Abstract
The participation of ADAM 17 in the proteolytic release of the ectodomain of different cell surface proteins, a process known as shedding, has been well established. The characterization of ADAM 17 knockout cell lines has unveiled an unexpectedly wide repertoire of substrates. However, despite the likely involvement of ADAM 17 in the development of several diseases, critical questions such as how its metalloprotease activity is regulated or how its substrates are recognized remain to be answered.
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References
Akatsu, T., Nakamura, M., Satoh, M. Hiramori, K., 2003, Increased mRNA expression of tumour necrosis factor-alpha and its converting enzyme in circulating leucocytes of patients with acute myocardial infarction. Clin Sci (Lond). 105:(1): 39–44.
Althoff, K., Reddy, P., Voltz, N., Rose-John, S. Mullberg, J., 2000, Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins. Eur J Biochem. 267:(9): 2624–31.
Althoff, K., Mullberg, J., Aasland, D., Voltz, N., Kallen, K., Grotzinger, J. Rose-John, S., 2001, Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins. Biochem J. 353: (Pt 3): 663–72.
Amin, A. R., 1999, Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis. Osteoarthritis Cartilage. 7:(4): 392–4.
Argast, G. M., Campbell, J. S., Brooling, J. T. Fausto, N., 2004, Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replication. J Biol Chem. 279:(33): 34530–6
Arribas, J. and Massague, J., 1995, Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism. J Cell Biol. 128:(3): 433–41.
Arribas, J., Coodly, L., Vollmer, P., Kishimoto, T. K., Rose-John, S. Massague, J., 1996, Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. J Biol Chem. 271:(19): 11376–82.
Arribas, J., Lopez-Casillas, F. Massague, J., 1997, Role of the juxtamembrane domains of the transforming growth factor-alpha precursor and the beta-amyloid precursor protein in regulated ectodomain shedding. J Biol Chem. 272:(27): 17160–5.
Arribas, J. and Borroto, A., 2002, Protein ectodomain shedding. Chem Rev. 102:(12): 4627–38.
Arribas, J. and Merlos-Suarez, A., 2003, Shedding of plasma membrane proteins. Curr Top Dev Biol. 54: 125–44.
Bax, D. V., Messent, A. J., Tart, J., Van Hoang, M., Kott, J., Maciewicz, R. A. Humphries, M. J., 2004, Integrin alpha 5beta 1 and TNFalpha converting enzyme (TACE/ADAM-17) interact in vitro and colocalise in migrating HeLa cells. J Biol Chem. 279:(21): 22377–86
Biggs, J. R., Kudlow, J. E. Kraft, A. S., 1996, The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells. J Biol Chem. 271:(2): 901–6.
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., Nelson, N., Boiani, N., Schooley, K. A., Gerhart, M., Davis, R., Fitzner, J. N., Johnson, R. S., Paxton, R. J., March, C. J. Cerretti, D. P., 1997, A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 385:(6618): 729–33.
Blobel, C. P., 2000, Remarkable roles of proteolysis on and beyond the cell surface. Curr Opin Cell Biol. 12:(5): 606–12.
Borrell-Pages, M., Fernandez-Larrea, J., Borroto, A., Rojo, F., Baselga, J. Arribas, J., 2000, The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein. Mol Biol Cell. 11:(12): 4217–25.
Borrell-Pages, M., Rojo, F., Albanell, J., Baselga, J. Arribas, J., 2003, TACE is required for the activation of the EGFR by TGF-alpha in tumors. Embo J. 22:(5): 1114–24.
Borroto, A., Ruiz-Paz, S., de la Torre, T. V., Borrell-Pages, M., Merlos-Suarez, A., Pandiella, A., Blobel, C. P., Baselga, J. Arribas, J., 2003, Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding. J Biol Chem. 278:(28): 25933–9.
Bosenberg, M. W., Pandiella, A. Massague, J., 1992, The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGF alpha into soluble growth factor. Cell. 71:(7): 1157–65.
Brakebusch, C., Varfolomeev, E. E., Batkin, M. Wallach, D., 1994, Structural requirements for inducible shedding of the p55 tumor necrosis factor receptor. J Biol Chem. 269:(51): 32488–96.
Budagian, V., Bulanova, E., Orinska, Z., Ludwig, A., Rose-John, S., Saftig, P., Borden, E. C. Bulfone-Paus, S., 2004, Natural soluble IL-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17). J Biol Chem. 279:(39): 40368–75
Buxbaum, J. D., Gandy, S. E., Cicchetti, P., Ehrlich, M. E., Czernik, A. J., Fracasso, R. P., Ramabhadran, T. V., Unterbeck, A. J. Greengard, P., 1990, Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci U S A. 87:(15): 6003–6.
Buxbaum, J. D., Oishi, M., Chen, H. I., Pinkas-Kramarski, R., Jaffe, E. A., Gandy, S. E. Greengard, P., 1992, Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc Natl Acad Sci U S A. 89:(21): 10075–8.
Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P. Black, R. A., 1998, Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem. 273:(43): 27765–7.
Bzowska, M., Jura, N., Lassak, A., Black, R. A. Bereta, J., 2004, Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells. Eur J Biochem. 271:(13): 2808–20.
Contin, C., Pitard, V., Itai, T., Nagata, S., Moreau, J. F. Dechanet-Merville, J., 2003, Membrane-anchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling. J Biol Chem. 278:(35): 32801–9.
Daub, H., Weiss, F. U., Wallasch, C. Ullrich, A., 1996, Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature. 379:(6565): 557–60.
Daub, H., Wallasch, C., Lankenau, A., Herrlich, A. Ullrich, A., 1997, Signal characteristics of G protein-transactivated EGF receptor. Embo J. 16:(23): 7032–44.
Diaz-Rodriguez, E., Montero, J. C., Esparis-Ogando, A., Yuste, L. Pandiella, A., 2002, Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. Mol Biol Cell. 13:(6): 2031–44.
Doedens, J. R. and Black, R. A., 2000, Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme. J Biol Chem. 275:(19): 14598–607.
Doedens, J. R., Mahimkar, R. M. Black, R. A., 2003, TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation. Biochem Biophys Res Commun. 308:(2): 331–8.
Dolnik, O., Volchkova, V., Garten, W., Carbonnelle, C., Becker, S., Kahnt, J., Stroher, U., Klenk, H. D. Volchkov, V., 2004, Ectodomain shedding of the glycoprotein GP of Ebola virus. Embo J. 23:(10): 2175–84
Duffy, M. J., Lynn, D. J., Lloyd, A. T. O’Shea, C. M., 2003, The ADAMs family of proteins: from basic studies to potential clinical applications. Thromb Haemost. 89:(4): 622–31.
Endres, K., Anders, A., Kojro, E., Gilbert, S., Fahrenholz, F. Postina, R., 2003, Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation. Eur J Biochem. 270:(11): 2386–93.
Fan, H. and Derynck, R., 1999, Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. Embo J. 18:(24): 6962–72.
Fan, H., Turck, C. W. Derynck, R., 2003, Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. J Biol Chem. 278:(20): 18617–27.
Fischer, O. M., Hart, S., Gschwind, A., Prenzel, N. Ullrich, A., 2004, Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor. Mol Cell Biol. 24:(12): 5172–83.
Fourie, A. M., Coles, F., Moreno, V. Karlsson, L., 2003, Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. J Biol Chem. 278:(33): 30469–77.
Franzke, C. W., Tasanen, K., Schacke, H., Zhou, Z., Tryggvason, K., Mauch, C., Zigrino, P., Sunnarborg, S., Lee, D. C., Fahrenholz, F. Bruckner-Tuderman, L., 2002, Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs. Embo J. 21:(19): 5026–35.
Garton, K. J., Gough, P. J., Blobel, C. P., Murphy, G., Greaves, D. R., Dempsey, P. J. Raines, E. W., 2001, Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem. 276:(41): 37993–8001.
Garton, K. J., Gough, P. J., Philalay, J., Wille, P. T., Blobel, C. P., Whitehead, R. H., Dempsey, P. J. Raines, E. W., 2003, Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17). J Biol Chem. 278:(39): 37459–64.
Gechtman, Z., Alonso, J. L., Raab, G., Ingber, D. E. Klagsbrun, M., 1999, The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading. J Biol Chem. 274:(40): 28828–35.
Gonzales, P. E., Solomon, A., Miller, A. B., Leesnitzer, M. A., Sagi, I. Milla, M. E., 2004, Inhibition of the TNFalpha converting enzyme (TACE) by its Pro domain. J Biol Chem.
Gschwind, A., Hart, S., Fischer, O. M. Ullrich, A., 2003, TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. Embo J. 22:(10): 2411–21.
Guo, L., Eisenman, J. R., Mahimkar, R. M., Peschon, J. J., Paxton, R. J., Black, R. A. Johnson, R. S., 2002, A proteomic approach for the identification of cell-surface proteins shed by metalloproteases. Mol Cell Proteomics. 1:(1): 30–6.
Hansen, H. P., Dietrich, S., Kisseleva, T., Mokros, T., Mentlein, R., Lange, H. H., Murphy, G. Lemke, H., 2000, CD30 shedding from Karpas 299 lymphoma cells is mediated by TNF-alpha-converting enzyme. J Immunol. 165:(12): 6703–9.
Hansen, H. P., Recke, A., Reineke, U., Von Tresckow, B., Borchmann, P., Von Strandmann, E. P., Lange, H., Lemke, H. Engert, A., 2004, The ectodomain shedding of CD30 is specifically regulated by peptide motifs in its cysteine-rich domains 2 and 5. Faseb J. 18:(7): 893–5.
Hart, S., Fischer, O. M. Ullrich, A., 2004, Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor. Cancer Res. 64:(6): 1943–50.
Hartmann, D., de Strooper, B., Serneels, L., Craessaerts, K., Herreman, A., Annaert, W., Umans, L., Lubke, T., Lena Illert, A., von Figura, K. Saftig, P., 2002, The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet. 11:(21): 2615–24.
Hinkle, C. L., Sunnarborg, S. W., Loiselle, D., Parker, C. E., Stevenson, M., Russell, W. E. Lee, D. C., 2004, Selective roles for TACE/ADAM17 in the shedding of the epidermal growth factor receptor ligand family. The juxtamembrane stalk determines cleavage efficiency. J Biol Chem. 279:(23): 24179–88
Hooper, N. M., Karran, E. H. Turner, A. J., 1997, Membrane protein secretases. Biochem J. 321 (Pt 2): 265–79.
Hung, A. Y. and Sheng, M., 2002, PDZ domains: structural modules for protein complex assembly. J Biol Chem. 277:(8): 5699–702.
Itai, T., Tanaka, M. Nagata, S., 2001, Processing of tumor necrosis factor by the membrane-bound TNF-alpha-converting enzyme, but not its truncated soluble form. Eur J Biochem. 268:(7): 2074–82.
Jolly-Tornetta, C. and Wolf, B. A., 2000, Protein kinase C regulation of intracellular and cell surface amyloid precursor protein (APP) cleavage in CHO695 cells. Biochemistry. 39:(49): 15282–90.
Kahn, J., Walcheck, B., Migaki, G. I., Jutila, M. A. Kishimoto, T. K., 1998, Calmodulin regulates L-selectin adhesion molecule expression and function through a protease-dependent mechanism. Cell. 92:(6): 809–18.
Knebel, A., Rahmsdorf, H. J., Ullrich, A. Herrlich, P., 1996, Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. Embo J. 15:(19): 5314–25.
Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C. Fahrenholz, F., 1999, Constitutive and regulated alpha-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A. 96:(7): 3922–7.
Lanni, C., Mazzucchelli, M., Porrello, E., Govoni, S. Racchi, M., 2004, Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein. Eur J Biochem. 271:(14): 3068–75.
Le Gall, S. M., Auger, R., Dreux, C. Mauduit, P., 2003, Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process. J Biol Chem. 278:(46): 45255–68.
Li, X. and Fan, H., 2004, Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE). J Biol Chem. 279:(26): 27365–75
Lopez-Otin, C. and Overall, C. M., 2002, Protease degradomics: a new challenge for proteomics. Nat Rev Mol Cell Biol. 3:(7): 509–19.
Luetteke, N. C., Qiu, T. H., Peiffer, R. L., Oliver, P., Smithies, O. Lee, D. C., 1993, TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell. 73:(2): 263–78.
Mann, G. B., Fowler, K. J., Gabriel, A., Nice, E. C., Williams, R. L. Dunn, A. R., 1993, Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell. 73:(2): 249–61.
Maskos, K., Fernandez-Catalan, C., Huber, R., Bourenkov, G. P., Bartunik, H., Ellestad, G. A., Reddy, P., Wolfson, M. F., Rauch, C. T., Castner, B. J., Davis, R., Clarke, H. R., Petersen, M., Fitzner, J. N., Cerretti, D. P., March, C. J., Paxton, R. J., Black, R. A. Bode, W., 1998, Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. Proc Natl Acad Sci U S A. 95:(7): 3408–12.
Massague, J. and Pandiella, A., 1993, Membrane-anchored growth factors. Annu Rev Biochem. 62: 515–41.
Matthews, V., Schuster, B., Schutze, S., Bussmeyer, I., Ludwig, A., Hundhausen, C., Sadowski, T., Saftig, P., Hartmann, D., Kallen, K. J. Rose-John, S., 2003, Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem. 278:(40): 38829–39.
McGeehan, G. M., Becherer, J. D., Bast, R. C., Jr., Boyer, C. M., Champion, B., Connolly, K. M., Conway, J. G., Furdon, P., Karp, S., Kidao, S. et al., 1994, Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor. Nature. 370:(6490): 558–61.
Merlos-Suarez, A., Fernandez-Larrea, J., Reddy, P., Baselga, J. Arribas, J., 1998, Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing. J Biol Chem. 273:(38): 24955–62.
Merlos-Suarez, A., Ruiz-Paz, S., Baselga, J. Arribas, J., 2001, Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme. J Biol Chem. 276:(51): 48510–7.
Mezyk, R., Bzowska, M. Bereta, J., 2003, Structure and functions of tumor necrosis factor-alpha converting enzyme. Acta Biochim Pol. 50:(3): 625–45.
Miettinen, P. J., Berger, J. E., Meneses, J., Phung, Y., Pedersen, R. A., Werb, Z. Derynck, R., 1995, Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 376:(6538): 337–41.
Milla, M. E., Leesnitzer, M. A., Moss, M. L., Clay, W. C., Carter, H. L., Miller, A. B., Su, J. L., Lambert, M. H., Willard, D. H., Sheeley, D. M., Kost, T. A., Burkhart, W., Moyer, M., Blackburn, R. K., Pahel, G. L., Mitchell, J. L., Hoffman, C. R. Becherer, J. D., 1999, Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE). J Biol Chem. 274:(43): 30563–70.
Mizui, Y., Yamazaki, K., Sagane, K. Tanaka, I., 1999, cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter. Gene. 233:(1–2): 67–74.
Mohan, M. J., Seaton, T., Mitchell, J., Howe, A., Blackburn, K., Burkhart, W., Moyer, M., Patel, I., Waitt, G. M., Becherer, J. D., Moss, M. L. Milla, M. E., 2002, The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. Biochemistry. 41:(30): 9462–9.
Montero, J. C., Yuste, L., Diaz-Rodriguez, E., Esparis-Ogando, A. Pandiella, A., 2000, Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor-alpha-converting enzyme. Mol Cell Neurosci. 16:(5): 631–48.
Montero, J. C., Yuste, L., Diaz-Rodriguez, E., Esparis-Ogando, A. Pandiella, A., 2002, Mitogen-activated protein kinase-dependent and-independent routes control shedding of transmembrane growth factors through multiple secretases. Biochem J. 363: (Pt 2): 211–21.
Moss, M. L., Jin, S. L., Milla, M. E., Bickett, D. M., Burkhart, W., Carter, H. L., Chen, W. J., Clay, W. C., Didsbury, J. R., Hassler, D., Hoffman, C. R., Kost, T. A., Lambert, M. H., Leesnitzer, M. A., McCauley, P., McGeehan, G., Mitchell, J., Moyer, M., Pahel, G., Rocque, W., Overton, L. K., Schoenen, F., Seaton, T., Su, J. L., Becherer, J. D. et al., 1997, Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature. 385:(6618): 733–6.
Moss, M. L. and Lambert, M. H., 2002, Shedding of membrane proteins by ADAM family proteases. Essays Biochem. 38: 141–53.
Mullberg, J., Schooltink, H., Stoyan, T., Heinrich, P. C. Rose-John, S., 1992, Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor. Biochem Biophys Res Commun. 189:(2): 794–800.
Mullberg, J., Oberthur, W., Lottspeich, F., Mehl, E., Dittrich, E., Graeve, L., Heinrich, P. C. Rose-John, S., 1994, The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site. J Immunol. 152:(10): 4958–68.
Mullberg, J., Althoff, K., Jostock, T. Rose-John, S., 2000, The importance of shedding of membrane proteins for cytokine biology. Eur Cytokine Netw. 11:(1): 27–38.
Nagano, O., Murakami, D., Hartmann, D., De Strooper, B., Saftig, P., Iwatsubo, T., Nakajima, M., Shinohara, M. Saya, H., 2004, Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation. J Cell Biol. 165:(6): 893–902.
Nelson, K. K., Schlondorff, J. Blobel, C. P., 1999, Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. Biochem J. 343 Pt 3: 673–80.
Pan, B., Farrugia, A. N., To, L. B., Findlay, D. M., Green, J., Lynch, K. Zannettino, A. C., 2004, The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). J Bone Mine Res. 19:(1): 147–54.
Pandiella, A. and Massague, J., 1991, Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process. Proc Natl Acad Sci U S A. 88:(5): 1726–30.
Patel, I. R., Attur, M. G., Patel, R. N., Stuchin, S. A., Abagyan, R. A., Abramson, S. B. Amin, A. R., 1998, TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. J Immunol. 160:(9): 4570–9.
Peiretti, F., Canault, M., Deprez-Beauclair, P., Berthet, V., Bonardo, B., Juhan-Vague, I. Nalbone, G., 2003a, Intracellular maturation and transport of tumor necrosis factor alpha converting enzyme. Exp Cell Res. 285:(2): 278–85.
Peiretti, F., Deprez-Beauclair, P., Bonardo, B., Aubert, H., Juhan-Vague, I. Nalbone, G., 2003b, Identification of SAP97 as an intracellular binding partner of TACE. J Cell Sci. 116: (Pt 10): 1949–57.
Peschon, J. J., Slack, J. L., Reddy, P., Stocking, K. L., Sunnarborg, S. W., Lee, D. C., Russell, W. E., Castner, B. J., Johnson, R. S., Fitzner, J. N., Boyce, R. W., Nelson, N., Kozlosky, C. J., Wolfson, M. F., Rauch, C. T., Cerretti, D. P., Paxton, R. J., March, C. J. Black, R. A., 1998, An essential role for ectodomain shedding in mammalian development. Science. 282:(5392): 1281–4.
Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C. Ullrich, A., 1999, EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature. 402:(6764): 884–8.
Reddy, P., Slack, J. L., Davis, R., Cerretti, D. P., Kozlosky, C. J., Blanton, R. A., Shows, D., Peschon, J. J. Black, R. A., 2000, Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme. J Biol Chem. 275:(19): 14608–14.
Russell, R. G. and Rogers, M. J., 1999, Bisphosphonates: from the laboratory to the clinic and back again. Bone. 25:(1): 97–106.
Sahin, U., Weskamp, G., Kelly, K., Zhou, H. M., Higashiyama, S., Peschon, J., Hartmann, D., Saftig, P. Blobel, C. P., 2004, Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol. 164:(5): 769–79.
Schantl, J. A., Roza, M., Van Kerkhof, P. Strous, G. J., 2004, The growth hormone receptor interacts with its sheddase, the tumour necrosis factor-alpha-converting enzyme (TACE). Biochem J. 377: (Pt 2): 379–84.
Schlondorff, J. and Blobel, C. P., 1999, Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J Cell Sci. 112 (Pt 21): 3603–17.
Schlondorff, J., Becherer, J. D. Blobel, C. P., 2000, Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE). Biochem J. 347 Pt 1: 131–8.
Schlondorff, J., Lum, L. Blobel, C. P., 2001, Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase. J Biol Chem. 276:(18): 14665–74.
Sibilia, M. and Wagner, E. F., 1995, Strain-dependent epithelial defects in mice lacking the EGF receptor. Science. 269:(5221): 234–8.
Slack, B. E., Ma, L. K. Seah, C. C., 2001, Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme. Biochem J. 357: (Pt 3): 787–94.
Srour, N., Lebel, A., McMahon, S., Fournier, I., Fugere, M., Day, R. Dubois, C. M., 2003, TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity. FEBS Lett. 554:(3): 275–83.
Tanaka, M., Nanba, D., Mori, S., Shiba, F., Ishiguro, H., Yoshino, K., Matsuura, N. Higashiyama, S., 2004, ADAM-binding protein eve-1 is required for Ectodomain shedding of EGF receptor ligands. J Biol Chem. ‘in press’.
Teixido, J., Wong, S. T., Lee, D. C. Massague, J., 1990, Generation of transforming growth factor-alpha from the cell surface by an O-glycosylation-independent multistep process. J Biol Chem. 265:(11): 6410–5.
Thabard, W., Collette, M., Bataille, R. Amiot, M., 2001, Protein kinase C delta and eta isoenzymes control the shedding of the interleukin 6 receptor alpha in myeloma cells. Biochem J. 358: (Pt 1): 193–200.
Thathiah, A., Blobel, C. P. Carson, D. D., 2003, Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding. J Biol Chem. 278:(5): 3386–94.
Thathiah, A. and Carson, D. D., 2004, MT1-MMP mediates MUC1 shedding independently of TACE/ADAM17. Biochem J. 382: Pt1: 363–73
Tsou, C. L., Haskell, C. A. Charo, I. F., 2001, Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine. J Biol Chem. 276:(48): 44622–6.
Villanueva de la Torre, T., Bech-Serra, J. J., Ruiz-Paz, S., Baselga, J. Arribas, J., 2004, Inactivating mutations block the tumor necrosis factor-alpha-converting enzyme in the early secretory pathway. Biochem Biophyhs Res Commun. 314:(4): 1028–35.
Vincent, B., Paitel, E., Saftig, P., Frobert, Y., Hartmann, D., De Strooper, B., Grassi, J., Lopez-Perez, E. Checler, F., 2001, The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. J Biol Chem. 276:(41): 37743–6.
von Tresckow, B., Kallen, K. J., von Strandmann, E. P., Borchmann, P., Lange, H., Engert, A. Hansen, H. P., 2004, Depletion of cellular cholesterol and lipid rafts increases shedding of CD30. J Immunol. 172:(7): 4324–31.
Wang, K. Y., Arima, N., Higuchi, S., Shimajiri, S., Tanimoto, A., Murata, Y., Hamada, T. Sasaguri, Y., 2000, Switch of histamine receptor expression from H2 to H1 during differentiation of monocytes into macrophages. FEBS Lett. 473:(3): 345–8.
Wang, X., He, K., Gerhart, M., Huang, Y., Jiang, J., Paxton, R. J., Yang, S., Lu, C., Menon, R. K., Black, R. A., Baumann, G. Frank, S. J., 2002, Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site. J Biol Chem. 277:(52): 50510–9.
Weiss, F. U., Daub, H. Ullrich, A., 1997, Novel mechanisms of RTK signal generation. Curr Opin Genet Dev. 7:(1): 80–6.
Weskamp, G., Schlondorff, J., Lum, L., Becherer, J. D., Kim, T. W., Saftig, P., Hartmann, D., Murphy, G. Blobel, C. P., 2004, Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J Biol Chem. 279:(6): 4241–9.
Wheeler, D. L., Ness, K. J., Oberley, T. D. Verma, A. K., 2003, Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. Cancer Res. 63:(19): 6547–55.
Yan, Y., Shirakabe, K. Werb, Z., 2002, The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol. 158:(2): 221–6.
Yarden, Y. and Sliwkowski, M. X., 2001, Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2:(2): 127–37.
Zeng, Y. X., Somasundaram, K. el-Deiry, W. S., 1997, AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression. Nat Genet. 15:(1): 78–82.
Zhang, Z., Kolls, J. K., Oliver, P., Good, D., Schwarzenberger, P. O., Joshi, M. S., Ponthier, J. L. Lancaster, J. R., Jr., 2000, Activation of tumor necrosis factor-alpha-converting enzyme-mediated ectodomain shedding by nitric oxide. J Biol Chem. 275:(21): 15839–44.
Zhang, Z., Oliver, P., Lancaster, J. J., Schwarzenberger, P. O., Joshi, M. S., Cork, J. Kolls, J. K., 2001, Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate. Faseb J. 15:(2): 303–5.
Zhao, L., Shey, M., Farnsworth, M. Dailey, M. O., 2001, Regulation of membrane metalloproteolytic cleavage of L-selectin (CD62l) by the epidermal growth factor domain. J Biol Chem. 276:(33): 30631–40.
Zheng, Y., Schlondorff, J. Blobel, C. P., 2002, Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem. 277:(45): 42463–70.
Zhou, A., Webb, G., Zhu, X. Steiner, D. F., 1999, Proteolytic processing in the secretory pathway. J Biol Chem. 274:(30): 20745–8.
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Arribas, J., Ruiz-Paz, S. (2005). ADAM 17. In: Hooper, N.M., Lendeckel, U. (eds) The ADAM Family of Proteases. Proteases in Biology and Disease, vol 4. Springer, Boston, MA. https://doi.org/10.1007/0-387-25151-0_8
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