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Animal Model Systems of HIV-Diseases

  • Eric R. Anderson
  • Huangui Xiong
  • Howard E. Gendelman
Part of the Infectious Diseases and Pathogenesis book series (IAPA)

Abstract

Human immunodeficiency virus (HIV) infection is arguably the most significant global health problem of the modern era. Infection has all but devastated third-world countries and continues to threaten public health in developed nations. With the numbers of deaths approaching tens of millions each year, the greatest imperative for world health is the realization of an effective preventative vaccine. The major obstacles prohibiting this goal include a better understanding of protective immunity in the natural host of the virus. In working toward this objective, animal model systems were developed to recapitulate disease processes and viral diversity as it occurs in natural infections of man. Nonetheless, HIV is species specific and is diffi- cult to study in animal systems. Transgenic animals have been developed expressing human receptors in order to overcome some of these limitations; but an animal model that can be progressively infected by HIV remains elusive. Thus, a number of animal models have been established that utilize “other” lentiviruses that mimic HIV infection in specific ways and provide the means to mirror natural infection in its human host. Alternatively, relevant animal models replicate aspects of human disease through the engraftment of infected human cells. Ultimately, these animal model systems of HIV disease provide insight into specific disease processes and serve to elucidate underlying mechanisms of infection and subsequent disease.

Keywords

Nonhuman Primate Equine Infectious Anemia Virus Animal Model System Caprine Arthritis Encephalitis Virus Visna Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Eric R. Anderson
    • 1
  • Huangui Xiong
    • 2
  • Howard E. Gendelman
    • 3
  1. 1.Department of Microbiology and Specialized NeuroSciences ProgramUniversity of Puerto Rico Medical Sciences CampusSan Juan
  2. 2.Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental NeuroscienceUniversity of Nebraska Medical CenterOmara
  3. 3.Center for Neurovirology and Neurodegenerative Disorders, Departments of Pharmacology and Experimental Neuroscience and Internal MedicineUniversity of Nebraska Medical CenterOmaha

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