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References

  • Arnold A, Kim HG, Gaz RD, Eddy RL, Fukushima Y, Byers MG, Shows TB, Kronenberg HM. (1989) Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma. J Clin Invest 83:2034–2040.

    PubMed  Google Scholar 

  • Autelitano DJ, Ridings R, Tang F. (2001) Adrenomedullin is a regulated modulator of neonatal cardiomyocyte hypertrophy in vitro. Cardiovasc Res 51:255–264.

    Article  PubMed  Google Scholar 

  • Barker S, Wood E, Clark AJ, Corder R. (1998) Cloning of bovine preproadrenomedullin and inhibition of its basal expression in vascular endothelial cells by staurosporine. Life Sci 62:1407–1415.

    Article  PubMed  Google Scholar 

  • Cameron VA, Autelitano DJ, Evans JJ, Ellmers LJ, Espiner EA, Nicholls MG, Richards AM. (2002) Adrenomedullin expression in rat uterus is correlated with plasma estradiol. Am J Physiol Endocrinol Metab 282:E139–E146.

    PubMed  Google Scholar 

  • Carluccio M, Soccio M, De Caterina R. (2001) Aspects of gene polymorphisms in cardiovascular disease: the renin-angiotensin system. Eur J Clin Invest 31:476–488.

    Article  PubMed  Google Scholar 

  • Chun TH, Itoh H, Ogawa Y, Tamura N, Takaya K, Igaki T, Yamashita J, Doi K, Inoue M, Masatsugu K, Korenaga R, Ando J, Nakao K. (1997) Shear stress augments expression of C-type natriuretic peptide and adrenomedullin. Hypertension 29:1296–1302.

    PubMed  Google Scholar 

  • Chun TH, Itoh H, Saito T, Yamahara K, Doi K, Mori Y, Ogawa Y, Yamashita J, Tanaka T, Inoue M, Masatsugu K, Sawada N, Fukunaga Y, Nakao K. (2000) Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedullin. J Hypertens 18:575–580.

    PubMed  Google Scholar 

  • Cormier-Regard S, Nguyen SV, Claycomb WC. (1998) Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. J Biol Chem 273:17787–17792.

    Article  PubMed  Google Scholar 

  • Daley GQ, Cargill M. (2001) The heart SNPs a beat: polymorphisms in candidate genes for cardiovascular disease. Trends Cardiovasc Med 11:60–66.

    Article  PubMed  Google Scholar 

  • Danser AH, Schunkert H (2000) Renin-angiotensin system gene polymorphisms: potential mechanisms for their association with cardiovascular diseases. Eur J Pharmacol 410:303–316.

    Article  PubMed  Google Scholar 

  • da Veiga Pereira L, Desnick RJ, Adler DA, Disteche CM, Schuchman EH. (1991) Regional assignment of the human acid sphingomyelinase gene (SMPD1) by PCR analysis of somatic cell hybrids and in situ hybridization to 11p15.1–p15.4. Genomics 9:229–234.

    Article  PubMed  Google Scholar 

  • Dotsch J, Harmjanz A, Christiansen H, Hanze J, Lampert F, Rascher W. (2000) Gene expression of neuronal nitric oxide synthase and adrenomedullin in human neuroblastoma using real-time PCR. Int J Cancer 88:172–175.

    Article  PubMed  Google Scholar 

  • Giacalone PL, Vuaroqueaux V, Daures JP, Houafic L, Martin PM, Laffargue F, Maudelonde T. (2003) Expression of adrenomedullin in human ovaries, ovarian cysts and cancers. Correlation with estrogens receptor status. Eur J Obstet Gynecol Reprod Biol 110:224–229.

    Article  PubMed  Google Scholar 

  • Hata K, Takebayashi Y, Akiba S, Fujiwaki R, Iida K, Nakayama K, Nakayama S, Fukumoto M, Miyazaki K. (2000) Expression of the adrenomedullin gene in epithelial ovarian cancer. Mol Hum Reprod 6:867–872.

    Article  PubMed  Google Scholar 

  • Heesom AE, Hibberd ML, Millward A, Demaine AG. (1997) Polymorphism in the 5’-end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type I diabetes. Diabetes 46:287–291.

    PubMed  Google Scholar 

  • Hirata Y, Mitaka C, Sato K, Nagura T, Tsunoda Y, Amaha K, Marumo F. (1996) Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab 81:1449–1453.

    Article  PubMed  Google Scholar 

  • Hofbauer KH, Schoof E, Kurtz A, Sandner P. (2002) Inflammatory cytokines stimulate adrenomedullin expression through nitric oxide-dependent and — independent pathways. Hypertension 39:161–167.

    Article  PubMed  Google Scholar 

  • Horio T, Kohno M, Kano H, Ikeda M, Yasunari K, Yokokawa K, Minami M, Takeda T. (1995) Adrenomedullin as a novel antimigration factor of vascular smooth muscle cells. Circ Res 77:660–664.

    PubMed  Google Scholar 

  • Ishimitsu T, Nishikimi T, Saito Y, Kitamura K, Eto T, Kangawa K, Matsuo H, Omae T, Matsuoka H. (1994a) Plasma levels of adrenomedullin, a newly identified hypotensive peplide, in patients with hypertension and renal failure. J Clin Invest 94:2158–2161.

    PubMed  Google Scholar 

  • Ishimitsu T, Kojima M, Kangawa K, Hino J, Matsuoka H, Kitamura K, Eto T, Matsuo H. (1994b) Genomic structure of human adrenomedullin gene. Biochem Biophys Res Commun 203:631–639.

    Article  PubMed  Google Scholar 

  • Ishimitsu T, Miyata A, Matsuoka H, Kangawa K. (1998) Transcriptional regulation of human adrenomedullin gene in vascular endothelial cells. Biochem Biophys Res Commun 243:463–470.

    Article  PubMed  Google Scholar 

  • Ishimitsu T, Minami J, Nishikimi T, Yoshida K, Tsukada H, Kangawa K, Matsuoka H. (1999) Changes in plasma adrenomedullin in physiological and pathological conditions in human subjects. J Cardiovasc Pharmacol 34(Suppl 4):S47–S51.

    Google Scholar 

  • Ishimitsu T, Hosoya K, Tsukada K, Minami J, Ono H, Ohrui M, Hino J, Kangawa K, Matsuoka H (2001a) Chromosomal sublocalization and microsatellite DNA polymorphism of human adrenomedullin gene. Peptides 22:1739–1744.

    Article  PubMed  Google Scholar 

  • Ishimitsu T, Hosoya K, Tsukada K, Minami J, Futoh Y, Ono H, Ohrui M, Hino J, Kangawa K, Matsuoka H. (2001b) Microsatellite DNA polymorphism of human adrenomedullin gene in normotensive subjects and patients with essential hypertension. Hypertension 38:9–12.

    PubMed  Google Scholar 

  • Ishimitsu T, Tsukada K, Minami J, Ono H, Ohrui M, Hino J, Kangawa K, Matsuoka H. (2003) Microsatellite DNA polymorphism of human adrenomedullin gene in type 2 diabetic patients with renal failure. Kidney Int 63:2230–2235.

    Article  PubMed  Google Scholar 

  • Isumi Y, Shoji H, Sugo S, Tochimoto T, Yoshioka M, Kangawa K, Matsuo H, Minamino N. (1998) Regulation of adrenomedullin production in rat endothelial cells. Endocrinology 139:838–846.

    Article  PubMed  Google Scholar 

  • Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, Corvol P. (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71:169–180.

    PubMed  Google Scholar 

  • Jimenez N, Abasolo I, Jongsma J, Calvo A, Garayoa M, van der Kwast TH, van Steenbrugge GJ, Montuenga LM. (2003) Androgen-independent expression of adrenomedullin and peptidylglycine alpha-amidating monooxygenase in human prostatic carcinoma. Mol Carcinog 38:14–24.

    Article  PubMed  Google Scholar 

  • Jougasaki M, Grantham JA, Redfield MM, Burnett JC Jr. (2001) Regulation of cardiac adrenomedullin in heart failure. Peptides 22:1841–1850.

    Article  PubMed  Google Scholar 

  • Kano H, Kohno M, Yasunari K, Yokokawa K, Horio T, Ikeda M, Minami M, Hanehira T, Takeda T, Yoshikawa J. (1996) Adrenomedullin as a novel antiproliferative factor of vascular smooth muscle cells. J Hypertens 14:209–213.

    PubMed  Google Scholar 

  • Kapas S, Tenchini ML, Farthing PM. (2001) Regulation of adrenomedullin secretion in cultured human skin and oral keratinocytes. J Invest Dermatol 117:353–359.

    Article  PubMed  Google Scholar 

  • Kato H, Shichiri M, Marumo F, Hirata Y. (1997) Adrenomedullin as an autocrine/paracrine apoptosis survival factor for rat endothelial cells. Endocrinology 138:2615–2620.

    Article  PubMed  Google Scholar 

  • Kato J, Kitamura K, Matsui E, Tanaka M, Ishizaka Y, Kita T, Kangawa K, Eto T. (1999) Plasma adrenomedullin and natriuretic peptides in patients with essential or malignant hypertension. Hypertens Res 22:61–65.

    PubMed  Google Scholar 

  • Katsuki A, Sumida Y, Gabazza EC, Murashima S, Urakawa H, Morioka K, Kitagawa N, Tanaka T, Araki-Sasaki R, Hori Y, Nakatani K, Yano Y, Adachi Y. (2002) Acute hyperinsulinemia is associated with increased circulating levels of adrenomedullin in patients with type 2 diabetes mellitus. Eur J Endocrinol 147:71–75.

    Article  PubMed  Google Scholar 

  • Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T: (1993a) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192:553–560.

    Article  PubMed  Google Scholar 

  • Kitamura K, Sakata J, Kangawa K, Kojima M, Matsuo H, Eto T: (1993b) Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem Biophys Res Commun 194:720–725.

    Article  PubMed  Google Scholar 

  • Kitamura K, Ichiki Y, Tanaka M, Kawamoto M, Emura J, Sakakibara S, Kangawa K, Matsuo H, Eto T: (1994) Immunoreactive adrenomedullin in human plasma. FEBS Lett 341:288–290.

    Article  PubMed  Google Scholar 

  • Kobayashi H, Yamamoto R, Kitamura K, Niina H, Masumoto K, Minami SI, Yanagita T, Izumi F, Aunis D, Eto T, Wada A. (1999) Cyclic AMP-dependent synthesis and release of adrenomedullin and proadrenomedullin N-terminal 20 peptide in cultured bovine adrenal chromaffin cells. Eur J Biochem 263:702–708.

    Article  PubMed  Google Scholar 

  • Kohno M, Hanehira T, Kano H, Horio T, Yokokawa K, Ikeda M, Minami M, Yasunari K, Yoshikawa J. (1996) Plasma adrenomedullin concentrations in essential hypertension. Hypertension 27:102–107.

    PubMed  Google Scholar 

  • Ladoux A, Frelin C. (2000) Coordinated Up-regulation by hypoxia of adrenomedullin and one of its putative receptors (RDC-1) in cells of the rat blood-brain bamrrier. J Biol Chem 275:39914–39919.

    Article  PubMed  Google Scholar 

  • Letizia C, Subioli S, Cerci S, Caliumi C, Verrelli C, Delfini E, Celi M, Scuro L, D’Erasmo E. (2002) High plasma adrenomedullin concentrations in patients with high-renin essential hypertension. J Renin Angiotensin Aldosterone Syst 3:126–129.

    PubMed  Google Scholar 

  • Letizia C, Caliumi C, Delfini E, Celi M, Subioli S, Diacinti D, Minisola S, D’erasmo E, Mazzuoli GF. (2003) Adrenomedullin concentrations are elevated in plasma of patients with primary hyperparathyroidism. Metabolism 52:159–162.

    Article  PubMed  Google Scholar 

  • Li SS, Luedemann M, Sharief FS, Takano T, Deaven LL. (1988) Mapping of human lactate dehydrogenase-A,-B, and-C genes and their related sequences: the gene for LDHC is located with that for LDHA on chromosome 11. Cytogenet Cell Genet 48:16–18.

    PubMed  Google Scholar 

  • Luodonpaa M, Rysa J, Pikkarainen S, Tenhunen O, Tokola H, Puhakka J, Marttila M, Vuolteenaho O, Ruskoaho H. (2003) Mechanisms regulating adrenomedullin gene expression in the left ventricle: role of mechanical load. Regul Pept 112:153–159.

    Article  PubMed  Google Scholar 

  • Miyashita K, Itoh H, Sawada N, Fukunaga Y, Sone M, Yamahara K, Yurugi T, Nakao K. (2003) Adrenomedullin promotes proliferation and migration of cultured endothelial cells. Hypertens Res 26Suppl:S93–S98.

    PubMed  Google Scholar 

  • Nakayama M, Takahashi K, Kitamuro T, Murakami O, Shirato K, Shibahara S (2000) Transcriptional control of adrenomedullin induction by phorbol ester in human monocytic leukemia cells. Eur J Biochem 267:3559–3566.

    Article  PubMed  Google Scholar 

  • Nishikimi T, Saito Y, Kitamura K, Ishimitsu T, Eto T, Kangawa K, Matsuo H, Omae T, Matsuoka H. (1995) Increased plasma levels of adrenomedullin in patients with heart failure. J Am Coll Cardiol 26:1424–1431.

    Article  PubMed  Google Scholar 

  • Ogita T, Hashimoto E, Yamasaki M, Nakaoka T, Matsuoka R, Kira Y, Fujita T. (2001) Hypoxic induction of adrenomedullin in cultured human umbilical vein endothelial cells. J Hypertens 19:603–608.

    Article  PubMed  Google Scholar 

  • Osajima A, Kato H, Uezono Y, Suda T, Okazaki M, Oishi Y, Tamura M, Tanaka H, Izumi F, Nakashima Y. (1999) Adrenomedullin inhibits transmural pressure induced mesangial cell proliferation through activation of protein kinase A. Nephron. 83:352–357.

    Article  PubMed  Google Scholar 

  • Parameswaran N, Nambi P, Brooks DP, Spielman WS. (1999) Regulation of glomerular mesangial cell proliferation in culture by adrenomedullin. (1999) Eur J Pharmacol 372:85–95.

    Article  PubMed  Google Scholar 

  • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. (1990) An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86:1343–1346.

    PubMed  Google Scholar 

  • Rocchi P, Boudouresque F, Zamora AJ, Muracciole X, Lechevallier E, Martin PM, Oualik L. (2001) Expression of adrenomedullin and peptide amidation activity in human prostate cancer and in human prostate cancer cell lines. Cancer Res 61:1196–1206.

    PubMed  Google Scholar 

  • Romppanen H, Marttila M, Magga J, Vuolteenaho O, Kinnunen P, Szokodi I, Ruskoaho H (1997) Adrenomedullin gene expression in the rat heart is stimulated by acute pressure overload: blunted effect in experimental hypertension. Endocrinology 138:2636–2639.

    Article  PubMed  Google Scholar 

  • Sharma P, Hingorani A, Jia H. Ashby M, Hopper R, Clayton D, Brown MJ. (1998) Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension. Hypertension 32:676–682.

    PubMed  Google Scholar 

  • Shichiri M, Kato H, Doi M, Marumo F, Hirata Y. (1999) Induction of max by adrenomedullin and calcitonin gene-related peptide antagonizes endothelial apoptosis. Mol Endocrinol 13:1353–1363.

    Article  PubMed  Google Scholar 

  • Shinoki N, Kawasaki T, Minamino N, Okahara K, Ogawa A, Ariyoshi H, Sakon M, Kambayashi J, Kangawa K, Monden M. (1998) Shear stress down-regulates gene transcription and production of adrenomedullin in human aortic endothelial cells. J Cell Biochem 71:109–115.

    Article  PubMed  Google Scholar 

  • Sugo S, Minamino N, Kangawa K, Miyamoto K, Kitamura K, Sakata J, Eto T, Matsuo H. (1994a) Endothelial cells actively synthesize and secrete adrenomedullin. Biochem Biophys Res Commun 201:1160–1166.

    Article  PubMed  Google Scholar 

  • Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T, Matsuo H. (1994b) Production and secretion of adrenomedullin from vascular smooth muscle cells: augmented production by tumor necrosis factor-alpha. Biochem Biophys Res Commun 203:719–726.

    Article  PubMed  Google Scholar 

  • Sugo S, Minamino N, Shoji H, Kangawa K, Matsuo H. (1995) Effects of vasoactive substances and cAMP related compounds on adrenomedullin production in cultured vascular smooth muscle cells. FEBS Lett 369:311–314.

    Article  PubMed  Google Scholar 

  • Takahashi K, Udono-Fujimori R, Totsune K, Murakami O, Shibahara S. (2003) Suppression of cytokine-induced expression of adrenomedullin and endothelin-1 by dexamethasone in T98G human glioblastoma cells. Peptides. 24:1053–1062.

    Article  PubMed  Google Scholar 

  • Tanaka T, Akiyama H, Kanai H, Sato M, Takeda S, Sekiguchi K, Yokoyama T, Kurabayashi M. (2002) Endothelial PAS domain protein 1 (EPAS1) induces adrenomedullin gene expression in cardiac myocytes: role of EPAS1 in an inflammatory response in cardiac myocytes. J Mol Cell Cardiol 34:739–748.

    Article  PubMed  Google Scholar 

  • Tang Z, Tracy RP. (2001) Candidate genes and confirmed genetic polymorphisms associated with cardiovascular diseases: a tabular assessment. J Thromb Thrombolys 11:49–81.

    Article  Google Scholar 

  • Tomoda Y, Kikumoto K, Isumi Y, Katafuchi T, Tanaka A, Kangawa K, Dohi K, Minamino N. (2001) Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro. Cardiovasc Res 49:721–730.

    Article  PubMed  Google Scholar 

  • Tsuruda T, Kato J, Kitamura K, Imamura T, Koiwaya Y, Kangawa K, Komuro I, Yazaki Y, Eto T. (2000) Enhanced adrenomedullin production by mechanical stretching in cultured rat cardiomyocytes. Hypertension 35:1210–1214.

    PubMed  Google Scholar 

  • Tsuruda T, Kato J, Kitamura K, Mishima K, Imamura T, Koiwaya Y, Kangawa K, Eto T (2001) Roles of protein kinase C and Ca2+-dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes. J Hypertens 19:757–763.

    Article  PubMed  Google Scholar 

  • Udono T, Totsune K, Takahashi K, Abe T, Sato M, Shibahara S, Tamai M. (2000) Increased expression of adrenomedullin mRNA in the tissues of intraocular and orbital tumors. Am J Ophthalmol 129:555–556.

    Article  PubMed  Google Scholar 

  • Uemura T, Kato J, Kuwasako K, Kitamura K, Kangawa K, Eto T. (2002) Aldosterone augments adrenomedullin production without stimulating pro-adrenomedullin N-terminal 20 peptide secretion in vascular smooth muscle cells. J Hypertens 20:1209–1214.

    Article  PubMed  Google Scholar 

  • Wang X, Yue TL, Barone FC, White RF, Clark RK, Willette RN, Sulpizio AC, Aiyar NV, Ruffolo RR Jr, Feuerstein GZ. (1995) Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage. Proc Nati Acad Sci U S A 92:11480–11484.

    Google Scholar 

  • Wang X, Peters MA, Utama FE, Wang Y, Taparowsky EJ. (1999) The Adrenomedullin gene is a target for negative regulation by the Myc transcription complex. Mol Endocrinol 13:254–267.

    Article  PubMed  Google Scholar 

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Ishimitsu, T., Tsukada, K., Minami, J., Ono, H., Matsuoka, H. (2005). Adrenomedullin Gene. In: Nishikimi, T. (eds) Adrenomedullin in Cardiovascular Disease. Basic Science for the Cardiologist, vol 19. Springer, Boston, MA. https://doi.org/10.1007/0-387-25405-6_3

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