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Miniaturized Multiplexed Protein Binding Assays

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Frontiers in Biochip Technology

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References

  1. Ekins, R.P.: Multi-analyte immunoassay. J Pharm Biomed Anal 7, 155–168 (1989)

    Article  Google Scholar 

  2. Lander, E.S et al. Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001)

    Article  Google Scholar 

  3. Venter, J.C. et al.: The sequence of the human genome. Science 291, 1304–1351 (2001)

    Article  Google Scholar 

  4. Linck, B., P. Boknik, T. Eschenhagen, F.U. Muller, J. Neumann, M. Nose, L.R. Jones, W. Schmitz & H. Scholz: Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts. Cardiovasc Res 31, 625–632 (1996)

    Article  Google Scholar 

  5. Gygi, S.P., Y. Rochon, B.R. Franza & R. Aebersold: Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19, 1720–1730 (1999)

    Google Scholar 

  6. Anderson, N.L. & N.G. Anderson: Proteome and proteomics: new technologies, new concepts, and new words. Electrophoresis 19, 1853–1861 (1998)

    Article  Google Scholar 

  7. Albala, J.S. & I. Humphery-Smith: Array-based proteomics: High-throughput expression and purification of IMAGE consortium cDNA clones. Curr Opin Pharm Proteomics 680–684 (1999)

    Google Scholar 

  8. Emili, A.Q. & G. Cagney: Large-scale functional analysis using peptide or protein arrays. Nat Biotechnol 18, 393–397 (2000)

    Article  Google Scholar 

  9. Cahill, D.J.: Protein arrays: a high-throughput solution for proteomics research ? Proteomics: A Trends Guide 47–51 (2000)

    Google Scholar 

  10. Ekins, R., F. Chu & E. Biggart: Multispot, multianalyte, immunoassay. Ann Biol Clin (Paris) 48, 655–666 (1990)

    Google Scholar 

  11. MacBeath, G. & S.L. Schreiber: Printing proteins as microarrays for highthroughput function determination. Science 289, 1760–1763 (2000)

    Google Scholar 

  12. Arenkov, P., A. Kukhtin, A. Gemmell, S. Voloshchuk, V. Chupeeva & A. Mirzabekov: Protein microchips: use for immunoassay and enzymatic reactions. Anal Biochem 278, 123–131 (2000)

    Article  Google Scholar 

  13. Disley, D.M., P.R. Morrill, K. Sproule & C.R. Lowe: An optical biosensor for monitoring recombinant proteins in process media. Biosens Bioelectron 14, 481–493 (1999)

    Article  Google Scholar 

  14. Sanders, G.H.W. & A. Manz: Chip-based microsystems for genomic and proteomic analysis. Trends in Analytical Chemistry 19, 364–378 (2000)

    Article  Google Scholar 

  15. Blawas, A.S. & W.M. Reichert: Protein patterning. Biomaterials 19, 595–609 (1998)

    Article  Google Scholar 

  16. Nakanishi, K., H. Muguruma & I. Karube: A novel method of immobilizing antibodies on a quartz crystal microbalance using plasma-polymerized films for immunosensors. Anal Chem 68, 1695–1700 (1996)

    Article  Google Scholar 

  17. Shriver-Lake, L.C., B. Donner, R. Edelstein, K. Breslin, S.K. Bhatia & F.S. Ligler: Antibody immobilization using heterobifunctional crosslinkers. Biosens Bioelectron 12, 1101–1106 (1997)

    Article  Google Scholar 

  18. Dontha, N., W.B. Nowall & W.G. Kuhr: Generation of biotin/avidin/enzyme nanostructures with maskless photolithography. Anal Chem 69, 2619–2625 (1997)

    Article  Google Scholar 

  19. Pritchard, D.J., H. Morgan & J.M. Cooper: Patterning and Regeneration of Surfaces with Antibodies. Anal. Chem. 67, 3605–3607 (1995)

    Article  Google Scholar 

  20. Ducree, J., H. Gruhler, N. Hey, M. Muller, S. Bekesi, M. Freygang, H. Sandmaiser & R. Zengerle: TOPSPOT-a new method for the fabrication of microarrays. In: Proceedings IEEE Thirteenth Annual International Conference on Micro Electro Mechanical Systems, IEEE, Piscataway, NJ, USA 317–322 (2000)

    Google Scholar 

  21. Schwarz, A., J.S. Rossier, E. Roulet, N. Mermod, M.A. Roberts & H.H. Girault: Micropatterning of biomolecules on polymer substrates. Langmuir 14, 5526–5531 (1998)

    Article  Google Scholar 

  22. Wadu-Mesthrige, K., X. Song, N.A. Amro & L. Gang-yu: Fabrication and imaging of nanometer-sized protein patterns. Langmuir 15, 8580–8583 (1999)

    Article  Google Scholar 

  23. Zhao, X.M., Y.N. Xia & G.M. Whitesides: Soft lithographic methods for nanofabrication. J. Mat. Chem. 7, 1069–1074 (1997)

    Article  Google Scholar 

  24. Bernard, A., E. Delamarche, H. Schmid, B. Michel, H.R. Bosshard & H. Biebuyck: Printing patterns of proteins. Langmuir 14, 2225–2229 (1998)

    Article  Google Scholar 

  25. McDonald, J.C., D.C. Duffy, J.R. Anderson, D.T. Chiu, H. Wu, O.J. Schueller & G.M. Whitesides: Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21, 27–40 (2000)

    Article  Google Scholar 

  26. Unger, M.A., H.P. Chou, T. Thorsen, A. Scherer & S.R. Quake: Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 288, 113–116 (2000)

    Article  Google Scholar 

  27. James, C.D., R.C. Davis, L. Kam, H.G. Craighead, M. Isaacson, J.N. Turner & W. Shain: Patterned protein layers on solid substrates by thin stamp microcontact printing. Langmuir 14, 741–744 (1998)

    Article  Google Scholar 

  28. Gaber, B.P., B.D. Martin & D.C. Turner: Create a protein microarray using a hydrogel “stamper”. Chemtech 29, 20–24 (1999)

    Google Scholar 

  29. Kane, R.S., S. Takayama, E. Ostuni, D.E. Ingber & G.M. Whitesides: Patterning proteins and cells using soft lithography. Biomaterials 20, 2363–2376 (1999)

    Article  Google Scholar 

  30. Morozov, V.N. & T.Y. Morozova: Electrospray deposition as a method for mass fabrication of mono-and multicomponent microarrays of biological and biologically active substances. Anal Chem 71, 3110–3117 (1999)

    Article  Google Scholar 

  31. Lundgren, J.S., A.N. Watkins, D. Racz & F.S. Ligler: A liquid crystal pixel array for signal discrimination in array biosensors. Biosens 15, 417–421 (2000)

    Article  Google Scholar 

  32. Pawlak, M., E. Grell, E. Schick, D. Anselmetti & M. Ehrat: Functional immobilization of biomembrane fragments on planar waveguides for the investigation of side-directed ligand binding by surface-confined fluorescence. Faraday Discuss 111, 273–288; discussion 331–243 (1998)

    Article  Google Scholar 

  33. Rowe, C.A., L.M. Tender, M.J. Feldstein, J.P. Golden, S.B. Scruggs, B.D. MacCraith, J.J. Cras & F.S. Ligler: Array biosensor for simultaneous identification of bacterial, viral, and protein analytes. Anal Chem 71, 3846–3852 (1999)

    Article  Google Scholar 

  34. Joos T.O., Stoll D. and Templin M.F. Miniaturised multiplexed immunoassays. Curr Opin Chem Biol, 6:76–80 (2002)

    Article  Google Scholar 

  35. Carson, R.T. & D.A. Vignali: Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay. J Immunol Methods 227, 41–52 (1999)

    Article  Google Scholar 

  36. Chen, R., L. Lowe, J.D. Wilson, E. Crowther, K. Tzeggai, J.E. Bishop & R. Varro: Simultaneous Quantification of Six Human Cytokines in a Single Sample Using Microparticle-based Flow Cytometric Technology. Clin Chem 45, 1693–1694 (1999)

    Google Scholar 

  37. Chan, W.C.W. & S.M. Nie: Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016–2018 (1998)

    Article  Google Scholar 

  38. Bruchez, M., M. Moronne, P. Gin, S. Weiss & A.P. Alivisatos: Semiconductor nanocrystals as fluorescent biological labels. Science 281, 2013–2016 (1998)

    Article  Google Scholar 

  39. Zhu, H., J.F. Klemic, S. Chang, P. Bertone, A. Casamayor, K.G. Klemic, D. Smith, M. Gerstein, M.A. Reed & M. Snyder: Analysis of yeast protein kinases using protein chips. Nat Genet 26, 283–289 (2000)

    Article  Google Scholar 

  40. Joos, T.O., M. Schrenk, P. Hopfl, K. Kroger, U. Chowdhury, D. Stoll, D. Schorner, M. Durr, K. Herick, S. Rupp, K. Sohn & H. Hammerle: A microarray enzyme-linked immunosorbent assay for autoimmune diagnostics. Electrophoresis 21, 2641–2650 (2000)

    Article  Google Scholar 

  41. Merchant, M. & S.R. Weinberger: Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry. Electrophoresis 21, 1164–1177 (2000)

    Article  Google Scholar 

  42. Nelson, B.P., T.E. Grimsrud, M.R. Liles, R.M. Goodman & R.M. Corn: Surface plasmon resonance imaging measurements of DNA and RNA. Analytical Chemistry 73, 1–7 (1999)

    Article  Google Scholar 

  43. Brecht, A., R. Burckardt, J. Rickert, I. Stemmler, A. Schuetz, S. Fischer, T. Friedrich, G. Gauglitz & W. Goepel: Transducer-based approaches for parallel binding assays in high throughput screening. J. Biomol. Screening 1, 191–201 (1996)

    Article  Google Scholar 

  44. Nelson, R.W., D. Nedelkov & K.A. Tubbs: Biosensor chip mass spectrometry: a chip-based proteomics approach. Electrophoresis 21, 1155–1163 (2000)

    Article  Google Scholar 

  45. Pei, R.J., Z.L. Cheng, E.K. Wang & X.R. Yang: Amplification of antigen-antibody interactions based on biotin labeled protein-streptavidin network complex using impedance spectroscopy. Biosensors & Bioelectronics, 16, 355–361 (2001)

    Article  Google Scholar 

  46. Renken, J., R. Dahint, M. Grunze & F. Josse: Multifrequency Evaluation of Different Immunosorbents on Acoustic Plate Mode Sensors. Anal. Chem. 68, 176–182 (1996)

    Article  Google Scholar 

  47. Rickert, J., T. Weiss, W. Kraas, G. Jung & W. Goepel: A new affinity biosensor: self-assembled thiols as selective monolayer coatings of quartz crystal microbalances. Biosens. Bioelectron. 11, 591–598 (1996)

    Article  Google Scholar 

  48. Fodor, S.P., R.P. Rava, X.C. Huang, A.C. Pease, C.P. Holmes & C.L. Adams: Multiplexed biochemical assays with biological chips. Nature 364, 555–556 (1993)

    Article  Google Scholar 

  49. Collins, F., S. & B. Phimister: The chipping forecast. Nat. Genet. 21suppl., 61 p (1999)

    Google Scholar 

  50. Reineke, U., R. Volkmer-Engert & J. Schneider-Mergener: Applications of peptide arrays prepared by the SPOT-technology. Curr Opin Biotechnol 12, 59–64 (2001)

    Article  Google Scholar 

  51. Toepert, F., J.R. Pires, C. Landgraf, H. Oschkinat & J. Schneider-Mergener: Synthesis of an Array Comprising 837 Variants of the hYAP WW Protein Domain. Angew. Chem. Int. Ed. Engl. 40, 897–900 (2001)

    Article  Google Scholar 

  52. Reineke, U., A. Kramer & J. Schneider-Mergener: Antigen sequence-and librarybased mapping of linear and discontinuous protein-protein-interaction sites by spot synthesis. Curr Top Microbiol Immunol 243, 23–36 (1999)

    Google Scholar 

  53. MacBeath, G., A. Koehler & S. Schreiber: Printing small molecules as microarrays and detecting protein-ligand interactions en masse. J. Am. Chem. Soc. 121, 7967–7968 (1999)

    Article  Google Scholar 

  54. Borrebaeck, C.A.: Antibodies in diagnostics-from immunoassays to protein chips. Immunol Today 21, 379–382 (2000)

    Article  Google Scholar 

  55. Gao, C., S. Mao, C.H. Lo, P. Wirsching, R.A. Lerner & K.D. Janda: Making artificial antibodies: A format for phage display of combinatorial heterodimeric arrays. Proc Natl Acad Sci U S A 96, 6025–6030 (1999)

    Article  Google Scholar 

  56. Knappik, A., L. Ge, A. Honegger, P. Pack, M. Fischer, G. Wellnhofer, A. Hoess, J. Wolle, A. Pluckthun & B. Virnekas: Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides. J Mol Biol 296, 57–86 (2000)

    Article  Google Scholar 

  57. Clackson, T. & J.A. Wells: In vitro selection from protein and peptide libraries. Trends Biotechnol 12, 173–184 (1994)

    Article  Google Scholar 

  58. Hoogenboom, H.R., A.P. de Bruine, S.E. Hufton, R.M. Hoet, J.W. Arends & R.C. Roovers: Antibody phage display technology and its applications. Immunotechnology 4, 1–20 (1998)

    Article  Google Scholar 

  59. Skerra, A. & A. Pluckthun: Assembly of a functional immunoglobulin Fv fragment in Escherichia coli. Science 240, 1038–1041 (1988)

    Google Scholar 

  60. Bass, S., R. Greene & J.A. Wells: Hormone phage: an enrichment method for variant proteins with altered binding properties. Proteins 8, 309–314 (1990)

    Article  Google Scholar 

  61. Barbas, C.F., A.S. Kang, R.A. Lerner & S.J. Benkovic: Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci U S A 88, 7978–7982 (1991)

    Article  Google Scholar 

  62. McCafferty, J., A.D. Griffiths, G. Winter & D.J. Chiswell: Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348, 552–554 (1990)

    Article  Google Scholar 

  63. Griffiths, A.D., M. Malmqvist, J.D. Marks, J.M. Bye, M.J. Embleton, J. McCafferty, M. Baier, K.P. Holliger, B.D. Gorick & N.C. Hughes-Jones: Human anti-self antibodies with high specificity from phage display libraries. Embo J 12, 725–734 (1993)

    Google Scholar 

  64. Hoogenboom, H.R., A.D. Griffiths, K.S. Johnson, D.J. Chiswell, P. Hudson & G. Winter: Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acids Res 19, 4133–4137 (1991)

    Google Scholar 

  65. Clackson, T., H.R. Hoogenboom, A.D. Griffiths & G. Winter: Making antibody fragments using phage display libraries. Nature 352, 624–628 (1991)

    Article  Google Scholar 

  66. Burton, D.R., C.F. Barbas, 3rd, M.A. Persson, S. Koenig, R.M. Chanock & R.A. Lerner: A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc Natl Acad Sci U S A 88, 10134–10137 (1991)

    Article  Google Scholar 

  67. Marks, J.D., H.R. Hoogenboom, T.P. Bonnert, J. McCafferty, A.D. Griffiths & G. Winter: By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J Mol Biol 222, 581–597 (1991)

    Article  Google Scholar 

  68. Xie, M.H., J. Yuan, C. Adams & A. Gurney: Direct demonstration of MuSK involvement in acetylcholine receptor clustering through identification of agonist ScFv. Nat Biotechnol 15, 768–771 (1997)

    Article  Google Scholar 

  69. Vaughan, T.J., A.J. Williams, K. Pritchard, J.K. Osbourn, A.R. Pope, J.C. Earnshaw, J. McCafferty, R.A. Hodits, J. Wilton & K.S. Johnson: Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library. Nat Biotechnol 14, 309–314 (1996)

    Article  Google Scholar 

  70. Schier, R., A. McCall, G.P. Adams, K.W. Marshall, H. Merritt, M. Yim, R.S. Crawford, L.M. Weiner, C. Marks & J.D. Marks: Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site. J Mol Biol 263, 551–567 (1996)

    Article  Google Scholar 

  71. Barbas, C.F., 3rd, D. Hu, N. Dunlop, L. Sawyer, D. Cababa, R.M. Hendry, P.L. Nara & D.R. Burton: In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity. Proc Natl Acad Sci U S A 91, 3809–3813 (1994)

    Article  Google Scholar 

  72. Hernaiz, M., J. Liu, R.D. Rosenberg & R.J. Linhardt: Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III. Biochem Biophys Res Commun 276, 292–297 (2000)

    Article  Google Scholar 

  73. Duff, R.J., S.F. Deamond, C. Roby, Y. Zhou & P.O. Ts’o: Intrabody tissue-specific delivery of antisense conjugates in animals: ligand-linker-antisense oligomer conjugates. Methods Enzymol 313, 297–321 (2000)

    Article  Google Scholar 

  74. Lecerf, J.M., T.L. Shirley, Q. Zhu, A. Kazantsev, P. Amersdorfer, D.E. Housman, A. Messer & J.S. Huston: Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington’s disease. Proc Natl Acad Sci U S A 98, 4764–4769 (2001)

    Article  Google Scholar 

  75. Soomets, U., M. Hallbrink & U. Langel: Antisense properties of peptide nucleic acids. Front Biosci 4, D782–786 (1999)

    Google Scholar 

  76. Braasch, D.A. & D.R. Corey: Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA. Chem Biol 8, 1–7 (2001)

    Article  Google Scholar 

  77. Brody, E.N., M.C. Willis, J.D. Smith, S. Jayasena, D. Zichi & L. Gold: The use of aptamers in large arrays for molecular diagnostics. Mol Diagn 4, 381–388 (1999)

    Article  Google Scholar 

  78. Brody, E.N. & L. Gold: Aptamers as therapeutic and diagnostic agents. J Biotechnol 74, 5–13 (2000)

    Google Scholar 

  79. Wilson, D.S., A.D. Keefe & J.W. Szostak: The use of mRNA display to select highaffinity protein-binding peptides. Proc Natl Acad Sci U S A 98, 3750–3755 (2001)

    Article  Google Scholar 

  80. Blum, J.H., S.L. Dove, A. Hochschild & J.J. Mekalanos: Isolation of peptide aptamers that inhibit intracellular processes. Proc Natl Acad Sci U S A 97, 2241–2246 (2000)

    Article  Google Scholar 

  81. Kronvall, G. & K. Jonsson: Receptins: a novel term for an expanding spectrum of natural and engineered microbial proteins with binding properties for mammalian proteins. J Mol Recognit 12, 38–44 (1999)

    Article  Google Scholar 

  82. Nord, K., O. Nord, M. Uhlen, B. Kelley, C. Ljungqvist & P.A. Nygren: Recombinant human factor VIII-specific affinity ligands selected from phage-displayed combinatorial libraries of protein A. Eur J Biochem 268, 4269–4277 (2001)

    Article  Google Scholar 

  83. Nord, K., E. Gunneriusson, J. Ringdahl, S. Stahl, M. Uhlen & P.A. Nygren: Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain. Nat Biotechnol 15, 772–777 (1997)

    Article  Google Scholar 

  84. Gunneriusson, E., P. Samuelson, J. Ringdahl, H. Gronlund, P.A. Nygren & S. Stahl: Staphylococcal surface display of immunoglobulin A (IgA)-and IgEspecific in vitro-selected binding proteins (affibodies) based on Staphylococcus aureus protein A. Appl Environ Microbiol 65, 4134–4140 (1999)

    Google Scholar 

  85. Gunneriusson, E., K. Nord, M. Uhlen & P. Nygren: Affinity maturation of a Taq DNA polymerase specific affibody by helix shuffling. Protein Eng 12, 873–878 (1999)

    Article  Google Scholar 

  86. Mendoza, L.G., P. McQuary, A. Mongan, R. Gangadharan, S. Brignac & M. Eggers: High-throughput microarray-based enzyme-linked immunosorbent assay (ELISA). Biotechniques 27, 778–780, 782–776, 788 (1999)

    Google Scholar 

  87. Silzel, J.W., B. Cercek, C. Dodson, T. Tsay & R.J. Obremski: Mass-sensing, multianalyte microarray immunoassay with imaging detection. Clin Chem 44, 2036–2043. (1998)

    Google Scholar 

  88. Huang, R.P.: Simultaneous detection of multiple proteins with an array-based enzyme-linked immunosorbent assay (ELISA) and enhanced chemiluminescence (ECL). Clin Chem Lab Med 39, 209–214 (2001)

    Article  Google Scholar 

  89. Haab, B.B., M.J. Dunham & P.O. Brown: Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions. Genome Biol 2, 4.1–4.13 (2001)

    Article  Google Scholar 

  90. Cahill, D.J.: Protein and antibody arrays and their medical applications. J Immunol Methods 250, 81–91 (2001)

    Article  Google Scholar 

  91. Weinberger, S.R., T.S. Morris & M. Pawlak: Recent trends in protein biochip technology. Pharmacogenomics 1, 395–416 (2000)

    Article  Google Scholar 

  92. Davies, H.A.: The ProteinChip System from Ciphergen: a new technique for rapid, micro-scale protein biology. J Mol Med 78, B29 (2000) MacBeath, G. & S.L. Schreiber: Printing proteins as microarrays for high-throughput function determination. Science 289, 1760–1763 (2000)

    Google Scholar 

  93. von Eggeling, F., H. Davies, L. Lomas, W. Fiedler, K. Junker, U. Claussen & G. Ernst: Tissue-specific microdissection coupled with ProteinChip array technologies: applications in cancer research. Biotechniques 29, 1066–1070 (2000)

    Google Scholar 

  94. Zhu, H. & M. Snyder: Protein arrays and microarrays. Curr Opin Chem Biol 5, 40–45 (2001)

    Article  Google Scholar 

  95. Caveman: “I’ll have a genome with chips, please”. By Caveman. J Cell Sci 113, 3543–3544. (2000)

    Google Scholar 

  96. Zhu, H., M. Bilgin, R. Bangham, D. Hall, A. Casamayor, P. Bertone, N. Lan, R. Jansen, S. Bidlingmaier, T. Houfek, T. Mitchell, P. Miller, R.A. Dean, M. Gerstein & M. Snyder: Global analysis of protein activities using proteome chips. Science 293, 2101–2105. (2001)

    Article  Google Scholar 

  97. Bulyk, M.L., E. Gentalen, D.J. Lockhart & G.M. Church: Quantifying DNA-protein interactions by double-stranded DNA arrays. Nat Biotechnol 17, 573–577 (1999)

    Article  Google Scholar 

  98. Disley, D.M., P.R. Morrill, K. Sproule & C.R. Lowe: An optical biosensor for monitoring recombinant proteins in process media. Biosens Bioelectron 14, 481–493 (1999)

    Article  Google Scholar 

  99. Sanders, G.H.W. & A. Manz: Chip-based microsystems for genomic and proteomic analysis. Trends in Analytical Chemistry 19, 364–378 (2000)

    Article  Google Scholar 

  100. Rowe, C.A., S.B. Scruggs, M.J. Feldstein, J.P. Golden & F.S. Ligler: An array immunosensor for simultaneous detection of clinical analytes. Anal Chem 71, 433–439 (1999)

    Article  Google Scholar 

  101. Hook, S.S. & A.R. Means: Ca(2+) / CaM-dependent kinases: from activation to function. Annu Rev Pharmacol Toxicol 41, 471–505 (2001)

    Article  Google Scholar 

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Authors and Affiliations

  1. NMI Natural and Medical Sciences Institute, University of Tuebingen, Markwiesenstrasse 55, 72770, Reutlingen, Germany

    Markus F. Templin, Oliver Poetz, Jochen M. Schwenk, Dieter Stoll & Thomas O. Joos

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  1. Markus F. Templin
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  2. Oliver Poetz
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  1. National Engineering Research Center for Beijing Biochip Technology, CapitalBio Corporation, Beijing, China

    Wan-Li Xing PhD (Senior Staff Scientist Deputy Director) & Jing Cheng PhD (Professor and Director) (Senior Staff Scientist Deputy Director) &  (Professor and Director)

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Templin, M.F., Poetz, O., Schwenk, J.M., Stoll, D., Joos, T.O. (2006). Miniaturized Multiplexed Protein Binding Assays. In: Xing, WL., Cheng, J. (eds) Frontiers in Biochip Technology. Springer, Boston, MA. https://doi.org/10.1007/0-387-25585-0_3

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