Skip to main content

Adrenomedullin Expression and Secretion

  • Chapter
Adrenomedullin in Cardiovascular Disease

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 19))

  • 404 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ando K, Ito Y, Kumada M, and Fujita T. (1998) Oxidative stress increases adrenomedullin mRNA levels in cultured rat vascular smooth muscle cells. Hypertens Res 21:187–191.

    PubMed  Google Scholar 

  • Cameron VA, and Fleming AM. (1998) Novel sites of adrenomedullin gene expression in mouse and rat tissues. Endocrinology 139:2253–2264.

    Article  PubMed  Google Scholar 

  • Chini EN, Chini CC, Bolliger C, Jougasaki M, Grande JP, Bumett JC, and Dousa TP. (1997) Cytoprotective effects of adrenomedullin in glomerular cell injury: central role of cAMP signaling pathway. Kidney Int 52:917–925.

    PubMed  Google Scholar 

  • Chun TH, Itoh H, Ogawa Y, Tamura N, Takaya K, Igaki T, Yamashita J, Doi K, Inoue M, Masatsugu K, Korenaga R, Ando J, and Nakao K. (1997) Shear stress augments expression of C-type natriuretic peptide and adrenomedullin. Hypertension 29:1296–1302.

    PubMed  Google Scholar 

  • Chun TH, Itoh H, Saito T, Yamahara K, Doi K, Mori Y, Ogawa Y, Yamashita J, Tanaka T, Inoue M, Masatsugu K, Sawada N, Fukunaga Y, and Nakao K. (2000) Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedullin. J Hypertens 18:575–580.

    PubMed  Google Scholar 

  • Clementi G., Caruso A, Cutuli VM, Prato A, Mangano NG, and Amico Roxas M. (1999) Antiinflammatory activity of adrenomedullin in the acetic acid peritonitis in rats. Life Sci 65:P.L203–208.

    Article  Google Scholar 

  • Cormier-Regard S, Nguyen SV, and Claycomb WC. (1998) Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. J Biol Chem 273:17787–17792.

    Article  PubMed  Google Scholar 

  • Eto T, Kitamura K, and Kato J. (1999) Biological and clinical roles of adrenomedullin in circulation control and cardiovascular diseases. Clin Exp Pharmacol Physiol 26:371–380.

    Article  PubMed  Google Scholar 

  • Eto T, Kato J, and Kitamura K. (2003) Regulation of production and secretion of adrenomedullin in the cardiovascular system. Regul Pept 112:61–69.

    Article  PubMed  Google Scholar 

  • Garayoa M, Martinez A, Lee S, Pio R, An WG, Neckers L, Trepel J, Montuenga LM, Ryan H, Johnson R, Gassmann M, and Cuttitta F. (2000) Hypoxa-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol Endocrinol 14:848–862.

    Article  PubMed  Google Scholar 

  • Hague S, Zhang L, Oehler MK., Manek S, MacKenzie IZ, Bicknell R, and Rees MC. (2000) Expression of the hypoxically regulated angiogenic factor adrenomedullin correlates with uterine leiomyoma vascular density Clin. Cancer Res 6:2808–2814.

    Google Scholar 

  • Hinson JP, Kapas S, and Smith DM. (2000) Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 21:138–167.

    Article  PubMed  Google Scholar 

  • Hirata Y, Mitaka C, Sato K, Nagura T, Tsunoda Y, Amaha K, and Marumo F. (1996) Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab 81:1449–1453.

    Article  PubMed  Google Scholar 

  • Horio T, Nishikimi T, Yoshihara F, Nagaya N, Matsuo H, Takishita S, and Kangawa K. (1998) Production and secretion of adrenomedullin in cultured rat cardiac myocytes and nonmyocytes: stimulation by interleukin-lbeta and tumor necrosis factor-alpha. Endocrinology 139:4576–4580.

    Article  PubMed  Google Scholar 

  • Isumi Y, Minamino N, Katafuchi T, Yoshioka M, Tsuji T, Kangawa K, and Matsuo H. (1998a) Adrenomedullin production in fibroblasts: its possible function as a growth regulator of Swiss 3T3 cells. Endocrinology 139:2552–2563.

    Article  PubMed  Google Scholar 

  • Isumi Y, Shoji H, Sugo S, Tochimoto T, Yoshioka M, Kangawa K, Matsuo H, and Minamino N. (1998b) Regulation of adrenomedullin production in rat endothelial cells. Endocrinology 139:838–846.

    Article  PubMed  Google Scholar 

  • Jougasaki M, Wei CM, Heublein DM, Sandberg SM, and Burnett JC. (1995b) Immunohistochemical localization of adrenomedullin in canine heart and aorta. Peptides 16:773–775.

    Article  PubMed  Google Scholar 

  • Kapas S, Martinez A, Cuttitta F, and Hinson JP. (1998) Local production and action of adrenomedullin in the rat adrenal zona glomerulosa. J Endocrinol 156:477–484.

    Article  PubMed  Google Scholar 

  • Kapas S, Tenchini ML, and Farthing PM. (2001) Regulation of adrenomedullin secretion in cultured human skin and oral keratinocytes. J Invest Dermatol 117:353–359.

    Article  PubMed  Google Scholar 

  • Kato H, Shichiri M, Marumo F, and Hirata Y. (1997) Adrenomedullin as an autocrine/paracrine apoptosis survival factor for rat endothelial cells. Endocrinology 138:2615–2620.

    Article  PubMed  Google Scholar 

  • Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, and Eto T. (1993) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192:553–560.

    Article  PubMed  Google Scholar 

  • Kitamura K, Kangawa K, and Eto T. (2002) Adrenomedullin and PAMP: discovery, structures, and cardiovascular functions. Microsc Res Tech 57: 3–13.

    Article  PubMed  Google Scholar 

  • Kitamuro T, Takahashi K, Nakayama M, Murakami O, Hida W, Shirato K, and Shibahara S. (2000) Induction of adrenomedullin during hypoxia in cultured human glioblastoma cells J Neurochem 75:1826–1833.

    Article  PubMed  Google Scholar 

  • Kobayashi H, Yamamoto R, Kitamura K, Niina H, Masumoto K, Minami SI, Yanagita T, Izumi F, Aunis D, Eto T, and Wada A. (1999) Cyclic AMP-dependent synthesis and release of adrenomedullin and PAMP in cultured bovine adrenal chromaffin cells. Eur J Biochem 263:702–708.

    Article  PubMed  Google Scholar 

  • Kubo A, Minamino N, Isumi Y, Kangawa K, Dohi K, and Matsuo H. (1998a) Adrenomedullin production is correlated with differentiation in human leukemia cell lines and peripheral blood monocytes. FEBS Lett 426:233–237.

    Article  PubMed  Google Scholar 

  • Kubo A, Minamino N, Isumi Y, Katafuchi T, Kangawa K, Dohi K, and Matsuo H. (1998b) Production of adrenomedullin in macrophage cell line and peritoneal macrophage. J Biol Chem 273:16730–16738.

    Article  PubMed  Google Scholar 

  • Ladoux A, and Frelin C. (2000) Coordinated Up-regulation by hypoxia of adrenomedullin and one of its putative receptors (RDC-1) in cells of the rat blood-brain barrier J Biol Chem 275:39914–39919.

    Article  PubMed  Google Scholar 

  • Lai KN, Leung JC, Yeung VT, Lewis LK, and Nicholls MG. (1998) Gene transcription and synthesis of adrenomedullin by cultured human renal cells. Biochem Biophys Res Commun 244:567–572.

    Article  PubMed  Google Scholar 

  • Leonard MO, Cottell DC, Godson C, Brady HR, and Taylor CT. (2003) The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia. J Biol Chem 278:40296–304.

    Article  PubMed  Google Scholar 

  • Li Y, Totsune K, Takeda K, Furuyama K, Shibahara S, and Takahashi K. (2003) Differential expression of adrenomedullin and resistin in 3T3-L1 adipocytes treated with tumor necrosis factor-alpha. Eur J Endocrinol 149:231–238.

    Article  PubMed  Google Scholar 

  • Ma Y, Freitag P, Zhou J, Brune B, Frede S, and Fandrey J. (2004) Thyroid hormone one induces erythropoietin gene expression through augmented accumulation of hypoxia-inducible factor-1. Am J Physiol in press.

    Google Scholar 

  • Makino Y, Nakamura H, Ikeda E, Ohnuma K, Yamauchi K, Yabe Y, Poellinger L, Okada Y, Morimoto C, and Tanaka H. (2003) Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells. J Immunol 171:6534–40.

    PubMed  Google Scholar 

  • Martinez A, Miller MJ, Unsworth EJ, Siegfried JM, and Cuttitta F. (1995) Expression of adrenomedullin in normal human lung and in pulmonary tumors. Endocrinology 136:4099–4105.

    Article  PubMed  Google Scholar 

  • Marutsuka K, Hatakeyama K, Sato Y, Yamashita A, Sumiyoshi A, and Asada Y. (2003) Immunohistological localization and possible functions of adrenomedullin. Hypertens Res 26:S33–40.

    PubMed  Google Scholar 

  • Matsuzawa Y, Funahashi T, Kihara S, and Shimomura I. (2004) Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 24:29–33.

    Article  PubMed  Google Scholar 

  • Michibata H, Mukoyama M, Tanaka I, Suga S, Nakagawa M, Ishibashi R, Goto M, Akaji K, Fujiwara Y, Kiso Y. and Nakao K. (1998) Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells. Kidney Int 53:979–985.

    Article  PubMed  Google Scholar 

  • Minamino N, Kikumoto K, and Isumi Y. (2002) Regulation of adrenomedullin expression and release. Microsc Res Tech 57: 28–39.

    Article  PubMed  Google Scholar 

  • Moriyama T, Otani T, and Maruo T. (2000) Expression of adrenomedullin by human granulosa lutein cells and its effect on progesterone production. Eur J Endocrinol 142:671–676.

    Article  PubMed  Google Scholar 

  • Nagata D, Hirata Y, Suzuki E, Kakoki M, Hayakawa H, Goto A, Ishimitsu T, Minamino N, Ono Y, Kangawa K, Matsuo H, and Omata M. (1999) Hypoxia-induced adrenomedullin production in the kidney. Kidney Int 55:1259–1267.

    Article  PubMed  Google Scholar 

  • Nakayama M, Takahashi K, Murakami O, Shirato K, and Shibahara S. (1999a) Induction of adrenomedullin by hypoxia in cultured human coronary artery endothelial cells. Peptides 20:769–772.

    Article  PubMed  Google Scholar 

  • Nakayama M, Takahashi K, Murakami O, Yanai M, Sasaki H, Shirato K, and Shibahara S. (1999b) Production and secretion of adrenomedullin in cultured human alveolar macrophages. Peptides 20:1123–1125.

    Article  PubMed  Google Scholar 

  • Nishikimi T, Yoshihara F, Horinaka S, Kobayashi N, Mori Y, Tadokoro K, Akimoto K, Minamino N, Kangawa K, and Matsuoka H. (2003) Chronic administration of adrenomedullin attenuates transition from left ventricular hypertrophy to heart failure in rats. Hypertension 42:1034–1041.

    Article  PubMed  Google Scholar 

  • Nishimura J, Seguchi H, Sakihara C, Kureishi Y, Yoshimura H, Kobayashi S, and Kanaide H. (1997) The relaxant effect of adrenomedullin on particular smooth muscles despite a general expression of its mRNA in smooth muscle, endothelial and epithelial cells. Br J Pharmacol 120:193–200.

    PubMed  Google Scholar 

  • Nishio K, Akai Y, Murao Y, Doi N, Ueda S, Tabuse H, Miyamoto S, Dohi K, Minamino N, Shoji H, Kitamura K, Kangawa K, and Matsuo H. (1997) Increased plasma concentrations of adrenomedullin correlate with relaxation of vascular tone in patients with septic shock. Crit Care Med 25:953–957.

    Article  PubMed  Google Scholar 

  • Niu P, Shindo T, Iwata H, Iimuro S, Takeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, and Nagai R. (2004) Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis, and renal damage. Circulation 109:1789–1794.

    Article  PubMed  Google Scholar 

  • Oehler MK, Norbury C, Hague S, Rees MC, and Bicknell R. (2001) Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth. Oncogene 20:2937–2945.

    Article  PubMed  Google Scholar 

  • Pewitt EB, Haleem R, and Wang Z. (1999) Adrenomedullin gene is abundantly expressed and directly regulated by androgen in the rat ventral prostate. Endocrinology 140:2382–2386.

    Article  PubMed  Google Scholar 

  • Sandner P, Hofbauer KH, Tinel H, Kurtz A, Thiesson HC, Ottosen PD, Walter S, Skott O, and Jensen BL. (2004) Expression of adrenomedullin in hypoxic and ischemic rat kidneys and human kidneys with arterial stenosis. Am J Physiol 286:R942–951.

    Google Scholar 

  • Sato K, Imai T, Iwashina M, Marumo F, and Hirata Y. (1998) Secretion of adrenomedullin by renal tubular cell lines. Nephron 78:9–14.

    Article  PubMed  Google Scholar 

  • Shimosawa T, Ogihara T, Matsui H, Asano T, Ando K, and Fujita T. (2003) Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress. Hypertension 41:1080–1085.

    Article  PubMed  Google Scholar 

  • Shindo T, Kurihara H, Maemura K, Kurihara Y, Kuwaki T, Izumida T, Minamino N, Ju KH, Morita H, Oh-hashi Y, Kumada M, Kangawa K, Nagai R, and Yazaki Y. (2000b) Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature. Circulation 101:2309–2316.

    PubMed  Google Scholar 

  • Shinoki N, Kawasaki T, Minamino N, Okahara K, Ogawa A, Ariyoshi H, Sakon M, Kambayashi J, Kangawa K, and Monden M. (1998) Shear stress down-regulates gene transcription and production of adrenomedullin in human aortic endothelial cells. J Cell Biochem 71:109–115.

    Article  PubMed  Google Scholar 

  • Shoji H, Minamino N, Kangawa K, and Matsuo H. (1995) Endotoxin markedly elevates plasma concentration and gene transcription of adrenomedullin in the rat. Biochem Biophys Res Commun 215:531–537.

    Article  PubMed  Google Scholar 

  • Sugo S, Minamino N, Kangawa K, Miyamoto K, Kitamura K, Sakata J, Eto T, and Matsuo H. (1994a) Endothelial cells actively synthesize and secrete adrenomedullin. Biochem Biophys Res Commun 201:1160–1166.

    Article  PubMed  Google Scholar 

  • Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T, and Matsuo H. (1994b) Production and secretion of adrenomedullin from vascular smooth muscle cells: augmented production by tumor necrosis factor-alpha. Biochem Biophys Res Commun 203:719–726.

    Article  PubMed  Google Scholar 

  • Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T, and Matsuo H. (1995a) Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells. Biochem Biophys Res Commun 207:25–32.

    Article  PubMed  Google Scholar 

  • Takahashi K, Satoh F, Hara E, Sone M, Murakami O, Kayama T, Yoshimoto T, and Shibahara S. (1997) Production and secretion of adrenomedullin from glial cell tumors and its effects on cAMP production. Peptides 18:1117–1124.

    Article  PubMed  Google Scholar 

  • Takahashi K, Nakayama M, Totsune K, Murakami O, Sone M, Kitamuro T, Yoshinoya A, and Shibahara S. (2000a) Increased secretion of adrenomedullin from cultured human astrocytes by cytokines. J Neurochem 74:99–103.

    Article  PubMed  Google Scholar 

  • Takahashi K, Yoshinoya A, Murakami O, Totsune K, and Shibahara S. (2000b) Production and secretion of two vasoactive peptides, adrenomedullin and endothelin-1, by cultured human adrenocortical carcinoma cells. Peptides 21:251–256.

    Article  PubMed  Google Scholar 

  • Tomoda Y, Kikumoto K, Isumi Y, Katafuchi T, Tanaka A, Kangawa K, Dohi K, and Minamino N. (2001a) Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro. Cardiovasc Res 49:721–730.

    Article  PubMed  Google Scholar 

  • Tomoda Y, Isumi Y, Katafuchi T, and Minamino N. (2001b) Regulation of adrenomedullin secretion from cultured cells. Peptides 22: 1783–1794.

    Article  PubMed  Google Scholar 

  • Tsuruda T, Kato J, Kitamura K, Kuwasako K, Imamura T, Koiwaya Y, Tsuji T, Kangawa K, and Eto T. (1998) Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes. Hypertension 31:505–510.

    PubMed  Google Scholar 

  • Tsuruda T, Kato J, Kitamura K, Kawamoto M, Kuwasako K, Imamura T, Koiwaya Y, Tsuji T, Kangawa K, and Eto T. (1999) An autocrine or a paracrine role of adrenomedullin in modulating cardiac fibroblast growth. Cardiovasc Res 43:958–967.

    Article  PubMed  Google Scholar 

  • Udono T, Takahashi K, Nakayama M, Yoshinoya A, Totsune K, Murakami O, Durlu YK, Tamai M, and Shibahara S. (2001) Induction of adrenomedullin by hypoxia in cultured retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 42:1080–6.

    PubMed  Google Scholar 

  • Ueda S, Nishio K, Minamino N, Kubo A, Akai Y, Kangawa K, Matsuo H, Fujimura Y, Yoshioka A, Masui K, Doi N, Murao Y, and Miyamoto S. (1999) Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome. Am J Respir Crit Care Med 160:132–136.

    PubMed  Google Scholar 

  • Yin H, Chao L, and Chao J. (2004) Adrenomedullin protects against myocardial apoptosis after ischemia/reperfusion through activation of Akt-GSK signaling. Hypertension 43:109–116.

    Article  PubMed  Google Scholar 

  • Yoshibayashi M, Kamiya T, Nishikimi T, Saito Y, Matsuo H, and Kangawa K. (1999) Elevated plasma levels of adrenomedullin in congenital cyanotic heart disease. Clin Sci (Lond) 96:543–547.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Minamino, N. (2005). Adrenomedullin Expression and Secretion. In: Nishikimi, T. (eds) Adrenomedullin in Cardiovascular Disease. Basic Science for the Cardiologist, vol 19. Springer, Boston, MA. https://doi.org/10.1007/0-387-25405-6_4

Download citation

  • DOI: https://doi.org/10.1007/0-387-25405-6_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25404-3

  • Online ISBN: 978-0-387-25405-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics