hydatidiform mole: chance or can hydropic villi precipitate placental massive subchorionic thrombosis? Pediat. Pathol. Molec. Med. 21:451–459, 2002.

    Article  Google Scholar 

  • King, G.: Hydatidiform mole and chorion-epithelioma—the problem of the borderline case. Proc. R. Soc. Med. 49:381–390, 1956.

    PubMed  CAS  Google Scholar 

  • Kliman, H.J. and Segel, L.: The placenta may predict the baby. J. Theoret. Biol. 225:143–145, 2003.

    Article  Google Scholar 

  • Ko, T.-M., Hsieh, C.-Y, Ho, H.-N., Hsieh, F.-J and Lee, T.-Y.: Restriction fragments length polymorphism analysis to study the genetic origin of complete hydatidiform mole. Amer. J. Obstet. Gynecol. 164:901–906, 1991.

    CAS  Google Scholar 

  • Kohorn, E.I.: Natural history of partial molar pregnancy. Obstet. Gynecol. 68:731–732, 1986.

    PubMed  CAS  Google Scholar 

  • Krone, H.A.: Blasenmole mit einem ausgetragenen lebenden Kind. Zentralbl. Gynäkol. 77:1391–1395, 1955.

    PubMed  CAS  Google Scholar 

  • Kronfol, N.M., Iliya, F.A. and Hajj, S.N.: Recurrent hydatidiform mole: a report of five cases with review of the literature. Lebanese Med. J. 22:507–520, 1969.

    CAS  Google Scholar 

  • Kubo, H., Abe, Y., Shimada, M., Katayama, S. and Date, R.: Two cases of hydatidiform mole with a surviving coexisting fetus. Congen. Anomal. 26:256, 1986.

    Google Scholar 

  • Kyodo, Y., Inatomi, K., Abe, T. and Kudo, K.: A case report of destructive mole after uterine rupture. Amer. J. Obstet. Gynecol. 158:1182–1183, 1988.

    CAS  Google Scholar 

  • Lage, J.M., Driscoll, S.G., Yavner, D.L., Olivier, A.P., Mark, S.D. and Weinberg, D.S.: Hydatidiform moles: application of flow cytometry in diagnosis. Amer. J. Clin. Pathol. 89:596–600, 1988.

    CAS  Google Scholar 

  • Lage, J.M., Weinberg, D.S., Yavner, D.L. and Bieber, F.R.: The biology of tetraploid hydatidiform moles: histopathology, cytogenetics, and flow cytometry. Hum. Pathol. 20:419–425, 1989.

    Article  PubMed  CAS  Google Scholar 

  • Lage, J.M., Berkowitz, R.S., Rice, L.W., Goldstein, D.P., Bernstein, M.R. and Weinberg, D.S.: Flow cytometric analysis of DNA content in partial hydatidiform moles with persistent gestational trophoblastic tumor. Obstet. Gynecol. 77:111–115, 1991.

    PubMed  CAS  Google Scholar 

  • Lage, J.M., Mark, S.D., Roberts, D.J., Goldstein, D.P., Bernstein, M.R. and Berkowitz, R.S.: A flow cytometric study of 137 fresh hydropic placentas: correlation between types of hydatidiform moles and nuclear DNA ploidy. Obstet. Gynecol. 79:403–410, 1992.

    PubMed  CAS  Google Scholar 

  • Lai, C.Y.L., Chan, K.Y.K., Khoo, U.-S., Ngan, H.Y.S., Xue, W.-C., Chiu, P.M., Tsao, S.-W. and Cheung, A.N.Y.: Analysis of gestational trophoblastic disease by genotyping and chromosome in situ hybridization. Modern Pathol. 17:40–48, 2004.

    Article  CAS  Google Scholar 

  • Lauslahti, K.: A histological and histochemical study of trophoblastic disease in a Finnish material 1958–1962. Acta Pathol. Microbiol. Scand. [Suppl.] 201:1–71, 1969.

    Google Scholar 

  • La Vecchia, C., Franceschi, S., Fasoli, M. and Mangioni, C.: Gestational trophoblastic neoplasms in homozygous twins. Obstet. Gynecol. 60:250–252, 1982.

    PubMed  Google Scholar 

  • La Vecchia, C.L., Parazzini, F., Decarli, A., Franceschi, S., Fasoli, M., Favalli, G., Negri, E. and Pampallona, S.: Age of parents and risk of gestational trophoblastic disease. J. Natl. Cancer Inst. 73:639–642, 1984.

    PubMed  Google Scholar 

  • Lawler, S.D. and Fisher, R.A.: Genetic studies in hydatidiform mole with clinical correlations. Placenta 8:77–88, 1987.

    PubMed  CAS  Google Scholar 

  • Lawler, S.D., Kloudas, P.T. and Bagshawe, K.D.: Immunogenicity of molar pregnancies in the HL-A system. Amer. J. Obstet. Gynecol. 120:857–861, 1974.

    CAS  Google Scholar 

  • Lawler, S.D., Pickthall, V.J., Fisher, R.A., Povey, S., Evans, M.W. and Szulman, A.E.: Genetic studies of complete and partial hydatidiform moles. Lancet 2:580, 1979.

    Article  PubMed  CAS  Google Scholar 

  • Lawler, S.D., Fisher, R.A. and Dent, J.: A prospective genetic study of complete and partial hydatidiform moles. Amer. J. Obstet. Gynecol. 164:1270–1277, 1991.

    CAS  Google Scholar 

  • Lee, A.T.C. and Siegel, I.: Hydatidiform mole with rupture of the uterus: report of a case. Obstet. Gynecol. 26:133–134, 1965.

    Google Scholar 

  • Lee, E.E.: Gross early enlargement of a hydatidiform mole with severe pre-eclampsia. Can. Med. Assoc. J. 93:79–80, 1965.

    PubMed  CAS  Google Scholar 

  • Lee, J.N., Salem, H.T., Al-Ani, A.T.M., Huang, S.C., Ouyang, P.C., Wei, P.Y. and Seppälä, M.: Circulating concentrations of specific placental proteins (human chorionic gonadotropin, pregnancy-specific beta-1 glycoprotein, and placental protein 5) in untreated gestational trophoblastic tumors. Amer. J. Obstet. Gynecol. 139:702–704, 1981.

    CAS  Google Scholar 

  • Lee, W., Ginsburg, K.A., Cotton, D.B. and Kaufman, R.H.: Squamous and trophoblastic cells in the maternal pulmonary circulation identified by invasive hemodynamic monitoring during the peripartum period. Amer. J. Obstet. Gynecol. 155:999–1001, 1986.

    CAS  Google Scholar 

  • Leeder, J.R.: Metastasizing hydatidiform mole. Amer. J. Obstet. Gynecol. 88:833–835, 1964.

    Google Scholar 

  • Leivo, I., Laurila, P., Wahlström, T. and Engvall, E.: Expression of merosin, a tissue-specific basement membrane protein, in the intermediate trophoblast cells of choriocarcinoma and placenta. Lab. Invest. 60:783–790, 1989.

    PubMed  CAS  Google Scholar 

  • Lewis, P.E. and Cefalo, R.C.: Triploidy syndrome with theca lutein cysts and severe pre-eclampsia. Amer. J. Obstet. Gynecol. 133:110–111, 1979.

    CAS  Google Scholar 

  • Li, M.C., Hertz, R. and Spencer, D.B.: Effect of methotrexate therapy upon choriocarcinoma and chorioadenomas. Proc. Soc. Exp. Biol. Med. 93:361–366, 1956.

    PubMed  Google Scholar 

  • Lindor, N.M., Ney, J.A., Gaffey, T.A., Jenkins, R.B., Thibodeau, S.N. and Dewald, G.W.: A genetic review of complete and partial hydatidiform moles and nonmolar triploidy. Mayo Clin. Proceed. 67:791–799, 1992.

    CAS  Google Scholar 

  • Lipp, R.G., Kindshi, J.D. and Schmitz, R.: Death from pulmonary embolism associated with hydatidiform mole. Amer. J. Obstet. Gynecol. 83:1644–1647, 1962.

    CAS  Google Scholar 

  • Llewellyn-Jones, D.: Relation of pregnancy toxaemia to trophoblastic tumours. Brit. Med. J. 2:720, 1967.

    Article  Google Scholar 

  • Lloyd, C.E.: A case of hydatidiform mole associated with toxaemia. J. Obstet. Gynaecol. Brit. Emp. 28:307–310, 1921.

    Google Scholar 

  • Logan, B.J.: Occurrence of a hydatidiform mole in twin pregnancy: case report. Amer. J. Obstet. Gynecol. 73:911–913, 1957.

    CAS  Google Scholar 

  • Loke, Y.W.: Sex chromatin of hydatidiform moles. J. Med. Genet. 6:22–25, 1969.

    PubMed  CAS  Google Scholar 

  • Looi, L.M. and Sivanesaratnam, V.: Malignant evolution with fatal outcome in a patient with partial hydatidiform mole. Aust. N.Z. J. Obstet. Gynaecol. 21:51–52, 1981.

    PubMed  CAS  Google Scholar 

  • Lurain, J.R., Brewer, J.I., Torok, E.E. and Halpern, B.: Natural history of hydatidiform mole after primary evacuation. Amer. J. Obstet. Gynecol. 145:591–595, 1983.

    CAS  Google Scholar 

  • MacDonald, P.C. and Siiteri, P.K.: The in vivo mechanisms of origin of estrogen in subjects with trophoblastic tumors. Steroids 8:589–603, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Makino, S., Sasaki, M.S. and Fukuschima, T.: Preliminary notes on the chromosomes of human chorionic lesions. Proc. Jpn. Acad. 39:54–58, 1963.

    Google Scholar 

  • Makino, S., Sasaki, M.S. and Fukuschima, T.: Triploid chromosome constitution in human chorionic lesions. Lancet 2:1273–1275, 1964.

    Article  PubMed  CAS  Google Scholar 

  • Makino, S., Sasaki, M.S. and Fukuschima, T.: Cytologic studies of tumors. XLI. Chromosomal instability in human chorionic lesions. Okajimas Fol. Anat. Jpn. 40:439–465, 1965.

    CAS  Google Scholar 

  • Makrydimas, G., Sebire, N.J., Thornton, S.E., Zagorianakou, N., Lolis, D. and Fisher, R.A.: Complete hydatidiform mole and normal live birth: a novel case of confined placental mosaicism: case report. Human Reprod. 17:2459–2463, 2002.

    Article  CAS  Google Scholar 

  • Malinowski, W., Biskup, I. and Dec, W.: Sad fetus syndrome—gestational disease concurrent with a living fetus or fetuses. Acta Genet. Med. Gemollol. 44:193–202, 1995.

    CAS  Google Scholar 

  • Mark, L.K. and Moel, M.: Pulmonary metastasis from trophoblastic tumors. Radiology 76:601–605, 1961.

    PubMed  CAS  Google Scholar 

  • Márquez-Monter, H.: Deoxyribonucleic acid synthesis of hydatidiform moles in organ culture: an autoradiographic investigation. Nature 209:1037–1038, 1966.

    Article  PubMed  Google Scholar 

  • Márquez-Monter, H., de la Vega, G.A., Robles, M. and Bolio-Cicero, A.: Epidemiology and pathology of hydatidiform mole in the general hospital in Mexico. Amer. J. Obstet. Gynecol. 85:856–864, 1963.

    Google Scholar 

  • Martin, D.A., Sutton, G.P., Ulbright, T.M., Sledge, G.W., Stehman, F.B. and Ehrlich, C.E.: DNA content as a prognostic index in gestational trophoblastic neoplasia. Gynecol. Oncol. 34:383–388, 1989.

    Article  PubMed  CAS  Google Scholar 

  • Matalon, M. and Modan, B.: Epidemiologic aspects of hydatidiform mole in Israel. Amer. J. Obstet. Gynecol. 112:107–112, 1972.

    CAS  Google Scholar 

  • Mathieu, A.: Hydatidiform mole and chorio-epithelioma: collective review of the literature for the years 1935, 1936 and 1937. Surg. Gynecol. Obstet. 68:52–70; 181–198, 1939.

    Google Scholar 

  • Matsui, H., Iitsuka, Y., Yamazawa, K., Tanaka, N., Mitsuhashi, A., Seki, K. and Skiya, S.: Placental mesenchymal dysplasia initially diagnosed as partial mole. Pathol. Int. 53:810–813, 2003.

    Article  PubMed  Google Scholar 

  • Maudsley, R.F. and Robertson, E.M.: Hydatidiform mole in a woman over 52 years old: report of a case. Obstet. Gynecol. 26:542–543, 1965.

    PubMed  CAS  Google Scholar 

  • Mazzanti, P., La Vecchia, C., Parazzini, F. and Bolis, G.: Frequency of hydatidiform mole in Lombardy, Northern Italy. Gynecol. Oncol. 24:337–342, 1986.

    Article  PubMed  CAS  Google Scholar 

  • McCorriston, C.C.: Racial incidence of hydatidiform mole. Amer. J. Obstet. Gynecol. 101:377–382, 1968.

    CAS  Google Scholar 

  • McFadden, D.E., Pantzer, J.T. and Langlois, S.: Parental origin of triploidy—digyny, not diandry. Modern Pathol. 7:abstract 28, p. 5P, 1994.

    Google Scholar 

  • McKay, D.G., Roby, C.C., Hertig, A.T. and Richardson, M.V.: Studies of the function of early human trophoblast. I. Observations on the chemical composition of the fluid of hydatidiform moles. Amer. J. Obstet. Gynecol. 69:722–734, 1955a.

    CAS  Google Scholar 

  • McKay, D.G., Richardson, M.V. and Hertig, A.T.: Studies of the function of early human trophoblast. III. A study of the protein structure of mole fluid, chorionic and amniotic fluids by paper electrophoresis. Amer. J. Obstet. Gynecol. 75:699–707, 1955b.

    Google Scholar 

  • Meinecke, B., Kuiper, H., Drögemüller, C., Leeb, T. and Meinecke-Tillmann, S.: A mola hydatidosa coexistent with a foetus in a bovine freemartin pregnancy. Placenta 24:107–112, 2002.

    Article  Google Scholar 

  • Merkow, L.P., Acevedo, H.F., Gilmore, J. and Pardo, M.: Trophoblastic disease: a correlative ultrastructural and biochemical study. Obstet. Gynecol. 37:348–357, 1971.

    PubMed  CAS  Google Scholar 

  • Messerli, M.L., Parmley, T., Woodruff, J.D., Lilienfeld, A.M., Bevilacqua, L. and Rosenshein, N.B.: Inter-and intrapathologist variability in the diagnosis of gestational trophoblastic neoplasia. Obstet. Gynecol. 69:622–626, 1987.

    PubMed  CAS  Google Scholar 

  • Meyer, J.S.: Benign pulmonary metastasis from hydatidiform mole: report of a case. Obstet. Gynecol. 28:826–829, 1966.

    PubMed  CAS  Google Scholar 

  • Minami, S., Yamoto, M. and Nakano R.: Immunohistochemical localization of inhibin-activin subunits in hydatidiform mole and invasive mole. Obstet. Gynecol. 82:414–418, 1993.

    PubMed  CAS  Google Scholar 

  • Moglabey, Y.B., Kircheisen, R., Seoud, M., Mogharbel, N.E., van den Veyver, I. and Slim, R.: Genetic mapping of a maternal locus responsible for familial hydatidiform moles. Human Molec. Genet. 8:667–671, 1999.

    Article  CAS  Google Scholar 

  • Montgomery, E.A., Roberts, E.F., Conran, R.M. and Hitchcock, C.L.: Triploid abortus presenting as an ectopic pregnancy. Arch. Pathol. Lab. Med. 117:652–653, 1993.

    PubMed  CAS  Google Scholar 

  • Mor-Joseph, S., Anteby, S.O., Granat, M., Brzezinsky, A. and Evron, S.: Recurrent molar pregnancies associated with clomiphene citrate and human gonadotropins. Amer. J. Obstet. Gynecol. 151:1085–1086, 1985.

    CAS  Google Scholar 

  • Morrish, D.W., Honoré, L.H. and Bhardwaj, D.: Partial hydatidiform moles have impaired differentiated function (human chorionic gonadotropin and human placental lactogen secretion) in response to epidermal growth factor and 8-bromocyclic adenosine monophosphate. Amer. J. Obstet. Gynecol. 166:160–166, 1992.

    CAS  Google Scholar 

  • Moscoso, G., Jauniaux, E. and Hustin, J.: Placental vascular anomaly with diffuse mesenchymal stem villous hyperplasia. A new clinico-pathologic entity? Pathol. Res. Practice 187:324–328, 1991.

    CAS  Google Scholar 

  • Muto, M.G., Lage, J.M., Berkowitz, R.S., Goldstein, D.P. and Bernstein, M.R.: Gestational trophoblastic disease of the fallopian tube. J. Reprod. Med. 36:57–60, 1991.

    PubMed  CAS  Google Scholar 

  • Mutter, G.L., Pomponio, R.J., Berkowitz, R.S. and Genest, D.R.: Sex chromosome composition of complete hydatidiform moles: relationship to metastasis. Amer. J. Obstet. Gynecol. 168:1547–1551, 1993.

    CAS  Google Scholar 

  • Natoli, W.J. and Rashad, M.N.: Hawaiian moles. Amer. J. Roentgenol. Radium Ther. Nucl. Med. 114:142–144, 1972.

    CAS  Google Scholar 

  • Nayer, R., Silverberg, S.G., Snell, J. and Lage, J.M.: Placental site nodule occurring in a fallopian tube. Hum. Pathol. 27:1243–1245, 1996.

    Article  Google Scholar 

  • Neudeck, H., Kronenberger, C. and Vogel, M.: Detection of villous blood vessels by CD34 in complete hydatidiform mole and hydropic abortion. Placenta 24(10):abstract P105, 2003.

    Google Scholar 

  • Niebuhr, E.: Triploidy in man: cytogenetical and clinical aspects. Humangenetik 21:103–125, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Nishimura, H., Takano, K., Tanimura, T. and Yasuda, M.: Normal and abnormal development of human embryos: first report of an analysis of 1,213 intact embryos. Teratology 1:281–290, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Nisula, B.C. and Taliafouros, G.S.: Thyroid function in gestational trophoblastic neoplasia: evidence that the thyrotropic activity of chorionic gonadotropin mediates the thyrotoxicosis of choriocarcinoma. Amer. J. Obstet. Gynecol. 138:77–85, 1980.

    CAS  Google Scholar 

  • Nobunaga, T., Azuma, C., Kimura, T., Tokugawa, Y., Takemura, M., Kamiura, S., Saji, F. and Tanizawa, O.: Differential diagnostic between complete mole and hydropic abortus by deoxyribonucleic acid fingerprint. Amer. J. Obstet. Gynecol. 163:634–638, 1990.

    CAS  Google Scholar 

  • Novak, E.: Pathological aspects of hydatidiform mole and choriocarcinoma. Amer. J. Obstet. Gynecol. 59:1355–1372, 1950.

    CAS  Google Scholar 

  • Novak, E. and Seah, C.S.: Benign trophoblastic lesions in the Mathieu Chorionepithelioma Registry (hydatidiform mole, syncytial endometritis). Amer. J. Obstet. Gynecol. 68:376–390, 1954.

    CAS  Google Scholar 

  • Novak, R., Agamanolis, D., Dasu, S., Igel, H., Platt, M., Robinson, H. and Shehata, B.: Histologic analysis of placental tissue in first trimester abortions. Pediat. Pathol. 8:477–482, 1988.

    CAS  Google Scholar 

  • Nugent, C.E., Punch, M.R., Barr, M., LeBlanc, L., Johnson, M.P. and Evans, M.I.: Persistence of partial molar placenta and severe preeclampsia after selective termination in a twin pregnancy. Obstet. Gynecol. 87:829–831, 1996.

    PubMed  CAS  Google Scholar 

  • Ockleford, C., Barker, C., Griffiths, J., McTurk, G., Fisher, R. and Lawler, S.: Hydatidiform mole: an ultrastructural analysis of syncytiotrophoblast surface organization. Placenta 10:195–212, 1989.

    PubMed  CAS  Google Scholar 

  • Ohama, K., Kajii, T., Okamoto, E., Fukuda, Y., Imaizumi, K., Tsukahara, M., Kobayashi, K. and Hagiwara, K.: Dispermic origin of XY hydatidiform moles. Nature 292:551–552, 1981.

    Article  PubMed  CAS  Google Scholar 

  • Ohama, K., Ueda, K., Okamoto, E., Takenaka, M. and Fujiwara, A.: Cytogenetic and clinicopathologic studies of partial moles. Obstet. Gynecol. 68:259–262, 1986.

    PubMed  CAS  Google Scholar 

  • Ohyama, M., Kojyo, T., Godota, H., Sato, T., Ijiri, R. and Tanaka, Y.: Mesenchymal dysplasia of the placenta. Pathol. Intern. 50:759–764, 2000.

    Article  CAS  Google Scholar 

  • Okudaira, Y. and Strauss, L.: Ultrastructure of molar trophoblast: observations on hydatidiform mole and choriocarcinoma destruens. Obstet. Gynecol. 30:172–187, 1967.

    PubMed  CAS  Google Scholar 

  • Olvera, M., Harris, S., Amezcua, C.A., McCourty, A., Rezk, S., Koo, C., Felix, J.C. and Brynes, R.K.: Immunohistochemical expression of cell cycle proteins E2F-1, Cdk-2, Cyclin E, p27kip, and Ki-67 in normal placenta and gestational trophoblastic disease. Modern Pathol. 14:1036–1042, 2001.

    Article  CAS  Google Scholar 

  • Orr, J.W., Austin, J.M., Hatch, K.D., Shingleton, H.M., Younger, J.B. and Boots, L.R.: Acute pulmonary edema associated with molar pregnancies: a high-risk factor for development of persistent trophoblastic disease. Amer. J. Obstet. Gynecol. 136:412–415, 1980.

    Google Scholar 

  • Osada, H., Kawata, M., Yamada, M., Okumura, K. and Takamizawa, H.: Genetic identification of pregnancies responsible for choriocarcinomas after multiple pregnancies by restriction fragment length polymorphism analysis. Amer. J. Obstet. Gynecol. 165:682–688, 1991.

    CAS  Google Scholar 

  • Ozturk, M., Berkowitz, R., Goldstein, D., Bellet, D. and Wands, J.R.: Differential production of human chorionic gonadotropin and free subunits in gestational trophoblastic disease. Amer. J. Obstet. Gynecol. 158:193–198, 1988.

    CAS  Google Scholar 

  • Paradinas, F.J.: The histologic diagnosis of hydatidiform moles. Curr. Diagn. Pathol. 1:24–32, 1994.

    Google Scholar 

  • Paradinas, F.J., Fisher, R.A., Browne, P. and Newlands, E.S.: Diploid hydatidiform moles with fetal red blood cells in molar villi. 1—pathology, incidence, and prognosis. J. Pathol. 181:183–188, 1997.

    Article  PubMed  CAS  Google Scholar 

  • Paradinas, F.J., Sebire, N.J., Fisher, R.A., Rees, H.C., Foskett, M., Seckl, M.J. and Newlands, E.S.: Pseudo-partial moles: placental stem vessel hydrops and the association with Beckwith-Wiedemann syndrome and complete moles. Histopathology 39:447–454, 2001.

    Article  PubMed  CAS  Google Scholar 

  • Parazzini, F., La Vecchia, C., Franceschi, S. and Mangili, G.: Familial trophoblastic disease: case report. Amer. J. Obstet. Gynecol. 149:382–383, 1984.

    CAS  Google Scholar 

  • Parazzini, F., La Vecchia, C., Pampallona, S. and Franceschi, S.: Reproductive patterns and the risk of gestational trophoblastic disease. Amer. J. Obstet. Gynecol. 152:866–870, 1985.

    CAS  Google Scholar 

  • Parazzini, F., Mangili, G., La Vecchia, C., Negri, E., Bocciolone, L. and Fasoli, M.: Risk factors for gestational trophoblastic disease: a separate analysis of complete and partial hydatidiform moles. Obstet. Gynecol. 78:1039–1045, 1991.

    PubMed  CAS  Google Scholar 

  • Park, W.W.: The occurrence of sex chromatin in chorionepitheliomas, and hydatidiform moles. J. Pathol. Bacteriol. 74:197–206, 1957.

    Article  Google Scholar 

  • Park, W.W.: Choriocarcinoma: A Study of Its Pathology. Davis, Philadelphia, 1971.

    Google Scholar 

  • Patek, E. and Johnson, P.: Recurrent hydatidiform mole: report of a case with five recurrences. Acta Obstet. Gynecol. Scand. 57:381–383, 1978.

    PubMed  CAS  Google Scholar 

  • Pattillo, R.A., Sasaki, S., Katayama, K.P., Roesler, M. and Mattingly, R.F.: Genesis of 46,XY hydatidiform mole. Amer. J. Obstet. Gynecol. 141:104–105, 1981.

    CAS  Google Scholar 

  • Petit, A., Geoffroy, P., Bessette, P. and Bélisle, S.: Expression of G proteins in human placentae from molar pregnancies. Placenta 17:337–343, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Pettit, M.D.W.: Hydatidiform mole following tubal pregnancy. Amer. J. Obstet. Gynecol. 42:1057–1060, 1941.

    Google Scholar 

  • Philipp, T., Grillenberger, K., Separovic, E.R., Philipp, K. and Kalousek, D.K.: Effect of triploidy on early human development. Prenat. Diagn. 24:276–281, 2004.

    Article  PubMed  CAS  Google Scholar 

  • Pool, C., Aplin, J.D., Taylor, G.M. and Boyd, R.D.H.: Trophoblast cells and maternal blood. Lancet 1:804–805, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Popek, E.J.: Complete hydatidiform mole with coexisting twin: 10 cases. Modern Pathol. 7:abstract 39, p. 7P, 1994.

    Google Scholar 

  • Qiao, S., Nagasaka, T. and Nakashima, N.: Numerous vessels detected by CD34 in the villous stroma of complete hydatidiform moles. Intern. J. Gynecol. Pathol. 16:233–238, 1997.

    Article  CAS  Google Scholar 

  • Ramsey, P.S., Winter, J.T.v., Gaffey, T.A. and Ramin, K.D.: Eclampsia complicating hydatidiform molar pregnancy with coexisting, viable fetus. A case report. J. Reprod. Med. 43:456–458, 1998.

    CAS  Google Scholar 

  • Reed, S., Coe, J.I. and Bergquist, J.: Invasive hydatidiform mole metastatic to the lung. Obstet. Gynecol. 13:749–753, 1959.

    PubMed  CAS  Google Scholar 

  • Rice, L.W., Lage, J.M., Berkowitz, R.S., Goldstein, D.P. and Bernstein, M.R.: Repetitive complete and partial hydatidiform mole. Obstet. Gynecol. 74:217–219, 1989.

    PubMed  CAS  Google Scholar 

  • Rice, L.W., Berkowitz, R.S., Lage, J.M., Goldstein, D.P. and Bernstein, M.R.: Persistent gestational trophoblastic tumor after partial hydatidiform mole. Gynecol. Oncol. 36:358–362, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Ring, A.M.: The concept of benign metastasizing hydatidiform moles. Amer. J. Clin. Pathol. 58:111–117, 1972.

    CAS  Google Scholar 

  • Ringertz, N.: Hydatidiform mole, invasive mole and choriocarcinoma in Sweden 1958–1965. Acta Obstet. Gynecol. Scand. 49:195–203, 1970.

    PubMed  CAS  Google Scholar 

  • Rolon, P.A. and de Lopez, B.H.: Epidemiological aspects of hydatidiform mole in the Republic of Paraguay (South America). Brit. J. Obstet. Gynaecol. 84:862–864, 1977.

    CAS  Google Scholar 

  • Rolon, P.A., Hochsztajn, B. and Llamosas, F.: Epidemiology of complete hydatidiform mole in Paraguay. J. Reprod. Med. 35:15–18, 1990.

    PubMed  CAS  Google Scholar 

  • Romaguera, R.L., Rodriguez, M.M., Bruce, J.H., Zuluaga, T., Viciana, A., Penalver, M.A. and Nadji, M.: Molar gestations and hydropic abortions differentiated by p57 immunostaining. Fetal Pediat. Pathol. 23:181–190, 2004.

    Article  CAS  Google Scholar 

  • Romero, R., Horgan, G., Kohorn, E.I., Kadar, N., Taylor, K.J.W. and Hobbins, J.C.: New criteria for the diagnosis of gestational trophoblastic disease. Obstet. Gynecol. 66:553–558, 1985.

    PubMed  CAS  Google Scholar 

  • Roper, H.H., Wolff, G. and Hitzeroth, H.W.: Preferential X-inactivation in human placenta membranes: is the paternal X-inactive in early embryonic development of female mammals? Hum. Genet. 43:265–273, 1978.

    Article  Google Scholar 

  • Rubin, N.W.: Chorioadenoma destruens—perforation, resection, and subsequent pregnancy. Amer. J. Obstet. Gynecol. 89:536–538, 1964.

    CAS  Google Scholar 

  • Sagawa, N., Mori, T., Masuzaki, H., Ogawa, Y. and Nakao, K.: Leptin production by hydatidiform mole. Lancet 350:1518–1519, 1997.

    Article  PubMed  CAS  Google Scholar 

  • Saji, F., Tokugawa, Y., Kimura, T., Nobunaga, T., Azuma, C. and Tanizawa, O.: A new approach using DNA fingerprinting for the determination of androgenesis as a cause of hydatidiform mole. Placenta 10:399–405, 1989.

    PubMed  CAS  Google Scholar 

  • Sanchez, J.C. and Sanchez, J.E.: Hyperthyroidism with a hydatidiform mole. Pathological case of the month. Arch. Pediat. Adolesc. Med. 152:827–828, 1998.

    CAS  Google Scholar 

  • Sand, P.K., Lurain, J.R. and Brewer, J.I.: Repeat gestational trophoblastic disease. Obstet. Gynecol. 63:140–144, 1984.

    PubMed  CAS  Google Scholar 

  • Sand, P.K., Stubblefield, P.A. and Orvy, S.J.: Methotrexate inhibition of normal trophoblast in vitro. Amer. J. Obstet. Gynecol. 155:324–329, 1986.

    CAS  Google Scholar 

  • Sande, H.A. and Eyjolfsson, O.: Case report: hydatidiform mole with a coexisting fetus. Acta Obstet. Gynecol. Scand. 64:353–355, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Sarkar, S., Kacinski, B.M., Kohorn, E.I., Merino, M.J., Carter, D. and Blakemore, K.J.: Demonstration of myc and ras oncogene expression by hybridization in situ in hydatidiform mole and in the BeWo choriocarcinoma cell line. Amer. J. Obstet. Gynecol. 154:390–393, 1986.

    CAS  Google Scholar 

  • Sarno, A.P., Moorman, A.J. and Kalousek, D.K.: Partial molar pregnancy with fetal survival: An unusual example of con-fined placental mosaicism. Obstet. Gynecol. 82:716–719, 1993.

    Article  PubMed  Google Scholar 

  • Sasagawa, M., Yamazaki, T., Sudo, Y., Kanazawa, K. and Takeuchi S.: Immunohistochemical localization of hCGα, hCGβ CTP, hPL and SP1 on villous and extravillous trophoblasts in normal human pregnancy. Acta Obstetr. Gynaecol. Jpn. 39:1073–1079, 1987.

    CAS  Google Scholar 

  • Sasaki, M., Fukushima, T. and Makino, S.: Some aspects of the chromosome constitution of hydatidiform moles and normal chorionic villi. Gann 53:101–106, 1962.

    PubMed  CAS  Google Scholar 

  • Sasaki, M., Makino, S., Muramoto, J.-I., Ikeuchi, T. and Shimba, H.: A chromosome survey of induced abortuses in a Japanese population. Chromosoma 20:267–283, 1967.

    Article  Google Scholar 

  • Sauter, H.: Uteroplazentare Apoplexie bei Blasenmole. Gynaecologia 159:296–300, 1965.

    PubMed  CAS  Google Scholar 

  • Saxena, A., Frank, D., Panichkul, P., van den Veyver, I.B., Tycko, B. and Thaker, H.: The product of the imprinted gen IPL marks human villous cytotrophoblast and is lost in complete hydatidiform mole. Placenta 24:835–842, 2003.

    Article  PubMed  CAS  Google Scholar 

  • Schlaerth, J.B., Morrow, C.P., Montz, F.J. and d’Ablaing, G.: Initial management of hydatidiform mole. Amer. J. Obstet. Gynecol. 158:1299–1306, 1988.

    CAS  Google Scholar 

  • Schlegel, R.J., Neu, R.L., Leao, J.C., Farias, E., Aspillaga, M.J. and Gardner, L.I.: Observations on the chromosomal, cytological and anatomical characteristics of 75 conceptuses: including euploid, triploid XXX, triploid XYY and mosaic triploid XXY/diploid XY cases. Cytogenetics 5:430–446, 1966.

    Google Scholar 

  • Schmickel, R.D., Silverman, E.M., Floyd, A.D., Payne, F.E., Pooley, J.M. and Beck, M.L.: A live-born infant with 69 chromosomes. J. Pediatr. 79:97–103, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Schmorl, G.: Über das Schicksal embolisch verschleppter Plazentarzellen. Verh. Dtsch. Pathol. Gesellsch. 8:39–46, 1905.

    Google Scholar 

  • Schneider, C.I. and Waxman, B.: Clomid therapy and subsequent hydatidiform mole formation: a case report. Obstet. Gynecol. 39:787–788, 1972.

    Google Scholar 

  • Sciarra, N.: Human chorionic gonadotrophin in hydatidiform moles. J. Obstet. Gynaecol. Brit. Commonw. 77:420–423, 1970.

    CAS  Google Scholar 

  • Scott, J.S.: Pregnancy toxaemia associated with hydrops foetalis, hydatidiform mole and hydramnios. J. Obstet. Gynaecol. Brit. Emp. 65:689–701, 1958.

    CAS  Google Scholar 

  • Sebire, M.J., Gillmore, R., Foskett, M., Sebire, N.J., Rees, H. and Newlands, E.S.: Routine terminations of pregnancy-should we screen for gestational trophoblastic neoplasia? Lancet 364:705–707, 2004 (and comment by B. Piura, pp. 645–646).

    Article  PubMed  Google Scholar 

  • Sebire, N.J., Fisher, R.A. and Rees, H.C.: Histopathological diagnosis of partial and complete hydatidiform mole in the first trimester of pregnancy. Pediatr. Developm. Pathol. 6:69–77, 2002a.

    Article  Google Scholar 

  • Sebire, N.J., Foskett, M., Paradinas, F.J., Fisher, R.A., Francis, R.J., Short, D., Newlands, E.S. and Seckl, M.: Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin. Lancet 359:2165–2166, 2002b.

    Article  PubMed  Google Scholar 

  • Sebire, N.J., Rees, H.C., Peston, D., Seckl, M.J., Newlands, E.S. and Fisher, R.A.: p57KIP2 immunohistochemical staining of gestational trophoblastic tumours does not identify the type of the causative pregnancy. Histopathol. 45:135–141, 2004.

    Article  CAS  Google Scholar 

  • Seckl, M.J., Fisher, R.A., Salerno, G., Rees, H., Paradinas, F.J., Foskett, M. and Newlands, E.S.: Choriocarcinoma and partial hydatidiform moles. Lancet 356:1443–1444, 2000.

    Article  Google Scholar 

  • Sensi, A., Gualandi, F., Pittalis, M.C., Calabrese, O., Falciano, F., Maestri, I., Bovicelli, L. and Calzolarri, E.: Mole maker phenotype: possible narrowing of the candidate region. Eur. J. Human Genet. 8:641–644, 2000.

    Article  CAS  Google Scholar 

  • Seoud, M., Khalil, A., Frangieh, A., Zahed, L., Azar, G. and Nuwayri-Salti, N.: Recurrent molar pregnancies in a family with extensive intermarriage: report of a family and review of the literature. Obstet. Gynecol. 86:692–695, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Sherer, D.M., Glantz, J.C., Metlay, L.A. and Saller, D.N.: Absent umbilical artery diastolic flow in a fetus with a partial mole at 18 weeks’ gestation. Amer. J. Obstet. Gynecol. 169:1167–1168, 1993.

    CAS  Google Scholar 

  • Shorofsky, M.: A karyometric comparison of the normal human chorion with that of the hydatidiform mole. Acta Anat. (Basel) 41:45–56, 1960.

    Article  Google Scholar 

  • Sicuranza, B.J. and Tisdall, L.H.: Hydatidiform mole and eclampsia with coexistent living fetus in the second trimester of pregnancy. Amer. J. Obstet. Gynecol. 126:513–514, 1976.

    CAS  Google Scholar 

  • Slattery, M.A., Khong, T.Y., Dawkins, R.R., Pridmore, B.R. and Hague, W.M.: Eclampsia in association with partial molar pregnancy and congenital abnormalities. Amer. J. Obstet. Gynecol. 169:1625–1627, 1993.

    CAS  Google Scholar 

  • Slim, R., Fallahian, M., Rivière, J.-B. and Zali, M.R.: Evidence of a genetic heterogeneity of familial hydatidiform moles. Placenta 26:5–9, 2005.

    Article  PubMed  CAS  Google Scholar 

  • Smalbraak, J.: Trophoblastic Growths. A Clinical, Hormonal and Histopathological Study of Hydatidiform Mole and Chorionepithelioma. Elsevier, Amsterdam, 1957.

    Google Scholar 

  • Smith, E.B., Szulman, A.E., Hinshaw, W., Tyrey, L., Surti, U. and Hammond, C.B.: Human chorionic gonadotropin levels in complete and partial hydatidiform moles and in nonmolar abortuses. Amer. J. Obstet. Gynecol. 149:129–132, 1984.

    CAS  Google Scholar 

  • Song, H.-Z., Wu, P.-C., Wang, Y.-E., Yang, X.-Y. and Dong, S.-Y.: Pregnancy outcomes after successful chemotherapy for choriocarcinoma and invasive mole: long-term follow-up. Amer. J. Obstet. Gynecol. 158:538–545, 1988.

    CAS  Google Scholar 

  • Soto-Wright, V., Bernstein, M., Goldstein, D.P. and Berkowitz, R.S.: The changing clinical presentation of complete molar pregnancy. Obstet. Gynecol. 86:775–779, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Spademan, L.C. and Tuttle, W.M.: Chorioadenoma destruens. Amer. J. Obstet. Gynecol. 88:549–550, 1964.

    CAS  Google Scholar 

  • Stanhope, C.R., Stuart, G.C.E. and Curtis, K.L.: Primary ovarian hydatidiform mole: review of the literature and report of a case. Amer. J. Obstet. Gynecol. 145:886–888, 1983.

    CAS  Google Scholar 

  • Steller, M.A., Genest, D.R., Bernstein, M.R., Lage, J.M., Goldstein, D.P. and Berkowitz, R.S.: Natural history of twin pregnancy with complete hydatidiform mole and coexisting fetus. Obstet. Gynecol. 83:35–42, 1994.

    PubMed  CAS  Google Scholar 

  • Stroup, P.E.: A study of thirty-eight cases of hydatidiform mole at the Pennsylvania hospital. Amer. J. Obstet. Gynecol. 72:294–303, 1956.

    CAS  Google Scholar 

  • Sunderland, C.A., Redman, C.W.G. and Stirrat, G.M.: Characterization and localization of HLA antigens on hydatidiform mole. Amer. J. Obstet. Gynecol. 151:130–135, 1985.

    CAS  Google Scholar 

  • Surani, M.A.H. and Barton, S.C.: Development of gynogenetic eggs in the mouse: implications for parthenogenetic embryos. Science 222:1034–1036, 1983.

    Article  PubMed  CAS  Google Scholar 

  • Surti, U., Szulman, A.E. and O’Brien, S.: Complete (classic) hydatidiform mole with 46,XY karyotype of paternal origin. Hum. Genet. 51:153–155, 1979.

    Article  PubMed  CAS  Google Scholar 

  • Surti, U., Szulman, A.E. and O’Brien, S.: Dispermic origin and clinical outcome of three complete hydatidiform moles with 46,XY karyotype. Amer. J. Obstet. Gynecol. 144:84–87, 1982.

    CAS  Google Scholar 

  • Suzuki, M., Matsunobu, A., Wakita, K., Nishijima, M. and Osanai, K.: Hydatidiform mole with a surviving coexisting fetus. Obstet. Gynecol. 56:384–386, 1980.

    PubMed  CAS  Google Scholar 

  • Sze, E.H.M., Adelson, M.D., Baggish, M.S. and Contente, N.: Combined tubal and molar pregnancy: case report. Amer. J. Obstet. Gynecol. 159:1217–1219, 1988.

    CAS  Google Scholar 

  • Szulman, A.E. and Buchsbaum, H.J., eds.: Gestational Trophoblastic Disease. Springer-Verlag, New York, 1987.

    Google Scholar 

  • Szulman, A.E. and Surti, U.: The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. Amer. J. Obstet. Gynecol. 131:665–671, 1978a.

    CAS  Google Scholar 

  • Szulman, A.E. and Surti, U.: The syndromes of hydatidiform mole. II. Morphologic evolution of the complete and partial mole. Amer. J. Obstet. Gynecol. 132:20–27, 1978b.

    CAS  Google Scholar 

  • Szulman, A.E. and Surti, U.: The clinicopathologic profile of the partial hydatidiform mole. Obstet. Gynecol. 59:597–602, 1982.

    PubMed  CAS  Google Scholar 

  • Szulman, A.E. and Surti, U.: Strict clinicopathologic criteria in the diagnosis of partial hydatidiform mole: a plea renewed. Amer. J. Obstet. Gynecol. 152:1107–1108, 1985.

    CAS  Google Scholar 

  • Szulman, A.E., Ma, H.-K., Wong, L.C. and Hsu, C.: Residual trophoblastic disease in association with partial hydatidiform mole. Obstet. Gynecol. 57:392–394, 1981.

    PubMed  CAS  Google Scholar 

  • Takagi, N. and Sasaki, M.: Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse. Nature 256:640–652, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Takagi, N., Asano, S.-I., Fujisawa, M. and Ichinoe, K.: A possible triploid/diploid case of hydatidiform mole. Chromos. Inform. Serv. 10:21–22, 1969.

    Google Scholar 

  • Takahashi, H., Kanazawa, K., Ikarashi, T., Sudo, N. and Tanaka, K.: Discrepancy in the diagnoses of hydatidiform mole by macroscopic and microscopic findings and the deoxyribonucleic acid fingerprint method. Amer. J. Obstet. Gynecol. 163:112–113, 1990.

    CAS  Google Scholar 

  • Tanimura, A., Natsuyama, H., Kawano, M., Tanimura, Y., Tanaka, T. and Kitazono, M.: Primary choriocarcinoma of the lung. Hum. Pathol. 16:1281–1284, 1985.

    PubMed  CAS  Google Scholar 

  • Tavassoli, F.A. and Devilee, P.: World Health Organization Classification of Tumours: Pathology and Genetics. Tumours of the Breast and Female Genital Organs. Lyon, France. IARC Press, 2003.

    Google Scholar 

  • Teng, N.N.H. and Ballon, S.C.: Partial hydatidiform mole with diploid karyotype: report of three cases. Amer. J. Obstet. Gynecol. 150:961–964, 1984.

    CAS  Google Scholar 

  • Teoh, E.S., Dawood, M.Y. and Ratnam, S.S.: Epidemiology of hydatidiform mole in Singapore. Amer. J. Obstet. Gynecol. 110:415–420, 1971.

    CAS  Google Scholar 

  • Thatcher, S.S., Grainger, D.A., True, L.D. and de Cherney, A.H.: Pelvic trophoblastic implants after laparoscopic removal of a tubal pregnancy. Obstet. Gynecol. 74:514–515, 1989.

    PubMed  CAS  Google Scholar 

  • Thiele, R.A. and de Alvarez, R.R.: Metastasizing benign trophoblastic tumors. Amer. J. Obstet. Gynecol. 84:1395–1406, 1962.

    CAS  Google Scholar 

  • Tobin, S.M.: A further aid in the diagnosis of hydatidiform mole—the serum glutamic oxalacetic transaminase. Amer. J. Obstet. Gynecol. 87:213–217, 1963.

    CAS  Google Scholar 

  • Tominaga, T. and Page, E.W.: Sex chromatin of trophoblastic tumors. Amer. J. Obstet. Gynecol. 96:305–309, 1966.

    CAS  Google Scholar 

  • Tomoda, Y., Kaseki, S., Goto, S., Nishi, H., Hara, T. and Naruki, M.: Rh-D factor in trophoblastic tumors: a possible cause of the high incidence in Asia. Amer. J. Obstet. Gynecol. 139:742–743, 1981.

    CAS  Google Scholar 

  • Tsuji, K., Yagi, S. and Nakano, R.: Increased risk of malignant transformation of hydatidiform moles in older gravidas: a cytogenetic study. Obstet. Gynecol. 58:351–355, 1981.

    PubMed  CAS  Google Scholar 

  • Tsukahara, M. and Kajii, T.: Replication of X chromosomes in complete moles. Hum. Genet. 71:7–10, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Uchida, I.A. and Freeman, V.C.: Triploidy and chromosomes. Amer. J. Obstet. Gynecol. 151:65–69, 1985.

    CAS  Google Scholar 

  • Uher, J., Jirasek, J.E. and Sima, A.: Histochemische Studie von Blasenmole und Plazenta eines fünf Monate alten Fetus. Zentralbl. Gynäkol. 85:477–482, 1963.

    PubMed  CAS  Google Scholar 

  • Urbanski, T.K., Higgins, P.G., Murray, M.L. and Joffe, G.: Hydatid mole with a coexisting pregnancy. J. Perinatol. 16:478–480, 1996.

    PubMed  CAS  Google Scholar 

  • Van de Kaa, C.A., Nelson, K.A.M., Ramaekers, F.C.S., Vooijs, P.G. and Hopman, A.H.N.: Interphase cytogenetics in paraffin sections of routinely processed hydatidiform moles and hydropic abortions. J. Pathol. 165:281–287, 1991.

    Article  PubMed  Google Scholar 

  • Van de Kaa, C.A., Hanselaar, A.G.J.M., Hopman, A.H.N., Nelson, K.A.M., Peperkamp, A.R., Gemmink, J.H., Beck, J. L.M., Wilde, P.C.M. de, Ramaekers, F.C.S. and Vooijs, G.P.: DNA cytometric and interphase cytogenetic analyses of paraffin-embedded hydatidiform moles and hydropic abortions. J. Pathol. 170:229–238, 1993.

    Article  PubMed  Google Scholar 

  • Van de Kaa, C.A., Robben, J.C.M., Hopman, A.H.N. and Hanselaar, A.G.J.M.: Complete hydatidiform mole in twin pregnancy: differentiation from partial mole with interphase cytogenetic and DNA cytometric analyses on paraffin embedded tissues. Histopathology 26:123–129, 1995.

    PubMed  Google Scholar 

  • Van de Kaa, C.A., Schijf, C.P.T., Wilde, P.C.M. de, Hanselaar, A.G.J.M. and Vooijs, P.G.: The role of deoxyribonucleic acid image cytometric and interphase cytogenetic analyses in the differential diagnosis, prognosis, and clinical follow-up of hydatidiform moles. A report from the central molar registration in the Netherlands. Amer. J. Obstet. Gynecol. 177:1219–1229, 1997.

    Article  Google Scholar 

  • Vassilakos, P. and Kajii, T.: Hydatidiform mole: two entities. Lancet 1:259, 1976. (See Stone, M. and Bagshawe, K.D.: Lancet 1:535–536, 1976.)

    Article  PubMed  CAS  Google Scholar 

  • Vassilakos, P., Riotton, G. and Kajii, T.: Hydatidiform mole: two entities. A morphologic and cytogenetic study with some clinical considerations. Amer. J. Obstet. Gynecol. 127:167–170, 1977.

    CAS  Google Scholar 

  • Vejerslev, L.O., Dueholm, M. and Nielsen, F.H.: Hydatidiform mole: cytogenetic marker analysis in twin gestation. Amer. J. Obstet. Gynecol. 155:614–617, 1986.

    CAS  Google Scholar 

  • Vejerslev, L.O., Dissing, J., Hansen, H.E. and Poulsen, H.: Hydatidiform mole: genetic markers in diploid abortuses with macroscopic villous enlargement. Cancer Genet. Cytogenet. 26:143–155, 1987a.

    Article  CAS  Google Scholar 

  • Vejerslev, L.O., Dissing, J., Hansen, H.E. and Poulsen, H.: Hydatidiform mole: genetic origin in polyploid conceptuses. Hum. Genet. 76:11–19, 1987b.

    Article  PubMed  CAS  Google Scholar 

  • Vejerslev, L.O., Fisher, R.A., Surti, U. and Wake, N.: Hydatidiform mole: cytogenetically unusual cases and their implications for the present classification. Amer. J. Obstet. Gynecol. 157:180–184, 1987c.

    CAS  Google Scholar 

  • Vejerslev, L.O., Fisher, R.A., Surti, U. and Wake, N.: Hydatidiform mole: parental chromosome aberrations in partial and complete moles. J. Med. Genet. 24:613–615, 1987d.

    Article  PubMed  CAS  Google Scholar 

  • Vejerslev, L.O., Sunde, L., Hansen, B.F., Larsen, J.K., Christensen, I.J. and Larsen, G.: Hydatidiform mole and fetus with normal karyotype: support of a separate entity. Obstet. Gynecol. 77:868–874, 1991.

    PubMed  CAS  Google Scholar 

  • Wake, N., Takagi, N. and Sasaki, M.: Androgenesis as a cause of hydatidiform mole. J. Natl. Cancer Inst. 60:51–57, 1978a.

    PubMed  CAS  Google Scholar 

  • Wake, N., Shiina, Y. and Ichinoe, K.: A further cytogenetic study of hydatidiform mole, with reference to its androgenetic origin. Proc. Jpn. Acad. 54:533–537, 1978b.

    Google Scholar 

  • Wake, N., Tanaka, K., Chapman, V., Matsui, S. and Sandberg, A.A.: Chromosomes and cellular origin of choriocarcinoma. Cancer Res. 41:3137–3143, 1981.

    PubMed  CAS  Google Scholar 

  • Wax, J.R., Pinette, M.G., Chard, R., Blackstone, J. and Cartin, A.: Prenatal diagnosis by DNA polymorphism analysis of complete mole with coexisting twin. Amer. J. Obstet, Gynecol. 188:1105–1106, 2003.

    Article  Google Scholar 

  • Weaver, D.T., Fisher, R.A., Newlands, E.S. and Paradinas, F.J.: Amniotic tissue in complete hydatidiform moles can be androgenetic. J. Pathol. 191:67–70, 2000.

    Article  PubMed  CAS  Google Scholar 

  • Westerhout, F.C.: Ruptured tubal hydatidiform mole: report of a case. Obstet. Gynecol. 23:138–139, 1964.

    PubMed  Google Scholar 

  • Woodward, R.M., Filly, R.A. and Callen, P.W.: First trimester molar pregnancy: nonspecific Ultrasonographic appearance. Obstet. Gynecol. 55:31S–33S, 1980.

    PubMed  CAS  Google Scholar 

  • Wu, F.Y.W.: Recurrent hydatidiform mole: a case report of nine consecutive molar pregnancies. Obstet. Gynecol. 41:200–204, 1973.

    PubMed  CAS  Google Scholar 

  • Wynn, R.M. and Davies, J.: Ultrastructure of hydatidiform mole: correlative electron microscopic and functional aspects. Amer. J. Obstet. Gynecol. 90:293–307, 1964.

    CAS  Google Scholar 

  • Wynn, R.M. and Harris, J.A.: Ultrastructure of trophoblast and endometrium in invasive hydatidiform mole (chorioadenoma destruens). Amer. J. Obstet. Gynecol. 99:1125–1135, 1967.

    CAS  Google Scholar 

  • Yamashita, L., Wake, N., Araki, T., Ichinoe, K. and Makoto, K.: Human lymphocyte antigen expression in hydatidiform mole: androgenesis following fertilization by a haploid sperm. Amer. J. Obstet. Gynecol. 135:597–600, 1979.

    CAS  Google Scholar 

  • Yedema, K.A., Verheijen, R.H., Kenemans, P., Schijf, C.P., Borm, G.F., Segers, M.F. and Thomas, C.M.: Identification of patients with persistent trophoblastic disease by means of a normal human chorionic gonadotropin regression curve. Amer. J. Obstet. Gynecol. 168:787–792, 1993.

    CAS  Google Scholar 

  • Yee, B., Tu, B. and Platt, L.D.: Coexisting hydatidiform mole with a live fetus presenting as a placenta previa on ultrasound. Amer. J. Obstet. Gynecol. 144:726–728, 1982.

    CAS  Google Scholar 

  • Yenen, E., Inanc, F.A. and Babuna, C.: Primary ovarian hydatidiform mole: report of a case. Obstet. Gynecol. 26:721–724, 1965.

    PubMed  CAS  Google Scholar 

  • Yorde, D.E., Hussa, R.O., Garancis, J.C. and Pattillo, R.A.: Immunocytochemical localization of human choriogonadotropin in human malignant trophoblast: model for human choriogonadotropin secretion. Lab. Invest. 40:391–398, 1979.

    PubMed  CAS  Google Scholar 

  • Yoshimatsu, N., Hoshi, K., Sato, A., Munakata, S. and Fukushima, T.: The significance of alpha-fetoprotein-negativity in the interstitial area of total hydatidiform mole tissue. Nippon Sanka Fujinka Gakkai Zasshi 39:918–924, 1987 [Japanese].

    PubMed  CAS  Google Scholar 

  • Yuen, B.H.: Relationship of prolactin and estradiol to human chorionic gonadotropin following molar gestation. Amer. J. Obstet. Gynecol. 145:618–620, 1983.

    Google Scholar 

  • Zaragoza, M.V., Keep, D., Genest, D.R., Hassold, T. and Redline, R.W.: Early complete hydatidiform moles contain inner cell mass derivatives. Amer. J. Med. Genet. 70:273–277, 1997.

    Article  CAS  Google Scholar 

  • Zaragoza, M.V., Surti, U., Redline, R.W., Millie, E., Chakravarti, A. and Hassold, T.J.: Parental origin and phenotype of triploidy in spontaneous abortions: Predominance of diandry and association with the partial hydatidiform mole. Amer. J. Hum. Genet. 66:1807–1820, 2000.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, P. and Benirschke, K.: Placental Pathology Casebook. J. Perinatol. 1:63–65, 2000.

    Google Scholar 

  • Zhang, P., McGinnis, M.J., Sawai, S. and Benirschke, K.: Diploid/triploid mosaic placenta with fetus. Towards a better understanding of ‘partial moles’. Early Human Develop. 60:1–11, 2000.

    Article  CAS  Google Scholar 

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(2006). Molar Pregnancies. In: Pathology of the Human Placenta. Springer, New York, NY . https://doi.org/10.1007/0-387-26742-5_22

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