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SIV as a Model for AIDS Pathogenesis Studies

  • Ulrike Sauermann
  • Sieghart Sopper
Part of the Infectious Diseases and Pathogenesis book series (IAPA)

Abstract

HIV vaccine trials are conducted in nonhuman primate models. Macaques infected with the simian immunodeficiency virus (SIV) and its genetically engineered derivatives, such as chimeras between HIV-1 and SIV (SHIV), are thus indispensable for the proof-of-concept testing and the definition of potential correlates of immune protection in HIV-vaccine design. SIVinfected macaques are also the animal model system of choice to perform etiopathological investigations. In contrast to humans, the monkeys are selected for age, sex, and provenance. They are infected under controlled experimental conditions with a pretitrated dose of a well-characterized viral isolate or a viral clone. The macaque model of AIDS is therefore most suited to study virus dissemination and host responses during the acute phase of infection, which is very difficult to study in HIV-infected humans. This phase is especially important since its outcome determines the disease course in HIV-1 infected humans and SIV-infected monkeys. Furthermore, organs usually not accessible for investigations in humans can be analyzed at any point during the infection. This animal model also provides the opportunity to intervene experimentally with the disease process. For example, much information has been gathered by depleting various lymphocyte subsets or by labeling lymphocytes in order to monitor their turnover. In addition, by selecting specific viral mutants or animals according to predefined criteria it is possible to decipher important viral and host factors influencing the course of the disease.

Keywords

Rhesus Macaque Cynomolgus Macaque Coreceptor Usage Sooty Mangabey Primary Viremia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Ulrike Sauermann
    • 1
  • Sieghart Sopper
    • 2
  1. 1.German Primate CenterGöttingenGermany
  2. 2.Bayerische Julius-Maximilians-UniversitätWürzburgGermany

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