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Anatomy and Pathology of the Umbilical Cord

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References

  • Abrams, S.L., Callen, P.W. and Filly, R.A.: Umbilical vein thrombosis: sonographic detection in utero. J. Ultrasound Med. 4:283–285, 1985.

    PubMed  CAS  Google Scholar 

  • Abuhamad, A., Shaffer, W., Mari, G., Copel, J., Hobbins, J. and Evans, A.: Single umbilical artery: does it matter which artery is missing? Amer. J. Obstet. Gynecol. 173:728–732, 1995.

    Article  CAS  Google Scholar 

  • Akiyama, H., Kohzu, H. and Matsuoka, M.: An approach to detection and expulsion with new clinical sign: a study based on hemodynamic method and ultrasonography. Amer. J. Obstet. Gynecol. 140:505–511, 1981.

    CAS  Google Scholar 

  • Allen, J.R., Carrera, G.M. and Weed, J.C.: Neonatal death due to embolism. JAMA 207:756–757, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Altemani, A.M.: Thrombosis of fetal placental vessels: a quantitative study in placentas of stillbirths. Pathol. Res. Pract. 182:685–689, 1987.

    PubMed  CAS  Google Scholar 

  • Altemani, A.M. and Lopes de Faria, J.: Non-thrombotic changes of fetal placental vessels. A qualitative and quantitative study. Pathol. Res. Pract. 182:676–683, 1987.

    PubMed  CAS  Google Scholar 

  • Altshuler, G.: Some placental considerations related to neurodevelopmental and other disorders. J. Child Neurol. 8:78–94, 1993.

    PubMed  CAS  Google Scholar 

  • Altshuler, G. and Hyde, S.: Meconium induced vasoconstriction: a potential cause of cerebral and other fetal hypoperfusion and of poor pregnancy outcome. Child Neurol. 4:137–142, 1989.

    CAS  Google Scholar 

  • Altshuler, G., Tsang, R. and Ermocilla, R.: Single umbilical artery: correlation of clinical status and umbilical cord histology. Amer. J. Dis. Child. 129:697–700, 1975.

    PubMed  CAS  Google Scholar 

  • Anagnostakis, D., Kazlaris, E., Xanthou, M. and Maounis, F.: Umbilical cord entanglement: A cause of neonatal pulmonary hemorrhage? Helv. Paediatr. Acta 29:167–171, 1974.

    PubMed  CAS  Google Scholar 

  • Andrade, A.: Anatomical and radiographic study on the anastomosis and branching of the umbilical arteries in white and non-white Brazilians. Acta Anat. (Basel) 70:66–75, 1968.

    PubMed  CAS  Google Scholar 

  • Anhalt, H., Marino, R.V. and Rosenfeld, W.: Retained umbilical stump: clinical approaches and separation anxiety. Amer. J. Dis. Childr. 146:1413–1414, 1992.

    CAS  Google Scholar 

  • Ankola, P.A. and Pradham, G.: Radiology casebook. J. Perinatol. 3:196–197, 2000.

    Article  Google Scholar 

  • Antoine, C., Young, B.K., Silverman, F., Greco, M.A. and Alvarez, S.P.: Sinusoidal fetal heart rate pattern with vasa previa in twin pregnancy. J. Reprod. Med. 27:295–300, 1982.

    PubMed  CAS  Google Scholar 

  • Arts, N.F.T.: Investigations on the vascular system of the placenta. I. General introduction and the fetal vascular system. Amer. J. Obstet. Gynecol. 82:147–158, 1961.

    CAS  Google Scholar 

  • Arvy, L. and Pilleri, G.: Le Cordon Ombilical. Funis Umbilicalis. Verlag Hirnanatomisches Institut, Ostermundigen (Bern), Switzerland, 1976a.

    Google Scholar 

  • Arvy, L. and Pilleri, G.: The cetacean umbilical cord; studies of the umbilical cord of two Platanistoidea: Platanista gangetica and Pontoporia blainvillei. In, Volume VII: Investigations on Cetacea, G. Pilleri, ed. Brain Anatomy Institute, Berne, Switzerland, pp. 91–103, 1976b.

    Google Scholar 

  • Asmussen, I.: Ultrastructure of human umbilical veins. Acta Obstet. Gynecol. Scand. 57:253–255, 1978.

    PubMed  CAS  Google Scholar 

  • Asmussen, I. and Kjeldsen, K.: Intimal ultrastructure of human umbilical arteries: observations on arteries from newborn children of smoking and nonsmoking mothers. Circ. Res. 36:579–589, 1975.

    PubMed  CAS  Google Scholar 

  • Atalla, R.K., Abrams, K., Bell, S.C. and Taylor, D.J.: Newborn acid-base status and umbilical cord morphology. Obstet. Gynecol. 92:865–868, 1998.

    Article  PubMed  CAS  Google Scholar 

  • Bacsich, P. and Riddell, W.J.B.: Structure and nutrition of the cornea, cartilage and Wharton’s jelly. Nature 155:271, 1945.

    CAS  Google Scholar 

  • Bacsich, P. and Smout, C.F.V.: Some observations on the foetal vessels of the human placenta with an account of the corrosion technique. J. Anat. 72:358–364, 1938.

    PubMed  CAS  Google Scholar 

  • Baergen, R., Benirschke, K. and Ulich, T.R.: Cytokine expression in the placenta. The role of interleukin 1 and interleukin 1 receptor antagonist expression in chorioamnionitis and parturition. Arch. Pathol. Lab. Med. 118:52–55, 1994.

    PubMed  CAS  Google Scholar 

  • Baergen, R.N., Malicki, D., Behling, C. and Benirschke, K.: Morbidity, mortality, and placental pathology in excessively long umbilical cords: retrospective study. Pediatr. Developm. Pathol. 4:144–153, 2001.

    Article  CAS  Google Scholar 

  • Bahary, C.M., Gabbai, M. and Eckerling, B.: Rupture of the umbilical cord: report of a case. Obstet. Gynecol. 26:130–132, 1965.

    Google Scholar 

  • Baill, I.C., Moore, G.W. and Hedrick, L.A.: Abscess of allantoic duct remnant. Amer. J. Obstet. Gynecol. 161:334–336, 1989.

    CAS  Google Scholar 

  • Bakotic, B.W., Boyd, T., Poppiti, R. and Pflueger, S.: Recurrent umbilical cord torsion leading to fetal death in 3 subsequent pregnancies. A case report and review of the literature. Arch. Pathol. Lab. Med. 124:1351–1355, 2000.

    Google Scholar 

  • Balls, S., Gitstein, S. and Kharash, J.: Fetal heart rate variation with umbilical haematoma. Postgrad. Med. J. 61:753–755, 1985.

    Google Scholar 

  • Barents, J.W.: Over tumoren van de navelstreng en de placenta. Nederl. Tijdschr. Verlosk. Gynaecol. 52:243–251, 1953.

    CAS  Google Scholar 

  • Barron, S., Riley, E.P., Smotherman, W.P. and Kotch, L.E.: Umbilical cord length in rats is altered by prenatal alcohol exposure. Teratology 31:49A–50A, 1985.

    Article  Google Scholar 

  • Barry, F.E., McCoy, C.P. and Callahan, W. P.: Hemangioma of the umbilical cord. Amer. J. Obstet. Gynecol. 62:675–680, 1951.

    CAS  Google Scholar 

  • Becker, V.: Funktionelle Morphologie der Placenta. Arch. Gynäkol. 198:1–28, 1962.

    Google Scholar 

  • Becker, V.: Plazenta bei Totgeburt. In, Die Plazenta des Menschen. V. Becker, Th.H. Schiebler and F. Kubli, eds., Thieme, Stuttgart, pp. 305–308, 1981.

    Google Scholar 

  • Becker, V. and Dolling, D.: Gefäßverschlüsse in der Placenta von Totgeborenen. Virchows Arch. [Pathol. Anat.] 338:305–314, 1965.

    Article  CAS  Google Scholar 

  • Becker, V. und Röckelein, G.: Pathologie der weiblichen Genitalor gane I. Pathologie der Plazenta und des Abortes. Springer-Verlag, Heidelberg, New York, 1989.

    Google Scholar 

  • Beer, D.C.: Vasa previa: review of current concepts of management and report of a case. Obstet. Gynecol. 3:595–597, 1954.

    PubMed  CAS  Google Scholar 

  • Bell, A.D., Gerlis, L.M. and Variend, S.: Persistent right umbilical vein—case report and review of literature. Intern. J. Cardiol. 10:167–176, 1986.

    Article  CAS  Google Scholar 

  • Bender, H.G., Werner, C. and Karsten, C.: Zum Einfluß der Nabelschnurstruktur auf Schwangerschafts-und Geburtsverlauf. Arch. Gynäkol. 225:347–362, 1978.

    PubMed  CAS  Google Scholar 

  • Bendon, R.W., Tyson, R.W., Baldwin, V.J., Cashner, K.A., Momouni, F. and Miodovnik, M.: Umbilical cord ulceration and intestinal atresia: a new association? Amer. J. Obstet. Gynecol. 164:582–586, 1991.

    CAS  Google Scholar 

  • Benirschke, K.: You need a sympathetic pathologist! The borderline of embryology and pathology revisited. Teratology 36:389–393, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Benirschke, K.: College of American Pathologists conference XIX on examination of the placenta: Summary. Arch. Path. Lab. Med. 115:720–721, 1991.

    Google Scholar 

  • Benirschke, K.: Obstetrically important lesions of the umbilical cord. J. Reprod. Med. 39:262–272, 1994.

    PubMed  CAS  Google Scholar 

  • Benirschke, K. and Bourne, G.L.: The incidence and prognostic implication of congenital absence of one umbilical artery. Amer. J. Obstet. Gynecol. 79:251–254, 1960.

    CAS  Google Scholar 

  • Benirschke, K. and Brown, W.H.: A vascular anomaly of the umbilical cord: the absence of one umbilical artery in the umbilical cords of normal and abnormal fetuses. Obstet. Gynecol. 6:399–404, 1953.

    Google Scholar 

  • Benirschke, K. and Dodds, J.P.: Angiomyxoma of the umbilical cord with atrophy of an umbilical artery. Obstet. Gynecol. 30:99–102, 1967.

    PubMed  CAS  Google Scholar 

  • Benirschke, K. and Driscoll, S.G.: The Pathology of the Human Placenta. Springer-Verlag, New York, 1967.

    Google Scholar 

  • Benirschke, K., Sullivan, M.M. and Marin-Padilla, M.: Size and number of umbilical vessels: a study of multiple pregnancy in man and the armadillo. Obstet. Gynecol. 24:819–834, 1964.

    PubMed  CAS  Google Scholar 

  • Benoit, R., Copel, J. and Williams, K.: Does single umbilical artery (SUA) predict IUGR? Amer. J. Obstet. Gynecol. 187:208 (abstract 546), 2002.

    Google Scholar 

  • Bergman, P., Lundin, P. and Malmström, T.: Mucoid degeneration of Wharton’s jelly: an umbilical cord anomaly threatening foetal life. Acta Obstet. Gynecol. Scand. 40:372–378, 1961.

    PubMed  CAS  Google Scholar 

  • Bergström, H.: Intrauterin fosterdöd genom förblödning. Nord. Med. 4:592–593, 1963.

    Google Scholar 

  • Bhargava, I. and Raja, P.T.K.: Arteriovenous crossings on the chorial surface of the human placenta in abnormal pregnancy and development. Experientia 25:831–832, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Bhargava, I., Chakravarty, A. and Raja, P.T.K.: Anatomy of foetal blood vessels on the chorial surface of the human placenta. IV. With absence of one umbilical artery. Acta Anat. (Basel) 80:620–635, 1971.

    PubMed  CAS  Google Scholar 

  • Bilek, K., Roth, K. and Piskazeck, K.: Insertio-velamentosa-Blutung vor dem Blasensprung. Zentralbl. Gynäkol. 84:1536–1541, 1962.

    PubMed  CAS  Google Scholar 

  • Blackburn, W. and Cooley, N.R.: The umbilical cord. In, Human Malformations and Related Anomalies, Volume II R.E. Stevenson, J.G. Hall and Goodman, R.M., eds. Oxford Monographs on Medical Genetics, Oxford University Press, New York and Oxford, pp. 1081–1141, 1993.

    Google Scholar 

  • Blackburn, W., Cooley, N.R. and Manci, E.A.: Correlations between umbilical cord structure-composition and normal and abnormal fetal development. In, Proceedings of the Greenwood Genetics Conference Vol. 7. R.A. Saul, ed., pp. 180–181. Jacobs Press, Clinton, SC, 1988.

    Google Scholar 

  • Blanc, W.A. and Allan, G.W.: Intrafunicular ulceration of persistent omphalomesenteric duct with intra-amniotic hemorrhage and fetal death. Amer. J. Obstet. Gynecol. 82:1392–1396, 1961.

    CAS  Google Scholar 

  • Bobitt, J.R.: Abnormal antepartum fetal heart rate tracings, failure to intervene, and fetal death: review of five cases reveals potential pitfalls of antepartum monitoring programs. Amer. J. Obstet. Gynecol. 133:415–421, 1979.

    CAS  Google Scholar 

  • Bodelsson, G., Sjöberg, N.-O. and Stjernquist, M.: Contractile effect of endothelin in the human uterine artery and autoradiographic localization of its binding sites. Amer. J. Obstetr. Gynecol. 167:745–750, 1992.

    CAS  Google Scholar 

  • Boué, D.R., Stanley, C. and Baergen, R.N.: Placental pathology casebook. J. Perinatol. 15:429–431, 1995.

    PubMed  Google Scholar 

  • Bourne, G.L.: The Human Amnion and Chorion. Lloyd-Luke, London, 1962.

    Google Scholar 

  • Boyd, J.D. and Hamilton, W.J.: The Human Placenta. W. Heffer & Sons, Cambridge, 1970.

    Google Scholar 

  • Brady, A.G.: Knotted umbilical cord as a cause of death in a Cercopithecus aethiops fetus. Lab. Anim. Sci. 33:375–376, 1983.

    PubMed  CAS  Google Scholar 

  • Brant, H.A. and Lewis, B.V.: Prolapse of the umbilical cord. Lancet 2:1443–1445, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Brar, H.S., Medearis, A.L., DeVore, G.R. and Platt, L.D.: Maternal and fetal blood flow velocity waveforms in patients with preterm labor: effect of tocolytics. Obstet. Gynecol. 72:209–214, 1988.

    PubMed  CAS  Google Scholar 

  • Bret, A.J. and Bardiaux, M.: Hématome du cordon. Rev. Fr. Gynécol. Obstét. 55:240–249, 1956.

    CAS  Google Scholar 

  • Broome, D.L., Kellogg, B., Weiss, B.A. and Wilson, M.G.: Needle puncture of the fetus during amniocentesis. Lancet 2:604, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Broome, D.L., Wilson, M.G., Weiss, B. and Kellogg, B.: Needle puncture of the fetus: a complication of secondtrimester amniocentesis. Amer. J. Obstet. Gynecol. 126: 247–252, 1976.

    CAS  Google Scholar 

  • Browne, F.J.: On the abnormalities of the umbilical cord which may cause antenatal death. J. Obstet. Gynaecol. Brit. Emp. 32:17–48, 1925.C

    Google Scholar 

  • Busacca, M., Dejana, E., Balconi, G., Olivieri, S., Pietra, A., Vergara-Dauden, M. and de Gaetano, G.: Reduced prostacyclin production by cultured endothelial cells from umbilical arteries of babies born to women who smoke. Lancet 2:609–610, 1982.

    Article  PubMed  CAS  Google Scholar 

  • Cai, W.Q., Bodin, P., Sexton, A., Loesch, A. and Burnstock, G.: Localization of neuropeptide Y and atrial natriuretic peptide in the endothelial cells of human umbilical blood vessels. Cell Tissue Res. 272:175–181, 1993a.

    Article  PubMed  CAS  Google Scholar 

  • Cai, W.Q., Terenghi, G., Bodin, P., Burnstock, G. and Polak, J.M.: In situ hybridization of atrial natriuretic peptide mRNA in the endothelial cells of human umbilical vessels. Histochemistry 100:277–283, 1993b.

    Article  PubMed  CAS  Google Scholar 

  • Calvano, C.J., Hoar, R.M., Mankes, R.F., Lefevre, R., Reddy, P.P., Moran, M.E. and Mandell, J.: Experimental study of umbilical cord length as a marker of fetal alcohol syndrome. Teratology 61:184–188, 2000.

    Article  PubMed  CAS  Google Scholar 

  • Camilleri, A.P.: Umbilical cord. Brit. Med. J. 2:757, 1964.

    Google Scholar 

  • Camman, W. and Marquardt, J.: Complex umbilical-cord knot. NEJM 349:159, 2003.

    Article  Google Scholar 

  • Cardoso, L.E.M., Erlich, R.B., Rudge, M.C., Peracoli, J.C. and Mourao, P.A.S.: A comparative analysis of glycosaminoglycans from human umbilical arteries in normal subjects and in pathological conditions affecting pregnancy. Lab. Invest. 67:588–595, 1992.

    PubMed  CAS  Google Scholar 

  • Carp, H.J.A., Mashiach, S. and Serr, D.M.: Vasa previa: a major complica tion and its management. Obstet. Gynecol. 53:273–275, 1979.

    PubMed  CAS  Google Scholar 

  • Chantler, C., Baum, J.D. and Scopes, J.W.: Giant umbilical cord associated with a patent urachus and fused umbilical arteries. J. Obstet. Gynaecol. Brit. Commonw. 76:273–274, 1969.

    CAS  Google Scholar 

  • Chasnoff, I.J. and Fletcher, M.A.: True knot of the umbilical cord. Amer. J. Obstet. Gynecol. 127:425–427, 1977.

    CAS  Google Scholar 

  • Chaurasia, B.D. and Agarwal, B.M.: Helical structure of the umbilical cord. Acta Anat. (Basel) 103:226–230, 1979.

    PubMed  CAS  Google Scholar 

  • Chénard, E., Bastide, A. and Fraser, W.D.: Umbilical cord hematoma following diagnostic funipuncture. Obstet. Gynecol. 76:994–996, 1990.

    PubMed  Google Scholar 

  • Clapp, J.F., Peress, N.S., Wesley, M. and Mann, L.I.: Brain damage after intermittent partial cord occlusion in the chronically instrumented fetal lamb. Amer. J. Obstet. Gynecol. 159:504–509, 1988.

    CAS  Google Scholar 

  • Clapp, J.F., III, Stepanchak, W., Hashimoto, K., Ehrenberg, H. and Lopez, B.: The natural history of antenatal nuchal cords. Amer. J. Obstet. Gynecol. 189:488–493, 2003.

    Article  Google Scholar 

  • Clare, N.M., Hayashi, R. and Khodr, G.: Intrauterine death from umbilical cord hematoma. Arch. Pathol. Lab. Med. 103:46–47, 1979.

    PubMed  CAS  Google Scholar 

  • Clarke, J.A.: An x-ray microscopic study of the vasa vasorum of the human umbilical arteries. Z. Zellforsch. 66:293–299, 1965.

    Article  PubMed  CAS  Google Scholar 

  • Colgan, T.J. and Luk, S.C.: Umbilical-cord torsion, thrombosis, and intrauterine death of a twin. Arch. Pathol. Lab. Med. 106:101, 1982.

    PubMed  CAS  Google Scholar 

  • Collins, J.C.: Umbilical cord accidents: human studies. Seminars Perinatol. 26:79–82, 2002.

    Article  Google Scholar 

  • Collins, J.C., Muller, R.J. and Collins, C.L.: Prenatal observation of umbilical cord abnormalities: a triple knot and torsion of the umbilical cord. Amer. J. Obstetr. Gynecol. 169:102–104, 1993.

    CAS  Google Scholar 

  • Collins, J.H.: Two cases of multiple umbilical cord abnormalities resulting in stillbirth: prenatal observation with ultrasonography and fetal heart rates. Amer. J. Obstetr. Gynecol. 168:125–128, 1993.

    CAS  Google Scholar 

  • Collins, J.H.: Fetal grasping of the umbilical cord. Reply. Amer. J. Obstet. Gynecol. 172:1071, 1995a.

    Article  Google Scholar 

  • Collins, J.H.: Prenatal observation of umbilical cord torsion with subsequent premature labor and delivery of a 31-week infant with mild nonimmune hydrops. Amer. J. Obstet. Gynecol. 172:1048–1049, 1995b.

    Article  CAS  Google Scholar 

  • Collins, J.H.: Nuchal cord type A and type B. Amer. J. Obstet. Gynecol. 177:94, 1997.

    Article  CAS  Google Scholar 

  • Collins, J.H., Geddes, D., Collins, C.L. and De Angelis, L.: Nuchal cord: a definition and a study associating placental location and nuchal cord incidence. J. Louisiana State Med. Soc. 143:18–23, 1991.

    CAS  Google Scholar 

  • Collins, J.H., Collins, C.L., Weckwerth, S.R. and De Angelis, L.: Nuchal cords: timing of prenatal diagnosis and duration. Amer. J. Obstet. Gynecol. 173:768, 1995.

    Article  CAS  Google Scholar 

  • Cook, F.G., Taylor, R. and Gillan, J.E.: Placental venous thrombosis—a clinically significant finding in intrauterine death. Lab. Invest. 56:1P, 1987.

    Google Scholar 

  • Cook, V., Weeks, J., Brown, J. and Bendon, R.: Umbilical artery occlusion and fetoplacental thromboembolism. Obstet. Gynecol. 85:870–872, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Cordero, D.R., Helfgott, A.W., Landy, H.J., Reik, R.F., Medina, C. and O’Sullivan, M.J.: A non-hemorrhagic manifestation of vasa previa: a clinicopathologic case report. Obstet. Gynecol. 82:698–700, 1993.

    PubMed  CAS  Google Scholar 

  • Corkill, T.F.: The infant’s vulnerable life-line. Aust. N.Z. J. Obstet. Gynaecol. 1:154–160, 1961.

    Google Scholar 

  • Corridan, M., Kendall, E.D. and Begg, J.D.: Cord entanglement causing premature separation and amniotic fluid embolism: case report. Brit. J. Obstet. Gynaecol. 87:935–940, 1980.

    CAS  Google Scholar 

  • Costakos, D.T., Williams, A.C., Love, L.A. and Wood, B.P.: Patent urachal duct. Amer. J. Dis. Childr. 146:951–952, 1992.

    CAS  Google Scholar 

  • Coulter, J.B.S., Scott, J.M. and Jordan, M.M.: Oedema of the umbilical cord and respiratory distress in the newborn. Brit. J. Obstet. Gynaecol. 82:453–459, 1975.

    CAS  Google Scholar 

  • Crawford, J.M.: A study of human placental growth with observations on the placenta in erythroblastosis foetalis. J. Obstet. Gynaecol. Brit. Emp. 66:885–896, 1959.

    CAS  Google Scholar 

  • Crawford, J.S.: Cord round the neck: incidence and sequelae. Acta Paediatr. (Stockh.) 51:594–603, 1962.

    PubMed  CAS  Google Scholar 

  • Crawford, J.S.: Cord around the neck: Further analysis of incidence. Acta Paediatr. (Stockh.) 53:553–557, 1964.

    PubMed  CAS  Google Scholar 

  • Crichton, J.L.: Tensile strength of the umbilical cord. Amer. J. Obstet. Gynecol. 115:77–80, 1973.

    CAS  Google Scholar 

  • Critchlow, C.W., Leet, T.L., Benedetti, T.J. and Daling, J.R.: Risk factors and infant outcomes associated with umbilical cord prolapse: a population-based case-control study among births in Washington State. Amer. J. Obstet. Gynecol. 170:613–618, 1994.

    CAS  Google Scholar 

  • Cullen, T.S.: Embryology, Anatomy, and Disease of the Umbilicus Together with Diseases of the Urachus. Saunders, Philadelphia, 1916.

    Google Scholar 

  • Dadak, C., Kefalides, A., Sinzinger, H. and Weber, G.: Reduced umbilical artery prostacyclin formation in complicated pregnancies. Amer. J. Obstet. Gynecol. 144:792–795, 1982.

    CAS  Google Scholar 

  • Dado, G.M., Dobrin, P.B. and Mrkvicka, R.S.: Venous flow through coiled and noncoiled umbilical cords. Effects of external compression, twisting and longitudinal stretching. J. Reprod. Med. 42:576–580, 1997.

    PubMed  CAS  Google Scholar 

  • Dargent, J.-L., Makke, M., Valaeys, V., Verdebout, J.-M., Thomas, D. and Barlow, P.: Corkscrew-like umbilical cord twist. Pediatr. Develop. Pathol. 5:103–104, 2002.

    Article  Google Scholar 

  • Davignon, J., Lorenz, R.R. and Shepherd, J.T.: Response of human umbilical artery to changes in transmural pressure. Amer. J. Physiol. 209:51–59, 1965.

    Google Scholar 

  • Degani, S., Lewinsky, R.M., Berger, H. and Spiegel, D.: Sonographic estimation of umbilical coiling index and correlation with Doppler flow characteristics. Obstet. Gynecol. 86:990–993, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Del Valle, G.O., Santerini, K., Sanchez-Ramos, L., Gaudier, F.L. and Delke, I.: The straight umbilical cord: Significance and perinatal implications. Amer. J. Obstet. Gynecol. 172:286 (abstract 83), 1995.

    Google Scholar 

  • De Sa, D.J.: Rupture of fetal vessels on placental surface. Arch. Dis. Child. 46:495–501, 1971.

    Google Scholar 

  • De Sa, D.J.: Intimal cushions in foetal placental veins. J. Pathol. 110:347–352, 1973.

    Article  Google Scholar 

  • De Sa, D.J.: Diseases of the umbilical cord. In, Pathology of the Placenta. E.V.D.K. Perrin, ed. Churchill Livingstone, New York, 1984.

    Google Scholar 

  • De Sa, M.F. and Meirelles, R.S.: Vasodilating effect of estrogen on the human umbilical artery. Gynecol. Invest. 8:307–313, 1977.

    Google Scholar 

  • DeVore, G.R., Mayden, K., Tortora, M., Berkowitz, R.L. and Hobbins, J.C.: Dilation of the umbilical vein in rhesus hemolytic anemia: a predictor of s severe disease. Amer. J. Obstet. Gynecol. 141:464–466, 1981.

    CAS  Google Scholar 

  • Didolkar, S.M., Hal, J., Phelan, J., Gutberlett, R. and Hill, J.L.: The prenatal diagnosis and management of a hepatoomphalocele. Amer. J. Obstet. Gynecol. 141:221–222, 1981.

    CAS  Google Scholar 

  • Dildy, G.A. and Clark, S.L.: Umbilical cord prolapse. Contemp. Ob/Gyn. 38:23–31, 1993.

    Google Scholar 

  • Dillon, W.P. and O’Leary, L.A.: Detection of fetal cord compromise secondary to umbilical cord hematoma with the nonstress test. Amer. J. Obstet. Gynecol. 141:102–1103, 1981.

    CAS  Google Scholar 

  • Dippel, A.L.: Hematomas of the umbilical cord. Surg. Gynecol. Obstet. 70:51–57, 1940.

    Google Scholar 

  • Dippel, A.L.: Maligned umbilical cord entanglements. Amer. J. Obstet. Gynecol. 88:1012–1018, 1964.

    CAS  Google Scholar 

  • Divon, M.Y.: Umbilical artery Doppler velocimetry: clinical utility in high-risk pregnancies. Amer. J. Obstet. Gynecol. 174:10–14, 1996.

    Article  CAS  Google Scholar 

  • Di Terlizzi, G. and Rossi, G.F.: Studio clinico-statistico sulle anomalie del funiculo. Ann. Obstet. Ginecol. 77:459–474, 1955. [see Fox, 1978.]

    Google Scholar 

  • Dolff, M.: Die sogenannten Rekanalisationen der Stammzottengefäße bei Endarteritis obliterans der Plazentagefäße. Arch. Gynecol. 226:325–332, 1978.

    Article  PubMed  CAS  Google Scholar 

  • Dolkart, L.A., Reimers, F.T. and Kuonen, C.A.: Discordant umbilical arteries: ultrasonographic and Doppler analysis. Obstet. Gynecol. 79:59–63, 1992.

    PubMed  CAS  Google Scholar 

  • Dombrowski, M.P., Budev, H., Wolfe, H.M., Sokol, R.J. and Perrin, E.: Fetal hemorrhage from umbilical cord hemangioma. Obstet. Gynecol. 70:439–442, 1987.

    PubMed  CAS  Google Scholar 

  • Doshi, N. and Klionsky, B.: Pathology of disseminated intravascular coagulation in the newborn. Lab. Invest. 40:303, 1979.

    Google Scholar 

  • Dreyfus, M., Magny, J.F., Bridey F., Schwarz, H.P., Planché, C., Dehan, M. and Tchernia, G.: Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. NEJM 325:1565–1568, 1991.

    PubMed  CAS  Google Scholar 

  • Drut, R. and Drut, R.M.: Pathology of the umbilical cord in adrenal fusion syndrome. Pediatr. Pathol. Molec. Med. 22:243–246, 2003.

    Article  Google Scholar 

  • Dudiak, C.M., Salomon, C.G., Posniak, H.V., Olson, M.C. and Flisak, M.E.: Sonography of the umbilical cord. RadioGraphics 15:1035–1050, 1995.

    PubMed  CAS  Google Scholar 

  • Dunn, P.M., Fraser, I.D. and Raper, A.B.: Influence of early cord ligation on the transplacental passage of foetal cells. J. Obstet. Gynaecol. Brit. Commonw. 73:757–760, 1966.

    CAS  Google Scholar 

  • Dyer, D.C.: Comparison of the constricting actions produced by serotonin and prostaglandins on isolated sheep umbilical arteries and veins. Gynecol. Invest. 1:204–209, 1970.

    PubMed  CAS  Google Scholar 

  • Earn, A.A.: The effect of congenital abnormalities of the umbilical cord and placenta on the newborn and mother: a survey of 5676 consecutive deliveries. J. Obstet. Gynaecol. Brit. Emp. 58:456–459, 1951.

    CAS  Google Scholar 

  • Eastman, N.J.: Editorial comments. Surg. Gynecol. Obstetr. 22:16, 1967.

    Google Scholar 

  • Eastman, N.J. and Hellman, L.M., eds.: Williams Obstetrics 12th ed. Appleton, New York, 1961.

    Google Scholar 

  • Eddleman, K.A., Lockwood, C.J., Berkowitz, G.S., Lapinski, R.H. and Berkowitz, R.L.: Clinical significance and sonographic diagnosis of velamentous umbilical cord insertion. Amer. J. Perinatol. 9:123–126, 1992.

    CAS  Google Scholar 

  • Editorial: Closure of umbilical blood-vessels. Lancet 2:381, 1966.

    Google Scholar 

  • Edmonds, H.W.: The spiral twist of the normal umbilical cord in twins and in singletons. Amer. J. Obstet. Gynecol. 67:102–120, 1954.

    CAS  Google Scholar 

  • Eggens, J.H. and Bruins, H.W.: An unusual case of fetal distress. Amer. J. Obstet. Gynecol. 148:219–220, 1984.

    CAS  Google Scholar 

  • Ellison, J.P.: The nerves of the umbilical cord in man and the rat. Amer. J. Anat. 132:53–60, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Ente, G., Penzer, P.H. and Kenigsberg, K.: Giant umbilical cord associated with patent urachus. Amer. J. Dis. Child. 120:82–83, 1970.

    PubMed  CAS  Google Scholar 

  • Feinstein, S.J., Lodeiro, J.G., Vintzileos, A.M., Weinbaum, P.J., Campbell, W.A. and Nochimson, D.J.: Intrapartum ultrasound diagnosis of nuchal cord as a decisive factor in management. Amer. J. Obstet. Gynecol. 153:308–309, 1985.

    CAS  Google Scholar 

  • Feldberg, D., Ben-David, M., Dicker, D., Samuel, N. and Goldman, J.: Hematoma of the umbilical cord with acute antepartum fetal distress. A case report. J. Reprod. Med. 31:65–66, 1986.

    PubMed  CAS  Google Scholar 

  • Ferrazzi, E., Brambati, B., Lanzani, A., Oldrini, A., Stripparo, L., Guerneri, A. and Makowski, E.L.: The yolk sac in early pregnancy failure. Amer. J. Obstet. Gynecol. 158:137–142, 1988.

    CAS  Google Scholar 

  • Fisk, N.M., Maclachlan, N., Ellis, C., Tannirandorn, Y., Tonge, H.M. and Rodeck, C.H.: Absent end-diastolic flow in first trimester umbilical artery. Lancet 2:1256–1257, 1988.

    Article  PubMed  CAS  Google Scholar 

  • Fletcher, S.: Chirality in the umbilical cord. Brit. J. Obstetr. Gynaecol. 100:234–236, 1993.

    CAS  Google Scholar 

  • Fok, R.Y., Pavlova, Z., Benirschke, K., Paul, R.H. and Platt, L.D.: The correlation of arterial lesions with umbilical artery Doppler velocimetry in placentas of small-for-dates pregnancies. Obstet. Gynecol. 75:578–583, 1990.

    PubMed  CAS  Google Scholar 

  • Foldes, J.J.: Spontaneous intrauterine rupture of the umbilical cord: report of a case. Obstet. Gynecol. 9:608–609, 1957.

    PubMed  CAS  Google Scholar 

  • Fortune, D.W. and Östör, A.G.: Umbilical artery aneurysm. Amer. J. Obstet. Gynecol. 131:339–340, 1978.

    CAS  Google Scholar 

  • Fortune, D.W. and Östör, A. G.: Angiomyxomas of the umbilical cord. Obstet. Gynecol. 55:375–378, 1980.

    PubMed  CAS  Google Scholar 

  • Fox, H.: Thrombosis of foetal arteries in the human placenta. J. Obstet. Gynaecol. Brit. Commonw. 73:961–965, 1966.

    CAS  Google Scholar 

  • Fox, H.: Abnormalities of the foetal stem arteries in the human placenta. J. Obstet. Gynaecol. Brit. Commonw. 74:734–738, 1967.

    CAS  Google Scholar 

  • Fox, H.: Pathology of the Placenta. Saunders, London, 1978.

    Google Scholar 

  • Fox, H.: Pathology of the Placenta. 2nd edition. Saunders, London, 1997.

    Google Scholar 

  • Fox, H. and Jacobson, H.N.: Innervation of the human umbilical cord and umbilical vessels. Amer. J. Obstet. Gynecol. 103:384–389, 1969.

    CAS  Google Scholar 

  • Fox, H. and Khong, T.Y.: Lack of innervation of human umbilical cord. An immunohistochemical and histochemical study. Placenta 11:59–62, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Fribourg, S.: Cord length and complications. Obstet. Gynecol. 58:533, 1981.

    PubMed  CAS  Google Scholar 

  • Fries, M.H., Goldstein, R.B., Kilpatrick, S.J., Golbus, M.S., Callen, P.W. and Filly, R.A.: The role of velamentous cord insertion in the etiology of twin-twin transfusion syndrome. Obstet. Gynecol. 81:569–574, 1993.

    PubMed  CAS  Google Scholar 

  • Froehlich, L.A. and Fujikura, T.: Significance of a single umbilical artery: report from the collaborative study of cerebral palsy. Amer. J. Obstet. Gynecol. 94:274–279, 1966.

    CAS  Google Scholar 

  • Fujikura, T.: Fused umbilical arteries near placental cord insertion. Amer. J. Obstet. Gynecol. 188:765–767, 2003.

    Article  Google Scholar 

  • Fujikura, T. and Benson, R.C.: Placentitis and fibrous occlusion of fetal vessels in the placenta of stillborn infants. Amer. J. Obstet. Gynecol. 89:225–229, 1964.

    CAS  Google Scholar 

  • Fujikura, T. and Carleton, J. H.: Unilateral thickening of fetal arteries on the placenta resembling arteriosclerosis. Amer. J. Obstet. Gynecol. 100:843–845, 1968.

    CAS  Google Scholar 

  • Fujikura, T. and Hosoda, Y.: Unilateral thickening of placental fetal veins. Placenta 11:241–245, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Fujinaga, M., Chinn, A. and Shepard, T.H.: Umbilical cord growth in human and rat fetuses: evidence against the “stretch hypothesis.” Teratology. 41:333–339, 1990.

    Article  PubMed  CAS  Google Scholar 

  • Gad, C.: A case of haemorrhage in labour from a placental vessel causing foetal death. Acta Obstet. Gynecol. Scand. 47:342–344, 1968.

    PubMed  CAS  Google Scholar 

  • Galle, P.C. and Meis, P.J.: Complications of amniocentesis: a review. J. Reprod. Med. 27:149–155, 1982.

    PubMed  CAS  Google Scholar 

  • Gardiner, J.P.: The umbilical cord: normal length; Length in cord complications; etiology and frequency of coiling. Surg. Gynecol. Obstet. 34:252–256, 1922.

    Google Scholar 

  • Gardner, D.G., Hedges, B.K., Lapointe, M.C. and Deschapper, C.F.: Expression of the atrial natriuretic peptide gene in human fetal heart. J. Clin. Endocrinol. Metab. 69:729–737, 1989.

    Article  PubMed  CAS  Google Scholar 

  • Gardner, R.F.R. and Trussell, R.R.: Ruptured hematoma of the umbilical cord. Obstet. Gynecol. 24:791–793, 1964.

    PubMed  CAS  Google Scholar 

  • Gassner, C.B. and Paul, R.H.: Laceration of umbilical cord vessels secondary to amniocentesis. Obstet. Gynecol. 48:627–630, 1976.

    PubMed  CAS  Google Scholar 

  • Gebrane-Younes, J., Minh, H.N. and Orcel, L.: Ultrastructure of human umbilical vessels: a possible role in amniotic fluid formation? Placenta 7:173–185, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Genest, D.R.: Estimating the time of death in stillborn fetuses: II. Histologic evaluation of the placenta; a study of 71 stillborns. Obstet. Gynecol. 80:585–592, 1992.

    PubMed  CAS  Google Scholar 

  • Gerlach, H.: Kongenitales Nabelarterienaneurysma. Z. Allg. Pathol. 111:420–423, 1968.

    CAS  Google Scholar 

  • Ghezzi, F., Raio, L. Di Naro, E., Franchi, M., Balestreri, D. and D’Addario, V.: Nomogram of Wharton’s jelly as depicted in the sonographic cross section of the umbilical cord. Ultrasound Obstet. Gynecol. 18:121–125, 2001a.

    Article  PubMed  CAS  Google Scholar 

  • Ghezzi, F., Raio, L., Di Naro, E., Franchi, M., Bruhwiler, H., D’Addario, V. and Schneider, H.: First-trimester sonographic umbilical cord diameter and the growth of the human embryo. Ultrasound Obstet. Gynecol. 18:348–351, 2001b.

    Article  PubMed  CAS  Google Scholar 

  • Ghezzi, F., Raio, L., Di Naro, E., Franchi, M., Buttarelli, M. and Schneider, H.: First-trimester umbilical diameter: a novel marker of fetal aneuploidy. Ultrasound Obstet. Gynecol. 19:235–239, 2002.

    Article  PubMed  CAS  Google Scholar 

  • Ghezzi, F., Raio, L., Di Naro, E., Franchi, M., Cromi, A. and Durig, P.: Single and multiple umbilical cord cysts in early gestation: two different entities. Ultrasound Obstet. Gynecol. 21:215–219, 2003.

    Article  PubMed  CAS  Google Scholar 

  • Ghosh, K.G., Ghosh, S.N. and Gupta, A.B.: Tensile properties of human umbilical cord. Indian J. Med. Res. 79:538–541, 1984.

    PubMed  CAS  Google Scholar 

  • Giacoia, G.P.: Body stalk anomaly: Congenital absence of the umbilical cord. Obstet. Gynecol. 80:527–529, 1992.

    PubMed  CAS  Google Scholar 

  • Giacomello, F.: Ultrasound determination of nuchal cord in breech presentation. Amer. J. Obstet. Gynecol. 159:531–532, 1988.

    CAS  Google Scholar 

  • Gianopoulos, J., Carver, T., Tomich, P.G., Karlman, R. and Gadwood, K.: Diagnosis of vasa previa with ultrasonography. Obstet. Gynecol. 69:488–491, 1987.

    PubMed  CAS  Google Scholar 

  • Gilbert, E.: The short cord syndrome. Pediatr. Pathol. 5:96, 1986.

    Google Scholar 

  • Gilbert-Barness, E., Drut, M.R., Grange, D.K. and Opitz, J.M.: Developmental abnormalities resulting in short umbilical cord. Birth Defects: Original Article Series 29(1):113–140, 1993.

    CAS  Google Scholar 

  • Giles, R.C., Donahue, J.M., Hong, C.B., Tuttle, P.A., Petrites-Murphy, M.B., Poonacha, K.B., Roberts, M.S., Tramontin, R.R., Smith, B. and Swerczek, T.W.: Causes of abortion, stillbirth, and perinatal death in horses: 3,527 cases (1986–1991). J. Amer. Vet. Med. Assoc. 203:1170–1175, 1993.

    CAS  Google Scholar 

  • Giles, W., O’Callaghan, S., Read, M., Gude, N., King, R. and Brennecke, S.: Placental nitric oxide synthase activity and abnormal umbilical artery flow velocity waveforms. Obstet. Gynecol. 89:49–52, 1997.

    Article  PubMed  CAS  Google Scholar 

  • Gill, P. and Jarjoura, D.: Wharton’s jelly in the umbilical cord: a study of its quantitative variations and clinical correlates. J. Reprod. Med. 38:611–614, 1993.

    PubMed  CAS  Google Scholar 

  • Glanfield, P.A. and Watson, R.: Intrauterine death due to umbilical cord torsion. Arch. Pathol. Lab. Med. 110:357–358, 1986.

    PubMed  CAS  Google Scholar 

  • Goerttler, K.: Die Bedeutung der funktionellen Struktur der Gefäßwand. I. Untersuchungen an der Nabelschnurarterie des Menschen. Gegenbaurs Morphol. Jahrb. 91:368–393, 1951.

    Google Scholar 

  • Golden, A.S.: Umbilical cord-Placental separation: a complication of IUD failure. J. Reprod. Med. 11:79–80, 1973.

    PubMed  CAS  Google Scholar 

  • Gonzalez-Crussi, F. and Roth, L.M.: The human yolk sac and yolk sac carcinoma. Hum. Pathol. 7:675–691, 1976.

    PubMed  CAS  Google Scholar 

  • Goodlin, R.C.: Fetal dysmaturity, “lean cord”, and fetal distress. Amer. J. Obstet. Gynecol. 156:1357, 1987.

    CAS  Google Scholar 

  • Goodlin, R.C. and Clewell, W.H.: Sudden fetal death following amniocentesis. Amer. J. Obstet. Gynecol. 118:285–288, 1974.

    CAS  Google Scholar 

  • Grange, D.K., Arya, S., Opitz, J.M., Laxova, R., Herrmann, J. and Gilbert, E.F.: The short umbilical cord. Birth Defects 23:191–214, 1987.

    PubMed  CAS  Google Scholar 

  • Grant, A., Elbourne, D., Valentin, L. and Alexander, S.: Routine formal fetal movement counting and risk of antepartum late death in normally formed singletons. Lancet. ii:345–349, 1989.

    Article  Google Scholar 

  • Graumann, W.: Polysaccharide. Ergebnisse der Polysaccharidhistochemie: Mensch und Säugetier. In, Handbuch der Histochemie, Vol. II/2. W. Graumann and K. Neumann, eds. Fischer, Stuttgart, 1964.

    Google Scholar 

  • Grieco, A.: Rilievi clinico-statistici sulla inserzione velamentosa ed a racchetta del cordone ombellicale. Monit. Ostet.-Ginecol. Endocrin. Metabol. 8:89–102, 1936.

    Google Scholar 

  • Grosser, O.: Frühentwicklung, Eihautbildung und Placentation des Menschen und der Säugetiere. J.F. Bergmann, München, 1927.

    Google Scholar 

  • Gruber, F.H.: Gas in the umbilical vessels as a sign of fetal death. Radiology 89:881–882, 1967.

    PubMed  CAS  Google Scholar 

  • Gruenwald, P.: The amount of fetal blood remaining in the placenta at birth. Proc. Soc. Exp. Biol. Med. 130:326–329, 1969.

    PubMed  CAS  Google Scholar 

  • Gu, J., Pinheiro, J.M.B., Yu, C.Z., D’Andrea, M., Muralidharan, S. and Malik, A.: Detection of endothelin-like immunoreactivity in epithelium and fibroblasts of the human umbilical cord. Tissue and Cell 23:437–444, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Guidetti, A.A., Divon, M.Y., Cavaleri, R.L., Langer, O. and Merkatz, I.R.: Fetal umbilical artery flow velocimetry in post-date pregnancies. Amer. J. Obstet. Gynecol. 157:1521–1523, 1987.

    CAS  Google Scholar 

  • Habek, D., Habek, J.C., Barbir, A., Barbir, M. and Granic, P.: Fetal grasping of the umbilical cord and perinatal outcome. Arch. Gynecol. Obstet. 268:274–277, 2003.

    Article  PubMed  Google Scholar 

  • Hall, S.P.: The thin cord syndrome. A review with a report of two cases. Obstet. Gynecol. 18:507–509, 1961.

    PubMed  CAS  Google Scholar 

  • Harding, J.A., Lewis, D.F., Major, C.A., Crade, M., Patel, J. and Nageotte, M.P.: Color glow Doppler—a useful instrument in the diagnosis of vasa previa. Amer. J. Obstet. Gynecol. 163:1566–1568, 1990.

    CAS  Google Scholar 

  • Hartman, K.R., Rawlings, J.S. and Feingold, M.: Protein C deficiency. Amer. J. Dis. Child. 144:1353–1354, 1990.

    PubMed  CAS  Google Scholar 

  • Harold, J.G., Siegel, R.J., Fitzgerald, G.A., Satoh, P. and Fishbein, M.C.: Differential prostaglandin production by human umbilical vasculature. Arch. Pathol. Lab. Med. 112:43–46, 1988.

    PubMed  CAS  Google Scholar 

  • Harris, L.E. and Wenzl, J.E.: Heterotopic pancreatic tissue and intestinal mucosa in the umbilical cord. NEJM 268:721–722, 1963.

    PubMed  CAS  Google Scholar 

  • Hathout, H.: The vascular pattern and mode of insertion of the umbilical cord in abortion material. J. Obstet. Gynaecol. Brit. Commonw. 71:963–964, 1964.

    CAS  Google Scholar 

  • Heckmann, U., Cornelius, H.V. and Freudenberg, V.: Das Teratom der Nabelschnur. Ein kasuistischer Beitrag zu den echten Tumoren der Nabelschnur. Geburtsh. Frauenheilk. 32:605–607, 1972.

    PubMed  CAS  Google Scholar 

  • Heifetz, S.A.: Single umbilical artery: a statistical analysis of 237 autopsy cases and review of the literature. Perspect. Pediatr. Pathol. 8:345–378, 1984.

    PubMed  CAS  Google Scholar 

  • Heifetz, S.A.: Thrombosis of the umbilical cord: analysis of 52 cases and literature review. Pediatr. Pathol. 8:37–54, 1988.

    PubMed  CAS  Google Scholar 

  • Heifetz, S.A.: The umbilical cord: obstetrically important lesions. Clin. Obstet. Gynecol. 39:571–587, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Heifetz, S.A. and Rueda-Pedraza, M.E.: Omphalomesenteric duct cysts of the umbilical cord. Pediatr. Pathol. 1:325–335, 1983a.

    PubMed  CAS  Google Scholar 

  • Heifetz, S.A. and Rueda-Pedraza, M.E.: Hemangiomas of the umbilical cord. Pediatr. Pathol. 1:385–398, 1983b.

    PubMed  CAS  Google Scholar 

  • Heinonen, S., Ryynänen, M., Kirkinen, P. and Saarikoski, S.: Perinatal diagnostic evaluation of velamentous umbilical cord insertion: clinical, Doppler, and ultrasonic findings. Obstet. Gynecol. 87:112–117, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Hempel, E.: Die ultrastrukturelle Differenzierung des menschlichen Amnionepithels unter besonderer Berücksichtigung des Nabelstrangs. Anat. Anz. 132:356–370, 1972.

    PubMed  CAS  Google Scholar 

  • Hemsen, A., Gillis, C., Larsson, O., Haegerstrand, A. and Lundberg J.M.: Characterization, localization and actions of endothelins in umbilical vessels and placenta. Acta Physiol. Scand. 143:395–404, 1991.

    PubMed  CAS  Google Scholar 

  • Herberz, O.: Über die Insertio furcata funiculi umbilicalis. Acta Obstet. Gynecol. Scand. 18:336–351, 1938.

    Google Scholar 

  • Herman, A., Zabow, P., Segal, M., Ron-el, R., Bukovsky, Y. and Caspi, E.: Extremely large number of twists of the umbilical cord causing torsion and intrauterine fetal death. Intern. J. Gynaecol. Obstet. 35:165–167, 1991.

    Article  CAS  Google Scholar 

  • Herrmann, U.J. and Sidiropoulos, D.: Single umbilical artery: prenatal findings. Prenat. Diagn. 8:275–280, 1988.

    PubMed  Google Scholar 

  • Hersh, J. and Buchino, J.J.: Umbilical cord torsion/constriction sequence. In, Proceedings of the Greenwood Genetics Conference Vol. 7. R.A. Saul, ed., pp. 181–182, Jacobs Press, Clinton, SC, 1988.

    Google Scholar 

  • Hershkovitz, R., Silberstein, T., Sheiner, E., Shoham-Vardi, I., Holcberg, G., Katz, M. and Mazor, M.: Risk factors associated with true knots of the umbilical cord. Europ. J. Obstet. Gynecol. Reprod. Biol. 98:36–39, 2001.

    Article  CAS  Google Scholar 

  • Hertig, A.T.: The placenta: Some new knowledge about an old organ. Obstet. Gynecol. 20:859–866, 1962.

    PubMed  CAS  Google Scholar 

  • Hertig, A.T.: Human Trophoblast. Charles C Thomas, Springfield, IL, 1968.

    Google Scholar 

  • Hey, A. und Röckelein, G.: Die sogenannten Endothelvakuolen der Plazentagefäße—Physiologie oder Krankheit. Pathologe 10:66–67, 1989.

    PubMed  CAS  Google Scholar 

  • Hill, L.M., DiNofrio, D.M. and Guzick, D.: Sonographic determination of first trimester umbilical cord length. J. Clin. Ultrasound 22:435–438, 1994a.

    PubMed  CAS  Google Scholar 

  • Hill, L.M., Mills, A., Peterson, C. and Boyles, D.: Persistent right umbilical vein: sonographic detection and subsequent neonatal outome. Obstet. Gynecol. 84:923–925, 1994b.

    PubMed  CAS  Google Scholar 

  • Hinson, R.M., Biswas, A., Mizelle, K.M. and Tunnessen, W.W.: Persistent omphalomesenteric duct. Arch. Pediatr. Adolesc. Med. 151:1161–1162, 1997.

    PubMed  CAS  Google Scholar 

  • Hitschold, T.P.: Doppler flow velocity waveforms of the umbilical arteries correlate with intravillous blood volume. Amer. J. Obstet. Gynecol. 179:540–543, 1998.

    Article  CAS  Google Scholar 

  • Hitschold, T., Weiss, E., Beck, T., Hüntefering, H. and Berle, P.: Low target birth weight or growth retardation? Umbilical Doppler flow velocity waveforms and histometric analysis of fetoplacental vascular tree. Amer. J. Obstetr. Gynecol. 168:1260–1264, 1993.

    CAS  Google Scholar 

  • Hoag, R.W.: Fetomaternal hemorrhage associated with umbilical vein thrombosis. Amer. J. Obstet. Gynecol. 154:1271–1274, 1986.

    CAS  Google Scholar 

  • Hobel, C.J., Emmanouilides, G.C., Townsend, D.E. and Yashiro, K.: Ligation of one umbilical artery in the fetal lamb: experimental production of fetal malnutrition. Obstet. Gynecol. 36:582–588, 1970.

    PubMed  CAS  Google Scholar 

  • Hoboken, W.: Anatomia secundinae. Ribbium, Ultrajecti, 1669.

    Google Scholar 

  • Hof, J. ten, Nijhuis, I.J.M., Nijhuis, J.G., Narayan, H., Taylor, D.J., Visser, G.H.A. and Mulder, E.J.H.: Quantitative analysis of fetal general movements: methodological considerations. Early Human Devel. 56:57–73, 1999.

    Article  Google Scholar 

  • Hong, C.B., Donahue, J.M., Giles, R.C., Petrites-Murphy, M.B., Poonacha, K.B., Roberts, A.W., Smith, B.J., Tramontin, R.R., Tuttle, P.A. and Swerczek, T.W.: Equine abortion and stillbirth in central Kentucky during 1988 and 1989 foaling seasons. J. Vet. Diagn. Invest. 5:560–566, 1993.

    PubMed  CAS  Google Scholar 

  • Horwitz, S.T., Finn, W.F. and Mastrota, V.F.: A study of umbilical cord encirclement. Amer. J. Obstet. Gynecol. 89:970–974, 1964.

    CAS  Google Scholar 

  • Howorka, E. and Kapczynski, W.: Unusual thickness of the fetal end of the umbilical cord. J. Obstet. Gynaecol. Brit. Commonw. 78:283, 1971.

    CAS  Google Scholar 

  • Hoyes, A.D.: Ultrastructure of the epithelium of the human umbilical cord. J. Anat. 105:149–162, 1969.

    PubMed  CAS  Google Scholar 

  • Hoyme, H.E., Jones, K.L., Allen, M.I.V., Saunders, B.S. and Benirschke, K.: Vascular pathogenesis of transverse limb reduction defects. J. Pediatr. 101:839–843, 1982.

    Article  PubMed  CAS  Google Scholar 

  • Hyrtl, J.: Die Blutgefäße der menschlichen Nachgeburt in normalen und abnormen Verhältnissen. Braumüller, Wien, 1870.

    Google Scholar 

  • Ikeda, T., Murata, Y., Quilligan, E.J., Choi, B.H., Parer, J.T., Dol, S. and Park, S.D.: Physiologic and histologic changes in near-term fetal lambs exposed to asphyxia by partial umbilical cord occlusion. Amer. J. Obstet. Gynecol. 178:24–32, 1998.

    Article  CAS  Google Scholar 

  • Inglis, C.G., Kingdom, J.C.P. and Nelson D.M.: Atrial natriuretic hormone: a paracrine or endocrine role within the human placenta? JCEM 76:1014–1018, 1993.

    PubMed  CAS  Google Scholar 

  • Irani, P.K.: Haematoma of the umbilical cord. Brit. Med. J. ii:1436–1437, 1964.

    Google Scholar 

  • Ivemark, B.I., Lagergren, C. and Ljungqvist, A.: Generalized arterial calcification associated with hydramnios in two stillborn infants. Acta Paediatr. [Suppl.] (Stockh.) 135:103–110, 1962.

    Google Scholar 

  • James, J.D. and Nickerson, C.W.: Laceration of umbilical artery and abruptio placentae secondary to amniocentesis. Obstet. Gynecol. 48s:44s–45s, 1976.

    Google Scholar 

  • Janosco, E.O., Lona, J.Z. and Belin, R.P.: Congenital anomalies of the umbilicus. Amer. Surg. 43:177–185, 1977.

    Google Scholar 

  • Jauniaux, E., Donner, C., Simon, P., Vanesse, M., Hustin, J. and Rodesch, F.: Pathological aspects of the umbilical cord after percutaneous umbilical blood sampling. Obstet. Gynecol. 73:215–218, 1989a.

    PubMed  CAS  Google Scholar 

  • Jauniaux, E., De Munter, C., Vanesse, M., Wilkin, P. and Hustin, J.: Embryonic remnants of the umbilical cord: morphologic and clinical aspects. Hum. Pathol. 20:458–462, 1989b.

    Article  PubMed  CAS  Google Scholar 

  • Javert, C.T. and Barton, B.: Congenital and acquired lesions of the umbilical cord and spontaneous abortion. Amer. J. Obstet. Gynecol. 63:1065–1077, 1952.

    CAS  Google Scholar 

  • Jimenez, E., Unger, M., Vogel, M., Lobeck, H., Wagner, G., Schwiermann, J., Schäfer, A. und Grosch-Wörner, I.: Morphologische Untersuchungen an Plazenten HIV-positiver Mütter. Pathologe 9:228–234, 1988.

    PubMed  CAS  Google Scholar 

  • Jogee, M., Myatt, L. and Elder, M.G.: Decreased prostacyclin production by placental cells in culture from pregnancies complicated by fetal growth retardation. Brit. J. Obstet. Gynaecol. 90:247–250, 1983.

    CAS  Google Scholar 

  • Jones, C.J.P., Jauniaux, E. and Campbell, S.: Development and degeneration of the secondary human yolk sac. Placenta 14:A32, 1993.

    Article  Google Scholar 

  • Jones, K.P., Wheater, A.W. and Musgrave, W.: Simple test for bleeding from vasa previa. Lancet 2:1430–1431, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Jones, T.B., Sorokin, Y., Bhatia, R., Zador, I.E. and Bottoms, S.F.: Single umbilical artery: Accurate diagnosis? Amer. J. Obstet. Gynecol. 169:538–540, 1993.

    CAS  Google Scholar 

  • Kalish, R.B., Hunter, T., Sharma, G. and Baergen, R.N.: Clinical significance of the umbilical cord twist. Amer. J. Obstet. Gynecol. 189:736–739, 2003.

    Article  Google Scholar 

  • Kan, P.S. and Eastman, N.J.: Coiling of the umbilical cord around the foetal neck. J. Obstet. Gynaecol. Brit. Emp. 64:227–228, 1957.

    Google Scholar 

  • Kaneko, M., White, S., Homan, J. and Richardson, B.: Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus. Amer. J. Obstet. Gynecol. 188:961–972, 2003.

    Article  Google Scholar 

  • Kaplan, C., August, D. and Mizrachi, H.: Single umbilical artery and cord accidents. Modern Pathol. 3(1):4P (Abstract No. 17), 1990.

    Google Scholar 

  • Karbowski, B., Bauch, H.J. and Schneider, H.P.G.: Functional differentiation of umbilical vein endothelial cells following pregnancy complicated by smoking or diabetes mellitus. Placenta 12:405, 1991.

    Google Scholar 

  • Katz, V., Blanchard, G., Dingman, C., Bowes, W.A. and Cefalo, R.C.: Atenolol and short umbilical cords. Amer. J. Obstet. Gynecol. 156:1271–1272, 1987.

    CAS  Google Scholar 

  • Katz, Z., Shosham, Z., Lancet, M., Blickstein, I., Mogilner, B.M. and Zalel, Y.: Management of labor with umbilical cord prolapse: a 5-year study. Obstet. Gynecol. 72:278–280, 1988.

    PubMed  CAS  Google Scholar 

  • Kelber, R.: Gespaltene “solitäre” Nabelschnurarterie. Arch. Gynäkol. 220:319–323, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Kernbach, M.: Das neuroektoblastische System der Plazenta des Menschen. Anat. Anz. 113:259–269, 1963.

    Google Scholar 

  • Kernbach, M.: Existe-t-il du tissu nerveux dans le placenta? Rev. Fr. Gynécol. 64:357–361, 1969.

    CAS  Google Scholar 

  • Kessler, A.: Blutungen aus den Nabelschnurgefässen in der Schwangerschaft. Gynaecologia 150:353–365, 1960.

    PubMed  CAS  Google Scholar 

  • Khong, T.Y. and Dilly, S.A.: Calcification of umbilical artery: two distinct lesions. J. Clin. Pathol. 42:931–934, 1989.

    PubMed  CAS  Google Scholar 

  • Khoury, A.D., Moretti, M.L., Barton, J.R., Shaver, D.C. and Sibai, B.M.: Fetal blood sampling in patients undergoing elective cesarean section: a correlation with cord blood gas values obtained at delivery. Amer. J. Obstet. Gynecol. 165:1026–1029, 1991.

    CAS  Google Scholar 

  • Khurana, A., Huettner, P.C. and Cole, F.S.: Umbilical cord ulceration as a cause of hypoxic-ischemic encephalopathy: report of a case and review of the literature. J. Perinatol. 15:423–425, 1995.

    PubMed  CAS  Google Scholar 

  • King, D.L.: Placental migration demonstrated by ultrasonography: a hypothesis of dynamic placentation. Radiology 109:167–170, 1973.

    PubMed  CAS  Google Scholar 

  • King, E.L.: Intrauterine death of the fetus due to abnormalities of the umbilical cord: report of three cases. Amer. J. Obstet. Gynecol. 12:812–816, 1926.

    Google Scholar 

  • King, S.: Patent omphalomesenteric duct. Arch. Surg. 96:545–548, 1968.

    Google Scholar 

  • Kishore, N. and Sarkar, S.C.: The arterial patterns of placenta. A postpartum radiological study. J. Obstet. Gynaecol. India 17:9–13, 1967.

    Google Scholar 

  • Kjeldsen, J. and Pedersen, J.: Relation of residual placental blood-volume to onset of respiration and the respiratorydistress syndrome in infants of diabetic and non-diabetic mothers. Lancet 1:180–184, 1967.

    Article  PubMed  CAS  Google Scholar 

  • Klebe, J.G. and Ingomar, C.J.: Placental transfusion in infants of diabetic mothers elucidated by placental residual blood volume. Acta Paediatr. (Stockh.) 63:59–64, 1974a.

    CAS  Google Scholar 

  • Klebe, J.G. and Ingomar, C.J.: The influence of the method of delivery and the clamping technique on the red cell volume in infants of diabetic and non-diabetic mothers. Acta Paediatr. (Stockh.) 63:65–69, 1974b.

    CAS  Google Scholar 

  • Korst, L.M., Phelan, J.P., Ahn, M.O. and Martin, G.I.: Nucleated red blood cells: An update on the marker for fetal asphyxia. Amer. J. Obstet. Gynecol. 175:843–846, 1996.

    Article  CAS  Google Scholar 

  • Kouyoumdjian, A.: Velamentous insertion of the umbilical cord. Obstet. Gynecol. 56:737–742, 1980.

    PubMed  CAS  Google Scholar 

  • Kraus, F.T.: Placenta: thrombosis of fetal stem vessels with fetal thrombotic vasculopathy and chronic villitis. Pediatr. Pathol. 16:143–148, 1996.

    Article  CAS  Google Scholar 

  • Kraus, F.T.: Cerebral palsy and thrombi in placental vessels of the fetus: insights from litigation. Human Pathol. 28:246–248, 1997.

    Article  CAS  Google Scholar 

  • Kreczy, A., Alge, A., Menardi, G., Gassner, I., Gschwendtner, A. and Mikuz, G.: Teratoma of the umbilical cord. Case report with review of the literature. Arch. Pathol. Lab. Med. 118:934–937, 1994.

    PubMed  CAS  Google Scholar 

  • Kreibich, Dr.: Über eine grosse Urachuscyste bei einer 80 jährigen Frau. Zentralbl. Gynäkol. 69:523–528, 1947.

    PubMed  CAS  Google Scholar 

  • Kreyberg, L.: A teratoma-like swelling in the umbilical cord possibly of acardiac nature. J. Pathol. Bacteriol. 75:109–112, 1958.

    Article  PubMed  CAS  Google Scholar 

  • Kristiansen, F.V. and Nielsen, V.T.: Intra-uterine fetal death and thrombosis of the umbilical vessels. Acta Obstet. Gynecol. Scand. 64:331–334, 1985.

    Google Scholar 

  • Krone, H.-A.: Die Bedeutung der Nidationsstörungen für die Pathologie der Embryonalentwicklung. Bibl. Microbiol. Fasc. 1:111–116, 1960 (Wiener Colloqium: Pränatale Infektionen, 1959).

    CAS  Google Scholar 

  • Krone, H.-A.: Die Bedeutung der Plazenta für die Entstehung von Mißbildungen. Wien. Med. Wochenschr. 117:393–397, 1967.

    PubMed  CAS  Google Scholar 

  • Krone, H.A., Jopp, H. and Schellerer, W.: Die Bedeutung anamnestischer Befunde für die verschiedenen Formen des Nabelschnuransatzes. Z. Geburtsh. Gynäkol. 163:205–213, 1965.

    CAS  Google Scholar 

  • Laatikainen, T.J., Lehtonen, P.J. and Hesso, A.E.: Fetal sulfated and nonsulfated bile acids in intrahepatic cholestasis of pregnancy. J. Lab. Clin. Med. 92:185–193, 1978.

    PubMed  CAS  Google Scholar 

  • Labarrere, C., Sebastiani, M., Siminovich, M., Torassa, E. and Althabe, O.: Absence of Wharton’s jelly around the umbilical arteries: an unusual cause of perinatal mortality. Placenta 6:555–559, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Lachenmayer, L.: Adrenergic innervation of the umbilical vessels: light-and fluorescence microscopic studies. Z. Zellforsch. 120:120–136, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Lacro, R.V., Jones, K.L. and Benirschke, K.: The umbilical cord twist: origin, direction, and relevance. Amer. J. Obstet. Gynecol. 157:833–838, 1987.

    CAS  Google Scholar 

  • Lang, I., Hartmann, M., Blaschitz, A., Dohr, G., Skofitsch, G. and Desoye, G.: Immunohistochemical evidence for the heterogeneity of maternal and fetal vascular endothelial cells in human full-term placenta. Cell Tissue Res. 274:211–218, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Lange, I.R., Manning, F.A., Morrison, I., Chamberlain, P.F. and Harman, C.R.: Cord prolapse: is antenatal diagnosis possible. Amer. J. Obstet. Gynecol. 151:1083–1085, 1985.

    CAS  Google Scholar 

  • Las Heras, J. and Haust, D.: Ultrastructure of fetal stem arteries of human placenta in normal pregnancy. Virchows Arch. 393:133–144, 1981.

    Article  Google Scholar 

  • Lauweryns, J.M., deBruyn, M., Peuskens, J. and Bourgeois, N.: Absence of intrinsic innervation of the human placenta. Experientia 25:432, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Learmont, J.G. and Poston, L.: Nitric oxide is involved in flow-induced dilation of isolated human small fetoplacental arteries. Amer. J. Obstet. Gynecol. 174:583–588, 1996.

    Article  CAS  Google Scholar 

  • LeDonne, A.T. and McGowan, L.: Effect of an oxytocic on umbilical cord venous pressure. Obstet. Gynecol. 30:103–107, 1967.

    PubMed  CAS  Google Scholar 

  • Lee, G.K., Chi, J.G. and Cha, K.S.: An unusual venous anomaly of the placenta. Amer. J. Clin. Pathol. 95:48–51, 1991.

    CAS  Google Scholar 

  • Lee, M.C.L. and Aterman, K.: An intestinal polyp of the umbilical cord. Amer. J. Dis. Child. 116:320–323, 1968.

    PubMed  CAS  Google Scholar 

  • Lee, S.T. and Hon, E.H.: Fetal hemodynamic response to umbilical cord compression. Obstet. Gynecol. 22:553–562, 1963.

    PubMed  CAS  Google Scholar 

  • Leff, M.: Hemorrhage from a ruptured varicosity in the placenta causing the death of the fetus. Amer. J. Obstet. Gynecol. 22:117–118, 1931.

    Google Scholar 

  • Lehman, R.E.: Umbilical cord prolapse following external cephalic version with tocolysis. Amer. J. Obstet. Gynecol. 146:963–964, 1983.

    Google Scholar 

  • Leinzinger, E.: Varixthrombose der Nabelschnur. Z. Geburtsh. Gynäkol. 171:82–87, 1969.

    CAS  Google Scholar 

  • Leinzinger, E.: Totaler Nabelschnurabriss intra partum bei Hydramnion. Zentralbl. Gynäkol. 94:1233–1238, 1972.

    Google Scholar 

  • Lemtis, H.: Über eine seltene Nabelschnurmißbildung. Geburtsh. Frauenh. 26:986–993, 1966.

    Google Scholar 

  • Lemtis, H.: Über Aneurysmen im fetalen Gefäßapparat der menschlichen Plazenta. Arch. Gynäkol. 206:330–347, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Lenke, R.R., Ashwood, E.R., Cyr, D.R., Gravett, M., Smith, J.R. and Stenchever, M.A.: Genetic amniocentesis: significance of intraamniotic bleeding and placental location. Obstet. Gynecol. 65:798–801, 1985.

    PubMed  CAS  Google Scholar 

  • Leu, A.J. and Leu, H.J.: Spezielle Probleme bei der histologischen Altersbestimmung von Thromben und Emboli. Pathologe 10:87–92, 1989.

    PubMed  CAS  Google Scholar 

  • Leung, A.K.C. and Robson, W.L.M.: Single umbilical artery: a report of 159 cases Amer. J. Dis. Child. 143:108–111, 1989.

    PubMed  CAS  Google Scholar 

  • Levy, H., Meier, P.R. and Makowski, E.L.: Umbilical cord prolapse. Obstet. Gynecol. 64:499–502, 1984.

    PubMed  CAS  Google Scholar 

  • Lewinsky, R.M., Degani, S., Berger, H. and Spiegel, D.: Umbilical venous flow may be dependent on umbilical coiling. Amer. J. Obstet. Gynecol. 174:456 (abstract 539), 1996.

    Google Scholar 

  • Lin, A.E., Genest, D.R. and Brown, D.L.: Circumferential abdominal skin defect possibly due to umbilical cord encirclement. Teratology 60:258–259, 1999.

    Article  PubMed  CAS  Google Scholar 

  • Loquet, P., Broughton-Pipkin, F., Symonds, E.M. and Rubin, P.C.: Blood velocity waveforms and placental vascular formation. Lancet 2:1252–1253, 1988.

    Article  PubMed  CAS  Google Scholar 

  • Ludwig, K.: Ein weiterer Beitrag zum Bau der Gorilla-Placenta. Acta Anat. (Basel) 46:304–310, 1961.

    PubMed  CAS  Google Scholar 

  • Macara, L.M., Kingdom, J.C.P. and Kaufmann, P.: Control of the fetoplacental circulation. Fetal Maternal Med. Rev. 5:167–179, 1993.

    Article  Google Scholar 

  • Maclean, M.R., Templeton, A.G.B. and McGrath, J.C.: The influence of endothelin-1 on human foeto-placental blood vessels: a comparison with 5-hydroxytryptamine. Brit. J. Pharmacol. 106:937–941, 1992.

    CAS  Google Scholar 

  • Mäkilä, U.M., Jouppila, P., Kirkinen, P., Viinikka, L. and Ylikorkala, O.: Relation between umbilical prostacyclin production and blood-flow in the fetus. Lancet 1:728–729, 1983.

    Article  PubMed  Google Scholar 

  • Malicki, D., Behling, C.A., Benirschke, K. and Baergen, R.N.: The excessively long umbilical cord: a clinicopathologic study of 924 cases. Modern Pathol. 10:156A (abstract 923), 1997.

    Google Scholar 

  • Maher, J.T. and Conti, J.A.: A comparison of umbilical cord blood gas values between newborns with and without true knots. Obstet. Gynecol. 88:863–866, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Mallard, E.C., Gunn, A.J., Williams, C.E., Johnston, B.M. and Gluckman, P.D.: Transient umbilical cord occlusion causes hippocampal damage in fetal sheep. Amer. J. Obstet. Gynecol. 167:1423–1430, 1992.

    CAS  Google Scholar 

  • Malpas, P.: Length of the umbilical cord at term. Brit. Med. J. 1:673–674, 1964.

    PubMed  CAS  Google Scholar 

  • Malpas, P. and Symonds, E.M.: Observations on the structure of the human umbilical cord. Surg. Obstet. Gynecol. 123:746–750, 1966.

    CAS  Google Scholar 

  • Manci, E.A., Ulmer, D.R., Nye, D.M., Shah, A. and Mvumbi, L.: Variations in normal umbilical cord length following birth. Modern Pathol. 6:p6p, abstract 33, Pediatric Pathol., 1993.

    Google Scholar 

  • Marchetti, A.A.: A consideration of certain types of benign tumors of the placenta. Surg. Gynecol. Obstet. 68:733–743, 1939.

    Google Scholar 

  • Marcianiak, E., Wilson, H.D. and Marlar, R.A.: Neonatal purpura fulminans: a genetic disorder related to the absence of protein C in blood. Blood 65:15–20, 1985.

    Google Scholar 

  • Marco-Johnson, M.J., Marlar, R.A., Jacobson, L.J., Hays, T. and Warady, B.A.: Severe protein C deficiency in newborn infants. J. Pediatr. 113:359–363, 1988.

    Article  Google Scholar 

  • Masliah, E. and Wahl, C.: Umbilical cord stricture in a 21-week fetus. J. Perinatol. 24:48–49, 2004.

    Article  PubMed  Google Scholar 

  • Matheus, M. and Sala, M.A.: The importance of placental examination in newborns with single umbilical artery. Z. Geburtsh. Perinatol. 184:231–232, 1980.

    CAS  Google Scholar 

  • McCoshen, J.A., Tulloch, H.V. and Johnson, K.A.: Umbilical cord is the major source of prostaglandin E2 in the gestational sac during term labor. Amer. J. Obstet. Gynecol. 160:973–978, 1989.

    CAS  Google Scholar 

  • McCowan, L.M., Mullen, B.M. and Ritchie, K.: Umbilical artery flow velocity waveforms and the placental vascular bed. Amer. J. Obstet. Gynecol. 157:900–902, 1987.

    CAS  Google Scholar 

  • McCurdy, C., Anderson, C., Borjon, N., Brzechffa, P., Miller, H., McNamara, M., Newman, A. and Seeds, J.: Antenatal sonographic diagnosis of nuchal cord. Amer. J. Obstet. Gynecol. 170:(abstract 329), 366, 1994.

    Google Scholar 

  • McDermott, M. and Gillan, J.E.: Trophoblast basement membrane haemosiderosis in the placental lesion of fetal artery thrombosis: A marker for disturbance of maternofetal transfer? Placenta 16:171–178, 1995a.

    Article  PubMed  CAS  Google Scholar 

  • McDermott, M. and Gillan, J.E.: Chronic reduction in fetal blood flow is associated with placental infarction. Placenta 16:165–170, 1995b.

    Article  PubMed  CAS  Google Scholar 

  • McKay, D.G., Roby, C.C., Hertig, A.T. and Richardson, M.V.: Studies of the function of early human trophoblast. II. Preliminary observations on certain chemical constituents of chorionic and early amniotic fluid. Amer. J. Obstet. Gynecol. 69:735–741, 1955.

    CAS  Google Scholar 

  • McLennan, J.E.: Implications of the eccentricity of the human umbilical cord. Amer. J. Obstet. Gynecol. 101:1124–1130, 1968.

    CAS  Google Scholar 

  • McLennan, H., Price, E., Urbanska, M., Craig, N. and Fraser, M.: Umbilical cord knots and encirclements. Aust. N.Z. J. Obstet. Gynaecol. 28:116–119, 1988.

    PubMed  CAS  Google Scholar 

  • Merttens, J.: Beiträge zur normalen und pathologischen Anatomie der menschlichen Placenta. Z. Geburtsh. Gynäkol. 30:1–97, 1894.

    Google Scholar 

  • Messer, R.H., Gomez, A.R. and Yambao, T.J.: Antepartum testing for vasa previa: current standard of care. Amer. J. Obstet. Gynecol. 156:1459–1462, 1987.

    CAS  Google Scholar 

  • Meyenburg, M.: Gibt es Veränderungen des Plazentasitzes im Bereich kaudaler Uterusabschnitte während der Schwangerschaft? Eine echographische Verlaufsstudie. Geburtsh. Frauenheilk. 36:715–721, 1976.

    PubMed  CAS  Google Scholar 

  • Meyer, A.W.: On the structure of the human umbilical vesicle. Amer. J. Anat. 3:155–166, 1904.

    Article  Google Scholar 

  • Meyer, W.J., Blumenthal, L., Cadkin, A., Gauthier, D.W. and Rotmensch, S.: Vasa previa: Prenatal diagnosis with transvaginal color Doppler flow imaging. Amer. J. Obstet. Gynecol. 169:1627–1629, 1993.

    CAS  Google Scholar 

  • Meyer, W.W., Rumpelt, H.J., Yao, A.C. and Lind, J.: Structure and closure mechanisms of the human umbilical artery. Eur. J. Pediatr. 128:247–259, 1978.

    Article  PubMed  CAS  Google Scholar 

  • Mildenberger, E., Biesel, B., Siegel, G. and Versmold, H.T.: Nitric oxide and endothelin in oxygen-dependent regulation of vascular tone of human umbilical vein. Amer. J. Physiol. Heart Circ. Physiol. 285:H1730–H1737, 2003.

    CAS  Google Scholar 

  • Miller, M.E., Higginbottom, M. and Smith, D.A.: Short umbilical cord: its origin and relevance. Pediatrics 67:618–621, 1981.

    PubMed  CAS  Google Scholar 

  • Mills, J.L., Harley, E.E. and Moessinger, A.C.: Standards for measuring umbilical cord length. Placenta 4:423–426, 1983.

    Article  PubMed  CAS  Google Scholar 

  • Mishriki, Y.Y., Vanyshelbaum, Y., Epstein, H. and Blanc, W.: Hemangioma of the umbilical cord. Pediatr. Pathol. 7:43–49, 1987.

    PubMed  CAS  Google Scholar 

  • Mitchell, A.P.B., Anderson, G.S. and Russell, J.K.: Perinatal death from foetal exsanguination. Brit. Med. J. 1:611–614, 1957.

    PubMed  CAS  Google Scholar 

  • Mitchell, K.E., Weiss, M.L., Mitchell, B.M., Martin, P., Davis, D., Morales, L., Helwig, B., Beerenstrauch, M., Abou-Easa, K., Hildreth, T., Troyer, D. and Medicetty, S.: Matrix cells from Wharton’s jelly form neurons and glia. Stem Cells 21:50–60, 2003.

    PubMed  CAS  Google Scholar 

  • Mochizuki, M., Maruo, T., Masuko, K. and Ohtsu, T.: Effects of smoking on fetoplacental-maternal system during pregnancy. Amer. J. Obstet. Gynecol. 149:413–420, 1984.

    CAS  Google Scholar 

  • Moessinger, A.C., Blanc, W.A., Marone, P.A. and Polsen, D.C.: Umbilical cord length as an index of fetal activity: experimental study and clinical implications. Pediatr. Res. 16:109–112, 1982.

    PubMed  CAS  Google Scholar 

  • Moessinger, A.C., Mills, J.L., Harley, E.E., Ramakrishnan, R., Berendes, H.W. and Blanc, W.A.: Umbilical cord length in Down’s syndrome. Amer. J. Dis. Child. 140:1276–1277, 1986.

    PubMed  CAS  Google Scholar 

  • Moise, K.J., Carpenter, R.J., Huhta, J.C. and Deter, R.L.: Umbilical cord hematoma secondary to in utero intravascular transfusion for Rh isoimmunization. Fetal Ther. 2:65–70, 1987.

    PubMed  Google Scholar 

  • Moncrieff, D., Parker-Williams, J. and Chamberlain, G.: Placental drainage and fetomaternal transfusion. Lancet 2:453, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Monie, I.W.: Velamentous insertion of cord in early pregnancy. Amer. J. Obstet. Gynecol. 93:276–281, 1965.

    CAS  Google Scholar 

  • Monie, I.W. and Khemmani, M.: Absent and abnormal umbilical arteries. Teratology 7:135–142, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Moore, R.D.: Mast cells of the human umbilical cord. Amer. J. Pathol. 32:1179–1183, 1956.

    CAS  Google Scholar 

  • Murdoch, D.E.: Umbilical-cord doubling. Obstet. Gynecol. 27:555–557, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Mvumbi, L., Manci, E.A., Ulmer, D. and Shah, A.K.: Glycogen levels in human term placental disks, umbilical cords, and membranes. Pediatr. Path. Lab. Med. 16:597–605, 1996.

    Article  CAS  Google Scholar 

  • Myatt, L., Brockman, D.E., Eis, A.L.W. and Pollock, J.S.: Immunohistochemical localization of nitric oxide synthase in the human placenta. Placenta 14:487–495, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Naaktgeboren, C. and van Wagtendonk, A.M.: Wahre Knoten in der Nabelschnur nebst Bemerkungen über Plazentophagie bei Menschenaffen. Z. Säugetierk. 31:376–382, 1966.

    Google Scholar 

  • Nadkarni, B.B.: Innervation of the human umbilical artery: an electron-microscope study. Amer. J. Obstet. Gynecol. 107:303–312, 1970.

    CAS  Google Scholar 

  • Naeye, R.L.: Umbilical cord length: clinical significance. J. Pediatr. 107:278–281, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Naeye, R.L. and Tafari, N.:Noninfectious disorders of the placenta, fetal membranes and umbilical cord. In, Risk Factors in Pregnancy and Disease of the Fetus and Newborn. Williams and Wilkins, Baltimore, pp. 145–172, 1983.

    Google Scholar 

  • Nanaev, A.K., Shirinsky, V.P. and Birukov, K.G.: Immunofluorescent study of heterogeneity in smooth muscle cells of human fetal vessels using antibodies to myosin, desmin and vimentin. Cell Tissue Res. 266:535–540, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Nanaev, A.K., Domogatsky, S.P. and Milovanov, A.P.: Immunohistochemical study of the extracellular matrix and intermediate filaments in the human umbilical cord. Placenta 13:A48, 1992.

    Google Scholar 

  • Nanaev, A.K., Kohnen, G., Milovanov, A.P., Domogatsky, S.P. and Kaufmann, P.: Stromal differentiation and architecture of the human umbilical cord. Placenta 18:53–64, 1997.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, K.B. and Grether, J.K.: Potentially asphyxiating conditions and spastic cerebral palsy in infants of normal birth weight. Amer. J. Obstet. Gynecol. 179:507–513, 1998.

    Article  CAS  Google Scholar 

  • Newman, R.S., Spear, G.S. and Kirschbaum, N.: Postmortem DNA diagnosis of factor V Leiden in a neonate with systemic thrombosis and probable antithrombin deficiency. Obstet. Gynecol. 92:702–705, 1998.

    Article  PubMed  CAS  Google Scholar 

  • Newton, M. and Moody, A.R.: Fetal and maternal blood in the human placenta. Obstet. Gynecol. 18:305–308, 1961.

    PubMed  CAS  Google Scholar 

  • Ney, J.A., Fee, S.C., Dooley, S.L., Socol, M.L. and Minogue, J.: Factors influencing hemostasis after umbilical vein puncture in vitro. Amer. J. Obstet. Gynecol. 160:424–426, 1989.

    CAS  Google Scholar 

  • Nieder, J. and Link, M.: Ein Beitrag zur Pathologie der Nabelschnurgeschwülste. Z. Gynäkol. 92:420–428, 1970.

    CAS  Google Scholar 

  • Nielsen, T.P., Nelson, R.M., Lee-Green, B., Lowe, P.N. and Reese, L.A.: Patent urachus complicating pregnancy: a review and report of a case. Amer. J. Obstet. Gynecol. 143:61–68, 1982.

    CAS  Google Scholar 

  • Nikolov, S.D. and Schiebler, T.H.: Über das fetale Gefäßsystem der reifen menschlichen Placenta. Z. Zellforsch. 139:333–350, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Nolan, D.G., Martin, L.S., Natarajan, S. and Hume, R.F.: Fetal compromise associated with extreme fetal bile acidemia and maternal primary sclerosing cholangitis. Obstet. Gynecol. 84:695–696, 1994.

    PubMed  CAS  Google Scholar 

  • Nöldeke, H.: Geburtskomplikationen bei Insertio velamentosa. Zentralbl. Gynäkol. 58:351–356, 1934.

    Google Scholar 

  • Novack, A.H., Mueller, B. and Ochs, H.: Umbilical cord separation in the newborn. Amer. J. Dis. Child. 142:220–223, 1988.

    PubMed  CAS  Google Scholar 

  • Obolensky, W.: Durch Blasensprung bedingte Blutung aus dem Fötalkreislauf, ihre Erkennung und Verhütung. Gynaecologia 164:279–282, 1967.

    Google Scholar 

  • Ohyama, M., Itani, Y., Yamanaka, M., Imaizumi, K., Nishi, T., Ijiri, R. and Tanaka, Y.: Umbilical cord ulcer: a serious in utero complication of intestinal atresia. Placenta 21:432–435, 2000.

    Article  PubMed  CAS  Google Scholar 

  • Okatani, Y., Taniguchi, K. and Sagara, Y.: Amplifying effect of endothelin-1 on serotonin-induced vasoconstriction of human umbilical artery. Amer. J. Obstet. Gynecol. 172:1240–1245, 1995.

    Article  CAS  Google Scholar 

  • Omar, H.A., Figueroa, R., Omar, R.A. and Wolin, M.S.: Properties of an endogenous arachidonic acid-elicited relaxing mechanism in human placental vessels. Amer. J. Obstetr. Gynecol. 167:1064–1070, 1992.

    CAS  Google Scholar 

  • Ornoy, A., Crone, K. and Altshuler, G.: Pathological features of the placenta in fetal death. Arch. Pathol. Lab. Med. 100:367–371, 1976.

    PubMed  CAS  Google Scholar 

  • Otto, A.W.: Lehrbuch der pathologischen Anatomie des Menschen und der Thiere. Ruecker, Berlin, 1830.

    Google Scholar 

  • Ottow, B.: Interpositio velamentosa funiculi umbilicalis, eine bisher übersehene Nabelstranganomalie, ihre Entstehung und klinische Bedeutung. Arch. Gynäkol. 116:176–199, 1922.

    Article  Google Scholar 

  • Ottow, B.: Über die Insertio furcata der Nabelschnur. Arch. Gynäkol. 118:378–382, 1923.

    Article  Google Scholar 

  • Oudesluys-Murphy, A.M., Eilers, G.A.M. and deGroot, C.J.: The time of separation of the umbilical cord. Eur. J. Pediatr. 146:387–389, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Painter, D. and Russell, P.: Four-vessel umbilical cord associated with multiple congenital anomalies. Obstet. Gynecol. 50:505–507, 1977.

    PubMed  CAS  Google Scholar 

  • Panigel, M.: Réactions vaso-motrices de l’arbre vasculaire foetal au cours de la perfusion de cotylédons placentaires isolés maintenus en survie. C. R. Acad. Sci. (Paris) 255:3238–3240, 1962.

    Google Scholar 

  • Panizza, V.H., Alvarez, H. and Benedetti, W.L.: The in vitro contractility of the human placental chorial vessels. J. Reprod. Med. 26:478–482, 1981.

    PubMed  CAS  Google Scholar 

  • Panter, K.R. and Hannah, M.E.: Umbilical cord prolapse: so far so good? Lancet 347:74, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Papaloucas, A., Avgoustiniatos, J. and Paisios, P.: Innervation of the umbilical cord in full term foetuses. IRCS Med. Sci. Anat. Hum. Biol. 3:117–118, 1975.

    Google Scholar 

  • Parilla, B.V., Tamura, R.K., MacGregor, S.N., Geibel, L.J. and Sabbagha, R.E.: The clinical significance of a single umbilical artery as an isolated finding on prenatal ultrasound. Obstet. Gynecol. 85:570–572, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Parry, E.W.: Some electron microscope observation on the mesenchymal structures of full-term umbilical cord. J. Anat. 107:505–518, 1970.

    PubMed  CAS  Google Scholar 

  • Parry, E.W. and Abramovich, D.R.: Some observations on the surface layer of full-term human umbilical cord epithelium. J. Obstet. Gynaecol. Brit. Commonw. 77:878–884, 1970.

    CAS  Google Scholar 

  • Parry, E.W. and Abramovich, D.R.: The ultrastructure of human umbilical vessel endothelium from early pregnancy to full term. J. Anat. 111:29–42, 1972.

    PubMed  CAS  Google Scholar 

  • Patel, D., Dawson, M., Kalyanam, P., Lungus, E., Weiss, H., Flaherty, E. and Nora, E.G.: Umbilical cord circumference at birth. Amer. J. Dis. Child. 143:638–639, 1989.

    PubMed  CAS  Google Scholar 

  • Pavlopoulos, P.M., Konstantinidou, A.E., Agapitos, E., Christodoulou, C.N. and Davaris, P.: Association of single umbilical artery with congenital malformations of vascular etiology. Pediat. Development. Pathol. 1:487–493, 1998.

    Article  CAS  Google Scholar 

  • Pearson, A.A. and Sauter, R.W.: The innervation of the umbilical vein in human embryos and fetuses. Amer. J. Anat. 125:345–352, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Pearson, A.A. and Sauter, R.W.: Nerve contributions to the pelvic plexus and the umbilical cord. Amer. J. Anat. 128:485–498, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Pekarske, S.L.: Placental pathology casebook. J. Perinatol. 15:81–83, 1995.

    PubMed  Google Scholar 

  • Pennati, G.: Biomechanical properties of the human umbilical cord. Biorheology 38:355–366, 2001.

    PubMed  CAS  Google Scholar 

  • Pent, D.: Vasa previa. Amer. J. Obstet. Gynecol. 134:151–155, 1979.

    CAS  Google Scholar 

  • Perez-Aytes, A., Montero, L., Gomez, J. and Paya, A.: Single aberrant umbilical artery in a fetus with severe caudal defects: Sirenomelia or caudal dysgenesis. Amer. J. Med. Genet. 69:409–412, 1997.

    Article  CAS  Google Scholar 

  • Perrin, E.V.D. and Bel, J.K-V.: Degeneration and calcification of the umbilical cord. Obstet. Gynecol. 26:371–376, 1965.

    PubMed  CAS  Google Scholar 

  • Petersson, K., Bremme, K., Bottinga, R., Hofsjö, A., Hulthén-V., I., Kublickas, M., Norman, M., Papadogiannakis, N., Wà6nggren, K. and Wolff, K.: Diagnostic evaluation of intrauterine fetal deaths in Stockholm 1998–1999. Acta Obstet. Gynecol. Scand. 81:284–292, 2002.

    Article  PubMed  Google Scholar 

  • Petrikovsky, B. and Kaplan, G.: Fetal grasping of the umbilical cord causing variable fetal heart rate decelerations. J. Clin. Ultrasound 21:642–644, 1993 (and Amer. J. Obstet. Gynecol. 172:1071, 1995).

    PubMed  CAS  Google Scholar 

  • Petrikovsky, B.M., Nochimson, D.J., Campbell, W.A. and Vintzileos, A.M.: Fetal jejunoileal atresia with persistent omphalomesenteric duct. Amer. J. Obstet. Gynecol. 158:173–175, 1988.

    CAS  Google Scholar 

  • Pfalzgraf, R.R., Zumwalt, R.E. and Kenny, M.R.: Mesodiverticular band and sudden death in children. Arch. Pathol. Lab. Med. 112:182–184, 1988.

    PubMed  CAS  Google Scholar 

  • Philip, A.G.S.: Further observations on placental transfusion. Obstet. Gynecol. 42:334–343, 1973.

    PubMed  CAS  Google Scholar 

  • Philip, A.G., Yee, A.B., Rosy, M., Surti, N., Tsamtsouris, A. and Ingall, D.: Placental transfusion as an intrauterine phenomenon in deliveries complicated by foetal distress. Brit. Med. J. 1:11–13, 1969.

    Google Scholar 

  • Pinto, A., Sorrentino, R., Sorrentino, P., Guerritore, T., Miranda, L., Biondi, A. and Martinelli, P.: Endothelialderived relaxing factor released by endothelial cells of human umbilical vessels and its impairment in pregnancyinduced hypertension. Amer. J. Obstet. Gynecol. 164:507–513, 1991.

    CAS  Google Scholar 

  • Poeschmann, R.P., Verheijen, R.H.M. and Dongen, P.W.J.: Differential diagnosis and causes of non-immunological hydrops fetalis: a review. Obstet. Gynecol. Surv. 46:223–231, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Potter, E.L.: Pathology of the Fetus and Infant. Yearbook Medical Publishers, Chicago, 1961.

    Google Scholar 

  • Predanic, M., Kolli, J., Yousefzadeh, P. and Pennisi, J.: Disparate blood flow patterns in parallel umbilical arteries. Obstet. Gynecol. 91:757–760, 1998.

    Article  PubMed  CAS  Google Scholar 

  • Priman, J.: A note on the anastomosis of the umbilical arteries. Anat. Rec. 134:1–5, 1959.

    Article  PubMed  CAS  Google Scholar 

  • Quek, S.P. and Tan, K.L.: Vasa previa. Aust. N.Z. J. Obstet. Gynaecol. 12:206–209, 1972.

    PubMed  CAS  Google Scholar 

  • Quinlan, D.K.: Coarctation in cord of twenty-one-week-old fetus, with atresia, fibrosis, secondary torsion. S. Afr. J. Obstet. Gynaecol. 3:1–2, 1965.

    Google Scholar 

  • Qureshi, F. and Jacques, S.M.: Marked segmental thinning of the umbilical cord vessels. Arch. Pathol. Lab. Med. 118:826–830, 1994.

    PubMed  CAS  Google Scholar 

  • Radcliffe, P.A., Sindelair, P.J. and Zeit, P.R.: Vasa previa with marginal placenta previa of an accessory lobe: report of a case. Obstet. Gynecol. 16:472–475, 1961.

    Google Scholar 

  • Raio, L., Ghezzi, F., Di Naro, E., Gomez, R., Saile, G. and Brühwiler, H.: The clinical significance of antenatal detection of discordant umbilical arteries. Obstet. Gynecol.91:86–91, 1998.

    Article  PubMed  CAS  Google Scholar 

  • Raio, L., Ghezzi, F., Di Naro, E., Franchi, M., Bruhwiler, H. and Luscher, K.P.: Prenatal assessment of Wharton’s jelly in umbilical cords with single artery. Ultrasound Obstet. Gynecol. 14:42–46, 1999.

    Article  PubMed  CAS  Google Scholar 

  • Raio, L., Ghezzi, F., Di Naro, E., Franchi, M., Balestreri, D., Dürig, P. and Schneider, H.: In-utero characterization of the blood flow in the Hyrtl anastomosis. Placenta 22:597–601, 2001.

    Article  PubMed  CAS  Google Scholar 

  • Raio, L., Ghezzi, F., Di Naro, E., Duwe, D.G., Cromi, A. and Schneider, H.: Umbilical cord morphologic characteristics and umbilical artery Doppler parameters in intrauterine growth-restricted fetuses. J. Ultrasound Med. 22:1341–1347, 2003.

    PubMed  Google Scholar 

  • Raio, L., Ghezzi, F., Cromi, A., Nelle, M., Durig, P. and Schneider, H.: The thick heterogeneous (jellylike) placenta: a strong predictor of adverse pregnancy outcome. Prenat. Diagn. 24:182–188, 2004.

    Article  PubMed  Google Scholar 

  • Ramirez, P., Haberman, S. and Baxi, L.: Significance of prenatal diagnosis of umbilical cord cyst in a fetus with trisomy 18. Amer. J. Obstet. Gynecol. 173:955–957, 1995.

    Article  CAS  Google Scholar 

  • Rana, J., Ebert, G.A. and Kappy, K.A.: Adverse perinatal outcome in patients with an abnormal umbilical coiling index. Obstet. Gynecol. 85:573–577, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Rath, W., Osterhage, G., Kuhn, W., Gröne, H.J. and Fuchs, E.: Visualization of 125I-endothelin-1 binding sites in human placenta and umbilical vessels. Gynecol. Obstet. Invest. 395:209–213, 1993.

    Google Scholar 

  • Ratten, G.J.: Spontaneous haematoma of the umbilical cord. Aust. N.Z. J. Obstet. Gynaecol. 9:125–126, 1969.

    PubMed  CAS  Google Scholar 

  • Rayburn, W.F., Beynen, A. and Brinkman, D.L.: Umbilical cord length and intrapartum complications. Obstet. Gynecol. 57:450–452, 1981.

    PubMed  CAS  Google Scholar 

  • Reece, E.A., Pinter, E., Green, J., Mahoney, M.J., Naftolin, F. and Hobbins, J.C.: Significance of isolated yolk sac visualised by ultrasonography. Lancet 1:269, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Reeves, T.B.: A double umbilicus. Anat. Rec. 10:15–18, 1916.

    Article  Google Scholar 

  • Rehsteiner, H.P.: Die Leitung der Placentarperiode—Der Zug an der Nabelschnur. Gynaecologia 167:185–196, 1969.

    PubMed  CAS  Google Scholar 

  • Reilly, F.D. and Russell, P.T.: Neurohistochemical evidence supporting an absence of adrenergic and cholinergic innervation in the human placenta and umbilical cord. Anat. Record 188:277–286, 1977.

    Article  CAS  Google Scholar 

  • Reinhart, R.D., Wells, W.A. and Harris, R.D.: Focal aneurysmal dilatation of subchorionic vessels simulating chorioangioma. Ultrasound Obstet. Gynecol. 13:147–149, 1999.

    Article  PubMed  CAS  Google Scholar 

  • Reiss, H.E.: Umbilical cord. Brit. Med. J. 2:511, 1964.

    Google Scholar 

  • Resta, R.G., Luthy, D.A. and Mahony, B.S.: Umbilical cord hemangioma associated with extremely high alpha-fetoprotein levels. Obstet. Gynecol. 72:488–491, 1988.

    PubMed  CAS  Google Scholar 

  • Rey, E.: Effects of methyldopa on umbilical and placental artery flow velocity waveforms. Obstetr. Gynecol. 80:783–787, 1992.

    CAS  Google Scholar 

  • Reynolds, S.R.M.: The proportion of Wharton’s jelly in the umbilical cord in relation to distention of the umbilical arteries and vein, with observations on the folds of Hoboken. Anat. Rec. 113:365–377, 1952.

    Article  PubMed  CAS  Google Scholar 

  • Rhen, K. and Kinnunen, O.: Ante-partum rupture of the umbilical cord. Acta Obstet. Gynecol. Scand. 41 86–89, 1962.

    PubMed  CAS  Google Scholar 

  • Richards, D.S., Lutfi, E., Mullins, D., Sandler, D.L. and Raynor, B.D.: Prenatal diagnosis of fetal disseminated intravascular coagulation associated with umbilical cord arteriovenous malformation. Obstet. Gynecol. 85:860–862, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Rissmann, Dr.: Aneurysma der Nabelschnurarterie. Zentralbl. Gynäkol. 55:550–551, 1931.

    Google Scholar 

  • Rizos, N., Doran, T.A., Miskin, M., Benzie, R.J. and Ford, J.A.: Natural history of placenta previa ascertained by diagnostic ultrasound. Amer. J. Obstet. Gynecol. 133:287–291, 1979.

    CAS  Google Scholar 

  • Robaut, C., Mondon, F., Bandet, J., Ferre, F. and Cavero. I.: Regional distribution and pharmacological characterization of [125I]endothelin-1 binding sites in human fetal placental vessels. Placenta 12:55–67, 1991.

    PubMed  CAS  Google Scholar 

  • Robertson, R.D., Rubinstein, L.M., Wolfson, W.L., Lebherz, T.B., Blanchard, J.B. and Crandall, B.F.: Constriction of the umbilical cord as a cause of fetal demise following midtrimester amniocentesis. J. Reprod. Med. 26:325–327, 1981.

    PubMed  CAS  Google Scholar 

  • Robinson, L.K., Jones, K.L. and Benirschke, K.: The nature of structural defects associated with velamentous and marginal insertion of the umbilical cord. Amer. J. Obstet. Gynecol. 146:191–193, 1983.

    CAS  Google Scholar 

  • Röckelein, G. and Hey, A.: Ultrastrukturelle Untersuchungen der Vakuolenbildung in arteriellen Choriongefäßen der reifen menschlichen Plazenta. Z. Geburtsh. Perinat. 189:65–68, 1985.

    Google Scholar 

  • Röckelein, G. and Scharl, A.: Scanning electron microscopic investigations of the human umbilical artery intima: a new conception on postnatal arterial closure mechanism. Virchows Arch. [A] 413:555–561, 1988.

    Google Scholar 

  • Röckelein, G., Kobras, G. and Becker, V.: Physiological and pathological morphology of the umbilical and placental circulation. Path. Res. Pract. 186:187–196, 1990.

    PubMed  Google Scholar 

  • Rolschau, J.: The relationship between some disorders of the umbilical cord and intrauterine growth retardation. Acta Obstet. Gynecol. Scand. [Suppl.] 72:15–21, 1978.

    CAS  Google Scholar 

  • Romero, R., Chervenak, F.A., Coustan, D., Berkowitz, R.L. and Hobbins, J.C.: Antenatal sonographic diagnosis of umbilical cord laceration. Amer. J. Obstet. Gynecol. 143:719–720, 1982.

    CAS  Google Scholar 

  • Ronchera-Oms, C., Hernandez, C. and Jimenez, N.V.: Antiseptic cord care reduces bacterial colonisation but delays cord detachment. Arch. Dis. Childh. 70:F70, 1994.

    Google Scholar 

  • Rotmensch, S., Liberati, M., Mittelmann, M. and Ben-Rafael, Z.: Activated protein C resistance and adverse pregnancy outcome. Amer. J. Obstet. Gynecol. 177:170–173, 1997.

    Article  CAS  Google Scholar 

  • Rucker, M.P. and Tureman, G.R.: Vasa previa. Va. Med. Monthly 72:202–207, 1945.

    Google Scholar 

  • Rust, W.: Seltsame Veränderungen an den Nabelschnurgefässen. Arch. Gynäkol. 165:58–62, 1937.

    Article  Google Scholar 

  • Ruvinsky, E.D., Wiley, T.L., Morrison, J.C. and Blake, P.G.: In utero diagnosis of umbilical cord hematoma by ultrasonography. Amer. J. Obstet. Gynecol. 140:833–834, 1981.

    CAS  Google Scholar 

  • Salas, S.P., Power, R.F., Singleton, A., Wharton, J., Polak, J.M. and Brown, J.: Heterogeneous binding sites for a-atrial natriuretic peptide in human umbilical cord and placenta. Amer. J. Physiol. 261:R633–R638, 1991.

    PubMed  CAS  Google Scholar 

  • Sander, C.H.: Hemorrhagic endovasculitis and hemorrhagic villitis of the placenta. Arch. Pathol. Lab. Med. 104:371–373, 1980.

    PubMed  CAS  Google Scholar 

  • Sander, C.M., Gilliland, D., Flynn, M.A. and Swart-Hills, L.A.: Risk factors for recurrence of hemorrhagic endovasculitis of the placenta. Obstet. Gynecol. 89:569–576, 1997.

    Article  PubMed  CAS  Google Scholar 

  • Schaefer, M., Laurichesse-Delmas, H. and Ville, Y.: The effect of nuchal cord on nuchal translucency measurement at 10–14 weeks. Ultrasound Obstetr. Gynecol. 11:271–273, 1998.

    Article  CAS  Google Scholar 

  • Scheffel, T. and Langanke, D.: Die Nabelschnurkomplikationen an der Universitäts-Frauenklinik von 1955 bis 1967. Zentralbl. Gynäkol. 92:429–434, 1970.

    PubMed  CAS  Google Scholar 

  • Schellong, G. and Pfeiffer, R.A.: Persistierender Ductus omphalo-mesentericus als Ursache ungewöhnlicher Komplikationen bei der Austauschtransfusion. Arch. Kinderheilk. 175:204–209, 1967.

    PubMed  CAS  Google Scholar 

  • Scheuner, G.: Über die Verankerung der Nabelschnur an der Plazenta. Morphol. Jahrb. 106:73–89, 1964.

    Google Scholar 

  • Scheuner, G.: Über die mikroskopische Struktur der Insertio velamentosa. Zentralbl. Gynäkol. 87:38–49, 1965.

    PubMed  CAS  Google Scholar 

  • Schiebler, T.H. and Kaufmann, P.: Reife Plazenta. In, Die Plazenta des Menschen. V. Becker, T.H. Schiebler and F. Kubli, eds. Thieme, Stuttgart, 1981.

    Google Scholar 

  • Schiff, I., Driscoll, S.G. and Naftolin, F.: Calcification of the umbilical cord. Amer. J. Obstetr. Gynecol. 126:1046–1048, 1976.

    CAS  Google Scholar 

  • Schordania, J.: Über das Gefäßsystem der Nabelschnur. Z. Ges. Anat. 89:696–726, 1929a.

    Article  Google Scholar 

  • Schordania, J.: Der architektonische Aufbau der Gefässe der menschlichen Nachgeburt und ihre Beziehungen zur Entwicklung der Frucht. Arch. Gynäkol. 135:568–598, 1929b.

    Article  Google Scholar 

  • Schreier, R. and Brown, S.: Hematoma of the umbilical cord: report of a case. Obstet. Gynecol. 20:798–800, 1962.

    PubMed  CAS  Google Scholar 

  • Schreiner, C.A. and Hoornbeek, F.K.: Developmental aspects of sirenomelia in the mouse. J. Morphol. 141:345–358, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Schwalbe, E.: Allgemeine Mißbildungslehre (Teratologie). Gustav Fischer, Jena, 1906.

    Google Scholar 

  • Scott, J.M. and Jordan, J.M.: Placental insufficiency and the small-for-dates baby. Amer. J. Obstet. Gynecol. 113:823–832, 1972.

    CAS  Google Scholar 

  • Scott, J.M. and Wilkinson, R.: Further studies on the umbilical cord and its water content. J. Clin. Pathol. 31:944–948, 1978.

    PubMed  CAS  Google Scholar 

  • Scott, J.S.: Placenta extrachorialis (placenta marginata and placenta circumvallata). J. Obstet. Gynaecol. Brit. Emp. 67:907–918, 1960.

    Google Scholar 

  • Seeds, J.W., Chescheir, N.C., Bowes, W.A. and Owl-Smith, F.A.: Fetal death as a complication of intrauterine intravascular transfusion. Obstet. Gynecol. 74:461–463, 1989.

    PubMed  CAS  Google Scholar 

  • Seifert, D.B., Ferguson, J.E., Behrens, C.M., Zemel, S., Stevenson, D.K. and Ross, J.C.: Nonimmune hydrops fetalis in association with hemangioma of the umbilical cord. Obstet. Gynecol. 66:283–286, 1985.

    Google Scholar 

  • Seligsohn, U., Berger, A., Abend, M., Rubin, L., Attias, D., Zivelin, A. and Rapaport, S.I.: Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn. NEJM 310:559–562, 1984.

    PubMed  CAS  Google Scholar 

  • Sepúlveda, W.H., González, C., Cruz, M.A. and Rudolph, M.I.: Vasoconstrictive effect of bile acids on isolated human placental chorionic veins. Eur. J. Obstetr. Gynecol. Reprod. Biol. 42:211–215, 1991.

    Article  Google Scholar 

  • Sexton, A.J., Turmaine, M., Cai, W.Q. and Burnstock, G.: A study of the ultrastructure of developing human umbilical vessels. J. Anat. 188:75–85.

    Google Scholar 

  • Shanklin, D.R.: The influence of placental lesions on the newborn infant. Pediatr. Clin. North America 17:25–42, 1970.

    CAS  Google Scholar 

  • Shaw, A. and Pierog, S.: “Ectopic” liver in the umbilicus: an unusual focus of infection in a newborn infant. Pediatrics 44:448–450, 1969.

    PubMed  CAS  Google Scholar 

  • Shen-Schwarz, S., Macpherson, T. and Mueller-Heubach, E.: Hemorrhagic endovasculitis of the placenta: incidence and clinical features in an unselected population. Pediatr. Pathol. 5:112, 1986.

    Google Scholar 

  • Shen-Schwarz, S., Macpherson, T.A. and Mueller-Heubach, E.: The clinical significance of hemorrhagic endovasculitis of the placenta. Amer. J. Obstet. Gynecol. 159:48–51, 1988.

    CAS  Google Scholar 

  • Shen-Schwarz, S., Ananth, C.V., Smulian, J.C. and Vintzleos, A.M.: Umbilical cord twist patterns in twin gestations. Amer. J. Obstet. Gynecol. 176:S154 (abstract 538), 1997a.

    Article  Google Scholar 

  • Shen-Schwarz, S., Smulian, J.C., Ananth, C.V., Lai-Ling, Y. and Vintzileos, A.M.: Placental cord insertion in relation to birth weight and placental weight discordancy in twin gestations. Amer. J. Obstet. Gynecol. 176:S134, abstract 457, 1997b.

    Google Scholar 

  • Shepherd, A.J., Richardson, C.J. and Brown, J.P.: Nuchal cords as a cause of neonatal anemia. Amer. J. Dis. Child. 139:71–73, 1985.

    PubMed  CAS  Google Scholar 

  • Shepherd, J.T.: Bayliss response in the umbilical artery. Fed. Proc. 27:1408–1409, 1968.

    PubMed  CAS  Google Scholar 

  • Sibulkin, M.: A note on the bathtub vortex and the earth’s rotation. Amer. Sci. 71:352–353, 1983.

    Google Scholar 

  • Siddall, R.S.: Spontaneous rupture of the umbilical cord. Amer. J. Obstet. Gynecol. 10:836–840, 1925.

    Google Scholar 

  • Siddiqi, T.A., Bendon, R., Schultz, D.M. and Miodovnik, M.: Umbilical artery aneurysm: Prenatal diagnosis and management. Obstet. Gynecol. 80:530–533, 1992.

    PubMed  CAS  Google Scholar 

  • Silva, P. de, Stoskopf, C.G., Keegan, K.A. and Murata, Y.: Use of fetal scalp hematocrit in the diagnosis of severe hemorrhage from vasa previa. Amer. J. Obstet. Gynecol. 153:307–308, 1985.

    CAS  Google Scholar 

  • Silver, M.M., Yeger, H. and Lines, L.D.: Hemorrhagic endovasculitis-like lesion in placental organ culture. Lab. Invest. 56:6P, 1987.

    Google Scholar 

  • Silver, M.M., Yeger, H. and Lines, L.D.: Hemorrhagic endovasculitis-like lesion induced in placental organ culture. Hum. Pathol. 19:251–256, 1988.

    Article  PubMed  CAS  Google Scholar 

  • Silver, R.K., Dooley, S.L., Tamura, R.K. and Depp, R.: Umbilical cord size and amniotic fluid volume in prolonged pregnancy. Amer. J. Obstet. Gynecol. 157:716–720, 1987.

    CAS  Google Scholar 

  • Singh, V., Khanum, S. and Singh, M.: Umbilical cord lesions in early intrauterine fetal demise. Arch. Pathol. Lab. Med. 127:850–853, 2003.

    PubMed  Google Scholar 

  • Sinha, A.A.: Ultrastructure of human amnion and amniotic plaques of normal pregnancy. Z. Zellforsch. 122:1–14, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Sinnathuray, T.A.: The nuchal cord incidence and significance. J. Obstet. Gynaecol. Brit. Commonw. 73:226–231, 1966.

    Google Scholar 

  • Slijper, E.J.: Die Geburt der Säugetiere. In, Handbuch der Zoologie, Vol. 8. W. Kükenthal, ed., pp. 1–108. de Gruyter, Berlin, 1960.

    Google Scholar 

  • Smart, P.J.G.: Some observations on the vascular morphology of the foetal side of the human placenta. J. Obstet. Gynaecol. Brit. Commonw. 69:929–933, 1962.

    CAS  Google Scholar 

  • Smith, D. and Majmudar, B.: Teratoma of the umbilical cord. Hum. Pathol. 16:190–193, 1985.

    PubMed  CAS  Google Scholar 

  • Snider, W.: Placental pathology casebook. J. Perinatol. 17:327–329, 1997.

    PubMed  CAS  Google Scholar 

  • Soernes, T.: Umbilical cord encirclements and fetal growth restriction. Obstet. Gynecol. 86:725–728, 1995.

    Article  Google Scholar 

  • Soernes, T. and Bakke, T.: The length of the human umbilical cord in vertex and breech presentations. Amer. J. Obstet. Gynecol. 154:1086–1087, 1986.

    CAS  Google Scholar 

  • Sotelo, A.K., Sotelo, C., Hathaway, C.S. and Vogler, C.A.: Incidental ectopic tissues in the placenta. Placenta 22(7):A29, 2001.

    Google Scholar 

  • Spatz, W.B.: Nabelschnur-Längen bei Insektivoren und Primaten. Z. Säugetierk. 33:226–239, 1968.

    Google Scholar 

  • Spellacy, W.N., Gravem, H. and Fisch, R.O.: The umbilical cord complications of true knots, nuchal coils, and cords around the body. Amer. J. Obstet. Gynecol. 94:1136–1142, 1966.

    CAS  Google Scholar 

  • Spiteri, M., Anh, N.H. and Panigel, M.: Ultrastructure du muscle lisse des artères du cordon ombilical humain. Pathol. Biol. 14:348–357, 1966.

    PubMed  CAS  Google Scholar 

  • Spivack, M.: On the anatomy of the so-called ‘valves’ of umbilical vessels, with especial reference to the valvulae Hobokenii. Anat. Rec. 66:127–148, 1936.

    Article  Google Scholar 

  • Spivack, M.: On the presence or absence of nerves in the umbilical blood vessels of man and guinea pig. Anat. Rec. 85:85–109, 1943.

    Article  Google Scholar 

  • Stevens, N.G. and Sander, C.H.: Placental hemorrhagic endovasculitis: risk factors and impact on pregnancy outcome. Lab. Invest. 50:57A, 1984.

    Google Scholar 

  • Stevenson, R.E., Jones, K.L., Phelan, M.C., Jones, M.C., Barr, M., Clericuzio, C., Harley, R.A. and Benirschke, K.: Vascular steal: the pathogenetic mechanism producing sirenomelia and associated defects of the viscera and soft tissues. Pediatrics 78:451–457, 1986.

    PubMed  CAS  Google Scholar 

  • Strassmann, P.: Placenta praevia. Arch. Gynäkol. 67:112–275, 1902.

    Article  Google Scholar 

  • Strong, T.H.: Factors that provide optimal umbilical protection during gestation. Contemporary Obstet. Gynecol. 42:82–105, 1997.

    Google Scholar 

  • Strong, T.H., Elliott, J.P. and Radin, T.R.: Non-coiled umbilical blood vessels: A new marker for the fetus at risk. Obstet. Gynecol. 81:409–411, 1993.

    PubMed  Google Scholar 

  • Strong, T.H., Jarles, D.L., Vega, J.S. and Feldman, D.B.: The umbilical coiling index. Amer. J. Obstet. Gynecol. 170:29–32, 1994.

    Google Scholar 

  • Summerville, J.W., Powar, J.S. and Ueland, K.: Umbilical cord hematoma resulting in intrauterine fetal demise. A case report. J. Reprod. Med. 32:213–216, 1987.

    CAS  Google Scholar 

  • Sun, Y., Arbuckle, S., Hocking, G. and Billson, V.: Umbilical cord stricture and intrauterine fetal death. Pediatr. Pathol. Lab. Med. 15:723–732, 1995.

    PubMed  CAS  Google Scholar 

  • Sutro, W.H., Tuck, S.M., Loesewitz, A., Novotny, P.L., Archbald, F. and Irwin, G.A.L.: Prenatal observation of umbilical cord hematoma. AJR 142:801–802, 1084.

    Google Scholar 

  • Swanberg, H. and Wiqvist, N.: Rupture of the umbilical cord during pregnancy. Acta Obstet. Gynecol. Scand. 30:323–337, 1951.

    Google Scholar 

  • Szécsi, K.: Beiträge zur spontanen Zerreißung der zu kurzen Nabelschnur. Zentralbl. Gynäkol. 77:1024–1028, 1955.

    PubMed  Google Scholar 

  • Takagi, T., Toda, T., Leszczynski, D. and Kummerow, F.: Ultrastructure of aging human umbilical artery and vein. Acta Anat. (Basel) 119:73–79, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Takechi, K., Kuwabara, Y. and Mizuno, M.: Ultrastructural and immunohistochemical studies of Wharton’s jelly umbilical cord cells. Placenta 14:235–245, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Ten Berge, B.S.: Nervenelemente in Plazenta und Nabelschnur. Gynaecologia 156:49–53, 1963.

    PubMed  Google Scholar 

  • Tharakan, T., Baxi, L.V. and Diuguid, D.: Protein S deficiency in pregnancy: A case report. Amer. J. Obstet. Gynecol. 168:141–142, 1993.

    CAS  Google Scholar 

  • Theuring, F.: Fibröse Obliterationen an Deckplatten-und Stammzottengefäßen der Placenta nach intrauterinem Fruchttod. Arch. Gynäkol. 206:237–251, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, J.: Untersuchungsergebnisse über die Aplasie einer Nabelarterie unter besonderer Berücksichtigung der Zwillingsschwangerschaft. Geburtsh. Frauenh. 21:984–992, 1961.

    PubMed  CAS  Google Scholar 

  • Thomas, J.: Die Entwicklung von Fetus und Placenta bei Nabelgefäßanomalien. Arch. Gynäkol. 198:216–223, 1963.

    Article  Google Scholar 

  • Thomson, L.L. and Hoo, J.J.: Linear disruption of umbilical cord: A rare anomaly of the cord associated with acute fetal distress and perinatal death/pronounced psychomotor retardation. Amer. J. Med. Genet. 62:348–349, 1996.

    Article  CAS  Google Scholar 

  • Thorarensen, O., Ryan, S., Hunter, J. and Younkin, D.P.: Factor V Leiden mutation: An unrecognized cause of hemiplegic cerebral palsy, neonatal stroke, and placental thrombosis. Ann. Neurol. 42:372–375, 1997.

    Article  PubMed  CAS  Google Scholar 

  • Thummala, M.R., Raju, T.N. and Langenberg, P.: Isolated single umbilical artery anomaly and the risk for congenital malformations: a meta-analysis. J. Pediatr. Surg. 33:580–585, 1998.

    Article  PubMed  CAS  Google Scholar 

  • Torpin, R.: Classification of human pregnancy based on depth of intrauterine implantation of ovum. Amer. J. Obstet. Gynecol. 66:791–800, 1953.

    CAS  Google Scholar 

  • Torrey, W.E.: Vasa previa. Amer. J. Obstet. Gynecol. 63:146–152, 1952.

    Google Scholar 

  • Tortora, M., Chervenak, F.A., Mayden, K. and Hobbins, J.C.: Antenatal sonographic diagnosis of single umbilical artery. Obstet. Gynecol. 63:693–696, 1984.

    PubMed  CAS  Google Scholar 

  • Trollmann, R., Amann, K., Schoof, E., Beinder, E., Wenzel, D., Rascher, W. and Dötsch, J.: Hypoxia activates the human placental vascular endothelial growth factor system in vitro and in vivo: Up-regulation of vascular endothelial growth factor in clinically relevant hypoxic ischemia in birth asphyxia. Amer. J. Obstet. Gynecol. 188:517–523, 2003.

    Article  CAS  Google Scholar 

  • Trudinger, B.J. and Cook, C.M.: Different umbilical artery flow velocity waveforms in one patient. Obstet. Gynecol. 71:1019–1021, 1988.

    PubMed  CAS  Google Scholar 

  • Trudinger, B.J., Stevens, D., Connelly, A., Hales, J.R.S., Alexander, G., Bradley, L., Fawcett, A. and Thompson, R.S.: Umbilical artery flow velocity waveforms and placental resistance: the effects of embolization of the umbilical circula tion. Amer. J. Obstet. Gynecol. 157:1443–1448, 1987.

    CAS  Google Scholar 

  • Tuggle, A.Q. and Cook, W.A.: Laceration of a placental vein: an injury possibly inflicted by the fetus. Amer. J. Obstet. Gynecol. 131:220–221, 1978.

    CAS  Google Scholar 

  • Uchide, K., Ueno, H., Inuyama, R., Murakami, K. and Terada, S.: Cord presentation with posterior placenta previa. Lancet 350:1448, 1997.

    Article  PubMed  CAS  Google Scholar 

  • Ukeshima, A., Hayashi, Y. and Fujimoto, T.: Surface morphology of the human yolk sac: endoderm and mesothelium. Arch. Histol. Jpn. 49:483–494, 1986.

    PubMed  CAS  Google Scholar 

  • Ullberg, U., Sandstedt, B. and Lingman, G.: Hyrtl’s anastomosis occurrence, morphology and relation to umbilical artery blood flow waveforms and fetal growth. Placenta 15:Abstract A.71, 1994.

    Google Scholar 

  • Ullberg, U., Sandstedt, B. and Lingman, G.: Hyrtl’s anastomosis, the only connection between the two umbilical arteries. A study in full term placentas from AGA infants with normal umbilical artery blood flow. Acta Obstet. Gynecol. Scand. 80:1–6, 2001.

    Article  PubMed  CAS  Google Scholar 

  • Ulm, M.R., Plöckinger, B., Pirich, C., Gryglewski, R.J. and Sinzinger, H.F.: Umbilical arteries of babies born to cigarette smokers generate less prostacyclin and contain less arginine and citrulline compared with those of babies born to control subjects. Amer. J. Obstet. Gynecol. 172:1485–1487, 1995.

    Article  CAS  Google Scholar 

  • Uyanwah-Akpom, P.O. and Fox, H.: The clinical significance of marginal or velamentous insertion of the cord. Brit. J. Obstet. Gynaecol. 84:941–943, 1977.

    CAS  Google Scholar 

  • Vandevijver, N., Hermans, R.H., Schrander-Stumpel, C.C., Arends, J.W., Peeters, L.L. and Moerman, P.L.: Aneurysm of the umbilical vein: case report and review of literature. Eur. J. Obstet. Gynecol. Reprod. Biol. 89:85–87, 2000.

    Article  PubMed  CAS  Google Scholar 

  • Vandriede, D.M. and Kammeraad, L.A.: Vasa previa: case report, review and presentation of a new diagnostic method. J. Reprod. Med. 26:577–580, 1981.

    Google Scholar 

  • Vanhaesebrouck, P., Vanneste, K., de Praeter, C. and van Trappen, Y: Tight nuchal cord and neonatal hypovolemic shock. Arch. Dis. Child. 62:1276–1277, 1987.

    PubMed  CAS  Google Scholar 

  • Vardi, P.: Placental transfusion: an attempt at physiological delivery. Lancet 2:12–13, 1965.

    Article  Google Scholar 

  • Virgilio, L.A. and Spangler, D.B.: Fetal death secondary to constriction and torsion of the umbilical cord. Arch. Pathol. Lab. Med. 102:32–33, 1978.

    PubMed  CAS  Google Scholar 

  • von Hayek, H.: Der funktionelle Bau der Nabelarterien und des Ductus Botalli. Z. Anat. Entwicklungsgesch. 105:15–24, 1936.

    Article  Google Scholar 

  • Vu, T., Baldwin, V.J., Perrin, E.V.D.K. and Shanklin, D.R.: Major umbilical vessel rupture in utero. Pediatr. Pathol. 2:494, 1984.

    Google Scholar 

  • Waidl, E.: Zur Genese und Klinik der Insertio velamentosa. Zentralbl. Gynäkol. 82:1902–1906, 1960.

    PubMed  CAS  Google Scholar 

  • Walker, C.W. and Pye, B.G.: The length of the umbilical cord; a statistical report. Brt. Med. J. 1:546–548, 1960.

    Article  CAS  Google Scholar 

  • Walker, M.C., Garner, P.R., Keely, E.J., Rock, G.A. and Reis, M.D.: Changes in activated protein C resistance during normal pregnancy. Amer. J. Obstet. Gynecol. 177:162–169, 1997.

    Article  CAS  Google Scholar 

  • Walsh, S.Z.: Maternal effects of early and late clamping of the umbilical cord. Lancet 1:996–997, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Walz, W.: Über das Ödem der Nabelschnur. Zentralbl. Gynäkol. 69:144–148, 1947.

    Google Scholar 

  • Wang, X., Yi, S., Athayde, N. and Trudinger, B.: Endothelial cell apoptosis is induced by fetal plasma from pregnancy with umbilical placental vascular disease. Amer. J. Obstet. Gynecol. 186:557–563, 2002.

    Article  Google Scholar 

  • Wang, X., Athayde, N. and Trudinger, B.: Fetal plasma stimulates endothelial cell production of cytokines and the family of suppressor of cytokine signaling in placental vascular disease. Amer. J. Obstet. Gynecol. 188:510–516, 2003.

    Article  CAS  Google Scholar 

  • Weber, J.: Constriction of the umbilical cord as a cause of foetal death. Acta Obstet. Gynecol. Scand. 42:259–268, 1963.

    PubMed  CAS  Google Scholar 

  • Weeks, J.W., Smith, A., Hogue, T., Spinnato, J.A. and Gall, S.A.: The umbilical coiling index and feto-placental characteristics. Amer. J. Obstet. Gynecol. 172:32v (abstract 211), 1995.

    Google Scholar 

  • Weiner, C.P., Wenstrom, K.D., Sipes, S.L. and Wiliamson, R.A.: Risk factors for cordocentesis and fetal intravascular transfusion. Amer. J. Obstet. Gynecol. 165:1020–1025, 1991.

    CAS  Google Scholar 

  • Weissman, A., Jakobi, P., Bronshtein, M. and Goldstein, I.: Sonographic measurements of the umbilical cord and vessels during normal pregnancies. J. Ultrasound Med. 13:11–14, 1994.

    PubMed  CAS  Google Scholar 

  • Wentworth, P.: Some anomalies of the foetal vessels of the human placenta. J. Anat. 99:273–282, 1965.

    PubMed  CAS  Google Scholar 

  • White, R.P.: Pharmacodynamic study of maturation and closure of human umbilical arteries. Amer. J. Obstet. Gynecol. 160:229–237, 1989.

    CAS  Google Scholar 

  • Whitwell, K.E.: Morphology and pathology of the equine umbilical cord. J. Reprod. Fertil., Suppl. 23:599–603, 1975.

    Google Scholar 

  • Widholm, O. and Nieminen, U.: Prolapse of umbilical cord. Acta Obstet. Gynecol. 42:21–29, 1963.

    Article  CAS  Google Scholar 

  • Wiedersberg, E., Wittstock, G. and Wiedersberg, H.: Pathologie der Nabelschnur in Abhängigkeit vom Gestationsalter. Befunde bei 4267 fetalen und neonatalen Autopsien. Verh. Dtsch. Ges. Pathol. 85:175–192, 2001.

    PubMed  CAS  Google Scholar 

  • Wigger, H.J., Kiu, T.W., Moessinger, A.C., Marboe, C.C. and Blanc, W.A.: Effect of cigarette smoking on the ultrastructure of the placenta. Lab. Invest. 50:14P, 1984.

    Google Scholar 

  • Williams, J.H. and Benirschke, K.: Chorionic vessel thrombosis: a possible etiology of neonatal purpura. J. Reprod. Med. 20:285–288, 1978.

    PubMed  CAS  Google Scholar 

  • Williams, J., Katzman, G.H. and Kripke, S.S.: Neck compression by nuchal cord. Amer. J. Obstet. Gynecol. 140:345–346, 1981.

    CAS  Google Scholar 

  • Williams, M. and O’Brien, W.: Umbilical cord entanglements are associated with increased placental mass and decreased fetal placental ration. Amer. J. Obstet. Gynecol. 187:p.S93 (abstract 114), 2000a.

    Google Scholar 

  • Williams, M. and O’Brien, W.: Multiple or tight nuchal cord loops are not associated with significant perinatal morbidity. Amer. J. Obstet. Gynecol. 187:p.S93 (abstract 113), 2000b.

    Google Scholar 

  • Wilson, R.D., Magee, J.F., Sorensen, P.H.B. and Johnson, A.: In utero decompression of umbilical cord angiomyxoma followed by vaginal delivery. Amer. J. Obstet. Gynecol. 171:1383–1385, 1994.

    CAS  Google Scholar 

  • Winter, R.: Die Rolle regressiver Veränderungen der Plazenta bei der sogenannten Plazentamigration. Geburtsh. Frauenheilk. 38:1093–1098, 1978.

    PubMed  CAS  Google Scholar 

  • Winters, R.H.: Unique vascular relationship in human umbilical cord. Nature 226:656, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Wolf, P.L., Jones, K.L., Longway, S.R., Benirschke, K. and Bloor, C.: Prenatal death from acute myocardial infarction and cardiac tamponade due to embolus from the placenta. Amer. Heart J. 109:603–605, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Wolfman, W.L., Purohit, D.M. and Self, S.E.: Umbilical vein thrombosis at 32 weeks’ gestation with delivery of a living infant. Amer. J. Obstet. Gynecol. 146:468–470, 1983.

    CAS  Google Scholar 

  • Woods, D.L. and Malan, A.F.: The site of umbilical cord insertion and birth weight. Brit. J. Obstet. Gynaecol. 85:332–333, 1978.

    CAS  Google Scholar 

  • Yamada, K. and Shimizu, S.: Concanavalin a-peroxidase-diaminobenzidine (Con A-PO-DAB)-alcian blue (AB): a reliable method for dual staining of complex carbohydrates. Histochemistry 47:159–169, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Yang, H.Y., Shum, A.Y.C., Ng, H.T. and Chen, C.F.: Effect of ethanol on human umbilical artery and vein in vitro. Gynecol. Obstet. Invest. 21:131–135, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Yao, A.C. and Lind, J.: Placental transfusion: review. Amer. J. Dis. Child. 127:128–141, 1974.

    PubMed  CAS  Google Scholar 

  • Yao, A.C. and Lind, J.: Placental transfusion. A Clinical and Physiological Study. Charles C. Thomas, Springfield, 1982.

    Google Scholar 

  • Yao, A.C., Hirvensalo, M. and Lind, J.: Placental transfusion-rate and uterine clamping. Lancet 1:380–383, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Yao, A.C., Moinian, M. and Lind, J.: Distribution of blood between infant and placenta after birth. Lancet 2:871–873, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Yao, A.C., Lind, J. and Lu, T.: Closure of the human umbilical artery: a physiological demonstration of Burton’s theory. Eur. J. Obstet. Gynecol. Reprod. Biol. 7:365–368, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Yavner, D.L. and Redline, R.W.: Angiomyxoma of the umbilical cord with massive cystic degeneration of Wharton’s jelly. Arch. Pathol. Lab. Med. 113:935–937, 1989.

    PubMed  CAS  Google Scholar 

  • Young, A.: The primate umbilical cord with special reference to the transverse communicating artery. J. Hum. Evol. 1:345–359, 1972.

    Article  Google Scholar 

  • Young, G.B.: The peripatetic placenta. Radiology 128:183–188, 1978.

    PubMed  CAS  Google Scholar 

  • Zhang, P. and Benirschke, K.: Placental pathology casebook. J. Perinatol. 1:163–65, 2000.

    Google Scholar 

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(2006). Anatomy and Pathology of the Umbilical Cord. In: Pathology of the Human Placenta. Springer, New York, NY . https://doi.org/10.1007/0-387-26742-5_12

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