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5. References
J. M. Siegel, Hypocretin (orexin). role in normal behavior and neuropathology, Annual Rev.of Psychol. 55:125–148 (2004).
B. E. Jones, Basic Mechanisms of Sleep-Wake States. In: Principles and Practice of Sleep Medicine, edited by M.H. Kryger, et al, pp. 134–154. W.B. Saunders, Philadelphia (2000).
J. M. Siegel, Brainstem mechanisms generating REM sleep, In: Principles and Practice of Sleep Medicine, edited by M.H. Kryger, et al, pp. 112–133. W.B. Saunders Company, Philadelphia. (2000).
S. Nishino, B. Ripley, S. Overeem, G. J. Lammers and E. Mignot, Hypocretin (orexin) deficiency in human narcolepsy, Lancet. 355, 39–40 (2000).
C. Peyron, J. Faraco, W. Rogers, B. Ripley, S. Overeem, Y. Charnay, S. Nevsimalova, M. Aldrich, D. Reynolds, R. Albin, R. Li, M. Hungs, M. Pedrazzoli, M. Padigaru, M. Kucherlapati, J. Fan, R. Maki, G. J. Lammers, C. Bouras, R. Kucherlapati, S. Nishino and E. Mignot, A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains, Nat Med. 6, 991–997 (2000).
T. C. Thannickal, R. Y. Moore, R. Nienhuis, L. Ramanathan, S. Gulyani, M. Aldrich, M. Cornford and J. M. Siegel, Reduced number of hypocretin neurons in human narcolepsy, Neuron. 27, 469–74 (2000).
J. John, M.-F. Wu, L. N. Boehmer and J. M. Siegel, Cataplexy-active neurons in the posterior hypothalamus: implications for the role of histamine in sleep and waking behavior, Neuron. 42:619 (2004).
G. Aston-Jones, M. Ennis, V. A. Pieribone, W. T. Nickell and M. T. Shipley, The brain nucleus locuscoeruleus: Restricted afferent control of a broad efferent network, Science. 234:734–737 (1986).
G. Aston-Jones, S. L. Foote and F. E. Bloom, Anatomy and physiology of locus coeruleus neurons: functional implications. In: Norepinephrine, edited by M. Ziegler, et al, pp. 92–116. Williams and Wilkins, Baltimore (1984).
G. Di Chiara, G. Tanda, and E. Carboni, Estimation of in-vivo neurotransmitter release by brain microdialysis: the issue of validity, Behav.Pharmacol. 7:640–657 (1996).
D. L. Marshall, P. H. Redfern and S. Wonnacott, Presynaptic nicotinic modulation of dopamine release in the three ascending pathways studied by in vivo microdialysis: comparison of naive and chronic nicotinetreated rats, J Neurochem. 68:1511–9 (1997).
L. R. J. Baxter, E. C. Clark, R. F. Ackermann, G. Lacan and W. P. Melega, Brain Mediation of Anolis Social Dominance Displays. ii. differential forebrain serotonin turnover, and effects of specific 5-ht receptor agonists, Brain Behav.Evol. 57:184–201 (2001).
L. I. Kiyashchenko, B. Y. Mileykovskiy, N. Maidment, H. A. Lam, M. F. Wu, J. John, J. Peever and J. M. Siegel, Release of hypocretin (orexin) during waking and sleep states, J Neurosci. 22: 5282–6 (2002).
M. F. Wu, J. John, N. Maidment, H. Lam and J. Siegel, Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement, Am J Physiol Regul Integr Comp Physiol. 283:R1079–86 (2002).
R. M. Chemelli, J. T. Willie, C. Sinton, J. Elmquist, T. Scammell, C. Lee, J. Richardson, S. Williams, Y. Xiong, Y. Kisanuki, T. Fitch, M. Nakazato, R. Hammer, C. Saper, and M. Yanagisawa, Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation, Cell. 98:437–451 (1999).
J. Hara, C. T. Beuckmann, T. Nambu, J. T. Willie, R. M. Chemelli, C. M. Sinton, F. Sugiyama, K. Yagami, K. Goto, M. Yanagisawa and T. Sakurai, Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity, Neuron. 30:345–354 (2001).
A. Schuld, J. Hebebrand, F. Geller and T. Pollmacher, Increased body-mass index in patients with narcolepsy, Lancet. 355:1274–5 (2000).
M. S. Aldrich, Diagnostic aspects of narcolepsy, Neurology. 50:S2–7 (1998)
M. F. Wu, S. A. Gulyani, E. Yau, E. Mignot, B. Phan and J. M. Siegel, Locus coeruleus neurons: cessation of activity during cataplexy, Neuroscience. 91:89–99 (1999).
M. F. Wu, J. John, G. B. Nguyen, and J. M. Siegel, Serotonergic dorsal raphe REM-off cells reduce discharge but do not shut off during cataplexy, Sleep. 23:A2–A3(2000).
J. M. Siegel, R. Nienhuis, H. M. Fahringer, R. Paul, P. Shiromani, W. C. Dement, E. Mignot and C. Chiu, Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla, Science. 252:1315–8 (1991).
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Siegel, J.M. (2005). An Approach to Determining the Functions of Hypocretin (Orexin). In: de Lecea, L., Sutcliffe, J.G. (eds) Hypocretins. Springer, Boston, MA. https://doi.org/10.1007/0-387-25446-3_16
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