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7. References
L. de Lecea, T. S. Kilduff, C. Peyron, X. Gao, P. E. Foye, P. E. Danielson, C. Fukuhara, E. L. Battenberg, V. T. Gautvik, F. S. Bartlett, 2nd, W. N. Frankel, A. N. van den Pol, F. E. Bloom, K. M. Gautvik and J. G. Sutcliffe, The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity, Proc Natl Acad Sci U S A. 95, 322–7 (1998).
T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R. M. Chemelli, H. Tanaka, S. C. Williams, J. A. Richardson, G. P. Kozlowski, S. Wilson, J. R. Arch, R. E. Buckingham, A. C. Haynes, S. A. Carr, R. S. Annan, D. E. McNulty, W. S. Liu, J. A. Terrett, N. A. Elshourbagy, D. J. Bergsma and M. Yanagisawa, Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior [see comments], Cell. 92, 573–85 (1998).
C. Peyron, D. K. Tighe, A. N. van den Pol, L. de Lecea, H. C. Heller, J. G. Sutcliffe and T. S. Kilduff, Neurons containing hypocretin (orexin) project to multiple neuronal systems, J Neurosci. 18, 9996–10015(1998).
S. Taheri, J. M. Zeitzer and E. Mignot, The role of hypocretins (orexins) in sleep regulation and narcolepsy, Annu Rev Neurosci. 25, 283–313 (2002).
J. G. Sutcliffe and L. de Lecea, The hypocretins: setting the arousal threshold, Nat Rev Neurosci. 3, 339–49 (2002).
T. L. Horvath, C. Peyron, D. Sabrina, A. Ivanov, G. Aston-Jones, T. Kilduff and A. N. van den Pol, Strong hypocretin (orexin) innervation of the locus coeruleus activates noradrenergic cells, J. Comp. Neurol. 415, 145–159 (1999).
A. Ivanov and G. Aston-Jones, Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons, Neuroreport. 11, 1755–1758 (2000).
J. J. Hagan, R. A. Leslie, S. Patel, M. L. Evans, T. A. Wattam, S. Holmes, C. D. Benham, S. G. Taylor, C. Routledge, P. Hemmati, R. P. Munton, T. E. Ashmeade, A. S. Shah, J. P. Hatcher, P. D. Hatcher, D. N. Jones, M. I. Smith, D. C. Piper, A. J. Hunter, R. A. Porter and N. Upton, Orexin A activates locus coeruleus cell firing and increases arousal in the rat, Proc Natl Acad Sci U S A. 96, 10911–6 (1999).
P. Bourgin, S. Huitron-Resendiz, A. D. Spier, V. Fabre, B. Morte, J. R. Criado, J. G. Sutcliffe, S. J. Henriksen and L. de Lecea, Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons, J Neurosci. 20, 7760–5 (2000).
R. E. Brown, O. A. Sergeeva, K. S. Eriksson and H. L. Haas, Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline), J Neurosci. 22, 8850–9 (2002).
R. J. Liu, A. N. van den Pol and G. K. Aghajanian, Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions, J Neurosci. 22, 9453–64 (2002).
K. S. Eriksson, O. Sergeeva, R. E. Brown and H. L. Haas, Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus, J Neurosci. 21, 9273–9 (2001).
L. Bayer, E. Eggermann, M. Serafin, B. Saint-Mleux, D. Machard, B. Jones and M. Muhlethaler, Orexins (hypocretins) directly excite tuberomammillary neurons, Eur J Neurosci. 14, 1571–5 (2001).
E. Eggermann, M. Serafin, L. Bayer, D. Machard, B. Saint-Mleux, B. E. Jones and M. Muhlethaler, Orexins/hypocretins excite basal forebrain cholinergic neurones, Neuroscience. 108, 177–81 (2001).
E. Mignot, S. Taheri and S. Nishino, Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders, Nat Neurosci. 5Suppl, 1071–5 (2002).
M. Mieda and M. Yanagisawa, Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors, Curr Opin Neurobiol. 12, 339–45 (2002).
M. T. Shipley, L. Fu, M. Ennis, W. Liu and G. Aston-Jones, Dendrites of locus coeruleus neurons extend preferentially into two pericoerulear zones, J. Comp. Neurol. 365, 56–68 (1996).
G. Aston-Jones, Y. Zhu and P. Card, Numerous GABAergic afferents to locus coeruleus in the pericoerulear dendritic zone: possible interneuronal pool, J. Neurosci. 24, 2313–2321 (2004).
G. Aston-Jones and J. P. Card, Use of Pseudorabies virus to delineate multisynaptic circuits in brain: opportunities and limitations, J. Neurosci. Meth. 103, 51–61 (2000).
G. Aston-Jones, M. Ennis, V. A. Pieribone, W. T. Nickell and M. T. Shipley, The brain nucleus locus coeruleus: restricted afferent control of a broad efferent network, Science. 234, 734–737 (1986).
L. W. Enquist, P. J. Husak, B. W. Banfield and G. A. Smith, Infection and spread of alphaherpesviruses in the nervous system, Advances in Viral Research. 51, 237–347 (1999).
Y. Zhu, J. P. Card and G. Aston-Jones, Frequent hypocretin innervation of GABA neurons in the peri-locus coeruleus region: ultrastructural studies, Soc. Neurosci. Abstr. 29, 931.15 (2003).
S. S. Osmanovic and S. A. Shefner, gamma-Aminobutyric acid responses in rat locus coeruleus neurones in vitro: a current-clamp and voltage-clamp study, J. Physiol. 421, 151–70 (1990).
M. Ennis and G. Aston-Jones, GABA-mediated inhibiton of locus coeruleus from the dorsomedial rostral medulla, J. Neurosci. 9, 2973–2981 (1989).
G. Aston-Jones, S. Chen, Y. Zhu and M. Oshinsky, A neural circuit for circadian regulation of arousal, Nature Neurosci. 4, 732–738 (2001).
G. Aston-Jones, S. L. Foote and F. E. Bloom. (1984). Anatomy and physiology of locus coeruleus neurons: functional implications. In Norepinephrine (Frontiers of Clinical Neuroscience, Vol. 2) (Ziegler, M. & Lake, C. R., eds.), pp. 92–116. Williams and Wilkins, Baltimore.
C. W. Berridge and B. D. Waterhouse, The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes, Brain Res Brain Res Rev. 42, 33–84 (2003).
G. Aston-Jones, M. M. Gonzalez and S. M. Doran. (in press). Role of the Locus Coeruleus-Norepinephrine System in Arousal and Circadian Regulation of the Sleep-Waking Cycle. In Norepinephrine: Neurobiology and Therapeutics for the 21st Century (Ordway, G. A., Schwartz, M. & Frazer, A., eds.).
M. C. Gonzalez, W. Lu and G. Aston-Jones, Role of the noradrenergic locus coeruleus system in sleep and waking: circadian factors, Soc. Neurosci. Abstr. 28, 871.11 (2002).
T. C. Chou, T. E. Scammell, J. J. Gooley, S. E. Gaus, C. B. Saper and J. Lu, Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms, J Neurosci. 23, 10691–702 (2003).
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Aston-Jones, G., Card, J.P., Zhu, Y., González, M., Haggerty, E. (2005). The Ne System as a Target for Hypocretin Neurons. In: de Lecea, L., Sutcliffe, J.G. (eds) Hypocretins. Springer, Boston, MA. https://doi.org/10.1007/0-387-25446-3_9
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